{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:58:34Z","timestamp":1780462714153,"version":"3.54.1"},"reference-count":37,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Elite Ed)"],"abstract":"<jats:p>Background: Animal-fats are rich in long-chain saturated fatty-acids, well known to induct diabetic distress among ingested insulin-insensitive individuals. In the current-study, bovine-fat was fed to selective mice breeds highly sensitized to heavy dietary lipid load. Methods: The later high fat diet (HFD) group indeed undergone diabetic-onset within weeks with a drastically altered feed-behavior pattern. It consumed more food, gained body mass, elevated homeostatic model assessment value and extensively glycosylated Hb transporters. Results: However, the hypothetical test drug (Cuminaldehyde or CA) with known therapeutic-potential worked-well to balance food efficiency-ratio and Hb- counts closer to control. The fat-soluble phytochemical mono-terpenoid (CA) promoted constitutive mono-hexose (glucose) consuming catabolic-cycles via mono-glycoprotein (insulin) signal-transduction. It resolved diabetogenic-upsurge of gluconeogenic-enzymes, reduced non-sugar (amino\/fatty acids) utilization by restricting transamination\/dephosphorylation and restored liver-glycogen reserves near to normal-group effectively at 10 mg\/kg b.w dose. Conclusions: Hence, the nutraceutical-potential (anti-diabetes\/transaminitis ability) of administered exogenous redox-active agent CA can be entertained for evoking therapeutic-heath in diabetic human-community.<\/jats:p>","DOI":"10.31083\/j.fbe1404024","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T01:19:36Z","timestamp":1664500776000},"source":"Crossref","is-referenced-by-count":10,"title":["Cuminaldehyde ameliorates hyperglycemia in diabetic mice"],"prefix":"10.31083","volume":"14","author":[{"given":"Kannan","family":"Duraisamy","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608001 Chidambaram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pari","family":"Leelavinothan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608001 Chidambaram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paari","family":"Ellappan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608001 Chidambaram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulsi Deepak Singh","family":"Balaji","sequence":"first","affiliation":[{"name":"Department of Food and nutrition, Pondicherry University, 605002 Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnulakshmi","family":"Rajagopal","sequence":"first","affiliation":[{"name":"Meenakshi Academy of Higher Education and Research, Central Research Laboratory, 600 078 Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraj","family":"Jayaraman","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Department of Biochemistry, Saveetha University, 600 077 Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamaldevi","family":"Babu","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Department of Biochemistry, Saveetha University, 600 077 Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. 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