{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:27:41Z","timestamp":1790202461785,"version":"4.1.0"},"reference-count":89,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"crossref","award":["343\/UN3.14\/PT\/2020."],"award-info":[{"award-number":["343\/UN3.14\/PT\/2020."]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background: Candida albicans is responsible for a wide range of medical ailments, from harmless cutaneous to life-threatening bloodstream infections. Growing cases of antifungal-drug resistance strains of C. albicans become a rationale to explore and develop novel anti-candida agents. In this paper, we assessed the anti-candida activity of the methanolic extracts of various tropical medicinal plants from Myrtaceae, Poaceae, and Zingiberaceae, commonly used in Indonesia to treat fungal infections. Methods: Candida albicans strain ATCC 10231 was used as a subject to assess the anti-Candida activities of plant methanolic extracts through disc diffusion assay. Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) were observed. Results: All plant extracts in this study showed antifungal activities against C. albicans. Among them, Cymbopogon citratus, Curcuma xanthorrhiza, Curcuma aeruginosa, and Zingiber officinale var. rubrum showed the lowest MIC and MFC value of 3.8 mg\/mL. Conclusions: The growth inhibition of C. albicans on disc diffusion assay was demonstrated by Z. officinale var. rubrum and C. longa, which were comparable to antifungal nystatin. Further investigation of the chemical constituents of the extracts and the cytotoxicity test is needed to further develop plant-derived anti-candida agents.<\/jats:p>","DOI":"10.31083\/j.fbl2709274","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T01:38:20Z","timestamp":1664501900000},"source":"Crossref","is-referenced-by-count":19,"title":["Tropical Medicinal Plant Extracts from Indonesia as Antifungal Agents against Candida Albicans"],"prefix":"10.31083","volume":"27","author":[{"given":"Almando","family":"Geraldi","sequence":"first","affiliation":[{"name":"Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, 60115 Surabaya, Indonesia"},{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"},{"name":"University CoE-Research Center for Bio-Molecule Engineering, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andika Pramudya","family":"Wardana","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanik Siti","family":"Aminah","sequence":"first","affiliation":[{"name":"Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, 60115 Surabaya, Indonesia"},{"name":"Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfinda Novi","family":"Kristanti","sequence":"first","affiliation":[{"name":"Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, 60115 Surabaya, Indonesia"},{"name":"Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliffa Yusti","family":"Sadila","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabilla Hapsari","family":"Wijaya","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mellya Rimadha Andra","family":"Wijaya","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noviana Indah Dwi","family":"Diningrum","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Versa Rachmania","family":"Hajar","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosephine Sri Wulan","family":"Manuhara","sequence":"first","affiliation":[{"name":"Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, 60115 Surabaya, Indonesia"},{"name":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ. Invasive candidiasis. Nature Reviews Disease Primers. 2018; 4: 18026.","DOI":"10.1038\/nrdp.2018.26"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Segal E, Frenkel M. Experimental in vivo models of candidiasis. Journal of Fungi. 2018; 4: 21.","DOI":"10.3390\/jof4010021"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Critical Reviews in Microbiology. 2016; 42: 905\u2013927.","DOI":"10.3109\/1040841X.2015.1091805"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Millsop JW, Fazel N. Oral candidiasis. Clinics in Dermatology. 