{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:24:05Z","timestamp":1791404645990,"version":"4.3.3"},"reference-count":140,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81602893"],"award-info":[{"award-number":["81602893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2015YL049"],"award-info":[{"award-number":["ZR2015YL049"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2021MH218"],"award-info":[{"award-number":["ZR2021MH218"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2022MH184"],"award-info":[{"award-number":["ZR2022MH184"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shandong Province Medical and Health Technology Development Plan","award":["202104020224"],"award-info":[{"award-number":["202104020224"]}]},{"name":"Shandong Province Medical and Health Technology Development Plan","award":["202312010854"],"award-info":[{"award-number":["202312010854"]}]},{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Plan","award":["Z-2023114"],"award-info":[{"award-number":["Z-2023114"]}]},{"name":"Jinan Science and Technology Plan","award":["202328074"],"award-info":[{"award-number":["202328074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Neurodegenerative disorders are typified by the progressive degeneration and subsequent apoptosis of neuronal cells. They encompass a spectrum of conditions, including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington\u2019s disease (HD), epilepsy, brian ischemia, brian injury, and neurodegeneration with brain iron accumulation (NBIA). Despite the considerable heterogeneity in their clinical presentation, pathophysiological underpinning and disease trajectory, a universal feature of these disorders is the functional deterioration of the nervous system concomitant with neuronal apoptosis. Ferroptosis is an iron (Fe)-dependent form of programmed cell death that has been implicated in the pathogenesis of these conditions. It is intricately associated with intracellular Fe metabolism and lipid homeostasis. The accumulation of Fe is observed in a variety of neurodegenerative diseases and has been linked to their etiology and progression, although its precise role in these pathologies has yet to be elucidated. This review aims to elucidate the characteristics and regulatory mechanisms of ferroptosis, its association with neurodegenerative diseases, and recent advances in ferroptosis-targeted therapeutic strategies. Ferroptosis may therefore be a critical area for future research into neurodegenerative diseases.<\/jats:p>","DOI":"10.31083\/j.fbl2908291","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T10:04:23Z","timestamp":1724925863000},"source":"Crossref","is-referenced-by-count":16,"title":["Understanding the Mechanism of Ferroptosis in Neurodegenerative Diseases"],"prefix":"10.31083","volume":"29","author":[{"given":"Jiazi","family":"Ma","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Liu","sequence":"first","affiliation":[{"name":"Public Health Monitoring and Evaluation Institute of Shandong Provincial Center for Disease Control and Prevention, 250000 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangya","family":"Chen","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Cao","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Qinghai University, 810000 Xining, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqun","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Children's Hospital Affiliated to Shandong University, 250022 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Du","sequence":"first","affiliation":[{"name":"Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, 250062 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Hu B, Shi Y, Lu C, Chen H, Zeng Y, Deng J, et al. Raspberry polyphenols alleviate neurodegenerative diseases: through gut microbiota and ROS signals. Food & Function. 2023; 14: 7760\u20137779.","DOI":"10.1039\/D3FO01835K"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Chen H, Wang T. Alzheimer\u2019s Target and the Treatment Progression of Classic and New Clinical Drugs. Highlights in Science, Engineering and Technology. 2023; 36: 755\u2013761.","DOI":"10.54097\/hset.v36i.5791"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, et al. Towards a transgenic model of Huntington\u2019s disease in a non-human primate. Nature. 2008; 453: 921\u20134.","DOI":"10.1038\/nature06975"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014; 55: 475\u2013482.","DOI":"10.1111\/epi.12550"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005; 46: 470\u2013472.","DOI":"10.1111\/j.0013-9580.2005.66104.x"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Pitk\u00e4nen A, Lukasiuk K, Dudek FE, Staley KJ. Epileptogenesis. Cold Spring Harbor Perspectives in Medicine. 2015; 5: a022822.","DOI":"10.1101\/cshperspect.a022822"},{"key":"ref7","unstructured":"GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. Neurology. 