{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:11:04Z","timestamp":1780445464759,"version":"3.54.1"},"reference-count":60,"publisher":"IMR Press","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background: Vitamin D receptor (VDR) can prevent myocardial ischemia reperfusion injury (MIRI). Hence, we aimed to illuminate the effect of VDR on cerebral ischemia\/reperfusion injury (CIRI). Methods: C57BL\/6 mice and SK-N-SH cells were utilized to establish CIRI and cellular oxygen deprivation\/reoxygenation (OGD\/R) models. Mice were injected with 1 \u03bcg\/kg Calcitriol or 1 \u03bcg\/kg Paricalcitol (PC) and adenovirus-mediated VDR overexpression or knockdown plasmids. 2,3,5-triphenyl-tetrazolium chloride (TTC) and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to measure the brain infarct volume and the apoptosis of cerebral cells. SK-N-SH cells were treated with 5 mM N-acetyl-L-cysteine (NAC) and transfected with VDR knockdown plasmid. Flow cytometry and Cell Counting Kit-8 (CCK-8) assays were employed to assess the apoptosis and cell viability. Enzyme-Linked Immunosorbent Assay (ELISA), quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) and Western blot were exploited to quantify the levels of reactive species oxygen (ROS), other oxidative stress-related factors, VDR and apoptosis-related factors. Results: The level of VDR in mouse cerebral tissue was elevated by CIRI (p &lt; 0.001). CIRI-induced cerebral infarction (p &lt; 0.001) and the apoptosis of cerebral cells (p &lt; 0.001) in mice were mitigated by the activation of VDR. VDR overexpression abrogated while VDR silencing enhanced CIRI-induced infarction, oxidative stress and apoptosis of cerebral cells (p &lt; 0.05). Furthermore, VDR silencing aggravated the oxidative stress and apoptosis in OGD\/R-treated SK-N-SH cells (p &lt; 0.05). NAC, a scavenger of oxidative stress, could reverse the effects of VDR silencing on apoptosis and oxidative stress in OGD\/R-treated SK-N-SH cells (p &lt; 0.01). Conclusion: VDR alleviates the oxidative stress to protect against CIRI.<\/jats:p>","DOI":"10.31083\/j.fbl2911389","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T14:35:55Z","timestamp":1732718155000},"source":"Crossref","is-referenced-by-count":3,"title":["Protective Role of Vitamin D Receptor in Cerebral Ischemia\/Reperfusion Injury In Vitro and In Vivo Model"],"prefix":"10.31083","volume":"29","author":[{"given":"Jie","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General surgery, The Second Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liucheng","family":"Wu","sequence":"first","affiliation":[{"name":"Laboratory Animal Center, Nantong University, 226019 Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Barfejani AH, Jafarvand M, Seyedsaadat SM, Rasekhi RT. Donepezil in the treatment of ischemic stroke: Review and future perspective. Life Sciences. 2020; 263: 118575.","DOI":"10.1016\/j.lfs.2020.118575"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Nian K, Harding IC, Herman IM, Ebong EE. Blood-Brain Barrier Damage in Ischemic Stroke and Its Regulation by Endothelial Mechanotransduction. Frontiers in Physiology. 2020; 11: 605398.","DOI":"10.3389\/fphys.2020.605398"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Gong L, Tang Y, An R, Lin M, Chen L, Du J. RTN1-C mediates cerebral ischemia\/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death & Disease. 2017; 8: e3080.","DOI":"10.1038\/cddis.2017.465"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Patel AMR, Apaijai N, Chattipakorn N, Chattipakorn SC. The Protective and Reparative Role of Colony-Stimulating Factors in the Brain with Cerebral Ischemia\/Reperfusion Injury. Neuroendocrinology. 2021; 111: 1029\u20131065.","DOI":"10.1159\/000512367"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Lee PW, Selhorst A, Lampe SG, Liu Y, Yang Y, Lovett-Racke AE. Neuron-Specific Vitamin D Signaling Attenuates Microglia Activation and CNS Autoimmunity. Frontiers in Neurology. 2020; 11: 19.","DOI":"10.3389\/fneur.2020.00019"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2001; 21: 98\u2013108.","DOI":"10.1523\/JNEUROSCI.21-01-00098.2001"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Drinkut A, Tillack K, Meka DP, Schulz JB, K\u00fcgler S, Kramer ER. Ret is essential to mediate GDNF\u2019s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell Death & Disease. 2016; 7: e2359. https:\/\/www.nature.com\/articles\/cddis2016263","DOI":"10.1038\/cddis.2016.263"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Zhu DM, Zhao W, Cui S, Jiang P, Zhang Y, Zhang C, et al. The Relationship Between Vitamin D, Clinical Manifestations, and Functional Network Connectivity in Female Patients With Major Depressive Disorder. Frontiers in Aging Neuroscience. 