2016; 34: 487\u2013494.","DOI":"10.1016\/j.clindermatol.2016.02.022"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Clancy CJ, Nguyen MH. Diagnosing Invasive Candidiasis. Journal of Clinical Microbiology. 2018; 56: e01909-17.","DOI":"10.1128\/JCM.01909-17"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Ciurea CN, Kosovski I-B, Mare AD, Toma F, Pintea-Simon IA, Man A. Candida and Candidiasis\u2014Opportunism Versus Pathogenicity: A Review of the Virulence Traits. Microorganisms. 2020; 8: 857.","DOI":"10.3390\/microorganisms8060857"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Arendrup MC, Patterson TF. Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment. The Journal of Infectious Diseases. 2017; 216: S445\u2013S451.","DOI":"10.1093\/infdis\/jix131"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. Journal of Fungi. 2017; 3: 57.","DOI":"10.3390\/jof3040057"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Denning DW, Kneale M, Sobel JD, Rautemaa-Richardson R. Global burden of recurrent vulvovaginal candidiasis: a systematic review. The Lancet Infectious Diseases. 2018; 18: e339\u2013e347.","DOI":"10.1016\/S1473-3099(18)30103-8"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Ben-Ami R. Treatment of Invasive Candidiasis: A Narrative Review. Journal of Fungi. 2018; 4: 97.","DOI":"10.3390\/jof4030097"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Logan C, Martin-Loeches I, Bicanic T. Invasive candidiasis in critical care: challenges and future directions. Intensive Care Medicine. 2020; 46: 2001\u20132014.","DOI":"10.1007\/s00134-020-06240-x"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Gong X, Luan T, Wu X, Li G, Qiu H, Kang Y, et al. Invasive candidiasis in intensive care units in China: Risk factors and prognoses of Candida albicans and non\u2013albicans Candida infections. American Journal of Infection Control. 2016; 44: e59\u2013e63.","DOI":"10.1016\/j.ajic.2015.11.028"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Volkova M, Atamas A, Tsarenko A, Rogachev A, Guskov A. Cation Transporters of Candida albicans\u2014New Targets to Fight Candidiasis? Biomolecules. 2021; 11: 584.","DOI":"10.3390\/biom11040584"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Sobel JD. Recurrent vulvovaginal candidiasis. American Journal of Obstetrics and Gynecology. 2016; 214: 15\u201321.","DOI":"10.1016\/j.ajog.2015.06.067"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Zeng Z, Tian G, Ding Y, Yang K, Liu J, Deng J. Surveillance study of the prevalence, species distribution, antifungal susceptibility, risk factors and mortality of invasive candidiasis in a tertiary teaching hospital in Southwest China. BMC Infectious Diseases. 2019; 19: 939.","DOI":"10.1186\/s12879-019-4588-9"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Vila T, Sultan AS, Montelongo-Jauregui D, Jabra-Rizk MA. Oral Candidiasis: A Disease of Opportunity. Journal of Fungi. 2020; 6: 15.","DOI":"10.3390\/jof6010015"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Bhattacharya S, Sae-Tia S, Fries BC. Candidiasis and Mechanisms of Antifungal Resistance. Antibiotics. 2020; 9: 312.","DOI":"10.3390\/antibiotics9060312"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Bohner F, Papp C, G\u00e1cser A. The effect of antifungal resistance development on the virulence of Candida species. FEMS Yeast Research. 2022; 22: foac019.","DOI":"10.1093\/femsyr\/foac019"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Hendrickson JA, Hu C, Aitken SL, Beyda N. Antifungal Resistance: a Concerning Trend for the Present and Future. Current Infectious Disease Reports. 2019; 21: 47.","DOI":"10.1007\/s11908-019-0702-9"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Arastehfar A, Lass-Fl\u00f6rl C, Garcia-Rubio R, Daneshnia F, Ilkit M, Boekhout T, et al. The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens. Journal of Fungi. 2020; 6: 138.","DOI":"10.3390\/jof6030138"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Serra E, Hidalgo-Bastida LA, Verran J, Williams D, Malic S. Antifungal activity of commercial essential oils and biocides against Candida albicans. Pathogens. 