{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:43:34Z","timestamp":1753890214568,"version":"3.41.2"},"reference-count":213,"publisher":"IMR Press","issue":"12","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>As one of the most common solid pediatric cancers, Neuroblastoma (NBL) accounts for 15% of all of the cancer-related mortalities in infants with increasing incidence all around the world. Despite current therapeutic approaches for NBL (radiotherapies, surgeries, and chemotherapies), these approaches could not be beneficial for all of patients with NBL due to their low effectiveness, and some severe side effects. These challenges lead basic medical scientists and clinical specialists toward an optimal medical interventions for clinical management of NBL. Regardingly, taking molecular and cellular immunopathophysiology involved in the hypoxic microenvironment of NBL into account, it can practically be a contributing approach in the development of \u201cmolecular medicine\u201d for treatment of NBL. Interestingly, pivotal roles of \u201cherbal medicine\u201d in the hypoxic microenvironment of NBL have been extensively interrogated for treating a NBL, functionally being served as an anti-cancer agent via inducing a wide range of molecular and cellular signaling, like apoptosis, cell cycle arrest, and inhibiting angiogenesis. Hence, in this review study, the authors aim to summarize the anti-tumor effects of some medicinal plants and their phytoconstituents through molecular immunopathophysiological mechanisms involved in the hypoxic microenvironment of NBL. In addition, they try to open promising windows to immune gene-based therapies for NBL \u201cprecision medicine\u201d through clinical advantages of herbal and molecular medicine. An interdisciplinary collaboration among translation and molecular medicine specialists, immunobiologists, herbal medicine specialists, and pediatric neuro-oncologists is highly recommended.<\/jats:p>","DOI":"10.31083\/j.fbl2912422","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T11:37:01Z","timestamp":1735558621000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of Hypoxia Induced by Medicinal Plants; A Revolutionary Era of Cellular and Molecular Herbal Medicine in Neuroblastoma Treatment"],"prefix":"10.31083","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-6583","authenticated-orcid":true,"given":"Samin","family":"Rahimi","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Natural Sciences, Tabriz University, 5166616471 Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0601-983X","authenticated-orcid":true,"given":"Fatemeh","family":"Shirin","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, 1651153311 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3313-4930","authenticated-orcid":true,"given":"Mahdi","family":"Moassesfar","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, 1651153311 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2871-7077","authenticated-orcid":true,"given":"Hossein","family":"Zafari","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Chemical Engineering, Shahreza Branch, Islamic Azad University, 8648146411 Shahreza, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9956-3644","authenticated-orcid":true,"given":"Nazila","family":"Bahmaie","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), 06800 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-0121","authenticated-orcid":true,"given":"Kimia","family":"Baghebani","sequence":"first","affiliation":[{"name":"Department of Biology, College of Basic Sciences, Kermanshah Branch, Islamic Azad University, 6718997551 Kermanshah, Iran"},{"name":"Now with Department of Biotechnology, College of Environmental and Bioresource Sciences, Jeonbuk National University, 54896 Jeonbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6149-1833","authenticated-orcid":true,"given":"Yasna","family":"Bidmeshki","sequence":"first","affiliation":[{"name":"Department of Biology, College of Basic Sciences, Kermanshah Branch, Islamic Azad University, 6718997551 Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4946-3642","authenticated-orcid":true,"given":"Seyede Masoumeh","family":"Sajjadi Manesh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Basic Sciences, Qom Branch, Islamic Azad University, 3716146611 Qom, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-6159","authenticated-orcid":true,"given":"Kasra","family":"Rasoulzadeh Darabad","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences, University of Maragheh, 5518779842 Maragheh, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0465-6156","authenticated-orcid":true,"given":"Massoud","family":"Bahmaie","sequence":"first","affiliation":[{"name":"Department of Herbal Medicine, University of Poona, 411007 Poona, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-0704","authenticated-orcid":true,"given":"Elham","family":"Nouri","sequence":"first","affiliation":[{"name":"Clinical Diagnosis Laboratory, Shahid Beheshti University-affiliated Hospital, Zanjan University of Medical Sciences (ZUMS), 4513956111 Zanjan, Iran"},{"name":"Department of Medical Laboratory Science, Faculty of Paramedicine, Zanjan University of Medical Sciences (ZUMS), 4513956111 Zanjan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-7685","authenticated-orcid":true,"given":"Ahmet","family":"Kilic","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University (AYBU), 06800 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2531-6007","authenticated-orcid":true,"given":"Melika","family":"Ansarin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), 1449614535 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-8100","authenticated-orcid":true,"given":"P\u0131nar","family":"\u00d6z\u0131\u015f\u0131k","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, Ankara Bilkent City 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