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(Landmark Ed)"],"abstract":"<jats:p>Several antiviral drugs are clinically approved to treat influenza that is a highly prevalent acute respiratory disease. However, emerging drug-resistant virus strains undermine treatment efficacy, highlighting the exigency for novel antiviral drugs to counter these drug-resistant strains. Plants and their derivates have been historically utilized as medicinal remedies, and extensive studies have evidenced the antiviral potential of phytochemicals. Notably, apigenin is a predominant flavonoid with minimal toxicity and substantial therapeutic effects in various disease models. Despite its many anti-inflammatory, anti-oxidant, anti-cancer, anti-bacterial, and other beneficial bioactivities, existing reviews have yet to focus on apigenin\u2019s antiviral effects. Therefore, this review elucidates apigenin\u2019s therapeutic and antiviral properties in vitro and in vivo, discussing its mode of action and future prospects. Apigenin\u2019s remarkable inhibition by modulating multiple mechanisms against viruses has promising potential for novel plant-derived antiviral drugs and further clinical study developments.<\/jats:p>","DOI":"10.31083\/j.fbl2810237","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T08:07:39Z","timestamp":1697789259000},"source":"Crossref","is-referenced-by-count":36,"title":["Apigenin\u2019s Therapeutic Potential Against Viral Infection"],"prefix":"10.31083","volume":"28","author":[{"given":"In-Gu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Life Science, Chung-Ang University, 06974 Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghyeon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Life Science, Chung-Ang University, 06974 Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Hee","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine, Ewha Womans University, 07804 Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jin","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Life Science, Chung-Ang University, 06974 Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Taubenberger JK, Morens DM. 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