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(Landmark Ed)"],"abstract":"<jats:p>Overnutrition, and specifically a high-fat diet (HFD) in which more than 30% of energy intake is derived from fat, has been unequivocally identified as a modifiable risk factor for several major diseases including osteoporosis, cardiovascular disorders, diabetes, and metabolic syndrome. The continued rise in prevalence of osteoporosis, particularly among younger populations, along with widespread adoption of HFD, has made the underlying mechanisms and preventative strategies related to HFD-induced osteoporosis a primary focus in the field of bone metabolism research. Early studies suggested that HFD-mediated weight gain might confer protective effects on skeletal health. However, emerging evidence reveals that HFD disrupts bone metabolic homeostasis and accelerates the progression of osteoporosis through multiple pathways, including pathological expansion of adipose tissue, systemic chronic inflammation, and gut microbial dysbiosis. The gut microbiota (GM) is a crucial mediator of dietary fat absorption and is increasingly recognized as a pivotal factor in the pathogenesis of HFD-associated osteoporosis. HFD-induced alterations in gut microbial composition and metabolic function compromise intestinal barrier integrity, triggering chronic systemic inflammation and metabolic disturbances that collectively exacerbate bone loss and promote osteoporosis. Targeted microbiota interventions have shown promise in ameliorating bone deterioration, paving the way for innovative therapeutic approaches against HFD-related osteoporosis. This review systematically examines the pathways through which HFD induces osteoporosis via modulation of GM, and evaluates emerging microbiota-focused treatment strategies.<\/jats:p>","DOI":"10.31083\/fbl46209","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:17:49Z","timestamp":1785413869000},"source":"Crossref","is-referenced-by-count":0,"title":["The Role of Gut Microbiota in Osteoporosis Triggered by High-Fat Diets: Mechanisms and Targeted Therapeutic Strategies"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2847-1166","authenticated-orcid":true,"given":"Xinping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China"},{"name":"First Clinical Medical College, Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5060-3835","authenticated-orcid":true,"given":"Lijie","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing, Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China"},{"name":"First Clinical Medical College, Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China"},{"name":"First Clinical Medical College, Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China"},{"name":"First Clinical Medical College, Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-4073","authenticated-orcid":true,"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi, China"},{"name":"First Clinical Medical College, Gannan Medical University, 341000 Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"He Y, Chen Y. The potential mechanism of the microbiota-gut-bone axis in osteoporosis: a review. Osteoporosis International : a Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2022; 33: 2495\u20132506.","DOI":"10.1007\/s00198-022-06557-x"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Pouresmaeili F, Kamalidehghan B, Kamarehei M, Goh YM. A comprehensive overview on osteoporosis and its risk factors. Therapeutics and Clinical Risk Management. 2018; 14: 2029\u20132049.","DOI":"10.2147\/TCRM.S138000"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Zhu X, Zheng H. Factors influencing peak bone mass gain. Frontiers of Medicine. 2021; 15: 53\u201369.","DOI":"10.1007\/s11684-020-0748-y"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"de Villiers TJ, Goldstein SR. Update on bone health: the International Menopause Society White Paper 2021. Climacteric : the Journal of the International Menopause Society. 2021; 24: 498\u2013504.","DOI":"10.1080\/13697137.2021.1950967"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Sheik Ali A. Osteoporosis: A Narrative Review. Cureus. 