{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:35:31Z","timestamp":1782830131964,"version":"3.54.5"},"reference-count":91,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Introduction: L-carnosine has been found to have multimodal activity. Aim: The aim of this review was to find out the efficacy of L-carnosine in patients with age-related diseases. Methods: Clinical studies evaluated the effect of L-carnosine on cancer, cardiovascular disease, diabetes, and neurodegenerative disorders were searched in electronic bibliographic databases. The protocol has been registered with PROSPERO (CRD42022314033). The revised Cochrane risk of bias tool for randomized trials was used to assess all of the reports for risk of bias. RevMan 5.4 was used to conduct the meta-analysis. Results: Following the screening process, 14 papers were selected for systematic review, with 9 of them being qualified for meta-analysis. Many of the included studies showed that L-carnosine has potential therapeutic activity in age related diseases. Results from the meta-analysis showed that in diabetes mellitus, HbA1c [mean difference (MD) 95% CI = \u20131.25 (\u20132.49, \u20130.022); p = 0.05; p = 0.001; I2 = 85%] and fasting blood sugar (FBS) [MD 95% CI = \u201312.44 (\u201322.44, \u20132.44); p = 0.01; p = 0.40; I2 = 0%] and in neurodegenerative disorder, Wechsler Memory Scale Logical Memory 2 (WMS-LM2) [MD 95% CI = 1.34 (0.83, 1.85); p &lt; 0.00001; p = 0.43; I2 = 0%], showed statistically significant difference, favoring the L-carnosine group over the control group. While in neurodegenerative disorder, Alzheimer \u2019s Disease Assessment Scale (ADAS) [MD 95% CI = 0.98 (\u20131.55, \u20130.42); p = 0.0007; p = 0.86; I2 = 0%] and Back Depression Inventory (BDI) [MD 95% CI = \u20131.12 (\u20131.87, \u20130.37); p = 0.003; p = 0.73; I2 = 0%] showed statistically significant difference, favoring the control group over L-carnosine group. Conclusions: Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.<\/jats:p>","DOI":"10.31083\/j.fbl2801018","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T08:28:59Z","timestamp":1674030539000},"source":"Crossref","is-referenced-by-count":15,"title":["Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis"],"prefix":"10.31083","volume":"28","author":[{"given":"Kaoshik","family":"Sureshkumar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, 600116 Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Durairaj","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, 600116 Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaviya","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, 600116 Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khang Wen","family":"Goh","sequence":"first","affiliation":[{"name":"Faculty of Data Science and Information Technology, INTI International University, 71800 Nilai, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Undela","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Changsari, 781101 Kamrup (R), Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayakumar Thangavel","family":"Mahalingam","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, 603203 Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrismawan","family":"Ardianto","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, 60115 Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long Chiau","family":"Ming","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, 60115 Surabaya, Indonesia"},{"name":"School of Medical and Life Sciences, Sunway University, Bandar Sunway, 47500 Selangor, Malaysia"},{"name":"PAP Rashidah Sa\u2019adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajanandh Muhasaparur","family":"Ganesan","sequence":"first","affiliation":[{"name":"Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Thandalam, 602105 Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Gariballa SE, Sinclair AJ. Carnosine: physiological properties and therapeutic potential. Age and Ageing. 2000; 29: 207\u2013210.","DOI":"10.1093\/ageing\/29.3.207"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Juki\u0107 I, Kolobari\u0107 N, Stupin A, Mati\u0107 A, Kozina N, Mihaljevi\u0107 Z, et al. Carnosine, small but mighty-prospect of use as functional ingredient for functional food formulation. Antioxidants. 2021; 10: 1037.","DOI":"10.3390\/antiox10071037"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, et al. Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids. 2011; 40: 1221\u20131229.","DOI":"10.1007\/s00726-010-0749-2"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Bellia F, Vecchio G, Rizzarelli E. Carnosine derivatives: new multifunctional drug-like molecules. Amino Acids. 