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(Landmark Ed)"],"abstract":"<jats:p>Background:Itaconic acid and its isomers citraconic acid and mesaconic acid are a recently identified class of metabolites with anti-inflammatory and antioxidant effects. This study investigates their roles in ischemia-reperfusion-induced acute kidney injury.Methods:In this study, a rat model of renal ischemia-reperfusion injury (IRI) was established, and itaconic acid, citraconic acid and mesaconic acid were administered as a preoperative intervention. After the operation, renal injury was evaluated by contrast-enhanced ultrasound, biochemical analyses and histopathological staining.Results:The intervention with itaconic acid and its isomers reduced the production of the inflammatory cytokines interleukin-18 (IL-18) (p &lt; 0.05), inhibited activation of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome (p &lt; 0.05), and reduced reactive oxygen species levels (p &lt; 0.05). The intervention with itaconic acid and mesaconic acid reduced the production of the inflammatory cytokine interleukin-1\u03b2 (IL-1\u03b2) (p &lt; 0.05). The expression of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) spot protein in the intervention group was significantly lower than that in the renal ischemia-reperfusion injury (IRI) group (p &lt; 0.01). Conclusions:These findings suggest that itaconic acid, citraconic acid, and mesaconic acid may be potential therapeutic agents for renal ischemia-reperfusion through their anti-inflammatory and antioxidant effects.<\/jats:p>","DOI":"10.31083\/fbl52184","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:35:31Z","timestamp":1788438931000},"source":"Crossref","is-referenced-by-count":0,"title":["Itaconic Acid and Its Isomers Ameliorate Renal Ischemia-Reperfusion Injury in Rats by Inhibiting NLRP3-Mediated Inflammation"],"prefix":"10.31083","volume":"31","author":[{"given":"Bin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 621000 Mianyang, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-9094","authenticated-orcid":true,"given":"Zhijian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Gonsalez SR, Cort\u00eas AL, Silva RCD, Lowe J, Prieto MC, Silva Lara LD. 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