2018; 7: 15.","DOI":"10.3390\/pathogens7010015"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Pedroso RD, Balbino BL, Andrade G, Dias MC, Alvarenga TA, Pedroso RC, et al. In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products. Plants. 2019; 8: 494.","DOI":"10.3390\/plants8110494"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Konuk HB, Erg\u00fcden B. Phenolic \u2013OH group is crucial for the antifungal activity of terpenoids via disruption of cell membrane integrity. Folia Microbiologica. 2020; 65: 775\u2013783.","DOI":"10.1007\/s12223-020-00787-4"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Marchese A, Barbieri R, Coppo E, Orhan IE, Daglia M, Nabavi SF, et al. Antimicrobial activity of eugenol and essential oils containing eugenol: a mechanistic viewpoint. Critical Reviews in Microbiology. 2017; 43: 668\u2013689.","DOI":"10.1080\/1040841X.2017.1295225"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Romulo A, Zuhud EAM, Rondevaldova J, Kokoska L. Screening of in vitro antimicrobial activity of plants used in traditional Indonesian medicine. Pharmaceutical Biology. 2018; 56: 287\u2013293.","DOI":"10.1080\/13880209.2018.1462834"},{"key":"ref26","unstructured":"Br Karo M, Tambaip T, Hatta M, Simanjuntak T, Irmawaty L, Rina T, et al. A mini review of Indonesian medicinal plants for Vulvovaginal candidiasis. Rasayan Journal of Chemistry. 2017; 10: 1280\u20131288."},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Rinanda T, Isnanda RP, Zulfitri. Chemical Analysis of Red Ginger (Zingiber officinale Roscoe var rubrum) Essential Oil and Its Anti-biofilm Activity against Candida albicans. Natural Product Communications. 2018; 13: 1934578X1801301206.","DOI":"10.1177\/1934578X1801301206"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Prastiyanto M, Rohmah NM, Efendi L, Arifin R, Wardoyo F, Wilson W, et al. Antifungal activities of the rhizome extract of five member Zingiberaceae against Candida albicans and Trichophyton rubrum. Biodiversitas Journal of Biological Diversity. 2021; 22: 1509\u20131513.","DOI":"10.13057\/biodiv\/d220355"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Oon SF, Nallappan M, Tee TT, Shohaimi S, Kassim NK, Sa\u2019ariwijaya MSF, et al. Xanthorrhizol: a review of its pharmacological activities and anticancer properties. Cancer Cell International. 2015; 15: 100.","DOI":"10.1186\/s12935-015-0255-4"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Dosoky NS, Setzer WN. Chemical Composition and Biological Activities of Essential Oils of Curcuma Species. Nutrients. 2018; 10: 1196.","DOI":"10.3390\/nu10091196"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Batiha GE-S, Alkazmi LM, Wasef LG, Beshbishy AM, Nadwa EH, Rashwan EK. Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities. Biomolecules. 2020; 10: 202.","DOI":"10.3390\/biom10020202"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Jones WP, Kinghorn AD. Extraction of Plant Secondary Metabolites. Natural products isolation (pp. 341\u2013366). Humana Press: Totowa, NJ, USA. 2012.","DOI":"10.1007\/978-1-61779-624-1_13"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Azmir J, Zaidul ISM, Rahman MM, Sharif KM, Mohamed A, Sahena F, et al. Techniques for extraction of bioactive compounds from plant materials: a review. Journal of Food Engineering. 2013; 117: 426\u2013436.","DOI":"10.1016\/j.jfoodeng.2013.01.014"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Tzanova M, Atanasov V, Yaneva Z, Ivanova D, Dinev T. Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials. Processes. 2020; 8: 1222.","DOI":"10.3390\/pr8101222"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Abubakar A, Haque M. Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. Journal of Pharmacy and Bioallied Sciences. 2020; 12: 1\u201310.","DOI":"10.4103\/jpbs.JPBS_175_19"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Gbenou JD, Ahounou JF, Akakpo HB, Laleye A, Yayi E, Gbaguidi F, et al. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats. Molecular Biology Reports. 