{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:09:44Z","timestamp":1785190184685,"version":"3.55.0"},"reference-count":48,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Higher Education Scientific Research Project of the Anhui Provincial Department of Education","award":["2024AH050545"],"award-info":[{"award-number":["2024AH050545"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background:Osteoporosis (OP) is a common metabolic bone disease characterized by chronic bone loss and structural deterioration of bone tissue, and it is closely associated with environmental exposure to heavy metals. Although lead (Pb) and iron (Fe) are known to affect bone metabolism, the impact of iron overload under fixed lead exposure, along with the underlying metabolic mechanisms, remains unclear. This study aimed to investigate the effects of combined iron and lead exposure on bone mineral homeostasis and metabolic remodeling.Methods:Male C57BL\/6 mice were exposed for 8 weeks to lead acetate (50 mg\/kg) in combination with either low-dose (100 mg\/kg) or high-dose (300 mg\/kg) iron dextran. Metal accumulation in femoral tissue was quantified using inductively coupled plasma mass spectrometer (ICP-MS). Bone microarchitecture was evaluated using microcomputed tomography (micro-CT). Bone-specific untargeted metabolomics and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to assess metabolic alterations.Results:Iron overload did not significantly affect lead accumulation but disrupted mineral balance in a dose-dependent manner, reducing levels of calcium, zinc, magnesium, and vanadium. Micro-CT analysis revealed significant alterations in bone microarchitecture. Metabolomic analysis identified 297 altered metabolites, primarily involved in amino acid, lipid, and nucleotide metabolism, as well as mineral absorption. KEGG pathway analysis revealed disturbances in amino acid biosynthesis, aminoacyl-tRNA biosynthesis, ATP-binding cassette (ABC) transporters, protein digestion and absorption, and mineral absorption, with distinct profiles observed between different iron doses.Conclusions:Iron overload is associated with further alterations in bone metabolic homeostasis under fixed lead exposure, as evidenced by structural deterioration, disruption of trace element homeostasis, and extensive metabolic reprogramming in bone tissue.<\/jats:p>","DOI":"10.31083\/fbl50432","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:50:51Z","timestamp":1783421451000},"source":"Crossref","is-referenced-by-count":1,"title":["The Interaction Between Iron Overload and Lead Exposure on Bone Metabolism"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5056-5484","authenticated-orcid":true,"given":"Yongjie","family":"Yang","sequence":"first","affiliation":[{"name":"Graduate School, Bengbu Medical University, 233030 Bengbu, Anhui, China"},{"name":"Department of Orthopedic Surgery, Anhui No. 2 Provincial People\u2019s Hospital, 230041 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbao","family":"Gong","sequence":"additional","affiliation":[{"name":"Graduate School, Bengbu Medical University, 233030 Bengbu, Anhui, China"},{"name":"Department of Orthopedic Surgery, Anhui No. 2 Provincial People\u2019s Hospital, 230041 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Ma","sequence":"additional","affiliation":[{"name":"Graduate School, Bengbu Medical University, 233030 Bengbu, Anhui, China"},{"name":"Department of Orthopedic Surgery, Anhui No. 2 Provincial People\u2019s Hospital, 230041 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Anhui Medical University, 230032 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Anhui No. 2 Provincial People\u2019s Hospital, 230041 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5051-6648","authenticated-orcid":true,"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School, Bengbu Medical University, 233030 Bengbu, Anhui, China"},{"name":"Department of Orthopedic Surgery, Anhui No. 2 Provincial People\u2019s Hospital, 230041 Hefei, Anhui, China"},{"name":"Now with Anhui Provincial Institute of Occupational Disease Control, 230041 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Wang J, Shu B, Tang DZ, Li CG, Xie XW, Jiang LJ, et al. The prevalence of osteoporosis in China, a community based cohort study of osteoporosis. Frontiers in Public Health. 