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This review proposes a phase-specific immune\u2013metabolic framework for precision stroke recovery. Rather than treating neuroinflammation as a uniformly detrimental process, this review conceptualizes neuroinflammation as a time-dependent biological gate that may either amplify injury or support repair, depending on the phase, cellular context, blood\u2013brain barrier integrity, and systemic metabolic state. In the acute phase, regulated cell death, oxidative stress, inflammasome activation, blood\u2013brain barrier disruption, and proteolytic remodeling contribute to secondary injury and neurovascular instability. During the subacute phase, controlled immune responses may facilitate debris clearance, angiogenesis, synaptic remodeling, and rehabilitation-induced neuroplasticity. In contrast, persistent low-grade inflammation in the chronic phase may impair network reorganization, promote glial reactivity, and contribute to delayed neurodegeneration or poor functional recovery. The available evidence suggests that metabolic and microbiome-related factors are not secondary modifiers but integral components of recovery biology. Nutritional status, sarcopenia, metabolic imbalance, and post-stroke gut dysbiosis may influence immune tone, blood-brain barrier function, microbial metabolite signaling, and neuroplastic potential. These interactions provide a rationale for defining biological recovery endotypes that integrate inflammatory, neurovascular, metabolic, microbiome-related, and plasticity-related signatures. By linking neuroinflammation with immune-metabolic regulation and repair biology, this review reframes stroke recovery as a phase-dependent and biologically stratified process. The framework may support the development of multimodal biomarkers, phase-matched interventions, and patient-stratification strategies for precision stroke recovery trials.<\/jats:p>","DOI":"10.31083\/fbl54110","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:35:31Z","timestamp":1788438931000},"source":"Crossref","is-referenced-by-count":0,"title":["From Neuroinflammation to Precision Stroke Recovery: A Phase-Specific Immune\u2013Metabolic Framework"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-7767","authenticated-orcid":true,"given":"Pratchaya","family":"Kaewkaen","sequence":"first","affiliation":[{"name":"Animal Cognitive Neuroscience Laboratory (ACoN), Burapha University, 20131 Chonburi, Thailand"},{"name":"Department of Research and Applied Psychology, Faculty of Education, Burapha University, 20131 Chonburi, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Prabhakaran S, Gonzalez NR, Zachrison KS, Adeoye O, Alexandrov AW, Ansari SA, et al. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association\/American Stroke Association. 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