2013; 40: 1127\u20131134.","DOI":"10.1007\/s11033-012-2155-1"},{"key":"ref37","unstructured":"Ling J, Jing, Mohamed M, Rahmat A, Abu Bakar MF. Phytochemicals, antioxidant properties and anticancer investigations of the different parts of several gingers species (Boesenbergia rotunda, Boesenbergia pulchella var attenuata and Boesenbergia armeniaca). Journal of Medicinal Plant Research. 2010; 4: 27\u201332."},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Akarchariya N, Sirilun S, Julsrigival J, Chansakaowa S. Chemical profiling and antimicrobial activity of essential oil from Curcuma aeruginosa Roxb., Curcuma glans K. Larsen & J. Mood and Curcuma cf. xanthorrhiza Roxb. collected in Thailand. Asian Pacific Journal of Tropical Biomedicine. 2017; 7: 881\u2013885.","DOI":"10.1016\/j.apjtb.2017.09.009"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Sabir SM, Zeb A, Mahmood M, Abbas SR, Ahmad Z, Iqbal N. Phytochemical analysis and biological activities of ethanolic extract of Curcuma longa rhizome. Brazilian Journal of Biology. 2020; 81: 737\u2013740.","DOI":"10.1590\/1519-6984.230628"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Sirat HM, Lee LM. Chemical Components of the Rhizome Oil of Curcuma Heyneana Val. Malaysian Journal of Science. 2009; 28: 232\u2013328.","DOI":"10.22452\/mjs.vol28no3.10"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Gharge S, Hiremath SI, Kagawad P, Jivaje K, Palled MS, Suryawanshi SS. Curcuma zedoaria Rosc (Zingiberaceae): a review on its chemical, pharmacological and biological activities. Future Journal of Pharmaceutical Sciences. 2021; 7: 166.","DOI":"10.1186\/s43094-021-00316-1"},{"key":"ref42","unstructured":"Zulkhairi AM, Aspollah SM, Lian EGC, Bustamam AA. Phytochemicals and cytotoxic studies of Zingiber cassumunarRoxb. Journal of Tropical Agriculture and Food Science. 2017; 45: 187\u2013197."},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Ghasemzadeh A, Jaafar HZE, Rahmat A. Variation of the Phytochemical Constituents and Antioxidant Activities of Zingiber officinale var. rubrum Theilade Associated with Different Drying Methods and Polyphenol Oxidase Activity. Molecules. 2016; 21: 780.","DOI":"10.3390\/molecules21060780"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"L\u00f3pez EIC, Balc\u00e1zar MFH, Mendoza JMR, Ortiz ADR, Melo MTO, Parrales RS, et al. Antimicrobial activity of essential oil of Zingiber officinale Roscoe (Zingiberaceae). American Journal of Plant Sciences. 2017; 8: 1511\u20131524.","DOI":"10.4236\/ajps.2017.87104"},{"key":"ref45","unstructured":"Wardana A, Aminah N, Fahmi Z, Kristanti AN, Zahrah HI, Takaya Y, et al. Nanoencapsulation of syzygium polycephalum extract using folate modified \u03ba-carrageenan as vehicles for pronounced anticancer activity. Tropical Journal of Natural Product Research. 2020; 4: 945\u2013952."},{"key":"ref46","unstructured":"Clsi WPA. Reference method for broth dilution antifungal susceptibility testing of yeasts. Clinical and Laboratory Standards Institute Wayne: PA. 2008."},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Soliman SSM, Semreen MH, El-Keblawy AA, Abdullah A, Uppuluri P, Ibrahim AS. Assessment of herbal drugs for promising anti-Candida activity. BMC Complementary and Alternative Medicine. 2017; 17: 1\u20139.","DOI":"10.1186\/s12906-017-1760-x"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Mostafa AA, Al-Askar AA, Almaary KS, Dawoud TM, Sholkamy EN, Bakri MM. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi Journal of Biological Sciences. 2018; 25: 361\u2013366.","DOI":"10.1016\/j.sjbs.2017.02.004"},{"key":"ref49","unstructured":"Lairungruang K, Itharat A, Panthong S. Antimicrobial activity of extracts from a Thai traditional remedy called Kabpi for oral and throat infection and its plant components. Journal of the Medical Association of Thailand. 2014; 97: S108\u2013S115."},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Jamal JA, Ghafar ZA, Husain K. Medicinal Plants used for Postnatal Care in Malay Traditional Medicine in the Peninsular Malaysia. Pharmacognosy Journal. 