2022; 14: 817607.","DOI":"10.3389\/fnagi.2022.817607"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Fernandes de Abreu DA, Eyles D, F\u00e9ron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009; 34: S265\u2013S277.","DOI":"10.1016\/j.psyneuen.2009.05.023"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Lv L, Tan X, Peng X, Bai R, Xiao Q, Zou T, et al. The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson\u2019s disease. Translational Neurodegeneration. 2020; 9: 34.","DOI":"10.1186\/s40035-020-00213-2"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Gil \u00c1, Plaza-Diaz J, Mesa MD. Vitamin D: Classic and Novel Actions. Annals of Nutrition & Metabolism. 2018; 72: 87\u201395.","DOI":"10.1159\/000486536"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Jeong SP, Sharma N, An SSA. Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer\u2019s Disease. International Journal of Molecular Sciences. 2024; 25: 4806.","DOI":"10.3390\/ijms25094806"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Bikle DD. The Vitamin D Receptor as Tumor Suppressor in Skin. Advances in Experimental Medicine and Biology. 2020; 1268: 285\u2013306.","DOI":"10.1007\/978-3-030-46227-7_14"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Sun J. Dietary vitamin D, vitamin D receptor, and microbiome. Current Opinion in Clinical Nutrition and Metabolic Care. 2018; 21: 471\u2013474.","DOI":"10.1097\/MCO.0000000000000516"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Morr\u00f3 M, Vil\u00e0 L, Franckhauser S, Mallol C, Elias G, Ferr\u00e9 T, et al. Vitamin D Receptor Overexpression in \u03b2-Cells Ameliorates Diabetes in Mice. Diabetes. 2020; 69: 927\u2013939.","DOI":"10.2337\/db19-0757"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Gerousi M, Psomopoulos F, Kotta K, Tsagiopoulou M, Stavroyianni N, Anagnostopoulos A, et al. The Calcitriol\/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia. Cancers. 2021; 13: 285.","DOI":"10.3390\/cancers13020285"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, et al. Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxidants & Redox Signaling. 2015; 22: 633\u2013650.","DOI":"10.1089\/ars.2014.5887"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Wu L, Xiong X, Wu X, Ye Y, Jian Z, Zhi Z, et al. Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury. Frontiers in Molecular Neuroscience. 2020; 13: 28.","DOI":"10.3389\/fnmol.2020.00028"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Wen Z, Hou W, Wu W, Zhao Y, Dong X, Bai X, et al. 6\u2019-O-Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion-Induced Neuroinflammation and Oxidative Stress via PI3K\/Akt\/Nrf2 Activation. Oxidative Medicine and Cellular Longevity. 2018; 2018: 8678267.","DOI":"10.1155\/2018\/8678267"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Velimirovi\u0107 M, Jevti\u0107 Do\u017eudi\u0107 G, Selakovi\u0107 V, Stojkovi\u0107 T, Pu\u0161ka\u0161 N, Zaletel I, et al. Effects of Vitamin D3 on the NADPH Oxidase and Matrix Metalloproteinase 9 in an Animal Model of Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity. 2018; 2018: 3273654.","DOI":"10.1155\/2018\/3273654"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, et al. Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system. Redox Biology. 2019; 26: 101295.","DOI":"10.1016\/j.redox.2019.101295"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Wu R, Li X, Xu P, Huang L, Cheng J, Huang X, et al. TREM2 protects against cerebral ischemia\/reperfusion injury. Molecular Brain. 2017; 10: 20.","DOI":"10.1186\/s13041-017-0296-9"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Bu J, Shi S, Wang HQ, Niu XS, Zhao ZF, Wu WD, et al. Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway. Neural Regeneration Research. 2019; 14: 605\u2013612.","DOI":"10.4103\/1673-5374.247465"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Ren Z, Xie P, Lv J, Hu Y, Guan Z, Chen L, et al. miR 187 3p inhibitor attenuates cerebral ischemia\/reperfusion injury by regulating Seipin mediated autophagic flux. International Journal of Molecular Medicine. 2020; 46: 1051\u20131062.","DOI":"10.3892\/ijmm.2020.4642"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Zhang B, Zhang HX, Shi ST, Bai YL, Zhe X, Zhang SJ, et al. Interleukin-11 treatment protected against cerebral ischemia\/reperfusion injury. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2019; 115: 108816.","DOI":"10.1016\/j.biopha.2019.108816"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Liang J, Wang Q, Li JQ, Guo T, Yu D. Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485\/AIM2 axis. Experimental Neurology. 