2012; 43: 153\u2013163.","DOI":"10.1007\/s00726-011-1178-6"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kitagawa J, Kobayashi R, Nagata Y, Kasahara S, Ono T, Sawada M, et al. Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi-institutional randomized controlled trial. International Journal of Cancer. 2021; 148: 1462\u20131469.","DOI":"10.1002\/ijc.33316"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Tang W, Liu H, Ooi TC, Rajab NF, Cao H, Sharif R. Zinc carnosine: Frontiers advances of supplement for cancer therapy. Biomedicine & Pharmacotherapy. 2022; 151: 113157.","DOI":"10.1016\/j.biopha.2022.113157"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Grothey A, Goldberg RM. A review of oxaliplatin and its clinical use in colorectal cancer. Expert Opinion on Pharmacotherapy. 2004; 5: 2159\u20132170.","DOI":"10.1517\/14656566.5.10.2159"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"McWhinney SR, Goldberg RM, McLeod HL. Platinum neurotoxicity pharmacogenetics. Molecular Cancer Therapeutics. 2009; 8: 10\u201316.","DOI":"10.1158\/1535-7163.MCT-08-0840"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Li W, Khor TO, Xu C, Shen G, Jeong W, Yu S, et al. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochemical Pharmacology. 2008; 76: 1485\u20131489.","DOI":"10.1016\/j.bcp.2008.07.017"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Negi G, Kumar A, Sharma S. Adopting Nrf2 and NF-\u03baB from cancer: Is there any role of the duo in diabetes. Nature Precedings. 2011; 8: 1.","DOI":"10.1038\/npre.2011.6581"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Peng S, Ying AF, Chan NJH, Sundar R, Soon YY, Bandla A. Prevention of Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis. Frontiers in Oncology. 2022; 12: 731223.","DOI":"10.3389\/fonc.2022.731223"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Liebetrau C, Hoffmann J, D\u00f6rr O, Gaede L, Blumenstein J, Biermann H, et al. Release kinetics of inflammatory biomarkers in a clinical model of acute myocardial infarction. Circulation Research. 2015; 116: 867\u2013875.","DOI":"10.1161\/CIRCRESAHA.116.304653"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Liu W, Liu T, Yin M. Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury. Food and Chemical Toxicology: an International Journal Published for the British Industrial Biological Research Association. 2008; 46: 1503\u20131509.","DOI":"10.1016\/j.fct.2007.12.013"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Guney Y, Turkcu UO, Hicsonmez A, Andrieu MN, Guney HZ, Bilgihan A, et al. Carnosine may reduce lung injury caused by radiation therapy. Medical Hypotheses. 2006; 66: 957\u2013959.","DOI":"10.1016\/j.mehy.2005.11.023"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Pi\u00f1a IL, Apstein CS, Balady GJ, Belardinelli R, Chaitman BR, Duscha BD, et al. Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation. 2003; 107: 1210\u20131225.","DOI":"10.1161\/01.CIR.0000055013.92097.40"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Hultman E, Sahlin K. Acid-base balance during exercise. Exercise and Sport Sciences Reviews. 1980; 8: 41\u2013128.","DOI":"10.1249\/00003677-198000080-00005"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Caruso J, Charles J, Unruh K, Giebel R, Learmonth L, Potter W. Ergogenic effects of \u03b2-alanine and carnosine: proposed future research to quantify their efficacy. Nutrients. 2012; 4: 585\u2013601.","DOI":"10.3390\/nu4070585"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Culbertson JY, Kreider RB, Greenwood M, Cooke M. Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature. Nutrients. 2010; 2: 75\u201398.","DOI":"10.3390\/nu2010075"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Derave W, Everaert I, Beeckman S, Baguet A. Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training. Sports Medicine. 2010; 40: 247\u2013263.","DOI":"10.2165\/11530310-000000000-00000"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Batrukova MA, Rubtsov AM. Histidine-containing dipeptides as endogenous regulators of the activity of sarcoplasmic reticulum Ca-release channels. Biochimica Et Biophysica Acta. 1997; 1324: 142\u2013150.","DOI":"10.1016\/S0005-2736(96)00216-7"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Ririe DG, Roberts PR, Shouse MN, Zaloga GP. Vasodilatory actions of the dietary peptide carnosine. Nutrition. 2000; 16: 168\u2013172.","DOI":"10.1016\/S0899-9007(99)00268-3"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Houjeghani S, Kheirouri S, Faraji E, Jafarabadi MA. L-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-\u03b1 levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial. Nutrition Research. 