2011; 3: 15\u201324.","DOI":"10.5530\/pj.2011.24.4"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Lefebvre T, Destandau E, Lesellier E. Selective extraction of bioactive compounds from plants using recent extraction techniques: a review. Journal of Chromatography A. 2021; 1635: 461770.","DOI":"10.1016\/j.chroma.2020.461770"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Manousi N, Sarakatsianos I, Samanidou V. 10 - Extraction Techniques of Phenolic Compounds and Other Bioactive Compounds From Medicinal and Aromatic Plants. In Grumezescu AM, Holban AM (eds.) Engineering Tools in the Beverage Industry (pp. 283\u2013314). Woodhead Publishing: Sawston, UK. 2019.","DOI":"10.1016\/B978-0-12-815258-4.00010-X"},{"key":"ref53","unstructured":"Addai ZR. Phytochemicals screening and evaluation of antioxidants and antibacterial activities of five medicinal plants. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8: 393\u2013397."},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Vizhi D, Irulandi K, Mehalingam P, Kumar N. In vitro antimicrobial activity and phytochemical analysis of fruits of Syzygium aromaticum (L.) Merr. & L.M.Perry - An important medicinal Plant. The Journal of Phytopharmacology. 2016; 5: 137\u2013140.","DOI":"10.31254\/phyto.2016.5403"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Yassin MT, Mostafa AA, Al-Askar AA. In vitro anticandidal potency of Syzygium aromaticum (clove) extracts against vaginal candidiasis. BMC Complementary Medicine and Therapies. 2020; 20: 25.","DOI":"10.1186\/s12906-020-2818-8"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Leite MCA, Bezerra APdB, de Sousa JP, Guerra FQS, Lima EdO. Evaluation of Antifungal Activity and Mechanism of Action of Citral against Candida albicans. Evidence-Based Complementary and Alternative Medicine. 2014; 2014: 378280.","DOI":"10.1155\/2014\/378280"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Sharma Y, Khan LA, Manzoor N. Anti-Candida activity of geraniol involves disruption of cell membrane integrity and function. Journal de Mycologie Medicale. 2016; 26: 244\u2013254.","DOI":"10.1016\/j.mycmed.2016.04.004"},{"key":"ref58","unstructured":"Aina VO, Ibrahim MB, Adewumi AAJ, Abdulsalami MS, Godwin A, Shehu A. Phytochemical Studies And Antimicrobial Properties Of Methanolic And Aqueous Extracts Of Lemon Grass Leaves (Cymbopogon Citratus). Journal of Pharmaceutical and Allied Sciences. 2014; 11: 2142\u20132153."},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Ewansiha J, Garba S, Mawak J, Oyewole O. Antimicrobial activity of Cymbopogon citratus (Lemon grass) and it\u2019s phytochemical properties. Frontiers in Science. 2012; 2: 214\u2013220.","DOI":"10.5923\/j.fs.20120206.14"},{"key":"ref60","unstructured":"Zulfa Z, Chia CT, Rukayadi Y. In vitro antimicrobial activity of Cymbopogon citratus (lemongrass) extracts against selected foodborne pathogens. International Food Research Journal. 2016; 23: 1262."},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Cheraghipour K, Ezatpour B, Masoori L, Marzban A, Sepahvand A, Rouzbahani AK, et al. Anti-Candida Activity of Curcumin: a Systematic Review. Current Drug Discovery Technologies. 2021; 18: 379\u2013390.","DOI":"10.2174\/1570163817666200518074629"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Lee JH, Kim YG, Choi P, Ham J, Park JG, Lee J. Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition. Frontiers in Cellular and Infection Microbiology. 2018; 8: 299.","DOI":"10.3389\/fcimb.2018.00299"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Irshad S, Ashfaq A, Muazzam A, Yasmeen A. Antimicrobial and Anti-Prostate Cancer Activity of Turmeric (Curcuma longa L.) and Black Pepper (Piper nigrum L.) used in Typical Pakistani Cuisine. Pakistan Journal of Zoology. 2017; 49: 1665\u20131669.","DOI":"10.17582\/journal.pjz\/2017.49.5.1665.1669"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Samadi FM, Suhail S, Sonam M, Sharma N, Singh S, Gupta S, et al. Antifungal efficacy of herbs. Journal of Oral Biology and Craniofacial Research. 2019; 9: 28\u201332.","DOI":"10.1016\/j.jobcr.2018.06.002"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"El-Kelany A. Phytochemical and Biological Studies on Some Medicinal Plants. Al-Azhar Journal of Pharmaceutical Sciences. 