{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:02:56Z","timestamp":1785416576253,"version":"3.56.0"},"reference-count":61,"publisher":"IMR Press","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Clinical Research Project of the \u201cKunyi Leading Research\u201d Program of Kunming Medical University","award":["NO. QL-JBGS-02"],"award-info":[{"award-number":["NO. QL-JBGS-02"]}]},{"name":"Joint Program of Applied Basic Research of Yunnan Provincial Department of Science and Technology - Kunming Medical University","award":["NO. 202301AY070001-106"],"award-info":[{"award-number":["NO. 202301AY070001-106"]}]},{"name":"Key Project of the Joint Special Program of Kunming Medical University","award":["NO. 202401AB070049"],"award-info":[{"award-number":["NO. 202401AB070049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background:Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer and remains a major cause of cancer-related mortality. Despite advances in targeted therapies, tumor heterogeneity and acquired resistance frequently undermine clinical outcomes. This study aimed to identify novel oncogenic drivers and underlying mechanisms in LUAD.Methods:We examined cellular retinoic acid-binding protein 2 (CRABP2) expression in human LUAD specimens and evaluated its functional role through in vitro assays (cell proliferation, migration, invasion, and apoptosis) and in vivo xenograft tumor growth. Mechanistic exploration involved RNA sequencing, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and immunoblotting for the nuclear factor kappa B (NF-\u03baB) signaling components, along with rescue experiments to dissect the pathway dependency.Results:CRABP2 was identified as a candidate oncogene in LUAD. Functional assays confirmed that CRABP2 promoted proliferation, migration, and invasion, suppressed apoptosis, and accelerated xenograft tumor growth. Mechanistically, CRABP2 potentiated retinoic acid (RA) signaling and activated the NF-\u03baB pathway, as evidenced by enhanced inhibitor of nuclear factor kappa-B kinase subunit beta (IKK\u03b2) phosphorylation, subsequent NF-\u03baB inhibitor alpha (I\u03baB\u03b1) phosphorylation, and nuclear translocation of total and phosphorylated p65. Rescue experiments revealed that CRABP2\u2011induced NF-\u03baB activation is RA-dependent and that this activation mediates the oncogenic effects of CRABP2.Conclusions:Our findings establish a CRABP2\/RA\/NF\u2011\u03baB axis that drives LUAD progression, highlighting this pathway as a potential therapeutic target for intervention in LUAD.<\/jats:p>","DOI":"10.31083\/fbl51377","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:17:49Z","timestamp":1785413869000},"source":"Crossref","is-referenced-by-count":0,"title":["CRABP2 Promotes Lung Adenocarcinoma Through Retinoic Acid Pathway-Mediated NF-\u03baB Activation"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7568-1109","authenticated-orcid":true,"given":"XiRui","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3841-0864","authenticated-orcid":true,"given":"BiaoFeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2306-5869","authenticated-orcid":true,"given":"Qing","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8610-7798","authenticated-orcid":true,"given":"ChenJun","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6261-5074","authenticated-orcid":true,"given":"XuanCheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1345-7467","authenticated-orcid":true,"given":"ZhongRui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1975-5921","authenticated-orcid":true,"given":"SiQi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, 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