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Biosci. (Landmark Ed)"],"abstract":"<jats:p>Myocardial infarction (MI) remains a major cause of global morbidity and mortality, with post-MI inflammation significantly exacerbating tissue damage and adverse cardiac remodeling. Recent advancements have highlighted the gut microbiota as a crucial regulator of cardiovascular health via the gut-heart axis. This review introduces a novel therapeutic perspective by exploring the potential mechanisms through which fucoidan, a sulfated polysaccharide derived from marine algae, may alleviate post-MI inflammation. Fucoidan demonstrates unique anti-inflammatory and antioxidant properties and has been shown to modulate the gut microbiota. Specifically, it enhances the abundance of beneficial gut bacteria, boosts short-chain fatty acids (SCFA) production, and reduces bacterial endotoxin translocation. Additionally, fucoidan directly inhibits inflammatory signaling pathways, decreases pro-inflammatory cytokine secretion, and protects cardiomyocytes through antioxidant effects. These multifaceted actions position fucoidan as a promising novel therapeutic strategy for mitigating post-MI inflammation and promoting cardiac recovery. Future research should focus on optimizing fucoidan extraction methods, identifying effective dosing regimens, and developing targeted delivery systems to maximize clinical efficacy.<\/jats:p>","DOI":"10.31083\/fbl41364","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:35:31Z","timestamp":1788438931000},"source":"Crossref","is-referenced-by-count":0,"title":["Fucoidan: Modulating Post-Myocardial Infarction Inflammation via the Gut-Heart Axis"],"prefix":"10.31083","volume":"31","author":[{"given":"Yuan","family":"Zou","sequence":"first","affiliation":[{"name":"School of Integrated Traditional and Western Medicine, Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-164X","authenticated-orcid":true,"given":"Mowei","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Chang SA, Kang HJ, Lee HY, Kim KH, Hur J, Han KS, et al. 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