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While cell senescence is sometimes equated with aging at the cellular level, its precise role and significance in shaping the aged phenotype in tissues and the whole organism remain debated. Current evidence suggests that each cell type in the liver may contribute specifically to aging and age-associated morbidities. This review focuses on the \u201cheterogeneity of senescence\u201d and highlights the multifaceted role of cell senescence and its associated secretory patterns in aging. However, a better understanding of the complex interplay among cell types is essential for modulating the positive impact of senescence and delaying the emergence of age-associated changes.<\/jats:p>","DOI":"10.31083\/fbl50660","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:21:51Z","timestamp":1790698911000},"source":"Crossref","is-referenced-by-count":0,"title":["Cell Senescence and the Aging Liver"],"prefix":"10.31083","volume":"31","author":[{"given":"Roberta","family":"Pisu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Laconi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5860-4227","authenticated-orcid":true,"given":"Fabio","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Paisley D, Bevan L, Choy KJ, Gross C. 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