{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:45Z","timestamp":1753889925924,"version":"3.41.2"},"reference-count":37,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Vitam. Nutr. Res."],"abstract":"<jats:p>Background: This study aimed to elucidate correlations between obesity-related indicators and vitamin D (VD) status in a nationally representative sample of U.S. adults. Methods: We analysed data from 9168 adults aged 20\u201359 years obtained from the 2011\u20132018 National Health and Nutrition Examination Survey. Serum 25 hydroxyvitamin D [25(OH)D] levels were measured and categorised into quartiles. Anthropometric measurements, including weight, waist circumference, and fat mass in various body regions quantified through dual-energy X-ray absorptiometry, were collected. Multiple imputation was employed to replace missing data. The importance of obesity-related indicators and serum 25(OH)D concentration was explored using multiple linear regression adjusted for demographics, lifestyle factors, dietary intake, and clinical biomarkers, and stepwise regression. Results: Weight, waist circumference, and fat mass across all body regions were inversely associated with serum 25(OH)D levels (all p &lt; 0.001). Notable differences were observed between men and women. Stepwise regression revealed a strong inverse correlation between visceral adipose tissue and serum 25(OH)D concentration in men [\u03b2 95% CI: \u201313.04 (\u201318.10, \u20137.99), p &lt; 0.001], whereas in women, only weight was significantly correlated with serum 25(OH)D concentration [\u03b2 95% CI: \u20130.20 (\u20130.28, \u20130.12), p &lt; 0.001]. Demographic attributes, seasonal sunlight exposure, dietary VD, calcium, phosphorus, and magnesium intake, and biomarkers including alkaline phosphatase and creatinine also emerged as significant predictors. Conclusions: Besides conventional obesity measures, abdominal fat metrics exhibit robust associations with VD deficiency, especially in men. Public health initiatives and clinical management strategies for hypovitaminosis D in obese populations should consider nuanced aspects of adiposity distribution alongside other demographic, lifestyle, and dietary factors influencing VD.<\/jats:p>","DOI":"10.31083\/ijvnr36625","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T12:20:46Z","timestamp":1735561246000},"source":"Crossref","is-referenced-by-count":0,"title":["Fat Distribution as a Determinant of Vitamin D Status: A Cross-Sectional Study of Adults in the United States"],"prefix":"10.31083","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-7903","authenticated-orcid":true,"given":"Yu","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital and Institute, 100142 Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Pich\u00e9 ME, Tchernof A, Despr\u00e9s JP. 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