{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:08:23Z","timestamp":1787195303641,"version":"build-2736575974"},"reference-count":67,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Schol Ed)"],"abstract":"<jats:p>Tuberculosis (TB) and Coronavirus Disease-19 (COVID-19) infection are two respiratory diseases that are of particular concern epidemiologically. Tuberculosis is one of the oldest diseases recorded in the history of mankind dating back thousands of years. It is estimated that approximately one quarter of the world\u2019s population is infected with latent Mycobacterium tuberculosis (LTBI). This contrasts with COVID-19, which emerged in late 2019. Data continues to accumulate and become available on this pathogen, but the long-term side effect of fibrotic damage in COVID-19 patients evokes parallels between this novel coronavirus and its ancient bacterial affiliate. This similarity as well as several others may incite inquiries on whether coinfection of individuals with latent TB and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lead to excessive fibrosis in the lungs and thus the emergence of an active TB infection. While it is well understood how TB leads to structural and immunological lung complications including granuloma formation, fibrosis, and T cell exhaustion, less is known about the disease course when coinfection with SARS-CoV-2 is present. Past and present research demonstrate that IL-10, TNF-\u03b1, IFN class I-III, TGF-\u03b2, IL-35, and Regulatory T cells (T-regs) are all important contributors of the characteristics of host response to mycobacterium tuberculosis. It has also been noted with current research that IL-10, TNF-\u03b1, IFN class I, II, and III, TGF-\u03b2, ACE-2, and T-regs are also important contributors to the host response to the SARS-CoV-2 virus in different ways than they are to the TB pathogen. Both pathogens may lead to an unbalanced inflammatory immune response, and together a shared dysregulation of immune response suggests an increased risk of severity and progression of both diseases. We have reviewed 72 different manuscripts between the years 1992 and 2021. The manuscripts pertaining to the SARS-COV-2 virus specifically are from the years 2020 and 2021. Our literature review aims to explore the biomolecular effects of these contributors to pathogenicity of both diseases along with current publications on TB\/COVID-19 coinfection, focusing on the pathogenicity of SARS-CoV-2 infection with both latent and active TB, as well as the challenges in treating TB during the COVID-19 pandemic. The compiled material will then aid the latticework foundation of knowledge for future research leading to a hopeful improved system of therapeutic strategies for coinfection.<\/jats:p>","DOI":"10.31083\/j.fbs1401006","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T09:35:30Z","timestamp":1647509730000},"source":"Crossref","is-referenced-by-count":44,"title":["TB and COVID-19: An Exploration of the Characteristics and Resulting Complications of Co-infection"],"prefix":"10.31083","volume":"14","author":[{"given":"Erica","family":"Luke","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Swafford","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Shirazi","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwanath","family":"Venketaraman","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"ref1","unstructured":"Programme GT. Global tuberculosis report 2020. World Health Organization. 2020. Available at: https:\/\/www.who.int\/publications\/i\/item\/9789240013131 (Accessed: 15 October 2021)."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Deutsch-Feldman M, Pratt RH, Price SF, Tsang CA, Self JL. Tuberculosis - United States, 2020. Morbidity and Mortality Weekly Report. 2021; 70: 409\u2013414.","DOI":"10.15585\/mmwr.mm7012a1"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Gupta E, Rastogi A, Padhi A, Syed S, Keshan P. Mapping the footprints of COVID-19 pandemic. Journal of Family Medicine and Primary Care. 2021; 10: 2467\u20132476.","DOI":"10.4103\/jfmpc.jfmpc_2361_20"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Raman R, Patel KJ, Ranjan K. COVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies. Biomolecules. 