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Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background: Our previous study verified that lipid nephrotoxicity mediated by hypoxia-inducible factor-1 alpha (HIF-1\u03b1) activation aggravates diabetic tubular injury. This study investigated whether emodin, an inhibitor of HIF-1\u03b1, improves tubular injury by reducing lipid accumulation in diabetic tubules, and examined its underlying mechanism. Methods: Type 1 diabetic rats were administered 40 mg\/kg emodin by gavage daily. For the in vitro study, HK-2 cells were pretreated with emodin for 6 h and then stimulated with HIF-1\u03b1 activator cobalt chloride (CoCl2). Results: In vivo, emodin significantly downregulated HIF-1\u03b1 protein expression in the kidneys of rats with diabetes. Emodin treatment substantially attenuated tubular pathological damage and reduced 24-h urinary total protein levels and the urinary albumin-to-creatinine ratio in rats with diabetes, accompanied by decreased expression of transforming growth factor-beta 1 (TGF-\u03b21) and connective tissue growth factor (CTGF). Meanwhile, lipid accumulation and mitochondrial dysfunction in diabetic kidneys markedly improved after emodin treatment. Similarly, in vitro, emodin effectively reduced HIF-1\u03b1 protein expression in CoCl2-treated HK-2 cells. Moreover, emodin ameliorated lipid accumulation, cellular injury, and mitochondrial homeostasis imbalance in these cells. Conclusion: These data demonstrate that emodin prevents lipid accumulation and cellular injury in diabetic tubular epithelial cells, possibly by inhibiting HIF-1\u03b1 activation and exerting a protective effect on mitochondria.<\/jats:p>","DOI":"10.31083\/fbl49862","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:29:27Z","timestamp":1777454967000},"source":"Crossref","is-referenced-by-count":1,"title":["Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1\u03b1 Expression"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6080-7697","authenticated-orcid":true,"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2240-8380","authenticated-orcid":true,"given":"Xue","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8897-3258","authenticated-orcid":true,"given":"Qian-wen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"},{"name":"Department of Clinical Laboratory, Meixian People\u2019s Hospital, 722300 Baoji, Shaanxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6298-6973","authenticated-orcid":true,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7638-3260","authenticated-orcid":true,"given":"Zhi-wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5393-1704","authenticated-orcid":true,"given":"Fang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9550-5402","authenticated-orcid":true,"given":"Shu-qin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5712-2924","authenticated-orcid":true,"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-5946","authenticated-orcid":true,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-4422","authenticated-orcid":true,"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0694-6888","authenticated-orcid":true,"given":"Ze-bo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical University, 241002 Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Sagoo MK, Gnudi L. 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