2020; 62: 110\u2013134.","DOI":"10.21608\/ajps.2020.118379"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Khan A, Azam M, Allemailem KS, Alrumaihi F, Almatroudi A, Alhumaydhi FA, et al. Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis. Infection and Drug Resistance. 2021; 14: 1585\u20131599.","DOI":"10.2147\/IDR.S305503"},{"key":"ref67","unstructured":"Taweechaisupapong S, Singhara S, Lertsatitthanakorn P, Khunkitti W. Antimicrobial effects of Boesenbergia pandurata and Piper sarmentosum leaf extracts on planktonic cells and biofilm of oral pathogens. Pakistan Journal of Pharmaceutical Sciences. 2010; 23: 224\u2013231."},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Jitvaropas R, Saenthaweesuk S, Somparn N, Thuppia A, Sireeratawong S, Phoolcharoen W. Antioxidant, Antimicrobial and Wound Healing Activities of Boesenbergia rotunda. Natural Product Communications. 2012; 7: 1934578X1200700727.","DOI":"10.1177\/1934578X1200700727"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Kanchanapiboon J, Kongsa U, Pattamadilok D, Kamponchaidet S, Wachisunthon D, Poonsatha S, et al. Boesenbergia rotunda extract inhibits Candida albicans biofilm formation by pinostrobin and pinocembrin. Journal of Ethnopharmacology. 2020; 261: 113193.","DOI":"10.1016\/j.jep.2020.113193"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Shinobu-Mesquita CS, Bertoni TA, Guilhermetti E, Svidzinski TI. Antifungal activity of the extract of Curcuma zedoaria against yeasts of the genus Candida isolated from the oral cavity of patients infected with the human immunodeficiency virus. Revista Brasileira de Farmacognosia. 2011; 21: 128\u2013132.","DOI":"10.1590\/S0102-695X2011005000017"},{"key":"ref71","unstructured":"Pithayanukul P, Tubprasert J, Wuthi-Udomlert M. In Vitro antimicrobial activity of Zingiber cassumunar (Plai) oil and a 5"},{"key":"ref72","unstructured":"Rahmawati D, Sukmawati A, Indrayudha P. Formulation Cream Containing Essential Oil of Curcuma Heyneana: Physical Characteristics Test and in Vitro Antifungal Activity Against Candida Albicans. Majalah Obat Tradisional. 2010; 15: 56\u201363."},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Manoharan RK, Lee JH, Lee J. Antibiofilm and Antihyphal Activities of Cedar Leaf Essential Oil, Camphor, and Fenchone Derivatives against Candida albicans. Frontiers in Microbiology. 2017; 8: 1476.","DOI":"10.3389\/fmicb.2017.01476"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Pinto \u00c2, Oliveira JC, Costa de Medeiros CA, Silva SL, Pereira FO. Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes. Letters in Applied Microbiology. 2021; 72: 292\u2013298.","DOI":"10.1111\/lam.13371"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Busri A, Puspitawati R, Utami S. Antibacterial effect of Java turmeric ethanol extract against dual-species Streptococcus mutans and Streptococcus sanguinis biofilm (in vitro). Asian Journal of Pharmaceutical and Clinical Research. 2017; 10: 57\u201360.","DOI":"10.22159\/ajpcr.2017.v10s5.23096"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Silva G, Pozzatti P, Rigatti F, H\u00f6rner R, Alves SH, Mallmann C, et al. Antimicrobial evaluation of sesquiterpene alpha-curcumene and its synergism with imipenem. Journal of Microbiology, Biotechnology and Food Sciences. 2015; 4: 434\u2013436.","DOI":"10.15414\/jmbfs.2015.4.5.434-436"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Philip K, Abd Malek SN, Sani W, Kae Shin S, Kumar S, Sok Lai H, et al. Antimicrobial Activity of some Medicinal Plants from Malaysia. American Journal of Applied Sciences. 2009; 6: 1613\u20131617.","DOI":"10.3844\/ajassp.2009.1613.1617"},{"key":"ref78","unstructured":"Rukayadi Y, Lau KY, Zainin NS, Zakaria M, Abas F. Screening antimicrobial activity of tropical edible medicinal plant extracts against five standard microorganisms for natural food preservative. International Food Research Journal. 2013; 20: 2905\u20132910."},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Novianti D, Kartika T. Fractionation of bioactive materials temulawak rhizome (Curcuma xanthorrhiza) on fungal Candida albicans in search of phytopharmaca. Journal of Physics: Conference Series. 