2018; 49: 96\u2013106.","DOI":"10.1016\/j.nutres.2017.11.003"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Semba RD, Nicklett EJ, Ferrucci L. Does accumulation of advanced glycation end products contribute to the aging phenotype? The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2010; 65: 963\u2013975.","DOI":"10.1093\/gerona\/glq074"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006; 114: 597\u2013605.","DOI":"10.1161\/CIRCULATIONAHA.106.621854"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Alhamdani MS, Al-Azzawie HF, Abbas FKH. Decreased formation of advanced glycation end-products in peritoneal fluid by carnosine and related peptides. Peritoneal Dialysis International. 2007; 27: 86\u201389.","DOI":"10.1177\/089686080702700118"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Baye E, Menon K, de Courten MP, Earnest A, Cameron J, de Courten B. Does supplementation with carnosine improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes? Study protocol for a randomised, double-blind, placebo-controlled trial. BMJ Open. 2017; 7: e017691.","DOI":"10.1136\/bmjopen-2017-017691"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Pfister F, Riedl E, Wang Q, vom Hagen F, Deinzer M, Harmsen MC, et al. Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy. Cellular Physiology and Biochemistry. 2011; 28: 125\u2013136.","DOI":"10.1159\/000331721"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Satirapoj B, Adler SG. Comprehensive approach to diabetic nephropathy. Kidney Research and Clinical Practice. 2014; 33: 121\u2013131.","DOI":"10.1016\/j.krcp.2014.08.001"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Schena FP, Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. Journal of the American Society of Nephrology. 2005; 16 Suppl 1: S30\u2013S33.","DOI":"10.1681\/ASN.2004110970"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Chang AS, Hathaway CK, Smithies O, Kakoki M. Transforming growth factor-\u03b21 and diabetic nephropathy. American Journal of Physiology Renal Physiology. 2016; 310: F689\u2013F696.","DOI":"10.1152\/ajprenal.00502.2015"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Zheng X, Bhalla V. The missing link: studying the alternative TGF-\u03b2 pathway provides a unifying theory for different components of diabetic nephropathy. Diabetes. 2015; 64: 1898\u20131900.","DOI":"10.2337\/db15-0184"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Hobart LJ, Seibel I, Yeargans GS, Seidler NW. Anti-crosslinking properties of carnosine: significance of histidine. Life Sciences. 2004; 75: 1379\u20131389.","DOI":"10.1016\/j.lfs.2004.05.002"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Federici A, Federici G, Milani M. Use of a urea, arginine and carnosine cream versus a standard emollient glycerol cream for treatment of severe xerosis of the feet in patients with type 2 diabetes: a randomized, 8 month, assessor-blinded, controlled trial. Current Medical Research and Opinion. 2015; 31: 1063\u20131069.","DOI":"10.1185\/03007995.2015.1037731"},{"key":"ref34","unstructured":"Uhoda E, Debatisse B, Paquet P, Pi\u00e9rard-Franchimont C, Pi\u00e9rard GE. The so-called dry skin of the diabetic patient. Revue Medicale De Liege. 2005; 60: 560\u2013563."},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Beck K, Javitt DC, Howes OD. Targeting glutamate to treat schizophrenia: lessons from recent clinical studies. Psychopharmacology. 2016; 233: 2425\u20132428.","DOI":"10.1007\/s00213-016-4318-6"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Field JR, Walker AG, Conn PJ. Targeting glutamate synapses in schizophrenia. Trends in Molecular Medicine. 2011; 17: 689\u2013698.","DOI":"10.1016\/j.molmed.2011.08.004"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Solana-Manrique C, Sanz FJ, Mart\u00ednez-Carri\u00f3n G, Paricio N. Antioxidant and Neuroprotective Effects of Carnosine: Therapeutic Implications in Neurodegenerative Diseases. Antioxidants. 2022; 11: 848.","DOI":"10.3390\/antiox11050848"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Karton A, O\u2019Reilly RJ, Pattison DI, Davies MJ, Radom L. Computational design of effective, bioinspired HOCl antioxidants: the role of intramolecular Cl+ and H+ shifts. Journal of the American Chemical Society. 2012; 134: 19240\u201319245.","DOI":"10.1021\/ja309273n"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Kulebyakin K, Karpova L, Lakonsteva E, Krasavin M, Boldyrev A. Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling. Amino Acids. 2012; 43: 91\u201396.","DOI":"10.1007\/s00726-011-1135-4"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Shen Y, He P, Fan Y, Zhang J, Yan H, Hu W, et al. Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity. Free Radical Biology & Medicine. 2010; 48: 727\u2013735.","DOI":"10.1016\/j.freeradbiomed.2009.12.021"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Shen Y, Hu W, Fan Y, Dai H, Fu Q, Wei E, et al. Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)\/H(3) receptors. Biochemical Pharmacology. 2007; 73: 709\u2013717.","DOI":"10.1016\/j.bcp.2006.11.007"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Hipkiss AR. Could carnosine or related structures suppress Alzheimer\u2019s disease? Journal of Alzheimer\u2019s Disease. 2007; 11: 229\u2013240.","DOI":"10.3233\/JAD-2007-11210"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science. 2002; 296: 1991\u20131995.","DOI":"10.1126\/science.1067122"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, et al. Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice. PLoS ONE. 2011; 6: e17971.","DOI":"10.1371\/journal.pone.0017971"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Park HY, Suh CH, Woo S, Kim PH, Kim KW. Quality Reporting of Systematic Review and Meta-Analysis According to PRISMA 2020 Guidelines: Results from Recently Published Papers in the Korean Journal of Radiology. Korean Journal of Radiology. 2022; 23: 355\u2013369.","DOI":"10.3348\/kjr.2021.0808"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of Clinical Epidemiology. 2009; 62: e1\u201334.","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. British Medical Journal. 2011; 343: d5928.","DOI":"10.1136\/bmj.d5928"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Szcze\u015bniak D, Budze\u0144 S, Kope\u0107 W, Rymaszewska J. Anserine and carnosine supplementation in the elderly: Effects on cognitive functioning and physical capacity. Archives of Gerontology and Geriatrics. 2014; 59: 485\u2013490.","DOI":"10.1016\/j.archger.2014.04.008"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Chengappa KNR, Turkin SR, DeSanti S, Bowie CR, Brar JS, Schlicht PJ, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophrenia Research. 2012; 142: 145\u2013152.","DOI":"10.1016\/j.schres.2012.10.001"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Ghajar A, Khoaie-Ardakani M, Shahmoradi Z, Alavi A, Afarideh M, Shalbafan M, et al. L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial. Psychiatry Research. 2018; 262: 94\u2013101.","DOI":"10.1016\/j.psychres.2018.02.012"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Hisatsune T, Kaneko J, Kurashige H, Cao Y, Satsu H, Totsuka M, et al. Effect of Anserine\/Carnosine Supplementation on Verbal Episodic Memory in Elderly People. Journal of Alzheimer\u2019s Disease. 2016; 50: 149\u2013159.","DOI":"10.3233\/JAD-150767"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Karkabounas S, Papadopoulos N, Anastasiadou C, Gubili C, Peschos D, Daskalou T, et al. Effects of \u03b1-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study. Journal of Medicinal Food. 2018; 21: 1197\u20131203.","DOI":"10.1089\/jmf.2018.0007"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Katakura Y, Totsuka M, Imabayashi E, Matsuda H, Hisatsune T. Anserine\/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People. Nutrients. 2017; 9: 1199.","DOI":"10.3390\/nu9111199"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Lombardi C, Carubelli V, Lazzarini V, Vizzardi E, Bordonali T, Ciccarese C, et al. Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure. Nutrition. 2015; 31: 72\u201378.","DOI":"10.1016\/j.nut.2014.04.021"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Yehia R, Saleh S, El Abhar H, Saad AS, Schaalan M. L-Carnosine protects against Oxaliplatin-induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf-2 and NF-\u03baB pathways. Toxicology and Applied Pharmacology. 2019; 365: 41\u201350.","DOI":"10.1016\/j.taap.2018.12.015"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Masuoka N, Yoshimine C, Hori M, Tanaka M, Asada T, Abe K, et al. Effects of Anserine\/Carnosine Supplementation on Mild Cognitive Impairment with APOE4. Nutrients. 2019; 11: 1626.","DOI":"10.3390\/nu11071626"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of Oral carnosine supplementation on urinary TGF-\u03b2 in diabetic nephropathy: a randomized controlled trial. BMC Nephrology. 2021; 22: 236.","DOI":"10.1186\/s12882-021-02434-7"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Yoshikawa F, Nakajima T, Hanada M, Hirata K, Masuyama T, Aikawa R. Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial. Medicine. 2019; 98: e14637.","DOI":"10.1097\/MD.0000000000014637"},{"key":"ref59","unstructured":"Miku\u0142a-Pietrasik J, Ksi\u0105\u017cek K. L-Carnosine Prevents the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells. Anticancer Research. 