{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:04:56Z","timestamp":1790701496586,"version":"4.1.0"},"reference-count":50,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VEGA SR","award":["2\/0016\/23"],"award-info":[{"award-number":["2\/0016\/23"]}]},{"name":"Slovak Research and Development Agency","award":["APVV-22-0264"],"award-info":[{"award-number":["APVV-22-0264"]}],"id":[{"id":"https:\/\/ror.org\/037nx0e70","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Slovak Research and Development Agency","award":["APVV-19-0540"],"award-info":[{"award-number":["APVV-19-0540"]}],"id":[{"id":"https:\/\/ror.org\/037nx0e70","id-type":"ROR","asserted-by":"crossref"}]},{"name":"EU NextGenerationEU through the Recovery and Resilience Plan for Slovakia","award":["09I03-03-V04-00437"],"award-info":[{"award-number":["09I03-03-V04-00437"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background: Mitochondria play a central role in cardiac energy metabolism and dynamically adapt to changes in metabolic demand. However, the early mitochondrial adaptations accompanying the acute phase of diabetes mellitus remain insufficiently understood. This study aimed to characterise diabetes-induced mitochondrial remodelling in the rat heart. Methods: Diabetes was induced using an established streptozotocin-induced rat model. Cardiac mitochondrial proteomes were analyzed by liquid chromatography\u2013tandem mass spectrometry (LC-MS\/MS) in control and diabetic animals. Differential protein abundance was assessed by statistical comparison between groups using the limma package in R, and machine learning classification was used to identify proteins with the strongest discriminatory power between control and diabetic states. Results: Diabetes was associated with distinct mitochondrial proteomic remodelling. In the diabetic group, monoamine oxidase A (AOFA, padjust = 0.003) was markedly upregulated, fatty acid \u03b2-oxidation-related enzymes including dienoyl-CoA isomerase (ECH1, padjust &lt; 0.001) and dienoyl-CoA reductase (DECR, padjust = 0.003) showed increased abundance, and respiratory chain complex I components, particularly NADH-ubiquinone oxidoreductase 75 kDa subunit (NDUS1, padjust = 0.016) and NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (NDUS2, padjust = 0.016), were elevated. Machine learning analysis consistently identified AOFA and key metabolic proteins as the strongest discriminators between diabetic and control animals (n = 6 per group). These changes indicate a coordinated shift towards enhanced lipid utilisation, altered mitochondrial respiratory function, and involvement of redox-associated processes. Conclusions: The observed proteomic changes may reflect early adaptive and compensatory mechanisms supporting mitochondrial function under increased energetic and oxidative load and highlight pathways that may represent promising candidates for targeted therapeutic modulation in diabetic cardiac dysfunction.<\/jats:p>","DOI":"10.31083\/fbl55463","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:21:51Z","timestamp":1790698911000},"source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Signatures of Cardiac Mitochondrial Remodelling During Acute Diabetes Reflect Metabolic and Redox Adaptations"],"prefix":"10.31083","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-0072","authenticated-orcid":true,"given":"Nat\u00e1lia","family":"Andelov\u00e1","sequence":"first","affiliation":[{"name":"Institute for Heart Research, Centre of Experimental Medicine of the Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9945-6544","authenticated-orcid":true,"given":"D\u00e1vid","family":"Janko","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Centre of Experimental Medicine of the Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-6066","authenticated-orcid":true,"given":"Milan","family":"Zvar\u00edk","sequence":"additional","affiliation":[{"name":"Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University Bratislava, 814 99 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-2780","authenticated-orcid":true,"given":"Iveta","family":"Waczul\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University Bratislava, 814 99 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7746-0762","authenticated-orcid":true,"given":"Simona","family":"Pape\u017e\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Centre of Experimental Medicine of the Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-6382","authenticated-orcid":true,"given":"Veronika","family":"Farka\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Centre of Experimental Medicine of the Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-6964","authenticated-orcid":true,"given":"T\u00e1\u0148a","family":"Ravingerov\u00e1","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Centre of Experimental Medicine of the Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-8942","authenticated-orcid":true,"given":"Miroslav","family":"Ferko","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Centre of Experimental Medicine of the Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Yang HM. Mitochondrial Dysfunction in Cardiovascular Diseases. International Journal of Molecular Sciences. 