2021; 20: 795\u2013820."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Yan HF, Zou T, Tuo QZ, Xu S, Li H, Belaidi AA, et al. Ferroptosis: mechanisms and links with diseases. Signal Transduction and Targeted Therapy. 2021; 6: 49.","DOI":"10.1038\/s41392-020-00428-9"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"He J, Li Z, Xia P, Shi A, FuChen X, Zhang J, et al. Ferroptosis and ferritinophagy in diabetes complications. Molecular Metabolism. 2022; 60: 101470.","DOI":"10.1016\/j.molmet.2022.101470"},{"key":"ref10","unstructured":"Chang XW, Zhao AP, Yao WT, Li WB, Wang R. Research progress of ferroptosis in hypoxia-associated brain injury. Acta Physiologica Sinica. 2023; 75: 255\u2013268. (In Chinese)"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nature Reviews. Molecular Cell Biology. 2021; 22: 266\u2013282.","DOI":"10.1038\/s41580-020-00324-8"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Walker VM, Davies NM, Jones T, Kehoe PG, Martin RM. Can commonly prescribed drugs be repurposed for the prevention or treatment of Alzheimer\u2019s and other neurodegenerative diseases? Protocol for an observational cohort study in the UK Clinical Practice Research Datalink. BMJ Open. 2016; 6: e012044.","DOI":"10.1136\/bmjopen-2016-012044"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Wu Z, Zhong M, Liu Y, Xiong Y, Gao Z, Ma J, et al. Application of natural products for inducing ferroptosis in tumor cells. Biotechnology and Applied Biochemistry. 2022; 69: 190\u2013197.","DOI":"10.1002\/bab.2096"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Ma TL, Chen JX, Zhu P, Zhang CB, Zhou Y, Duan JX. Focus on ferroptosis regulation: Exploring novel mechanisms and applications of ferroptosis regulator. Life Sciences. 2022; 307: 120868.","DOI":"10.1016\/j.lfs.2022.120868"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Miyake S, Murai S, Kakuta S, Uchiyama Y, Nakano H. Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy. Biochemical and Biophysical Research Communications. 2020; 527: 839\u2013844.","DOI":"10.1016\/j.bbrc.2020.04.127"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Du G, Zhang Q, Huang X, Wang Y. Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes. Frontiers in Genetics. 2022; 13: 1018829.","DOI":"10.3389\/fgene.2022.1018829"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Stockwell BR. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022; 185: 2401\u20132421.","DOI":"10.1016\/j.cell.2022.06.003"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019; 575: 688\u2013692.","DOI":"10.1038\/s41586-019-1705-2"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Liu J, Kang R, Tang D. Signaling pathways and defense mechanisms of ferroptosis. The FEBS Journal. 2022; 289: 7038\u20137050.","DOI":"10.1111\/febs.16059"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Sun Y, Sun P, Guo W. Fluorescent probes for iron, heme, and related enzymes. Coordination Chemistry Reviews. 2021; 429: 213645.","DOI":"10.1016\/j.ccr.2020.213645"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Galasko D, Simuni T. Lack of Benefit of Iron Chelation in Early Parkinson\u2019s Disease. The New England Journal of Medicine. 2022; 387: 2087\u20132088.","DOI":"10.1056\/NEJMe2213120"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Hermann E, Oliveira T, Montgomery MK. The contributions of iron regulatory proteins 1 and 2 to ferroptosis activation and ferroptotic cell death. Cancer Research. 2021; 81: 2006\u20132006.","DOI":"10.1158\/1538-7445.AM2021-2006"},{"key":"ref23","unstructured":"Parrow N, Gonzalez A, Li Y, Prasad P, Mammen L, Ali F, et al. Iron Binding to Specific Lobes of Transferrin Differentially Affects Erythropoiesis and Hepcidin Signaling. Blood. 2017; 130: 173."},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Jiang S, Guo S, Li H, Ni Y, Ma W, Zhao R. Identification and Functional Verification of MicroRNA-16 Family Targeting Intestinal Divalent Metal Transporter 1 (DMT1) in vitro and in vivo. Frontiers in Physiology. 2019; 10: 819.","DOI":"10.3389\/fphys.2019.00819"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Knutson M. Non-transferrin-mediated iron delivery. Blood. 2016; 128: SCI-22.","DOI":"10.1182\/blood.V128.22.SCI-22.SCI-22"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Li N, Wang W, Zhou H, Wu Q, Duan M, Liu C, et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radical Biology & Medicine. 2020; 160: 303\u2013318.","DOI":"10.1016\/j.freeradbiomed.2020.08.009"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Ajoolabady A, Aslkhodapasandhokmabad H, Libby P, Tuomilehto J, Lip GYH, Penninger JM, et al. Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends in Endocrinology and Metabolism. 2021; 32: 444\u2013462.","DOI":"10.1016\/j.tem.2021.04.010"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Research. 