2023; 11: 1084005.","DOI":"10.3389\/fpubh.2023.1084005"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, et al. The clinician's guide to prevention and treatment of osteoporosis. Osteoporosis International : a Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2022; 33: 2049\u20132102.","DOI":"10.1007\/s00198-021-05900-y"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F. Secondary Osteoporosis. Endocrine Reviews. 2022; 43: 240\u2013313.","DOI":"10.1210\/endrev\/bnab028"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet (London, England). 2019; 393: 364\u2013376.","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Wang S, Li Q, Gao Y, Zhou Z, Li Z. Influences of lead exposure on its accumulation in organs, meat, eggs and bone during laying period of hens. Poultry Science. 2021; 100: 101249.","DOI":"10.1016\/j.psj.2021.101249"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Liu S, Wang H, Cao Y, Lu L, Wu Y, Lian F, et al. The association between low-concentration heavy metal exposure and chronic kidney disease risk through \u03b1-klotho. Scientific Reports. 2025; 15: 11320.","DOI":"10.1038\/s41598-025-96016-4"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Zhang S, Deng Z, Yin X, Fang H, Song G, Liu Y, et al. Bioaccessibility of lead and cadmium in soils around typical lead-acid power plants and their effect on gut microorganisms. Environmental Geochemistry and Health. 2024; 46: 107.","DOI":"10.1007\/s10653-023-01840-0"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Wei M, Huang Q, Dai Y, Zhou H, Cui Y, Song W, et al. Manganese, iron, copper, and selenium co-exposure and osteoporosis risk in Chinese adults. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). 2022; 72: 126989.","DOI":"10.1016\/j.jtemb.2022.126989"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Zhang J, Hu W, Ding C, Yao G, Zhao H, Wu S. Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling. Toxicology Letters. 2019; 313: 50\u201359.","DOI":"10.1016\/j.toxlet.2019.06.007"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Li C, Qu M, Tian X, Zhuang W, Zhu M, Lv S, et al. Epidemiological and transcriptome data identify association between iron overload and metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis. Nutrition Research (New York, N.Y.). 2024; 131: 121\u2013134.","DOI":"10.1016\/j.nutres.2024.09.011"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Snega Priya P, Pratiksha Nandhini P, Arockiaraj J. A comprehensive review on environmental pollutants and osteoporosis: Insights into molecular pathways. Environmental Research. 2023; 237: 117103.","DOI":"10.1016\/j.envres.2023.117103"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Yang Y, Yuan S, Gong T, Zhang J, Ma H, Yu D, et al. Metallic Contaminants and Osteoporosis: a Review of the Gut-Bone Axis. Biological Trace Element Research. 2025.","DOI":"10.1007\/s12011-025-04913-6"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Chang J, Kueon C, Kim J. Influence of lead on repetitive behavior and dopamine metabolism in a mouse model of iron overload. Toxicological Research. 2014; 30: 267\u2013276.","DOI":"10.5487\/TR.2014.30.4.267"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Zhu G, Fan G, Feng C, Li Y, Chen Y, Zhou F, et al. The effect of lead exposure on brain iron homeostasis and the expression of DMT1\/FP1 in the brain in developing and aged rats. Toxicology Letters. 2013; 216: 108\u2013123.","DOI":"10.1016\/j.toxlet.2012.11.024"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Zhou F, Chen Y, Fan G, Feng C, Du G, Zhu G, et al. Lead-induced iron overload and attenuated effects of ferroportin 1 overexpression in PC12 cells. Toxicology in Vitro : an International Journal Published in Association with BIBRA. 2014; 28: 1339\u20131348.","DOI":"10.1016\/j.tiv.2014.07.005"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Zhu H, Shen F, Liao T, Qian H, Liu Y. Sporidiobolus pararoseus polysaccharides relieve rheumatoid arthritis by regulating arachidonic acid metabolism and bone remodeling signaling pathway. International Journal of Biological Macromolecules. 2024; 281: 136272.","DOI":"10.1016\/j.ijbiomac.2024.136272"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Nelea V, Ittah E, McKee MD, Reznikov N. Bone mineral tessellation: Atomic force microscopy of the volume-filling mineralization pattern in hydrated and dehydrated states. Acta Biomaterialia. 2025; 200: 251\u2013264.","DOI":"10.1016\/j.actbio.2025.05.016"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"He Y, Su J, Gao H, Li J, Feng Z, Yin Y. Untargeted Metabolomics Reveals the Function of GPRC6A in Amino Acid and Lipid Metabolism in Mice. Metabolites. 