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Increasing evidence indicates that diet and nutrition play an important role in modulating the outcomes of IBD. Although a wide range of dietary interventions has been explored, no universally effective approach has been established. Investigations have also proven that different dietary interventions can significantly affect clinical outcomes by altering gut microbial composition. This review explores a novel approach to IBD management by integrating gut microbiome modulation into personalized patient diets. The review examines various dietary interventions commonly used in IBD treatment and their impact on the gut microbiome composition. Furthermore, the study proposes a framework for creating personalized nutrition based on individual microbiome profiles. Finally, the review discusses the potential of personalized nutrition as a long-term therapeutic strategy for IBD management, offering insights into its feasibility and implications for patient care.<\/jats:p>","DOI":"10.31083\/fbl47779","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:29:27Z","timestamp":1777454967000},"source":"Crossref","is-referenced-by-count":0,"title":["An Emerging Approach to IBD Treatment: Personalized Nutrition Through Gut Microbiome Optimization"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-9193","authenticated-orcid":true,"given":"Kafayat","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA"},{"name":"Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-4437","authenticated-orcid":true,"given":"Thomas M","family":"Attard","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Children\u2019s Mercy Hospital, Kansas City, MO 64108, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8946-7737","authenticated-orcid":true,"given":"Mazin","family":"Al-Kasspooles","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-6813","authenticated-orcid":true,"given":"Shahid","family":"Umar","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"ref1","unstructured":"McDowell C, Farooq U, Haseeb M. 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