2016; 26: 1021\u20131032.","DOI":"10.1038\/cr.2016.95"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ke K, Li L, Lu C, Zhu Q, Wang Y, Mou Y, et al. The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer. Frontiers in Oncology. 2022; 12: 916082.","DOI":"10.3389\/fonc.2022.916082"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Research. 2021; 31: 107\u2013125.","DOI":"10.1038\/s41422-020-00441-1"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Zheng N, Lian Y, Zhou Q, Wang R, He X, Hu R, et al. An effective Fenton reaction by using waste ferric iron and red phosphorus. Chemical Engineering Journal. 2022; 437: 135265.","DOI":"10.1016\/j.cej.2022.135265"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Santoro MM. The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved! Cell Metab. 2020; 31: 13\u201315.","DOI":"10.1016\/j.cmet.2019.12.007"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Clemente LP, Rabenau M, Tang S, Stanka J, Cors E, Stroh J, et al. Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells. 2020; 9: 2259.","DOI":"10.3390\/cells9102259"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Himmelfarb J. Iron regulation. Journal of the American Society of Nephrology. 2007; 18: 379\u2013381.","DOI":"10.1681\/ASN.2006101097"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Liu J, Huang C, Liu J, Meng C, Gu Q, Du X, et al. Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury. Pharmacological Research. 2023; 187: 106563.","DOI":"10.1016\/j.phrs.2022.106563"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Chen L, Ma Y, Ma X, Liu L, Jv X, Li A, et al. TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner. Free Radical Biology & Medicine. 2023; 208: 445\u2013457.","DOI":"10.1016\/j.freeradbiomed.2023.09.004"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Qin X, Zhang J, Wang B, Xu G, Yang X, Zou Z, et al. Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy. 2021; 17: 4266\u20134285.","DOI":"10.1080\/15548627.2021.1911016"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Ovcinnikovs V, Ross EM, Petersone L, Edner NM, Heuts F, Ntavli E, et al. CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells. Science Immunology. 2019; 4: eaaw0902.","DOI":"10.1126\/sciimmunol.aaw0902"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Habib HM, Ibrahim S, Zaim A, Ibrahim WH. The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators. Biomedicine & Pharmacotherapy. 2021; 136: 111228.","DOI":"10.1016\/j.biopha.2021.111228"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Fekri K, Khoshdel A, Rasoulynezhad M, Kheiri S, Malekpour A, Zamanzad B. In vitro effect of iron chelators on the growth of Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, Yersinia enterocolitica, and Pseudomonas aeruginosa Strains. Journal of Shahrekord University of Medical Sciences. 2019; 21: 244\u2013249.","DOI":"10.34172\/jsums.2019.42"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y, Vergely C. Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis. International Journal of Molecular Sciences. 2022; 24: 449.","DOI":"10.3390\/ijms24010449"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Ma S, Adzavon YM, Wen X, Zhao P, Xie F, Liu M, et al. Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma. Frontiers in Cell and Developmental Biology. 2022; 10: 873029.","DOI":"10.3389\/fcell.2022.873029"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. The American Journal of Clinical Nutrition. 1993; 57: 715S\u2013725S.","DOI":"10.1093\/ajcn\/57.5.715S"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Sharma A, Flora SJS. Positive and Negative Regulation of Ferroptosis and Its Role in Maintaining Metabolic and Redox Homeostasis. Oxidative Medicine and Cellular Longevity. 2021; 2021: 9074206.","DOI":"10.1155\/2021\/9074206"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Sepand MR, Bigdelou B, Maghsoudi AS, Sanadgol N, Ho JQ, Chauhan P, et al. Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences. Coordination Chemistry Reviews. 2023; 480: 215024.","DOI":"10.1016\/j.ccr.2023.215024"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Yao X, Li W, Fang D, Xiao C, Wu X, Li M, et al. Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells. Advanced Science. 2021; 8: e2100997.","DOI":"10.1002\/advs.202100997"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Maru D, Hothi A, Bagariya C, Kumar A. Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy. Current Cancer Drug Targets. 2022; 22: 234\u2013244.","DOI":"10.2174\/1568009622666220211122745"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Lei G, Horbath A, Li Z, Gan B. PKC\u03b2II-ACSL4 pathway mediating ferroptosis execution and anti-tumor immunity. Cancer Communications. 2022; 42: 583\u2013586.","DOI":"10.1002\/cac2.12319"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Sha W, Hu F, Xi Y, Chu Y, Bu S. Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2021; 2021: 9999612.","DOI":"10.1155\/2021\/9999612"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Das UN. Saturated Fatty Acids, MUFAs and PUFAs Regulate Ferroptosis. Cell Chemical Biology. 2019; 26: 309\u2013311.","DOI":"10.1016\/j.chembiol.2019.03.001"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Luo X, Gong HB, Gao HY, Wu YP, Sun WY, Li ZQ, et al. Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Cell Death and Differentiation. 2021; 28: 1971\u20131989.","DOI":"10.1038\/s41418-020-00719-2"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Cao F, Sang Y, Liu C, Bai F, Zheng L, Ren J, et al. Self-Adaptive Single-Atom Catalyst Boosting Selective Ferroptosis in Tumor Cells. ACS Nano. 2022; 16: 855\u2013868.","DOI":"10.1021\/acsnano.1c08464"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Radbruch H, Mothes R, Bremer D, Seifert S, K\u00f6hler R, Pohlan J, et al. Analyzing Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Aging and Vascular Amyloid Pathology. Frontiers in Immunology. 2017; 8: 844.","DOI":"10.3389\/fimmu.2017.00844"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Wang J, Liu Y, Shen H, Li H, Wang Z, Chen G. Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats. Acta Neurochirurgica. Supplement. 2020; 127: 47\u201354.","DOI":"10.1007\/978-3-030-04615-6_8"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Wang J, Swanson RA. Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity. Frontiers in Neuroscience. 2020; 4: 861.","DOI":"10.3389\/fnins.2020.00861"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"He J, Wang X, Chen K, Zhang M, Wang J. The amino acid transporter SLC7A11-mediated crosstalk implicated in cancer therapy and the tumor microenvironment. Biochemical Pharmacology. 2022; 205: 115241.","DOI":"10.1016\/j.bcp.2022.115241"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Garza-Lomb\u00f3 C, Petrosyan P, Tapia-Rodr\u00edguez M, Valdovinos-Flores C, Gonsebatt ME. Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF\/TrkA and mTOR signaling in the cerebellum. Neurochemistry International. 2018; 121: 8\u201318.","DOI":"10.1016\/j.neuint.2018.10.007"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Cramer SL, Saha A, Liu J, Tadi S, Tiziani S, Yan W, et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nature Medicine. 2017; 23: 120\u2013127.","DOI":"10.1038\/nm.4232"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Arsalane K, Dubois CM, Muanza T, B\u00e9gin R, Boudreau F, Asselin C, et al. Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase. American Journal of Respiratory Cell and Molecular Biology. 1997; 17: 599\u2013607.","DOI":"10.1165\/ajrcmb.17.5.2833"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, et al. Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Cancer Cell. 2019; 35: 177\u2013190.e8.","DOI":"10.1016\/j.ccell.2018.12.009"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Rao Z, Xia Y, Jia Q, Zhu Y, Wang L, Liu G, et al. Iron-based metal-organic framework co-loaded with buthionine sulfoximine and oxaliplatin for enhanced cancer chemo-ferrotherapy via sustainable glutathione elimination. Journal of Nanobiotechnology. 2023; 21: 265.","DOI":"10.1186\/s12951-023-01998-w"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Bottino F, Lucignani M, Napolitano A, Dellepiane F, Visconti E, Rossi Espagnet MC, et al. In Vivo Brain GSH: MRS Methods and Clinical Applications. Antioxidants. 2021; 10: 1407.","DOI":"10.3390\/antiox10091407"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Fisher D, Mentor S. Antioxidant-induced reductive stress has untoward consequences on the brain microvasculature. Neural Regeneration Research. 2017; 12: 743\u2013744.","DOI":"10.4103\/1673-5374.206640"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Zhang ML, Wu HT, Chen WJ, Xu Y, Ye QQ, Shen JX, et al. Involvement of glutathione peroxidases in the occurrence and development of breast cancers. Journal of Translational Medicine. 2020; 18: 247.","DOI":"10.1186\/s12967-020-02420-x"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Weaver K, Skouta R. The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities. Biomedicines. 2022; 10: 891.","DOI":"10.3390\/biomedicines10040891"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Gong D, Chen M, Wang Y, Shi J, Hou Y. Role of ferroptosis on tumor progression and immunotherapy. Cell Death Discovery. 2022; 8: 427.","DOI":"10.1038\/s41420-022-01218-8"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Yen CC, Chen SC, Chen CH, Wang JY, Chen CM, Wu PK, et al. Exploring ferroptosis pathway for the development of therapeutic strategy in liposarcoma. Cancer Research. 2023; 83: 4777\u20134777.","DOI":"10.1158\/1538-7445.AM2023-4777"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Liu Y, Zhou L, Lv C, Liu L, Miao S, Xu Y, et al. PGE2 pathway mediates oxidative stress-induced ferroptosis in renal tubular epithelial cells. The FEBS Journal. 