2025; 26: 1917.","DOI":"10.3390\/ijms26051917"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Pagliaro P, Alloatti G, Penna C. Cardioprotection Reloaded: Reflections on 40 Years of Research. Antioxidants (Basel, Switzerland). 2025; 14: 889.","DOI":"10.3390\/antiox14070889"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Korkmaz-Ic\u00f6z S, Lehner A, Li S, Vater A, Radovits T, Heged\u0171s P, et al. Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to Ischemia\/Reperfusion Injury: Identification of Underlying Gene Expression Changes. Journal of Diabetes Research. 2015; 2015: 396414.","DOI":"10.1155\/2015\/396414"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Kondratieva DS, Afanasiev SA, Muslimova EF. Diabetes mellitus\u2014metabolic preconditioning in protecting the heart from ischemic damage? Diabetes Mellitus. 2022; 25: 548\u2013555.","DOI":"10.14341\/DM12933"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Ferko M, Kancirov\u00e1 I, Ja\u0161ov\u00e1 M, Waczul\u00edkov\u00e1 I, \u010carnick\u00e1 S, Kucharsk\u00e1 J, et al. Participation of heart mitochondria in myocardial protection against ischemia\/reperfusion injury: benefit effects of short-term adaptation processes. Physiological Research. 2015; 64: S617\u2013S625.","DOI":"10.33549\/physiolres.933218"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Penna C, Andreadou I, Aragno M, Beauloye C, Bertrand L, Lazou A, et al. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols. British Journal of Pharmacology. 2020; 177: 5312\u20135335.","DOI":"10.1111\/bph.14993"},{"key":"ref7","unstructured":"Ferko M, Gvozdjakov\u00e1 A, Kucharsk\u00e1 J, Mujkosov\u00e1 J, Waczul\u00edkov\u00e1 I, Styk J, et al. Functional remodeling of heart mitochondria in acute diabetes: interrelationships between damage, endogenous protection and adaptation. General Physiology and Biophysics. 2006; 25: 397\u2013413."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Kancirov\u00e1 I, Ja\u0161ov\u00e1 M, Mur\u00e1rikov\u00e1 M, Sumbalov\u00e1 Z, Uli\u010dn\u00e1 O, Ravingerov\u00e1 T, et al. Cardioprotection induced by remote ischemic preconditioning preserves the mitochondrial respiratory function in acute diabetic myocardium. Physiological Research. 2016; 65: S611\u2013S619.","DOI":"10.33549\/physiolres.933533"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Ferko M, Habod\u00e1szov\u00e1 D, Waczul\u00edkov\u00e1 I, Mujko\u0161ov\u00e1 J, Kucharsk\u00e1 J, \u0160ikurov\u00e1 L, et al. Endogenous protective mechanisms in remodeling of rat heart mitochondrial membranes in the acute phase of streptozotocin-induced diabetes. Physiological Research. 2008; 57: S67\u2013S73.","DOI":"10.33549\/physiolres.931554"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Ziegelh\u00f6ffer A, Waczul\u00edkov\u00e1 I, Ferko M, \u0160ikurov\u00e1 L, Mujko\u0161ov\u00e1 J, Ravingerov\u00e1 T. Involvement of membrane fluidity in endogenous protective processes running on subcellular membrane systems of the rat heart. Physiological Research. 2012; 61: S11\u2013S21.","DOI":"10.33549\/physiolres.932361"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Lu X, Kwong JQ, Molkentin JD, Bers DM. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circulation Research. 2016; 118: 834\u2013841.","DOI":"10.1161\/CIRCRESAHA.115.308093"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Andelova N, Waczulikova I, Kunstek L, Talian I, Ravingerova T, Jasova M, et al. Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization. Scientific Reports. 2022; 12: 16348.","DOI":"10.1038\/s41598-022-20696-5"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Ja\u0161ov\u00e1 M, Kancirov\u00e1 I, Waczul\u00edkov\u00e1 I, Ferko M. Mitochondria as a target of cardioprotection in models of preconditioning. Journal of Bioenergetics and Biomembranes. 2017; 49: 357\u2013368.","DOI":"10.1007\/s10863-017-9720-1"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Song J, Yang X, Yan LJ. Role of pseudohypoxia in the pathogenesis of type 2 diabetes. Hypoxia (Auckland, N.Z.). 2019; 7: 33\u201340.","DOI":"10.2147\/HP.S202775"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Krediet RT, Parikova A. Glucose-induced pseudohypoxia and advanced glycosylation end products explain peritoneal damage in long-term peritoneal dialysis. Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis. 2024; 44: 6\u201315.","DOI":"10.1177\/08968608231196033"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Ravingerov\u00e1 T, Neck\u00e1r J, Kol\u00e1r F. Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes. Molecular and Cellular Biochemistry. 