2022; 12: 776.","DOI":"10.3390\/metabo12090776"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Kang H, Strong AL, Sun Y, Guo L, Juan C, Bancroft AC, et al. The HIF-1\u03b1\/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair. Bone Research. 2024; 12: 17.","DOI":"10.1038\/s41413-024-00320-0"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Fan J, Jahed V, Klavins K. Metabolomics in Bone Research. Metabolites. 2021; 11: 434.","DOI":"10.3390\/metabo11070434"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, et al. Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research. International Journal of Molecular Sciences. 2016; 17: 2018.","DOI":"10.3390\/ijms17122018"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Zhang J, Ma H, Yang Y, Liu L, Luo D, Yu D, et al. Iron-lead mixed exposure causes bone damage in mice: A multi-omics analysis. Ecotoxicology and Environmental Safety. 2025; 292: 117967.","DOI":"10.1016\/j.ecoenv.2025.117967"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Kondaiah P, Yaduvanshi PS, Sharp PA, Pullakhandam R. Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption? Nutrients. 2019; 11: 1885.","DOI":"10.3390\/nu11081885"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Ravet K, Pilon M. Copper and iron homeostasis in plants: the challenges of oxidative stress. Antioxidants & Redox Signaling. 2013; 19: 919\u2013932.","DOI":"10.1089\/ars.2012.5084"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Gao Z, Chen Z, Xiong Z, Liu X. Ferroptosis - A new target of osteoporosis. Experimental Gerontology. 2022; 165: 111836.","DOI":"10.1016\/j.exger.2022.111836"},{"key":"ref26","unstructured":"Coman M, H\u00eencu M, Surlin P, Mateescu G, Nechita A, Banu M. Comparative histomorphometric study of bone tissue synthesized after electric and ultrasound stimulation. Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie et Embryologie. 2011; 52: 455\u2013458."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Mani MS, Dsouza VL, Dsouza HS. Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals. Toxicology Letters. 2021; 353: 13\u201319.","DOI":"10.1016\/j.toxlet.2021.10.002"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Cheli VT, Santiago Gonz\u00e1lez DA, Marziali LN, Zamora NN, Guitart ME, Spreuer V, et al. The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 2018; 38: 9142\u20139159.","DOI":"10.1523\/JNEUROSCI.1447-18.2018"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Ga\u00e1l A, Torma L, Bakos \u00c9, N\u00e9met K, Kregsamer P, Streli C, et al. ABCC1 promotes GSH-dependent iron transport and resistance to Fe(II) and Cu(II) chelators. Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine. 2025; 38: 1881\u20131895.","DOI":"10.1007\/s10534-025-00736-z"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Liziczai M, Fuchs A, Manatschal C, Dutzler R. Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1. Nature Communications. 2025; 16: 761.","DOI":"10.1038\/s41467-024-54705-0"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Illing AC, Shawki A, Cunningham CL, Mackenzie B. Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1. The Journal of Biological Chemistry. 2012; 287: 30485\u201330496.","DOI":"10.1074\/jbc.M112.364208"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Roli\u0107 T, Yazdani M, Mandi\u0107 S, Distante S. Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review. Biological Trace Element Research. 2025; 203: 2216\u20132225.","DOI":"10.1007\/s12011-024-04289-z"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Cheng Q, Zhang X, Jiang J, Zhao G, Wang Y, Xu Y, et al. Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen. BioMed Research International. 2017; 2017: 1345193.","DOI":"10.1155\/2017\/1345193"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Syn NL, Lee PC, Kovalik JP, Tham KW, Ong HS, Chan WH, et al. Associations of Bariatric Interventions With Micronutrient and Endocrine Disturbances. JAMA Network Open. 2020; 3: e205123.","DOI":"10.1001\/jamanetworkopen.2020.5123"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Chen Y, Zhu M, Sheng S, Yang H, Zhang Q, Chen X, et al. Biomimetic Extracellular Vesicles Containing Biominerals for Targeted Osteoporosis Therapy. ACS Applied Materials & Interfaces. 