2023; 15: e43031.","DOI":"10.7759\/cureus.43031"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Qiao J, Wu Y, Ren Y. The impact of a high fat diet on bones: potential mechanisms. Food & Function. 2021; 12: 963\u2013975.","DOI":"10.1039\/d0fo02664f"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 1993; 8: 567\u2013573.","DOI":"10.1002\/jbmr.5650080507"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Shu L, Beier E, Sheu T, Zhang H, Zuscik MJ, Puzas EJ, et al. High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment. Calcified Tissue International. 2015; 96: 313\u2013323.","DOI":"10.1007\/s00223-015-9954-z"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Lu L, Tang M, Li J, Xie Y, Li Y, Xie J, et al. Gut Microbiota and Serum Metabolic Signatures of High-Fat-Induced Bone Loss in Mice. Frontiers in Cellular and Infection Microbiology. 2021; 11: 788576.","DOI":"10.3389\/fcimb.2021.788576"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Rodrigues FG, Ormanji MS, Meca R, Montenegro H, Cuppari L, de Borst MH, et al. 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Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review. Frontiers of Medicine. 2025; 19: 474\u2013492.","DOI":"10.1007\/s11684-025-1129-3"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Imamura F, Micha R, Khatibzadeh S, Fahimi S, Shi P, Powles J, et al. Dietary quality among men and women in 187 countries in 1990 and 2010: a systematic assessment. The Lancet. Global Health. 2015; 3: e132\u2013e142.","DOI":"10.1016\/S2214-109X(14)70381-X"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Martyniak K, Wei F, Ballesteros A, Meckmongkol T, Calder A, Gilbertson T, et al. Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population? Bone. 2021; 143: 115736.","DOI":"10.1016\/j.bone.2020.115736"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Niazi S, Mazloomi M, Ostovar A, Fahimfar N, Nematy H, Rezaie M, et al. Fatty acid dietary intakes and blood concentrations in relation to hip fracture risk in adults: a systematic review and meta-analysis of prospective cohort studies. Osteoporosis International : a Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2025; 36: 2053\u20132069.","DOI":"10.1007\/s00198-025-07587-x"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Wanders AJ, Zock PL, Brouwer IA. Trans Fat Intake and Its Dietary Sources in General Populations Worldwide: A Systematic Review. Nutrients. 2017; 9: 840.","DOI":"10.3390\/nu9080840"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Wang Y, Mi J, Shan XY, Wang QJ, Ge KY. Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China. International Journal of Obesity (2005). 2007; 31: 177\u2013188.","DOI":"10.1038\/sj.ijo.0803354"},{"key":"ref19","unstructured":"Su C, Zhang B, Wang H, Zhang J, Du W, Zhai F. The trends of nutrients intake of Chinese residents in nine provinces from 1989 to 2009.(V) Dietary fat and cholesterol intake trend of Chinese adults aged 18-49 years. Acta Nutrimenta Sinica. 2011; 33: 546\u2013550. (In Chinese)"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Zeng W, Jin Q, Wang X. Reassessing the Effects of Dietary Fat on Cardiovascular Disease in China: A Review of the Last Three Decades. Nutrients. 2023; 15: 4214.","DOI":"10.3390\/nu15194214"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Storz MA, St\u00fcbing F, Huber R. Special Diets and Nutrient Intakes in Morbidly Obese US Adults in Comparison to the 2020-2025 Dietary Guidelines for Americans. Nutrition Journal. 2025; 24: 37.","DOI":"10.1186\/s12937-025-01088-7"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Chen X, Chen B, Li Z, Ma L, Zhu Q, Liu C, et al. The Extract of Camellia Seed Cake Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice by Promoting Coenzyme Q Synthesis. Nutrients. 2025; 17: 1032.","DOI":"10.3390\/nu17061032"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Fattore E, Massa E. Dietary fats and cardiovascular health: a summary of the scientific evidence and current debate. International Journal of Food Sciences and Nutrition. 