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Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background: Type 1 diabetes mellitus (T1D) represents a severe threat to human health. Persistent hyperglycemia and dyslipidemia can lead to damaged liver function, while effective interventions for these complications are currently lacking. Deer antler stem cells (AnSCs), a novel type of adult stem cells, significantly reduced liver injury, which was speculated to be achieved through the paracrine pathway. Methods: In this study, AnSC-conditioned medium (AnSC-CM) was used to treat C57BL\/6 mice with T1D symptoms induced by streptozotocin (STZ). The therapeutic effects of AnSC-CM on T1D were evaluated, and the underlying mechanism was investigated. Results: It was shown that AnSC-CM alleviated the T1D symptom: decreased body weight, increased blood glucose levels and islet lesions, and reduced insulin secretion. Moreover, AnSC-CM treatment improved liver function and mitigated liver injury in T1D mice. Impressively, the therapeutic effects of AnSC-CM on T1D were better than those of bone marrow mesenchymal stem cell-CM (BMSC-CM). The mechanistic study revealed that AnSC-CM significantly downregulated the NF-\u03baB signaling pathway in both pancreatic and liver tissues. Conclusions: Therapeutic effects of AnSC-CM on STZ-induced T1D and liver injury may be achieved through targeting the NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.31083\/j.fbl2903096","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T02:21:22Z","timestamp":1710728482000},"source":"Crossref","is-referenced-by-count":7,"title":["Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-\u03baB Signaling Pathway"],"prefix":"10.31083","volume":"29","author":[{"given":"Dongxu","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ren","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"},{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, 130118 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Li","sequence":"first","affiliation":[{"name":"Scientific Research center, China-Japan Union Hospital, Jilin University, 130033 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchi","family":"Ying","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, 130118 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, 130118 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Pan","sequence":"first","affiliation":[{"name":"Scientific Research center, China-Japan Union Hospital, Jilin University, 130033 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Guo","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7275-4440","authenticated-orcid":true,"given":"Chunyi","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"},{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, 130118 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-418X","authenticated-orcid":true,"given":"Guokun","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Pozzilli P. 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