2020; 325: 113139.","DOI":"10.1016\/j.expneurol.2019.113139"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Liu L, Chen H, Jin J, Tang Z, Yin P, Zhong D, et al. Melatonin ameliorates cerebral ischemia\/reperfusion injury through SIRT3 activation. Life Sciences. 2019; 239: 117036.","DOI":"10.1016\/j.lfs.2019.117036"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Yin M, Chen WP, Yin XP, Tu JL, Hu N, Li ZY. LncRNA TUG1 Demethylated by TET2 Promotes NLRP3 Expression, Contributes to Cerebral Ischemia\/Reperfusion Inflammatory Injury. ASN Neuro. 2021; 13: 17590914211003247.","DOI":"10.1177\/17590914211003247"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Yang Z, Huang Y, Zhu L, Yang K, Liang K, Tan J, et al. SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1\u03b1 and reactive oxygen species. Cell Death & Disease. 2021; 12: 77.","DOI":"10.1038\/s41419-020-03372-2"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Yu S, Zhai J, Yu J, Yang Q, Yang J. miR-98-5p protects against cerebral ischemia\/reperfusion injury through anti-apoptosis and anti-oxidative stress in mice. Journal of Biochemistry. 2021; 169: 195\u2013206.","DOI":"10.1093\/jb\/mvaa099"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Luo H, Sun W, Shao J, Ma H, Jia Z, Jing L. Protective effect of nitronyl nitroxide against hypoxia-induced damage in PC12 cells. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire. 2020; 98: 345\u2013353.","DOI":"10.1139\/bcb-2019-0269"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif.). 2001; 25: 402\u2013408.","DOI":"10.1006\/meth.2001.1262"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Lu Y, Han Y, He J, Zhou B, Fang P, Li X. LncRNA FOXD3-AS1 knockdown protects against cerebral ischemia\/reperfusion injury via miR-765\/BCL2L13 axis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2020; 132: 110778.","DOI":"10.1016\/j.biopha.2020.110778"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1\u03b1,25(OH)\u2082vitamin D\u2083: genomic and non-genomic mechanisms. Best Practice & Research. Clinical Endocrinology & Metabolism. 2011; 25: 543\u2013559.","DOI":"10.1016\/j.beem.2011.05.010"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews. 2008; 29: 726\u2013776.","DOI":"10.1210\/er.2008-0004"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Cui P, Lu W, Wang J, Wang F, Zhang X, Hou X, et al. Microglia\/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model. Journal of Neuroinflammation. 2023; 20: 63.","DOI":"10.1186\/s12974-023-02705-0"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Tang S, Wu X, Dai Q, Li Z, Yang S, Liu Y, et al. Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4. Cell Death Discovery. 2023; 9: 158.","DOI":"10.1038\/s41420-023-01456-4"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Staessens S, De Meyer SF. Thrombus heterogeneity in ischemic stroke. Platelets. 2021; 32: 331\u2013339.","DOI":"10.1080\/09537104.2020.1748586"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Barreto AD. Intravenous thrombolytics for ischemic stroke. Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics. 2011; 8: 388\u2013399.","DOI":"10.1007\/s13311-011-0049-x"},{"key":"ref40","unstructured":"Shan J, Sun L, Wang D, Li X. Comparison of the neuroprotective effects and recovery profiles of isoflurane, sevoflurane and desflurane as neurosurgical pre-conditioning on ischemia\/reperfusion cerebral injury. International Journal of Clinical and Experimental Pathology. 2015; 8: 2001\u20132009."},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Wang PR, Wang JS, Zhang C, Song XF, Tian N, Kong LY. Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia\/reperfusion via MAPK-mTOR signaling pathway. Journal of Ethnopharmacology. 2013; 149: 270\u2013280.","DOI":"10.1016\/j.jep.2013.06.035"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Lu H, Wang B, Cui N, Zhang Y. Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS dependent p38 MAPK and protects against cerebral ischemia reperfusion injury. Molecular Medicine Reports. 2018; 17: 6639\u20136646.","DOI":"10.3892\/mmr.2018.8666"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Atif F, Yousuf S, Espinosa-Garcia C, Harris WAC, Stein DG. Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone. Neuropharmacology. 2020; 181: 108327.","DOI":"10.1016\/j.neuropharm.2020.108327"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Zhou Y, Liao J, Mei Z, Liu X, Ge J. Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke. Oxidative Medicine and Cellular Longevity. 2021; 2021: 9991001.","DOI":"10.1155\/2021\/9991001"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Edlich F. BCL-2 proteins and apoptosis: Recent insights and unknowns. Biochemical and Biophysical Research Communications. 