2023; 290: 533\u2013549.","DOI":"10.1111\/febs.16609"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Panday S, Talreja R, Kavdia M. The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species. Microvascular Research. 2020; 131: 104010.","DOI":"10.1016\/j.mvr.2020.104010"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Fefelova N, Siri-angkul N, Gwathmey JK, Xie LH. Cardiac Ferroptosis Induced Through Novel Signaling Pathways. Circulation. 2021; 144: A11118\u2013A11118.","DOI":"10.1161\/circ.144.suppl_1.11118"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Gleitze S, Ram\u00edrez OA, Vega-V\u00e1squez I, Yan J, Lobos P, Bading H, et al. Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition. Antioxidants. 2023; 12: 705.","DOI":"10.3390\/antiox12030705"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Zhao G, Wang H, Cui N. Regulation of mammalian target of rapamycin on ferroptosis: from mechanism to therapeutics in septic cardiomyopathy. Chinese Medical Journal. 2022; 135: 2815\u20132817.","DOI":"10.1097\/CM9.0000000000002301"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Li X, Zou Y, Fu YY, Xing J, Wang KY, Wan PZ, et al. A-Lipoic Acid Alleviates Folic Acid-Induced Renal Damage Through Inhibition of Ferroptosis. Frontiers in Physiology. 2021; 12: 680544.","DOI":"10.3389\/fphys.2021.680544"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Angajala A, Lim S, Phillips JB, Kim JH, Yates C, You Z, et al. Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism. Frontiers in Immunology. 2018; 9: 1605.","DOI":"10.3389\/fimmu.2018.01605"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Liu P, Wu D, Duan J, Xiao H, Zhou Y, Zhao L, et al. NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway. Redox Biology. 2020; 37: 101702.","DOI":"10.1016\/j.redox.2020.101702"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez\u2010Graciani K, Chapa\u2010Dubocq X, Chorna N, Javadov S. Metabolomic Profile of Ferroptosis in Cardiac Cells. The FASEB Journal. 2021; 35.","DOI":"10.1096\/fasebj.2021.35.S1.05458"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Wang X, Chen G, Pan C, Liu Y. Ferroptosis in cancer and beyond. Frontiers in Molecular Biosciences. 2023; 9: 1115974.","DOI":"10.3389\/fmolb.2022.1115974"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Hou MJ, Wang P, Zhu BT. Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells. Acta Biochimica et Biophysica Sinica. 2023; 55: 853\u2013865.","DOI":"10.3724\/abbs.2023058"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Zhang C, Liu X, Jin S, Chen Y, Guo R. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Molecular Cancer. 2022; 21: 47.","DOI":"10.1186\/s12943-022-01530-y"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Tian HY, Huang BY, Nie HF, Chen XY, Zhou Y, Yang T, et al. The Interplay between Mitochondrial Dysfunction and Ferroptosis during Ischemia-Associated Central Nervous System Diseases. Brain Sciences. 2023; 13: 1367.","DOI":"10.3390\/brainsci13101367"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Wang P, Lu YQ. Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells. Frontiers in Immunology. 2022; 13: 877634.","DOI":"10.3389\/fimmu.2022.877634"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Jiang X, Wu K, Ye XY, Xie T, Zhang P, Blass BE, et al. Novel druggable mechanism of Parkinson\u2019s disease: Potential therapeutics and underlying pathogenesis based on ferroptosis. Medicinal Research Reviews. 2023; 43: 872\u2013896.","DOI":"10.1002\/med.21939"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Lejman J, Panuciak K, Nowicka E, Mastalerczyk A, Wojciechowska K, Lejman M. Gene Therapy in ALS and SMA: Advances, Challenges and Perspectives. International Journal of Molecular Sciences. 2023; 24: 1130.","DOI":"10.3390\/ijms24021130"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, et al. Ferroptosis: past, present and future. Cell Death & Disease. 2020; 11: 88.","DOI":"10.1038\/s41419-020-2298-2"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Feng F, Luo R, Mu D, Cai Q. Ferroptosis and Pyroptosis in Epilepsy. Molecular Neurobiology. 2024. (online ahead of print)","DOI":"10.1007\/s12035-024-04018-6"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Fang XL, Ding SY, Du XZ, Wang JH, Li XL. Ferroptosis-A Novel Mechanism With Multifaceted Actions on Stroke. Frontiers in Neurology. 2022; 13: 881809.","DOI":"10.3389\/fneur.2022.881809"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Hambright WS, Fonseca RS, Chen L, Na R, Ran Q. Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. Redox Biology. 2017; 12: 8\u201317.","DOI":"10.1016\/j.redox.2017.01.021"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Dang X, Huan X, Du X, Chen X, Bi M, Yan C, et al. Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases. Neuroscience Bulletin. 2022; 38: 938\u2013952.","DOI":"10.1007\/s12264-022-00861-6"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Knopman DS, Amieva H, Petersen RC, Ch\u00e9telat G, Holtzman DM, Hyman BT, et al. Alzheimer disease. Nature Reviews. Disease Primers. 2021; 7: 33.","DOI":"10.1038\/s41572-021-00269-y"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Bloom GS. Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurology. 2014; 71: 505\u2013508.","DOI":"10.1001\/jamaneurol.2013.5847"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Rahman MA, Rahman MS, Rahman MDH, Rasheduzzaman M, Mamun-Or-Rashid A, Uddin MJ, et al. Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer\u2019s Disease. Biomedicines. 2020; 9: 5.","DOI":"10.3390\/biomedicines9010005"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"Hur JY. \u03b3-Secretase in Alzheimer\u2019s disease. Experimental & Molecular Medicine. 2022; 54: 433\u2013446.","DOI":"10.1038\/s12276-022-00754-8"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, et al. APP intracellular domain-WAVE1 pathway reduces amyloid-\u03b2 production. Nature Medicine. 2015; 21: 1054\u20131059.","DOI":"10.1038\/nm.3924"},{"key":"ref94","doi-asserted-by":"crossref","unstructured":"Gao W, Wang W, Dong X, Sun Y. Nitrogen-Doped Carbonized Polymer Dots: A Potent Scavenger and Detector Targeting Alzheimer\u2019s \u03b2-Amyloid Plaques. Small. 2020; 16: e2002804.","DOI":"10.1002\/smll.202002804"},{"key":"ref95","doi-asserted-by":"crossref","unstructured":"Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, et al. Iron-export ferroxidase activity of \u03b2-amyloid precursor protein is inhibited by zinc in Alzheimer\u2019s disease. Cell. 2010; 142: 857\u2013867.","DOI":"10.1016\/j.cell.2010.08.014"},{"key":"ref96","unstructured":"Sharma C, Kim SR. Oxidative stress: culprit or consequence in Alzheimer\u2019s amyloidopathy. Neural Regeneration Research. 2023; 18: 1948\u20131949."},{"key":"ref97","doi-asserted-by":"crossref","unstructured":"Li X, Le L, Shi Q, Xu H, Wang C, Xiong Y, et al. Zinc exacerbates tau-induced Alzheimer-like pathology in C57BL\/6J mice. International Journal of Biological Macromolecules. 2023; 242: 124652.","DOI":"10.1016\/j.ijbiomac.2023.124652"},{"key":"ref98","unstructured":"Johannesson T, Kristinsson J, Torsdottir G, Snaedal J. Ceruloplasmin (Cp) and iron in connection with Parkinson\u2019s disease (PD) and Alzheimer\u2019s disease (AD). Laeknabladid. 2012; 98: 531\u2013537. (In Icelandic)"},{"key":"ref99","doi-asserted-by":"crossref","unstructured":"Otero-Garcia M, Mahajani SU, Wakhloo D, Tang W, Xue YQ, Morabito S, et al. Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer\u2019s disease. Neuron. 2022; 110: 2929\u20132948.e8.","DOI":"10.1016\/j.neuron.2022.06.021"},{"key":"ref100","doi-asserted-by":"crossref","unstructured":"Zhao X, Xiong L, She L, Li L, Huang P, Liang G. The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer\u2019s disease. Biomedicine & Pharmacotherapy. 2022; 151: 113188.","DOI":"10.1016\/j.biopha.2022.113188"},{"key":"ref101","doi-asserted-by":"crossref","unstructured":"Spotorno N, Acosta-Cabronero J, Stomrud E, Lampinen B, Strandberg OT, van Westen D, et al. Relationship between cortical iron and tau aggregation in Alzheimer\u2019s disease. Brain. 2020; 143: 1341\u20131349.","DOI":"10.1093\/brain\/awaa089"},{"key":"ref102","doi-asserted-by":"crossref","unstructured":"Zhao D, Yang K, Guo H, Zeng J, Wang S, Xu H, et al. Mechanisms of ferroptosis in Alzheimer\u2019s disease and therapeutic effects of natural plant products: A review. Biomedicine & Pharmacotherapy. 2023; 164: 114312.","DOI":"10.1016\/j.biopha.2023.114312"},{"key":"ref103","doi-asserted-by":"crossref","unstructured":"Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nature Reviews. Neurology. 2019; 15: 501\u2013518.","DOI":"10.1038\/s41582-019-0228-7"},{"key":"ref104","doi-asserted-by":"crossref","unstructured":"Gopalakrishna R, Oh A, Bhat NR, Mack WJ. Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer\u2019s disease prevention. Neural Regeneration Research. 2023; 18: 2675\u20132676.","DOI":"10.4103\/1673-5374.373664"},{"key":"ref105","doi-asserted-by":"crossref","unstructured":"Andrade V, Guzm\u00e1n-Mart\u00ednez L, Pulgar KV, Maccioni R. Neuroimmune dynamics in Alzheimer\u2019s disease progression. Mechanisms of Neuroinflammation. 2017; 77\u201399.","DOI":"10.5772\/intechopen.68941"},{"key":"ref106","doi-asserted-by":"crossref","unstructured":"Blesa J, Trigo-Damas I, Obeso JA. Parkinson\u2019s disease and thalamus: facts and fancy. The Lancet. Neurology. 2016; 15: e2.","DOI":"10.1016\/S1474-4422(16)30048-5"},{"key":"ref107","doi-asserted-by":"crossref","unstructured":"Mao C, Lei G, Zhuang L, Gan B. Phospholipase iPLA2\u03b2 acts as a guardian against ferroptosis. Cancer Communications. 