2016; 36: 665\u2013671."},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Renner C, Zemitzsch N, Fuchs B, Geiger KD, Hermes M, Hengstler J, et al. Carnosine retards tumor growth in vivo in an NIH3T3-HER2\/neu mouse model. Molecular Cancer. 2010; 9: 2.","DOI":"10.1186\/1476-4598-9-2"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Hwang B, Shin S, Song J, Choi YH, Kim W, Moon S. Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis. The Journal of Nutritional Biochemistry. 2019; 74: 108230.","DOI":"10.1016\/j.jnutbio.2019.108230"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Cheng J, Yang J, Liu Y, Xu M, Huang Y, Zhang J, et al. Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine. Acta Pharmacologica Sinica. 2019; 40: 938\u2013948.","DOI":"10.1038\/s41401-018-0182-8"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Zhang Z, Miao L, Wu X, Liu G, Peng Y, Xin X, et al. Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt\/mTOR\/p70S6K Signaling. Journal of Cancer. 2014; 5: 382\u2013389.","DOI":"10.7150\/jca.8024"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Ding M, Jiao G, Shi H, Chen Y. Investigations on in vitro anti-carcinogenic potential of L-carnosine in liver cancer cells. Cytotechnology. 2018; 70: 163\u2013167.","DOI":"10.1007\/s10616-017-0123-2"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Horii Y, Shen J, Fujisaki Y, Yoshida K, Nagai K. Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation. Neuroscience Letters. 2012; 510: 1\u20135.","DOI":"10.1016\/j.neulet.2011.12.058"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Kumral A, Giri\u015f M, Soluk-Tekke\u015fin M, Olga\u00e7 V, Do\u011fru-Abbaso\u011flu S, T\u00fcrko\u011flu \u00dc, et al. Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats. Human & Experimental Toxicology. 2016; 35: 635\u2013643.","DOI":"10.1177\/0960327115597468"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Mohamed MA. The protective effect of carnosine on kidneys of albino rats in methotrexate induced oxidative injury. Egyptian Journal of Forensic Sciences. 2018; 18: 69\u201381.","DOI":"10.21608\/ejfsat.2019.6910.1041"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Xu M, He R, Zhai Y, Abe K, Kurihara H. Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice. The American Journal of Chinese Medicine. 2014; 42: 131\u2013142.","DOI":"10.1142\/S0192415X14500098"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Fujii H, Hirose C, Ishihara M, Iihara H, Imai H, Tanaka Y, et al. Improvement of Dysgeusia by Polaprezinc, a Zinc-L-carnosine, in Outpatients Receiving Cancer Chemotherapy. Anticancer Research. 2018; 38: 6367\u20136373.","DOI":"10.21873\/anticanres.12995"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Funato M, Ozeki M, Suzuki A, Ishihara M, Kobayashi R, Nozawa A, et al. Prophylactic Effect of Polaprezinc, a Zinc-L-carnosine, Against Chemotherapy-induced Oral Mucositis in Pediatric Patients Undergoing Autologous Stem Cell Transplantation. Anticancer Research. 2018; 38: 4691\u20134697.","DOI":"10.21873\/anticanres.12775"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Bae O, Serfozo K, Baek S, Lee KY, Dorrance A, Rumbeiha W, et al. Safety and efficacy evaluation of carnosine, an endogenous neuroprotective agent for ischemic stroke. Stroke. 2013; 44: 205\u2013212.","DOI":"10.1161\/STROKEAHA.112.673954"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Fedorova TN, Devyatov AA, Berezhnoi DS, Stvolinskii SL, Morozova MP, Gavrilova SA, et al. Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine. Bulletin of Experimental Biology and Medicine. 2018; 165: 746\u2013750.","DOI":"10.1007\/s10517-018-4256-x"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Jain S, Kim E, Kim D, Burrows D, De Felice M, Kim M, et al. Comparative Cerebroprotective Potential of d- and l-Carnosine Following Ischemic Stroke in Mice. International Journal of Molecular Sciences. 2020; 21: 3053.","DOI":"10.3390\/ijms21093053"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Keskin A, Kanar BG, Kanar RG, Kepez A, Tunerir B. An investigation on the impact of carnosine on the myocardium in lower extremity ischemia-reperfusion injury in rats. International Journal of the Cardiovascular Academy. 2017; 3: 109\u2013113.","DOI":"10.1016\/j.ijcac.2016.11.054"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Menini S, Iacobini C, Ricci C, Scipioni A, Blasetti Fantauzzi C, Giaccari A, et al. D-Carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation. British Journal of Pharmacology. 