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Biosci. (Landmark Ed)"],"abstract":"<jats:p>Transcription factors (TFs) are essential proteins regulating gene expression by binding to specific nucleotide sequences upstream of genes. Among TF families, the forkhead box (FOX) proteins, characterized by a conserved DNA-binding domain, play vital roles in various cellular processes, including cancer. The FOXA subfamily, encompassing FOXA1, FOXA2, and FOXA3, stands out for its pivotal role in mammalian development. FOXA1, initially identified in the liver, exhibits diverse expression across multiple organ tissues and plays a critical role in cell proliferation, differentiation, and tumor development. Its structural composition includes transactivation domains and a DNA-binding domain, facilitating its function as a pioneer factor, which is crucial for chromatin interaction and the recruitment of other transcriptional regulators. The involvement of FOXA1 in sex hormone-related tumors underscores its significance in cancer biology. This review provides an overview of multifaceted roles of FOXA1 in normal development and its implications in the pathogenesis of hormone-related cancers, particularly breast cancer and prostate cancer.<\/jats:p>","DOI":"10.31083\/j.fbl2906225","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:21:20Z","timestamp":1718961680000},"source":"Crossref","is-referenced-by-count":14,"title":["The Role of FOXA1 in Human Normal Development and Its Functions in Sex Hormone-Related Cancers"],"prefix":"10.31083","volume":"29","author":[{"given":"Juan","family":"Zhu","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research & Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, National Center for International Research \u201cChina-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease\u201d by the Ministry of Science and Technology of China, Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, 571101 Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjian","family":"Wei","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research & Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, National Center for International Research \u201cChina-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease\u201d by the Ministry of Science and Technology of China, Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, 571101 Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangnan","family":"Deng","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research & Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, National Center for International Research \u201cChina-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease\u201d by the Ministry of Science and Technology of China, Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, 571101 Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research & Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, National Center for International Research \u201cChina-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease\u201d by the Ministry of Science and Technology of China, Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, 571101 Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaijia","family":"Yang","sequence":"first","affiliation":[{"name":"School of Management, Hainan Medical University, 571199 Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Ma","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research & Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, National Center for International Research \u201cChina-Myanmar Joint Research Center for Prevention and Treatment of Regional Major Disease\u201d by the Ministry of Science and Technology of China, Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, 571101 Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Haberle V, Stark A. 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