2019; 1375: 012015.","DOI":"10.1088\/1742-6596\/1375\/1\/012015"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Lestari AYU, Puspitawati RIA, Djais A. The Potency of Javanese Turmeric (Curcuma Xanthorrhiza Roxb.) Ethanol Extract to Eradicate Wild Strain Candida Albicans Biofilm. International Journal of Applied Pharmaceutics. 2019; 11: 5\u20139.","DOI":"10.22159\/ijap.2019.v11s1.150"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Puspitawati R, Maira U, Suniarti D, Salma A. Inhibition and Eradication Effect of Javanese turmeric (Curcuma xanthorrhiza Roxb.) Extract Against Mature Phase Biofilm of Candida albicans. Pesquisa Brasileira em Odontopediatria e Cl\u00ednica Integrada. 2019; 19: 1\u20138.","DOI":"10.4034\/PBOCI.2019.191.89"},{"key":"ref82","unstructured":"Sukandar E, Kurniati N, Wikaningtyas P, Agprikani D. Antibacterial interaction of combination of ethanolic extract of Zingiber officinale var rubrum rhizome, Boesenbergia pandurata rhizome, and Stevia rebaudiana leaves with certain antibiotics against infectious mouth microbial. Asian Journal of Pharmaceutical and Clinical Research. 2016; 9: 332\u2013335."},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Patel M, Coogan MM. Antifungal activity of the plant Dodonaea viscosa var. angustifolia on Candida albicans from HIV-infected patients. Journal of Ethnopharmacology. 2008; 118: 173\u2013176.","DOI":"10.1016\/j.jep.2008.03.009"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Motsei ML, Lindsey KL, van Staden J, J\u00e4ger AK. Screening of traditionally used South African plants for antifungal activity against Candida albicans. Journal of Ethnopharmacology. 2003; 86: 235\u2013241.","DOI":"10.1016\/S0378-8741(03)00082-5"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Braga FG, Bouzada MLM, Fabri RL, de O. Matos M, Moreira FO, Scio E, et al. Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil. Journal of Ethnopharmacology. 2007; 111: 396\u2013402.","DOI":"10.1016\/j.jep.2006.12.006"},{"key":"ref86","unstructured":"Nacsa-Farkas E. Antifungal effect of selected European herbs against Candida albicans and emerging pathogenic non-albicans Candida species. Acta Biologica Szegediensis. 2014; 58: 61\u201364."},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"V\u00e1zquez-Le\u00f3n LA, P\u00e1ramo-Calder\u00f3n DE, Robles-Olvera VJ, Vald\u00e9s-Rodr\u00edguez OA, P\u00e9rez-V\u00e1zquez A, Garc\u00eda-Alvarado MA, et al. Variation in bioactive compounds and antiradical activity of Moringa oleifera leaves: influence of climatic factors, tree age, and soil parameters. European Food Research and Technology. 2017; 243: 1593\u20131608.","DOI":"10.1007\/s00217-017-2868-4"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Przybylska-Balcerek A, Frankowski J, Stuper-Szablewska K. The influence of weather conditions on bioactive compound content in sorghum grain. European Food Research and Technology. 2020; 246: 13\u201322.","DOI":"10.1007\/s00217-019-03391-0"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Muscolo A, Sidari M, Settineri G, Papalia T, Mallamaci C, Attin\u00e0 E. Influence of Soil Properties on Bioactive Compounds and Antioxidant Capacity of Brassica rupestris Raf. Journal of Soil Science and Plant Nutrition. 2019; 19: 808\u2013815.","DOI":"10.1007\/s42729-019-00080-5"}],"container-title":["Frontiers in Bioscience-Landmark"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/27\/9\/10.31083\/j.fbl2709274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T12:30:11Z","timestamp":1732710611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/27\/9\/10.31083\/j.fbl2709274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":89,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022]]}},"alternative-id":["S2768-6701(22)00646-3"],"URL":"https:\/\/doi.org\/10.31083\/j.fbl2709274","relation":{},"ISSN":["2768-6701","2768-6698"],"issn-type":[{"value":"2768-6701","type":"print"},{"value":"2768-6698","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"article-number":"274"}}