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J. Vitam. Nutr. Res."],"abstract":"<jats:p>Background: Retinol-binding protein 4 (RBP4) is a vitamin A transport protein synthesized in the liver and also plays a crucial role in inflammation and immune regulation. Low serum vitamin A levels have been observed in both pediatric and adult patients with ulcerative colitis (UC). The association between serum vitamin A levels and serum RBP4 levels, as well as the underlying mechanism involved inimpaired vitamin A transport during inflammation in UC patients, has yet to been investigated. Methods: A validation cohort comprising 103 UC patients and 22 controls was analyzed. Serum RBP4 levels were measured using anenzyme-linked immunosorbent assay (ELISA), and correlations with vitamin A levels and disease severity wereassessed. A dextran sulfate sodium (DSS)-induced colitis mouse model was used to valuatehepatic RBP4 expression and inflammatory changes. Primary hepatocytes from C57BL\/6 mice were exposed to inflammatory cytokines to assess the impact of these cytokines on RBP4 expression. Results: Serum vitamin A (p &lt; 0.001) and RBP4 levels (p &lt; 0.001) were significantly lower in UC patients compared to controls, exhibiting a pronounced decreasing trend as disease severity increased (vitamin A: p &lt; 0.001; RBP4: p &lt; 0.001), while vitamin A levels increased after effective treatment (p &lt; 0.001). Hepatic RBP4 expression was reduced in the DSS-induced colitis model and negatively correlated with TNF-\u03b1, IL-6, and IL-17. Conclusions: Serum RBP4 levels are decreased in UC patients and negatively correlate with disease severity, possibly due to proinflammatory cytokine-induced suppression which might contribute to inflammation-driven vitamin A transport dysfunction.<\/jats:p>","DOI":"10.31083\/ijvnr37353","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:18:17Z","timestamp":1757330297000},"source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory-Driven Vitamin A Transport Dysfunction in Ulcerative Colitis"],"prefix":"10.31083","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-7340","authenticated-orcid":true,"given":"Zhe","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Department of Nutrition, The Third Central Hospital of Tianjin, 300170 Tianjin, China"},{"name":"Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, 300170 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0752-0922","authenticated-orcid":true,"given":"Junming","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-0879","authenticated-orcid":true,"given":"Yang","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0207-7307","authenticated-orcid":true,"given":"Xiaojing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7008-9816","authenticated-orcid":true,"given":"Yifei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2325-2416","authenticated-orcid":true,"given":"Xinyue","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-9946","authenticated-orcid":true,"given":"Zelin","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6608-856X","authenticated-orcid":true,"given":"Huizhen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-4943","authenticated-orcid":true,"given":"Qiuyue","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6774-450X","authenticated-orcid":true,"given":"Hetong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8537-7328","authenticated-orcid":true,"given":"Qinghua","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5119-4842","authenticated-orcid":true,"given":"Mo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China"},{"name":"Key Laboratory of Digestive Diseases, Tianjin Institute of Digestive Diseases, Tianjin Medical University General Hospital, 300070 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-2577","authenticated-orcid":true,"given":"Xue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, Zhejiang, 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