2003; 249: 167\u2013174.","DOI":"10.1023\/a:1024751109196"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Ziegelh\u00f6ffer A, Waczul\u00edkov\u00e1 I, Ferko M, Kincelov\u00e1 D, Ziegelh\u00f6ffer B, Ravingerov\u00e1 T, et al. Calcium signaling-mediated endogenous protection of cell energetics in the acutely diabetic myocardium. Canadian Journal of Physiology and Pharmacology. 2009; 87: 1083\u20131094.","DOI":"10.1139\/Y09-108"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 1976; 72: 248\u2013254.","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"ref19","unstructured":"Kancirov\u00e1 I, Ja\u0161ov\u00e1 M, Waczul\u00edkov\u00e1 I, Ravingerov\u00e1 T, Ziegelh\u00f6ffer A, Ferko M. Effect of antihypertensive agents - captopril and nifedipine - on the functional properties of rat heart mitochondria. Iranian Journal of Basic Medical Sciences. 2016; 19: 615\u2013623."},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Andelova N, Waczulikova I, Talian I, Sykora M, Ferko M. mPTP Proteins Regulated by Streptozotocin-Induced Diabetes Mellitus Are Effectively Involved in the Processes of Maintaining Myocardial Metabolic Adaptation. International Journal of Molecular Sciences. 2020; 21: 2622.","DOI":"10.3390\/ijms21072622"},{"key":"ref21","unstructured":"R Core Team. R: a language and environment for statistical computing [Computer software]. R Foundation for Statistical Computing: Vienna, Austria. 2023. Available at: https:\/\/www.R-project.org\/ (Accessed: 29 June 2026)."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Kuhn M. Building predictive models in R using the caret package. Journal of statistical software. 2008; 28: 1\u201326.","DOI":"10.18637\/jss.v028.i05"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Th\u00e9venot EA, Roux A, Xu Y, Ezan E, Junot C. Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses. Journal of Proteome Research. 2015; 14: 3322\u20133335.","DOI":"10.1021\/acs.jproteome.5b00354"},{"key":"ref24","unstructured":"Liaw A, Wiener M. Classification and regression by randomForest. R News. 2002. Available at: https:\/\/CRAN.R-project.org\/doc\/Rnews\/ (Accessed: 29 June 2026)."},{"key":"ref25","unstructured":"Meyer D, Dimitriadou E, Hornik K, Weingessel A, Leisch F. e1071: Misc Functions of the Department of Statistics, Probability Theory Group (Formerly: E1071), TU Wien (version 1.7-16) [Computer software]. Comprehensive R Archive Network (CRAN). 2024. https:\/\/CRAN.R-project.org\/package=e1071"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Research. 2015; 43: e47.","DOI":"10.1093\/nar\/gkv007"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Research. 2023; 51: D638\u2013D646.","DOI":"10.1093\/nar\/gkac1000"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Doncheva NT, Morris JH, Gorodkin J, Jensen LJ. Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data. Journal of Proteome Research. 2019; 18: 623\u2013632.","DOI":"10.1021\/acs.jproteome.8b00702"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Kanehisa M, Furumichi M, Sato Y, Kawashima M, Ishiguro-Watanabe M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Research. 2023; 51: D587\u2013D592.","DOI":"10.1093\/nar\/gkac963"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Acharya D, Mukhopadhyay A. A comprehensive review of machine learning techniques for multi-omics data integration: challenges and applications in precision oncology. Briefings in Functional Genomics. 2024; 23: 549\u2013560.","DOI":"10.1093\/bfgp\/elae013"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez-P\u00e9rez R, Fern\u00e1ndez L, Marco S. Overoptimism in cross-validation when using partial least squares-discriminant analysis for omics data: a systematic study. Analytical and Bioanalytical Chemistry. 2018; 410: 5981\u20135992.","DOI":"10.1007\/s00216-018-1217-1"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Kaludercic N, Arusei RJ, Di Lisa F. Recent advances on the role of monoamine oxidases in cardiac pathophysiology. Basic Research in Cardiology. 2023; 118: 41.","DOI":"10.1007\/s00395-023-01012-2"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Ferko M, Alanova P, Janko D, Opletalova B, Andelova N. Mitochondrial Peroxiredoxins and Monoamine Oxidase-A: Dynamic Regulators of ROS Signaling in Cardioprotection. Physiological Research. 2024; 73: 887\u2013900.","DOI":"10.33549\/physiolres.935513"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Zhang D, Liang X, He XY, Alipui OD, Yang SY, Schulz H. Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study. The Journal of Biological Chemistry. 2001; 276: 13622\u201313627.","DOI":"10.1074\/jbc.M011315200"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Houten SM, Wanders RJA. A general introduction to the biochemistry of mitochondrial fatty acid \u03b2-oxidation. Journal of Inherited Metabolic Disease. 