2012; 166: 1344\u20131356.","DOI":"10.1111\/j.1476-5381.2012.01834.x"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Stefani GP, Capalonga L, da Silva LR, Heck TG, Frizzo MN, Sulzbacher LM, et al. Effects of aerobic and resistance exercise training associated with carnosine precursor supplementation on maximal strength and V\u0307O2max in rats with heart failure. Life Sciences. 2021; 282: 119816.","DOI":"10.1016\/j.lfs.2021.119816"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Zeb A, Cha JH, Noh AR, Qureshi OS, Kim KW, Choe YH, et al. Neuroprotective effects of carnosine-loaded elastic liposomes in cerebral ischemia rat model. Journal of Pharmaceutical Investigation. 2020; 50: 373\u2013381.","DOI":"10.1007\/s40005-019-00462-y"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Zhang X, Xia L, Huang Z, Xu F. The effects of carnosine pretreatment on the inflammatory response and the PI3K\/Akt signaling pathway following hypoxia-ischemia in neonatal rats. bioRxiv. 2019: 766063.","DOI":"10.1101\/766063"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Ahshin-Majd S, Zamani S, Kiamari T, Kiasalari Z, Baluchnejadmojarad T, Roghani M. Carnosine ameliorates cognitive deficits in streptozotocin-induced diabetic rats: Possible involved mechanisms. Peptides. 2016; 86: 102\u2013111.","DOI":"10.1016\/j.peptides.2016.10.008"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Peters V, Riedl E, Braunagel M, H\u00f6ger S, Hauske S, Pfister F, et al. Carnosine treatment in combination with ACE inhibition in diabetic rats. Regulatory Peptides. 2014; 194\u2013195: 36\u201340.","DOI":"10.1016\/j.regpep.2014.09.005"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Abdelkader H, Longman M, Alany RG, Pierscionek B. On the Anticataractogenic Effects of L-Carnosine: Is It Best Described as an Antioxidant, Metal-Chelating Agent or Glycation Inhibitor? Oxidative Medicine and Cellular Longevity. 2016; 2016: 3240261.","DOI":"10.1155\/2016\/3240261"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Albrecht T, Schilperoort M, Zhang S, Braun JD, Qiu J, Rodriguez A, et al. Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob\/ob Mice. Scientific Reports. 2017; 7: 44492.","DOI":"10.1038\/srep44492"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Ansurudeen I, Sunkari VG, Gr\u00fcnler J, Peters V, Schmitt CP, Catrina S, et al. Carnosine enhances diabetic wound healing in the db\/db mouse model of type 2 diabetes. Amino Acids. 2012; 43: 127\u2013134.","DOI":"10.1007\/s00726-012-1269-z"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Brown JM, Baker LS, Seroogy KB, Genter MB. Intranasal Carnosine Mitigates \u03b1-Synuclein Pathology and Motor Dysfunction in the Thy1-aSyn Mouse Model of Parkinson\u2019s Disease. ACS Chemical Neuroscience. 2021; 12: 2347\u20132359.","DOI":"10.1021\/acschemneuro.1c00096"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Col\u00edn-Barenque L, Bizarro-Nevares P, Gonz\u00e1lez Villalva A, Pedraza-Chaverri J, Medina-Campos ON, Jimenez-Mart\u00ednez R, et al. Neuroprotective effect of carnosine in the olfactory bulb after vanadium inhalation in a mouse model. International Journal of Experimental Pathology. 2018; 99: 180\u2013188.","DOI":"10.1111\/iep.12285"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Ding Q, Tanigawa K, Kaneko J, Totsuka M, Katakura Y, Imabayashi E, et al. Anserine\/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4. Aging and Disease. 2018; 9: 334\u2013345.","DOI":"10.14336\/AD.2017.0809"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Herculano B, Tamura M, Ohba A, Shimatani M, Kutsuna N, Hisatsune T. \u03b2-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease. 2013; 33: 983\u2013997.","DOI":"10.3233\/JAD-2012-121324"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Tsuji T, Furuhara K, Gerasimenko M, Shabalova A, Cherepanov SM, Minami K, et al. Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release. Nutrients. 2022; 14: 803.","DOI":"10.3390\/nu14040803"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Chmielewska K, Dzierzbicka K, Inkielewicz-St\u0119pniak I, Przyby\u0142owska M. Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases. Chemical Research in Toxicology. 2020; 33: 1561\u20131578.","DOI":"10.1021\/acs.chemrestox.0c00010"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Mahmood A, FitzGerald AJ, Marchbank T, Ntatsaki E, Murray D, Ghosh S, et al. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut. 2007; 56: 168\u2013175.","DOI":"10.1136\/gut.2006.099929"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Caruso G, Godos J, Castellano S, Micek A, Murabito P, Galvano F, et al. The Therapeutic Potential of Carnosine\/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis. 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