2018; 500: 26\u201334.","DOI":"10.1016\/j.bbrc.2017.06.190"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Wu H, Medeiros LJ, Young KH. Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances. Blood Reviews. 2018; 32: 8\u201328.","DOI":"10.1016\/j.blre.2017.08.004"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Liu G, Wang T, Wang T, Song J, Zhou Z. Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats. Biomedical Reports. 2013; 1: 861\u2013867.","DOI":"10.3892\/br.2013.153"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, et al. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke. 2003; 34: 207\u2013213.","DOI":"10.1161\/01.str.0000047101.87575.3c"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Wu X, Tang S, Dai Q, Yi B, Yang S, Sun J, et al. Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology. 2023; 37: e22738.","DOI":"10.1096\/fj.202201400R"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Shen MH, Zhang CB, Zhang JH, Li PF. Electroacupuncture Attenuates Cerebral Ischemia and Reperfusion Injury in Middle Cerebral Artery Occlusion of Rat via Modulation of Apoptosis, Inflammation, Oxidative Stress, and Excitotoxicity. Evidence-based Complementary and Alternative Medicine: ECAM. 2016; 2016: 9438650.","DOI":"10.1155\/2016\/9438650"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Palencia G, Medrano J\u00c1N, Ortiz-Plata A, Farf\u00e1n DJ, Sotelo J, S\u00e1nchez A, et al. Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia\/reperfusion injury in rats. Journal of the Neurological Sciences. 2015; 351: 78\u201387.","DOI":"10.1016\/j.jns.2015.02.043"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Su D, Li P, Wang X, Zhang W, Zhang Y, Wu C, et al. Observing Malondialdehyde-Mediated Signaling Pathway in Cerebral Ischemia Reperfusion Injury with a Specific Nanolight. Analytical Chemistry. 2020; 92: 2748\u20132755.","DOI":"10.1021\/acs.analchem.9b05008"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Reddy MK, Labhasetwar V. Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology. 2009; 23: 1384\u20131395.","DOI":"10.1096\/fj.08-116947"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Titova E, Ostrowski RP, Rowe J, Chen W, Zhang JH, Tang J. Effects of superoxide dismutase and catalase derivates on intracerebral hemorrhage-induced brain injury in rats. Acta Neurochirurgica. Supplement. 2008; 105: 33\u201335.","DOI":"10.1007\/978-3-211-09469-3_7"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Khorobrykh A. Hydrogen Peroxide and Superoxide Anion Radical Photoproduction in PSII Preparations at Various Modifications of the Water-Oxidizing Complex. Plants (Basel). 2019; 8: 329.","DOI":"10.3390\/plants8090329"},{"key":"ref56","unstructured":"Younus H. Therapeutic potentials of superoxide dismutase. International Journal of Health Sciences. 2018; 12: 88\u201393."},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Armogida M, Spalloni A, Amantea D, Nutini M, Petrelli F, Longone P, et al. The protective role of catalase against cerebral ischemia in vitro and in vivo. International Journal of Immunopathology and Pharmacology. 2011; 24: 735\u2013747.","DOI":"10.1177\/039463201102400320"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Yu H, Xie Y, Dai M, Pan Y, Xie C. SMAD3 interacts with vitamin D receptor and affects vitamin D-mediated oxidative stress to ameliorate cerebral ischaemia-reperfusion injury. The European Journal of Neuroscience. 2022; 56: 6055\u20136068.","DOI":"10.1111\/ejn.15833"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Won S, Sayeed I, Peterson BL, Wali B, Kahn JS, Stein DG. Vitamin D prevents hypoxia\/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kB signaling pathways. PloS One. 2015; 10: e0122821.","DOI":"10.1371\/journal.pone.0122821"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Desai A, Singh N, Raghubir R. Neuroprotective potential of the NF-\u03baB inhibitor peptide IKK-NBD in cerebral ischemia-reperfusion injury. Neurochemistry International. 2010; 57: 876\u2013883.","DOI":"10.1016\/j.neuint.2010.09.006"}],"container-title":["Frontiers in Bioscience-Landmark"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/29\/11\/10.31083\/j.fbl2911389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T17:00:39Z","timestamp":1732726839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBL\/29\/11\/10.31083\/j.fbl2911389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2768-6701(24)01535-1"],"URL":"https:\/\/doi.org\/10.31083\/j.fbl2911389","relation":{},"ISSN":["2768-6701","2768-6698"],"issn-type":[{"value":"2768-6701","type":"print"},{"value":"2768-6698","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"article-number":"389"}}