2010; 33: 469\u2013477.","DOI":"10.1007\/s10545-010-9061-2"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Panov AV. The Structure of the Cardiac Mitochondria Respirasome Is Adapted for the \u03b2-Oxidation of Fatty Acids. International Journal of Molecular Sciences. 2024; 25: 2410.","DOI":"10.3390\/ijms25042410"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Panwar A, Malik SO, Adib M, Lopaschuk GD. Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications. American Journal of Physiology. Heart and Circulatory Physiology. 2025; 328: H1089\u2013H1112.","DOI":"10.1152\/ajpheart.00615.2024"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Fiorentino TV, Monroy A, Kamath S, Sotero R, Cas MD, Daniele G, et al. Pioglitazone corrects dysregulation of skeletal muscle mitochondrial proteins involved in ATP synthesis in type 2 diabetes. Metabolism: Clinical and Experimental. 2021; 114: 154416.","DOI":"10.1016\/j.metabol.2020.154416"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Miao Y, Yan L, Cao H, Jiao X, Shao F. The Mitochondrial Metabolism Gene ECH1 Was Identified as a Novel Biomarker for Diabetic Nephropathy: Using Bioinformatics Analysis and Experimental Confirmation. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 2025; 18: 1087\u20131098.","DOI":"10.2147\/DMSO.S494644"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Duan Z, Huang Z, Lei W, Zhang K, Xie W, Jin H, et al. Bone Morphogenetic Protein 9 Protects Against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics. Circulation. 2024; 150: 1684\u20131701.","DOI":"10.1161\/CIRCULATIONAHA.123.065935"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Tian J, He Q, Li N, Sun Y, Zhang A, Wang H. FTO-Mediated m6A Demethylation of MZF1 Regulates DECR1 to Promote Fatty Acid Oxidation and Exacerbate Myocardial Ischemia\/Reperfusion Injury : FTO-Mediated m6A Demethylation of MZF1 Enhances Fatty Acid Oxidation and Aggravates Myocardial I\/R Injury. Biochemical Genetics. 2026; 64: 4353\u20134374.","DOI":"10.1007\/s10528-025-11251-8"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Khan MS, Nasiripour S, Oyarzabal M, Banerjee S, Sharma K, Bhat MA, et al. Mic60\/Mitofilin inhibitor, Miclxin, induces rat H9C2 cardiomyoblast death by inhibiting the removal of damaged mitochondria. American Journal of Translational Research. 2025; 17: 6743\u20136754.","DOI":"10.62347\/UPML8062"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Bugger H, Abel ED. Mitochondria in the diabetic heart. Cardiovascular Research. 2010; 88: 229\u2013240.","DOI":"10.1093\/cvr\/cvq239"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Stacpoole PW, McCall CE. The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat. Mitochondrion. 2023; 70: 59\u2013102.","DOI":"10.1016\/j.mito.2023.02.007"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Wan SR, Teng FY, Fan W, Xu BT, Li XY, Tan XZ, et al. BDH1-mediated \u03b2OHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway. Aging. 2023; 15: 13384\u201313410.","DOI":"10.18632\/aging.205248"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Liu S, Liu J, Wang Y, Deng F, Deng Z. Oxidative Stress: Signaling Pathways, Biological Functions, and Disease. MedComm. 2025; 6: e70268.","DOI":"10.1002\/mco2.70268"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Sun Y, Lu Y, Saredy J, Wang X, Drummer Iv C, Shao Y, et al. ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes. Redox Biology. 2020; 37: 101696.","DOI":"10.1016\/j.redox.2020.101696"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Schulz R, Schl\u00fcter KD. Importance of Mitochondria in Cardiac Pathologies: Focus on Uncoupling Proteins and Monoamine Oxidases. International Journal of Molecular Sciences. 2023; 24: 6459.","DOI":"10.3390\/ijms24076459"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Murphy E, Liu JC. Mitochondrial calcium and reactive oxygen species in cardiovascular disease. Cardiovascular Research. 2023; 119: 1105\u20131116.","DOI":"10.1093\/cvr\/cvac134"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Sandhu JK, Sodja C, Ribecco-Lutkiewicz M, Wu YT, Ma YS, Wei YH, et al. Effects of Tolerance-Induced Preconditioning on Mitochondrial Biogenesis in Undifferentiated and Differentiated Neuronal Cells. Frontiers in Bioscience (Landmark Edition). 2022; 27: 115.","DOI":"10.31083\/j.fbl2704115"}],"container-title":["Frontiers in Bioscience-Landmark"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/31\/9\/10.31083\/FBL55463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:21:57Z","timestamp":1790698917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/31\/9\/10.31083\/FBL55463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2768-6701(26)02301-4"],"URL":"https:\/\/doi.org\/10.31083\/fbl55463","relation":{},"ISSN":["2768-6701","2768-6698"],"issn-type":[{"value":"2768-6701","type":"print"},{"value":"2768-6698","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]},"article-number":"55463"}}