2025; 17: 5823\u20135840.","DOI":"10.1021\/acsami.4c17238"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Hayann L, Socorro M, Vilela AFL, Cominal JG, Andrilli LHDS, Ciancaglini P, et al. Strontium Changes Lipid Profile, Release, and Function of Matrix Vesicles Produced by Mineralization-Competent Cells. Frontiers in Bioscience (Landmark edition). 2025; 30: 47664.","DOI":"10.31083\/FBL47664"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Si Z, Zhou S, Shen Z, Luan F. High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC\/Q-TOF-MS Coupled With Multivariate Data Analysis. Frontiers in Pharmacology. 2020; 11: 741.","DOI":"10.3389\/fphar.2020.00741"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Ahn J, Son MK, Jung KH, Kim K, Kim GJ, Lee SH, et al. Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGF\u03b2 signaling. International Journal of Oncology. 2016; 48: 747\u2013755.","DOI":"10.3892\/ijo.2015.3303"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Liu S, Zheng Y, Ma Y, Sarwar A, Zhao X, Luo T, et al. Evaluation and Proteomic Analysis of Lead Adsorption by Lactic Acid Bacteria. International Journal of Molecular Sciences. 2019; 20: 5540.","DOI":"10.3390\/ijms20225540"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Guo Z, Yuan X, Li L, Zeng M, Yang J, Tang H, et al. Genome-Wide Analysis of the ATP-Binding Cassette (ABC) Transporter Family in Zea mays L. and Its Response to Heavy Metal Stresses. International Journal of Molecular Sciences. 2022; 23: 2109.","DOI":"10.3390\/ijms23042109"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y, Vergely C. Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis. International Journal of Molecular Sciences. 2022; 24: 449.","DOI":"10.3390\/ijms24010449"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Guangji W, Huixin P, Hongfei H, Hai L, Yang F, Shihua L, et al. Aluminum exposure induces ferroptosis in spermatogenic cells of mice through iron overload and lipid peroxidation. Free Radical Biology & Medicine. 2025; 241: 789\u2013806.","DOI":"10.1016\/j.freeradbiomed.2025.09.043"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Wang W, Shi F, Cui J, Pang S, Zheng G, Zhang Y. MiR-378a-3p\/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure. Ecotoxicology and Environmental Safety. 2022; 239: 113639.","DOI":"10.1016\/j.ecoenv.2022.113639"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Zhang L, Lin Y, Lu AX, Liu JX, Li J, Yan CH. Metabolomics insights into the effects of pre-pregnancy lead exposure on bone metabolism in pregnant rats. Environmental Pollution (Barking, Essex : 1987). 2023; 337: 122468.","DOI":"10.1016\/j.envpol.2023.122468"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Du J, Cui H, Zhao Y, Xue H, Chen J. Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: a Mendelian randomization study. Osteoporosis International : a Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2024; 35: 2215\u20132223.","DOI":"10.1007\/s00198-024-07249-4"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Kupraszewicz E, Brz\u00f3ska MM. Excessive ethanol consumption under exposure to lead intensifies disorders in bone metabolism: a study in a rat model. Chemico-biological Interactions. 2013; 203: 486\u2013501.","DOI":"10.1016\/j.cbi.2013.01.002"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Chen S, Yang JL, Zhang YS, Wang HY, Lin XY, Xue RY, et al. Microplastics affect arsenic bioavailability by altering gut microbiota and metabolites in a mouse model. Environmental Pollution (Barking, Essex : 1987). 2023; 324: 121376.","DOI":"10.1016\/j.envpol.2023.121376"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Zhou L, Chen SZ, Li YY, Xue RY, Duan X, Lin XY, et al. Gut Dysbiosis Exacerbates Intestinal Absorption of Cadmium and Arsenic from Cocontaminated Rice in Mice Due to Impaired Intestinal Barrier Functions. Environmental Science & Technology. 2025; 59: 3459\u20133471.","DOI":"10.1021\/acs.est.5c00817"}],"container-title":["Frontiers in Bioscience-Landmark"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/31\/6\/10.31083\/FBL50432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:53:56Z","timestamp":1783421636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/31\/6\/10.31083\/FBL50432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2768-6701(26)02117-9"],"URL":"https:\/\/doi.org\/10.31083\/fbl50432","relation":{},"ISSN":["2768-6701","2768-6698"],"issn-type":[{"value":"2768-6701","type":"print"},{"value":"2768-6698","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"article-number":"50432"}}