{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:38:18Z","timestamp":1791409098126,"version":"4.3.3"},"reference-count":101,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070638"],"award-info":[{"award-number":["82070638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Provincial Medical Key Discipline Cultivation Unit","award":["JSDW202229"],"award-info":[{"award-number":["JSDW202229"]}]},{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["KYCX23_3764"],"award-info":[{"award-number":["KYCX23_3764"]}]},{"name":"Science and Technology Planning Project of Guangdong Province of China","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Circadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24-hour cycle, are known to have a profound effect on the human body. Light plays an important role in the regulation of circadian rhythm in human body. When light from the outside enters the eyes, cones, rods, and specialized retinal ganglion cells receive the light signal and transmit it to the suprachiasmatic nucleus of the hypothalamus. The central rhythm oscillator of the suprachiasmatic nucleus regulates the rhythm oscillator of tissues all over the body. Circadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24-hour cycle, are known to have a profound effect on the human body. As the largest organ in the human body, skin plays an important role in the peripheral circadian rhythm regulation system. Like photoreceptor cells in the retina, melanocytes express opsins. Studies show that melanocytes in the skin are also sensitive to light, allowing the skin to \u201csee\u201d light even without the eyes. Upon receiving light signals, melanocytes in the skin release hormones that maintain homeostasis. This process is called \u201cphotoneuroendocrinology\u201d, which supports the health effects of light exposure. However, inappropriate light exposure, such as prolonged work in dark environments or exposure to artificial light at night, can disrupt circadian rhythms. Such disruptions are linked to a variety of health issues, emphasizing the need for proper light management in daily life. Conversely, harnessing light\u2019s beneficial effects through phototherapy is gaining attention as an adjunctive treatment modality. Despite these advancements, the field of circadian rhythm research still faces several unresolved issues and emerging challenges. One of the most exciting prospects is the use of the skin\u2019s photosensitivity to treat diseases. This approach could revolutionize how we think about and manage various health conditions, leveraging the skin\u2019s unique ability to respond to light for therapeutic purposes. As research continues to unravel the complexities of circadian rhythms and their impact on health, the potential for innovative treatments and improved wellbeing is immense.<\/jats:p>","DOI":"10.31083\/j.fbl2906206","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T09:22:05Z","timestamp":1717147325000},"source":"Crossref","is-referenced-by-count":12,"title":["Molecular Pathways Regulating Circadian Rhythm and Associated Diseases"],"prefix":"10.31083","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4224-8956","authenticated-orcid":true,"given":"Min","family":"Ding","sequence":"first","affiliation":[{"name":"Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001 Zhenjiang, Jiangsu, China"},{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, and South China Institute of Large Animal Models for Biomedicine, Wuyi University, 529020 Jiangmen, Guangdong, China"},{"name":"School of Pharmacy and Food Engineering, Wuyi University, 529020 Jiangmen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-5030","authenticated-orcid":true,"given":"Hang","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001 Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-5314","authenticated-orcid":true,"given":"Yu-Mei","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001 Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-3190","authenticated-orcid":true,"given":"Yun-Wen","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001 Zhenjiang, Jiangsu, China"},{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, and South China Institute of Large Animal Models for Biomedicine, Wuyi University, 529020 Jiangmen, Guangdong, China"},{"name":"School of Pharmacy and Food Engineering, Wuyi University, 529020 Jiangmen, Guangdong, China"},{"name":"Department of Medical and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 278-8510 Chiba, Japan"},{"name":"Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, 108-8639 Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Wegrzyn LR, Tamimi RM, Rosner BA, Brown SB, Stevens RG, Eliassen AH, et al. 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