2018; 69: 916\u2013927.","DOI":"10.1080\/09637486.2018.1455813"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Harcombe Z. US dietary guidelines: is saturated fat a nutrient of concern? British Journal of Sports Medicine. 2019; 53: 1393\u20131396.","DOI":"10.1136\/bjsports-2018-099420"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Stocks T, Taylor MA, Angquist L, Macdonald IA, Arner P, Holst C, et al. Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors. Obesity Facts. 2013; 6: 217\u2013227.","DOI":"10.1159\/000351726"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Tremblay AJ, Lamarche B, Guay V, Charest A, Lemelin V, Couture P. Short-term, high-fat diet increases the expression of key intestinal genes involved in lipoprotein metabolism in healthy men. The American Journal of Clinical Nutrition. 2013; 98: 32\u201341.","DOI":"10.3945\/ajcn.113.060251"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Osterberg KL, Boutagy NE, McMillan RP, Stevens JR, Frisard MI, Kavanaugh JW, et al. Probiotic supplementation attenuates increases in body mass and fat mass during high-fat diet in healthy young adults. Obesity (Silver Spring, Md.). 2015; 23: 2364\u20132370.","DOI":"10.1002\/oby.21230"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Corwin RL, Hartman TJ, Maczuga SA, Graubard BI. Dietary saturated fat intake is inversely associated with bone density in humans: analysis of NHANES III. The Journal of Nutrition. 2006; 136: 159\u2013165.","DOI":"10.1093\/jn\/136.1.159"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Woods GN, Ewing SK, Schafer AL, Gudnason V, Sigurdsson S, Lang T, et al. Saturated and Unsaturated Bone Marrow Lipids Have Distinct Effects on Bone Density and Fracture Risk in Older Adults. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 2022; 37: 700\u2013710.","DOI":"10.1002\/jbmr.4504"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Omer M, Ali H, Orlovskaya N, Ballesteros A, Cheong VS, Martyniak K, et al. Omega-9 Modifies Viscoelasticity and Augments Bone Strength and Architecture in a High-Fat Diet-Fed Murine Model. Nutrients. 2022; 14: 3165.","DOI":"10.3390\/nu14153165"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"LLabre JE, Sroga GE, Tice MJL, Vashishth D. Induction and rescue of skeletal fragility in a high-fat diet mouse model of type 2 diabetes: An in vivo and in vitro approach. Bone. 2022; 156: 116302.","DOI":"10.1016\/j.bone.2021.116302"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Bielohuby M, Matsuura M, Herbach N, Kienzle E, Slawik M, Hoeflich A, et al. Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 2010; 25: 275\u2013284.","DOI":"10.1359\/jbmr.090813"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Minematsu A, Nishii Y, Sakata S. High-fat\/high-sucrose diet results in higher bone mass in aged rats. Bone Reports. 2018; 8: 18\u201324.","DOI":"10.1016\/j.bonr.2018.01.001"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Vandewalle S, Taes Y, Van Helvoirt M, Debode P, Herregods N, Ernst C, et al. Bone size and bone strength are increased in obese male adolescents. The Journal of Clinical Endocrinology and Metabolism. 2013; 98: 3019\u20133028.","DOI":"10.1210\/jc.2012-3914"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Kim HY, Jung HW, Hong H, Kim JH, Shin CH, Yang SW, et al. The Role of Overweight and Obesity on Bone Health in Korean Adolescents with a Focus on Lean and Fat Mass. Journal of Korean Medical Science. 2017; 32: 1633\u20131641.","DOI":"10.3346\/jkms.2017.32.10.1633"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Wee NKY, Enriquez RF, Nguyen AD, Horsnell H, Kulkarni R, Khor EC, et al. Diet-induced obesity suppresses cortical bone accrual by a neuropeptide Y-dependent mechanism. International Journal of Obesity (2005). 2018; 42: 1925\u20131938.","DOI":"10.1038\/s41366-018-0028-y"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Rinonapoli G, Pace V, Ruggiero C, Ceccarini P, Bisaccia M, Meccariello L, et al. Obesity and Bone: A Complex Relationship. International Journal of Molecular Sciences. 