2021; 41: 1082\u20131085.","DOI":"10.1002\/cac2.12231"},{"key":"ref108","doi-asserted-by":"crossref","unstructured":"Johnson WM, Wilson-Delfosse AL, Mieyal JJ. Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients. 2012; 4: 1399\u20131440.","DOI":"10.3390\/nu4101399"},{"key":"ref109","doi-asserted-by":"crossref","unstructured":"Wexler A, Wild EJ, Tabrizi SJ. George Huntington: a legacy of inquiry, empathy and hope. Brain. 2016; 139: 2326\u20132333.","DOI":"10.1093\/brain\/aww165"},{"key":"ref110","doi-asserted-by":"crossref","unstructured":"Chen J, Marks E, Lai B, Zhang Z, Duce JA, Lam LQ, et al. Iron accumulates in Huntington\u2019s disease neurons: protection by deferoxamine. PLoS ONE. 2013; 8: e77023.","DOI":"10.1371\/journal.pone.0077023"},{"key":"ref111","doi-asserted-by":"crossref","unstructured":"Song S, Su Z, Kon N, Chu B, Li H, Jiang X, et al. ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington\u2019s disease. Genes & Development. 2023; 37: 204\u2013217.","DOI":"10.1101\/gad.350211.122"},{"key":"ref112","doi-asserted-by":"crossref","unstructured":"Agrawal S, Fox J, Thyagarajan B, Fox JH. Brain mitochondrial iron accumulates in Huntington\u2019s disease, mediates mitochondrial dysfunction, and can be removed pharmacologically. Free Radical Biology & Medicine. 2018; 120: 317\u2013329.","DOI":"10.1016\/j.freeradbiomed.2018.04.002"},{"key":"ref113","doi-asserted-by":"crossref","unstructured":"Zimmer TS, David B, Broekaart DWM, Schidlowski M, Ruffolo G, Korotkov A, et al. Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy. Acta Neuropathologica. 2021; 142: 729\u2013759.","DOI":"10.1007\/s00401-021-02348-6"},{"key":"ref114","doi-asserted-by":"crossref","unstructured":"Petrillo S, Pietrafusa N, Trivisano M, Calabrese C, Saura F, Gallo MG, et al. Imbalance of Systemic Redox Biomarkers in Children with Epilepsy: Role of Ferroptosis. Antioxidants. 2021; 10: 1267.","DOI":"10.3390\/antiox10081267"},{"key":"ref115","doi-asserted-by":"crossref","unstructured":"Chen KN, Guan QW, Yin XX, Wang ZJ, Zhou HH, Mao XY. Ferrostatin-1 obviates seizures and associated cognitive deficits in ferric chloride-induced posttraumatic epilepsy via suppressing ferroptosis. Free Radical Biology & Medicine. 2022; 179: 109\u2013118.","DOI":"10.1016\/j.freeradbiomed.2021.12.268"},{"key":"ref116","doi-asserted-by":"crossref","unstructured":"Akyuz E, Doganyigit Z, Eroglu E, Moscovicz F, Merelli A, Lazarowski A, et al. Myocardial Iron Overload in an Experimental Model of Sudden Unexpected Death in Epilepsy. Frontiers in Neurology. 2021; 12: 609236.","DOI":"10.3389\/fneur.2021.609236"},{"key":"ref117","doi-asserted-by":"crossref","unstructured":"Su Y, Cao N, Zhang D, Wang M. The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy. Ageing Research Reviews. 2024; 96: 102248.","DOI":"10.1016\/j.arr.2024.102248"},{"key":"ref118","doi-asserted-by":"crossref","unstructured":"Xu D, Chu M, Chen Y, Fang Y, Wang J, Zhang X, et al. Identification and verification of ferroptosis-related genes in the pathology of epilepsy: insights from CIBERSORT algorithm analysis. Frontiers in Neurology. 2023; 14: 1275606.","DOI":"10.3389\/fneur.2023.1275606"},{"key":"ref119","doi-asserted-by":"crossref","unstructured":"Zhang Y, Lu X, Tai B, Li W, Li T. Ferroptosis and Its Multifaceted Roles in Cerebral Stroke. Frontiers in Cellular Neuroscience. 2021; 15: 615372.","DOI":"10.3389\/fncel.2021.615372"},{"key":"ref120","doi-asserted-by":"crossref","unstructured":"Wei Z, Xie Y, Wei M, Zhao H, Ren K, Feng Q, et al. New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke. Frontiers in Pharmacology. 2022; 13: 1020918.","DOI":"10.3389\/fphar.2022.1020918"},{"key":"ref121","doi-asserted-by":"crossref","unstructured":"Li N, Wang R, Ai X, Guo J, Bai Y, Guo X, et al. Electroacupuncture Inhibits Neural Ferroptosis in Rat Model of Traumatic Brain Injury via Activating System Xc-\/GSH\/GPX4 Axis. Current Neurovascular Research. 2024. (online ahead of print)","DOI":"10.2174\/0115672026297775240405073502"},{"key":"ref122","doi-asserted-by":"crossref","unstructured":"Zhang XY, Han PP, Zhao YN, Shen XY, Bi X. Crosstalk between autophagy and ferroptosis mediate injury in ischemic stroke by generating reactive oxygen species. Heliyon. 2024; 10: e28959.","DOI":"10.1016\/j.heliyon.2024.e28959"},{"key":"ref123","doi-asserted-by":"crossref","unstructured":"Wang ZB, Liu JY, Xu XJ, Mao XY, Zhang W, Zhou HH, et al. Neurodegeneration with brain iron accumulation: Insights into the mitochondria dysregulation. Biomedicine & Pharmacotherapy. 2019; 118: 109068.","DOI":"10.1016\/j.biopha.2019.109068"},{"key":"ref124","doi-asserted-by":"crossref","unstructured":"Diaw SH, Ganos C, Zittel S, Pl\u00f6tze-Martin K, Kulikovskaja L, Vos M, et al. Mutant WDR45 Leads to Altered Ferritinophagy and Ferroptosis in \u03b2-Propeller Protein-Associated Neurodegeneration. International Journal of Molecular Sciences. 