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Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background:Cervical cancer (CC) is a prevalent malignancy in women. RNA-binding motif single-stranded interacting protein 3 (RBMS3) acts as a tumor suppressor in many cancer types, but its role and underlying regulatory mechanisms in CC remain unclear.Methods:The expression levels of RBMS3 and heat shock protein family A member 6 (HSPA6) were evaluated in clinical CC tissues. Gain- and loss-of-function assays, transcriptome sequencing, and rescue experiments were performed in CC cell lines and nude mouse xenograft models.Results:RBMS3 expression was notably lower in CC tissues (n = 306) than in normal cervical tissues (n = 22), with reduced levels linked to shorter overall patient survival (p &lt; 0.05). Overexpression of RBMS3 reduced cell proliferation, migration, and invasion in vitro, as well as tumor growth in vivo (p &lt; 0.001). HSPA6 was identified as a key target of RBMS3 and was also downregulated in CC tissues. RBMS3 potentially binds to HSPA6 mRNA and enhances its stability. Knockdown of HSPA6 reversed the tumor-suppressive effects of RBMS3 (p &lt; 0.001).Conclusions:RBMS3 inhibits CC progression by stabilizing HSPA6 mRNA. The RBMS3\u2013HSPA6 axis may represent a prognostic biomarker and therapeutic target in CC.<\/jats:p>","DOI":"10.31083\/fbl51761","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:17:49Z","timestamp":1785413869000},"source":"Crossref","is-referenced-by-count":0,"title":["RNA-Binding Protein RBMS3 Inhibits Cervical Cancer Progression by Enhancing HSPA6 mRNA Stability"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3718-3127","authenticated-orcid":true,"given":"Huaping","family":"Huang","sequence":"first","affiliation":[{"name":"The Reproductive Medicine Center, The Second Affiliated Hospital of Soochow University, 215004 Suzhou, Jiangsu, China"},{"name":"Department of Gynecology, The First People\u2019s Hospital of Kunshan, 215300 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-9945","authenticated-orcid":true,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First People\u2019s Hospital of Kunshan, 215300 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-8511","authenticated-orcid":true,"given":"Lixia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First People\u2019s Hospital of Kunshan, 215300 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1531-3071","authenticated-orcid":true,"given":"Yawei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First People\u2019s Hospital of Kunshan, 215300 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0079-2465","authenticated-orcid":true,"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First People\u2019s Hospital of Kunshan, 215300 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4943-1859","authenticated-orcid":true,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Reproductive Medicine Center, The Second Affiliated Hospital of Soochow University, 215004 Suzhou, Jiangsu, China"},{"name":"Jiangsu Institute of Clinical Immunology, 215006 Suzhou, Jiangsu, China"},{"name":"Medical Biotechnology Institute, Soochow University, 215031 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. 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