2021; 22: 13662.","DOI":"10.3390\/ijms222413662"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Kato I, Toniolo P, Zeleniuch-Jacquotte A, Shore RE, Koenig KL, Akhmedkhanov A, et al. Diet, smoking and anthropometric indices and postmenopausal bone fractures: a prospective study. International Journal of Epidemiology. 2000; 29: 85\u201392.","DOI":"10.1093\/ije\/29.1.85"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Ma X, Tian M, Liu J, Tong L, Ding W. Impact of high fat and low lean mass phenotype on bone mineral content: A cross-sectional study of Chinese adolescent population. Bone. 2024; 186: 117170.","DOI":"10.1016\/j.bone.2024.117170"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Varley I, James LJ, Willis SA, King JA, Clayton DJ. One week of high-fat overfeeding alters bone metabolism in healthy males: A pilot study. Nutrition (Burbank, Los Angeles County, Calif.). 2022; 96: 111589.","DOI":"10.1016\/j.nut.2022.111589"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Tencerova M, Figeac F, Ditzel N, Taipaleenm\u00e4ki H, Nielsen TK, Kassem M. High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 2018; 33: 1154\u20131165.","DOI":"10.1002\/jbmr.3408"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Tang L, Yang X, Gao X, Du H, Han Y, Zhang D, et al. Inhibiting myostatin signaling prevents femoral trabecular bone loss and microarchitecture deterioration in diet-induced obese rats. Experimental Biology and Medicine (Maywood, N.J.). 2016; 241: 308\u2013316.","DOI":"10.1177\/1535370215606814"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Montalvany-Antonucci CC, Zicker MC, Ferreira AVM, Macari S, Ramos-Junior ES, Gomez RS, et al. High-fat diet disrupts bone remodeling by inducing local and systemic alterations. The Journal of Nutritional Biochemistry. 2018; 59: 93\u2013103.","DOI":"10.1016\/j.jnutbio.2018.06.006"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Sato K, Yamazaki K, Kato T, Nakanishi Y, Tsuzuno T, Yokoji-Takeuchi M, et al. Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid. mbio. 2021; 12: e0077121.","DOI":"10.1128\/mBio.00771-21"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Zheng LC, Chen RX, Wang NN, Wang M, Qian J, Li LL, et al. Effects of obesity on alveolar bone resorption and gut microbiota in periodontitis mice. Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology. 2025; 60: 482\u2013491.","DOI":"10.3760\/cma.j.cn112144-20241222-00502"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Khan J, Sadie-Van Gijsen H, Kotz\u00e9-H\u00f6rstmann LM, Kotze SH, Layman-Lemphane JI. Characterisation of the influence of dietary fat and sugar on bone health utilising densitometry, micro-computed tomography and histomorphometry. Bone. 2025; 192: 117380.","DOI":"10.1016\/j.bone.2024.117380"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Yang Y, Feng X, Zhang Y, Sun Y, Xu J, Chen J. Effect of high-fat diet on osteoporosis in mice of different ages. Chinese Journal of Osteoporosis. 2022; 28: 1571\u20131576.  (In Chinese)","DOI":"10.3969\/j.issn.1006-7108.2022.11.002"},{"key":"ref48","unstructured":"Fan J, Jiang Y, Zhang Q. Relationship between abnormal infiltration of bone marrow fat and senile osteoporosis. Chinese Journal of Osteoporosis and Bone Mineral Research. 2022; 15: 66\u201373. (In Chinese)"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Hafner H, Chang E, Carlson Z, Zhu A, Varghese M, Clemente J, et al. Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring. Nutrients. 2019; 11: 1393.","DOI":"10.3390\/nu11061393"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Dong X, Bi L, He S, Meng G, Wei B, Jia S, et al. FFAs-ROS-ERK\/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in co-culture. Biochimie. 2014; 101: 123\u2013131.","DOI":"10.1016\/j.biochi.2014.01.002"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Al Saedi A, Bermeo S, Plotkin L, Myers DE, Duque G. Mechanisms of palmitate-induced lipotoxicity in osteocytes. Bone. 2019; 127: 353\u2013359.","DOI":"10.1016\/j.bone.2019.06.016"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Yeh LCC, Ford JJ, Lee JC, Adamo ML. Palmitate attenuates osteoblast differentiation of fetal rat calvarial cells. Biochemical and Biophysical Research Communications. 