2022; 23: 9524.","DOI":"10.3390\/ijms23179524"},{"key":"ref125","doi-asserted-by":"crossref","unstructured":"Song X, Long D. Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases. Frontiers in Neuroscience. 2020; 14: 267.","DOI":"10.3389\/fnins.2020.00267"},{"key":"ref126","doi-asserted-by":"crossref","unstructured":"Lane DJR, Metselaar B, Greenough M, Bush AI, Ayton SJ. Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer\u2019s disease. Essays in Biochemistry. 2021; 65: 925\u2013940.","DOI":"10.1042\/EBC20210017"},{"key":"ref127","doi-asserted-by":"crossref","unstructured":"Sun Y, Xia X, Basnet D, Zheng JC, Huang J, Liu J. Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 2022; 14: 904152.","DOI":"10.3389\/fnagi.2022.904152"},{"key":"ref128","doi-asserted-by":"crossref","unstructured":"Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochimica et Biophysica Acta. 1982; 710: 197\u2013211.","DOI":"10.1016\/0005-2760(82)90150-3"},{"key":"ref129","doi-asserted-by":"crossref","unstructured":"Xia C, Xing X, Zhang W, Wang Y, Jin X, Wang Y, et al. Cysteine and homocysteine can be exploited by GPX4 in ferroptosis inhibition independent of GSH synthesis. Redox Biology. 2024; 69: 102999.","DOI":"10.1016\/j.redox.2023.102999"},{"key":"ref130","doi-asserted-by":"crossref","unstructured":"Carriba P, Comella JX. Neurodegeneration and neuroinflammation: two processes, one target. Neural Regeneration Research. 2015; 10: 1581\u20131583.","DOI":"10.4103\/1673-5374.165269"},{"key":"ref131","doi-asserted-by":"crossref","unstructured":"Soula M, Weber RA, Zilka O, Alwaseem H, La K, Yen F, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nature Chemical Biology. 2020; 16: 1351\u20131360.","DOI":"10.1038\/s41589-020-0613-y"},{"key":"ref132","doi-asserted-by":"crossref","unstructured":"Kraft VAN, Bezjian CT, Pfeiffer S, Ringelstetter L, M\u00fcller C, Zandkarimi F, et al. GTP Cyclohydrolase 1\/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling. ACS Central Science. 2020; 6: 41\u201353.","DOI":"10.1021\/acscentsci.9b01063"},{"key":"ref133","doi-asserted-by":"crossref","unstructured":"Wang P, Huang Y, Sun B, Chen H, Ma Y, Liu Y, et al. Folic acid blocks ferroptosis induced by cerebral ischemia and reperfusion through regulating folate hydrolase transcriptional adaptive program. The Journal of Nutritional Biochemistry. 2024; 124: 109528.","DOI":"10.1016\/j.jnutbio.2023.109528"},{"key":"ref134","doi-asserted-by":"crossref","unstructured":"Wang C, Leng M, Ding C, Zhu X, Zhang Y, Sun C, et al. Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box 1 (HMGB1). Liver International. 2024; 44: 691\u2013705.","DOI":"10.1111\/liv.15811"},{"key":"ref135","doi-asserted-by":"crossref","unstructured":"Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021; 593: 586\u2013590.","DOI":"10.1038\/s41586-021-03539-7"},{"key":"ref136","doi-asserted-by":"crossref","unstructured":"Ren JX, Sun X, Yan XL, Guo ZN, Yang Y. Ferroptosis in Neurological Diseases. Frontiers in Cellular Neuroscience. 2020; 14: 218.","DOI":"10.3389\/fncel.2020.00218"},{"key":"ref137","doi-asserted-by":"crossref","unstructured":"Chen X, Li J, Kang R, Klionsky DJ, Tang D. Ferroptosis: machinery and regulation. Autophagy. 2021; 17: 2054\u20132081.","DOI":"10.1080\/15548627.2020.1810918"},{"key":"ref138","unstructured":"Zhang RF, Zeng M, Lv N, Wang LM, Yang QY, Gan JL, et al. Ferroptosis in neurodegenerative diseases: inhibitors as promising candidate mitigators. European Review for Medical and Pharmacological Sciences. 2023; 27: 46\u201365."},{"key":"ref139","doi-asserted-by":"crossref","unstructured":"Mill\u00e1n M, DeGregorio-Rocasolano N, P\u00e9rez de la Ossa N, Revert\u00e9 S, Costa J, Giner P, et al. Targeting Pro-Oxidant Iron with Deferoxamine as a Treatment for Ischemic Stroke: Safety and Optimal Dose Selection in a Randomized Clinical Trial. Antioxidants. 2021; 10: 1270.","DOI":"10.3390\/antiox10081270"},{"key":"ref140","doi-asserted-by":"crossref","unstructured":"Kahn-Kirby AH, Amagata A, Maeder CI, Mei JJ, Sideris S, Kosaka Y, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLoS ONE. 2019; 14: e0214250.","DOI":"10.1371\/journal.pone.0214250"}],"container-title":["Frontiers in Bioscience-Landmark"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/29\/8\/10.31083\/j.fbl2908291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T14:34:11Z","timestamp":1732718051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/29\/8\/10.31083\/j.fbl2908291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":140,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2768-6701(24)01366-2"],"URL":"https:\/\/doi.org\/10.31083\/j.fbl2908291","relation":{},"ISSN":["2768-6701","2768-6698"],"issn-type":[{"value":"2768-6701","type":"print"},{"value":"2768-6698","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"article-number":"291"}}