2014; 450: 777\u2013781.","DOI":"10.1016\/j.bbrc.2014.06.063"},{"key":"ref53","unstructured":"Wang X, Li M, Wang L, Yu B, Hua Y. Establishment of a lipotoxic inhibition model of bone formation in zebrafish induced by palmitic acid. Acta Laboratorium Animalis Scientia Sinica. 2024; 32: 461\u2013467. (In Chinese)"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Gunaratnam K, Vidal C, Gimble JM, Duque G. Mechanisms of palmitate-induced lipotoxicity in human osteoblasts. Endocrinology. 2014; 155: 108\u2013116.","DOI":"10.1210\/en.2013-1712"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Yang L, Guan G, Lei L, Lv Q, Liu S, Zhan X, et al. Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy. Cell Stress & Chaperones. 2018; 23: 1283\u20131294.","DOI":"10.1007\/s12192-018-0936-8"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Gillet C, Spruyt D, Rigutto S, Dalla Valle A, Berlier J, Louis C, et al. Oleate Abrogates Palmitate-Induced Lipotoxicity and Proinflammatory Response in Human Bone Marrow-Derived Mesenchymal Stem Cells and Osteoblastic Cells. Endocrinology. 2015; 156: 4081\u20134093.","DOI":"10.1210\/en.2015-1303"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Yaghooti H, Mohammadtaghvaei N, Mahboobnia K. Effects of palmitate and astaxanthin on cell viability and proinflammatory characteristics of mesenchymal stem cells. International Immunopharmacology. 2019; 68: 164\u2013170.","DOI":"10.1016\/j.intimp.2018.12.063"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Sardar A, Rai D, Tripathi AK, Chutani K, Sinha S, Dhaniya G, et al. FDA-approved polypeptide PTH 1-34 impedes palmitic acid-mediated osteoblasts dysfunction by promoting its differentiation and thereby improving skeletal health. Molecular and Cellular Endocrinology. 2025; 597: 112445.","DOI":"10.1016\/j.mce.2024.112445"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Al Saedi A, Myers DE, Stupka N, Duque G. 1,25(OH)2D3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function. Bone. 2020; 141: 115672.","DOI":"10.1016\/j.bone.2020.115672"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Mazi\u00e8re C, Louvet L, Gomila C, Kamel S, Massy Z, Mazi\u00e8re JC. Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. Journal of Cellular Physiology. 2009; 221: 572\u2013578.","DOI":"10.1002\/jcp.21886"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Sul OJ, Kim JE, Ke K, Suh JH, Choi HS. Atherogenic diet-induced bone loss is primarily due to increased osteoclastogenesis in mice. 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Serum leptin levels negatively correlate with trabecular bone mineral density in high-fat diet-induced obesity mice. Journal of Musculoskeletal & Neuronal Interactions. 2012; 12: 84\u201394."},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"Shen CL, Chen L, Wang S, Chyu MC. Effects of dietary fat levels and feeding durations on musculoskeletal health in female rats. Food & Function. 2014; 5: 598\u2013604.","DOI":"10.1039\/c3fo60334b"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"Yue R, Zhou BO, Shimada IS, Zhao Z, Morrison SJ. Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow. Cell Stem Cell. 2016; 18: 782\u2013796.","DOI":"10.1016\/j.stem.2016.02.015"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"G\u0142ogowska-Szel\u0105g J, Kos-Kud\u0142a B, Marek B, Nowak M, Siemi\u0144ska L. Assessment of selected adipocytokines in obese women with postmenopausal osteoporosis. 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Activation of TGR5 promotes osteoblastic cell differentiation and mineralization. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2018; 108: 1797\u20131803.","DOI":"10.1016\/j.biopha.2018.08.093"},{"key":"ref136","doi-asserted-by":"publisher","unstructured":"Li Z, Huang J, Wang F, Li W, Wu X, Zhao C, et al. Dual Targeting of Bile Acid Receptor-1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen-Dependent Bone Loss in Mice. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 2019; 34: 765\u2013776.","DOI":"10.1002\/jbmr.3652"},{"key":"ref137","doi-asserted-by":"publisher","unstructured":"Ushiroda C, Naito Y, Takagi T, Uchiyama K, Mizushima K, Higashimura Y, et al. Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice. Journal of Clinical Biochemistry and Nutrition. 2019; 65: 34\u201346.","DOI":"10.3164\/jcbn.18-116"},{"key":"ref138","doi-asserted-by":"publisher","unstructured":"Carson MD, Warner AJ, Hathaway-Schrader JD, Geiser VL, Kim J, Gerasco JE, et al. Minocycline-induced disruption of the intestinal FXR\/FGF15 axis impairs osteogenesis in mice. JCI Insight. 2023; 8: e160578.","DOI":"10.1172\/jci.insight.160578"},{"key":"ref139","doi-asserted-by":"publisher","unstructured":"Zheng X, Xu X, Liu M, Yang J, Yuan M, Sun C, et al. Bile acid and short chain fatty acid metabolism of gut microbiota mediate high-fat diet induced intestinal barrier damage in Macrobrachium rosenbergii. Fish & Shellfish Immunology. 2024; 146: 109376.","DOI":"10.1016\/j.fsi.2024.109376"},{"key":"ref140","doi-asserted-by":"publisher","unstructured":"Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. 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Behavioural Neurology. 2022; 2022: 6711160.","DOI":"10.1155\/2022\/6711160"},{"key":"ref147","doi-asserted-by":"publisher","unstructured":"Ma R, Wang L, Zhao B, Liu C, Liu H, Zhu R, et al. Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A\/IGF-1\/\u03b2-Catenin in Rats. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2017; 41: 55\u201366.","DOI":"10.1159\/000455936"},{"key":"ref148","doi-asserted-by":"publisher","unstructured":"Fan Y, Lyu L, Vazquez-Uribe R, Zhang W, Bongers M, Koulouktsis A, et al. Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism. Nature Microbiology. 2025; 10: 1918\u20131939.","DOI":"10.1038\/s41564-025-02064-x"},{"key":"ref149","doi-asserted-by":"publisher","unstructured":"Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. 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Lactobacillus rhamnosus Strain LRH05 Intervention Ameliorated Body Weight Gain and Adipose Inflammation via Modulating the Gut Microbiota in High-Fat Diet-Induced Obese Mice. Molecular Nutrition & Food Research. 2022; 66: e2100348.","DOI":"10.1002\/mnfr.202100348"},{"key":"ref163","doi-asserted-by":"publisher","unstructured":"Lindsey RC, Rundle CH, Mohan S. Role of IGF1 and EFN-EPH signaling in skeletal metabolism. Journal of Molecular Endocrinology. 2018; 61: T87\u2013T102.","DOI":"10.1530\/JME-17-0284"},{"key":"ref164","doi-asserted-by":"publisher","unstructured":"Wein MN, Kronenberg HM. Regulation of Bone Remodeling by Parathyroid Hormone. Cold Spring Harbor Perspectives in Medicine. 2018; 8: a031237.","DOI":"10.1101\/cshperspect.a031237"},{"key":"ref165","doi-asserted-by":"publisher","unstructured":"Fern\u00e1ndez-Murga ML, Olivares M, Sanz Y. Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis. 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Immunity. 2018; 49: 1116\u20131131.e7.","DOI":"10.1016\/j.immuni.2018.10.013"},{"key":"ref169","doi-asserted-by":"publisher","unstructured":"Zhong S, Huang L, Lin T, Li Y, Deng B, Kong D, et al. The Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Liraglutide Regulates Sirtuin-1-Mediated Neutrophil Extracellular Traps to Improve Diabetes-Induced Bone Metabolism Imbalance. Iranian Journal of Pharmaceutical Research : IJPR. 2024; 23: e148139.","DOI":"10.5812\/ijpr-148139"},{"key":"ref170","doi-asserted-by":"publisher","unstructured":"Xue Y, Li R, Zhao Y, Li L, Zhou Y. Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats. BMC Endocrine Disorders. 2021; 21: 173.","DOI":"10.1186\/s12902-021-00843-1"},{"key":"ref171","doi-asserted-by":"publisher","unstructured":"Schett G. Effects of inflammatory and anti-inflammatory cytokines on the bone. European Journal of Clinical Investigation. 2011; 41: 1361\u20131366.","DOI":"10.1111\/j.1365-2362.2011.02545.x"},{"key":"ref172","doi-asserted-by":"publisher","unstructured":"Wang X, Zhang C, Zhao G, Yang K, Tao L. Obesity and lipid metabolism in the development of osteoporosis (Review). International Journal of Molecular Medicine. 2024; 54: 61.","DOI":"10.3892\/ijmm.2024.5385"},{"key":"ref173","doi-asserted-by":"publisher","unstructured":"Zhou M, Li S, Pathak JL. Pro-inflammatory Cytokines and Osteocytes. Current Osteoporosis Reports. 2019; 17: 97\u2013104.","DOI":"10.1007\/s11914-019-00507-z"},{"key":"ref174","doi-asserted-by":"publisher","unstructured":"Srivastava RK, Dar HY, Mishra PK. Immunoporosis: Immunology of Osteoporosis-Role of T Cells. Frontiers in Immunology. 2018; 9: 657.","DOI":"10.3389\/fimmu.2018.00657"},{"key":"ref175","doi-asserted-by":"publisher","unstructured":"Bozec A, Zaiss MM, Kagwiria R, Voll R, Rauh M, Chen Z, et al. 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Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review. Nutrients. 2021; 13: 3211.","DOI":"10.3390\/nu13093211"},{"key":"ref201","doi-asserted-by":"publisher","unstructured":"Chung E, Elmassry MM, Cao JJ, Kaur G, Dufour JM, Hamood AN, et al. Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure in obese mice is associated with suppression of proinflammation and modification of gut microbiome. Nutrition Research (New York, N.Y.). 2021; 93: 27\u201337.","DOI":"10.1016\/j.nutres.2021.07.001"},{"key":"ref202","doi-asserted-by":"publisher","unstructured":"Zhou JH, Ding LJ, Chen W, Wang YF. Green tea catechin epigallocatechin gallate alleviates high-fat diet-induced obesity in mice by regulating the gut-brain axis. 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Food & Function. 2025; 16: 7900\u20137918.","DOI":"10.1039\/d5fo02537k"},{"key":"ref206","doi-asserted-by":"publisher","unstructured":"L\u00f3pez P, S\u00e1nchez M, Perez-Cruz C, Vel\u00e1zquez-Villegas LA, Syeda T, Aguilar-L\u00f3pez M, et al. Long-Term Genistein Consumption Modifies Gut Microbiota, Improving Glucose Metabolism, Metabolic Endotoxemia, and Cognitive Function in Mice Fed a High-Fat Diet. Molecular Nutrition & Food Research. 2018; 62: e1800313.","DOI":"10.1002\/mnfr.201800313"},{"key":"ref207","doi-asserted-by":"publisher","unstructured":"Li J, Li J, Ni J, Zhang C, Jia J, Wu G, et al. Berberine Relieves Metabolic Syndrome in Mice by Inhibiting Liver Inflammation Caused by a High-Fat Diet and Potential Association With Gut Microbiota. Frontiers in Microbiology. 2022; 12: 752512.","DOI":"10.3389\/fmicb.2021.752512"},{"key":"ref208","doi-asserted-by":"publisher","unstructured":"Charoensiddhi S, Kovitvadhi A, Sukmak R, Manatchaiworakul W, Sae-Tan S. 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ACS Omega. 2020; 5: 12865\u201312876.","DOI":"10.1021\/acsomega.0c00649"},{"key":"ref211","doi-asserted-by":"publisher","unstructured":"Zhou P, Wang L, An SY, Wang C, Jiang QY, Li XY. Fabrication of quercetin-loaded nanoparticles based on Hohenbuehelia serotina polysaccharides and their modulatory effects on intestinal function and gut microbiota in vivo. Innovative Food Science & Emerging Technologies. 2022; 78: 102993.","DOI":"10.1016\/j.ifset.2022.102993"},{"key":"ref212","doi-asserted-by":"publisher","unstructured":"Wang Q, Ge G, Liang X, Bai J, Wang W, Zhang W, et al. Punicalagin ameliorates wear-particle-induced inflammatory bone destruction by bi-directional regulation of osteoblastic formation and osteoclastic resorption. Biomaterials Science. 2020; 8: 5157\u20135171.","DOI":"10.1039\/d0bm00718h"},{"key":"ref213","doi-asserted-by":"publisher","unstructured":"Rains TM, Agarwal S, Maki KC. Antiobesity effects of green tea catechins: a mechanistic review. The Journal of Nutritional Biochemistry. 2011; 22: 1\u20137.","DOI":"10.1016\/j.jnutbio.2010.06.006"},{"key":"ref214","doi-asserted-by":"publisher","unstructured":"Shen CL, Elmassry MM, Grue K, Joiner HE, Jacobo AU, Hamood A, et al. Geranylgeraniol and Green Tea Polyphenols Mitigate Negative Effects of a High-Fat Diet on Skeletal Muscle and the Gut Microbiome in Male C57BL\/6J Mice. 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