2021; 11: 993.","DOI":"10.3390\/biom11070993"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Low JG, Lee CC, Leo YS, Low JG, Lee CC, Leo YS. Severe Acute Respiratory Syndrome and Pulmonary Tuberculosis. Clinical Infectious Diseases. 2004; 38: e123\u2013e125.","DOI":"10.1086\/421396"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Redford PS, Mayer-Barber KD, McNab FW, Stavropoulos E, Wack A, Sher A, et al. Influenza a Virus Impairs Control of Mycobacterium tuberculosis Coinfection through a Type i Interferon Receptor\u2013Dependent Pathway. The Journal of Infectious Diseases. 2014; 209: 270\u2013274.","DOI":"10.1093\/infdis\/jit424"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"de Paus RA, van Crevel R, van Beek R, Sahiratmadja E, Alisjahbana B, Marzuki S, et al. The influence of influenza virus infections on the development of tuberculosis. Tuberculosis. 2013; 93: 338\u2013342.","DOI":"10.1016\/j.tube.2013.02.006"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Walaza S, Cohen C, Tempia S, Moyes J, Nguweneza A, Madhi SA, et al. Influenza and tuberculosis co\u2010infection: a systematic review. Influenza and other Respiratory Viruses. 2020; 14: 77\u201391.","DOI":"10.1111\/irv.12670"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Liu W, Fontanet A, Zhang PH, Zhan L, Xin ZT, Tang F, et al. Pulmonary tuberculosis and SARS, China. Emerging Infectious Diseases. 2006; 12 707\u2013709.","DOI":"10.3201\/eid1204.050264"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Fratti RA, Backer JM, Gruenberg J, Corvera S, Deretic V. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. The Journal of Cell Biology. 2001; 154: 631\u2013644.","DOI":"10.1083\/jcb.200106049"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Mousquer GT, Peres A, Fiegenbaum M. Pathology of TB\/COVID-19 Co-Infection: the phantom menace. Tuberculosis. 2021; 126: 102020.","DOI":"10.1016\/j.tube.2020.102020"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Guinn KM, Rubin EJ. Tuberculosis: Just the FAQs. MBio. 2017; 8: e01910\u2013e01917.","DOI":"10.1128\/mBio.01910-17"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Negishi H, Taniguchi T, Yanai H. The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family. Cold Spring Harbor Perspectives in Biology. 2018; 10: a028423.","DOI":"10.1101\/cshperspect.a028423"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Mesev EV, LeDesma RA, Ploss A. Decoding type i and III interferon signalling during viral infection. Nature Microbiology. 2019; 4: 914\u2013924.","DOI":"10.1038\/s41564-019-0421-x"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Stanifer ML, Pervolaraki K, Boulant S. Differential Regulation of Type i and Type III Interferon Signaling. International Journal of Molecular Sciences. 2019; 20: 1445.","DOI":"10.3390\/ijms20061445"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Robert M, Miossec P. Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor. Cellular & Molecular Immunology. 2021; 18: 1644\u20131651.","DOI":"10.1038\/s41423-021-00694-9"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Pag\u00e1n AJ, Ramakrishnan L. The Formation and Function of Granulomas. Annual Review of Immunology. 2018; 36: 639\u2013665.","DOI":"10.1146\/annurev-immunol-032712-100022"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Segovia-Juarez JL, Ganguli S, Kirschner D. Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. Journal of Theoretical Biology. 2004; 231: 357\u2013376.","DOI":"10.1016\/j.jtbi.2004.06.031"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Ahmed A, Vyakarnam A. Emerging patterns of regulatory T cell function in tuberculosis. Clinical and Experimental Immunology. 2020; 202: 273\u2013287.","DOI":"10.1111\/cei.13488"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Chen W. Tregs in immunotherapy: opportunities and challenges. Immunotherapy. 2011; 3: 911\u2013914.","DOI":"10.2217\/imt.11.79"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Cardona P, Cardona PJ. Regulatory T Cells in Mycobacterium tuberculosis Infection. Frontiers in Immunology. 2019; 10: 2139.","DOI":"10.3389\/fimmu.2019.02139"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Zdanov A, Schalk-Hihi C, Gustchina A, Tsang M, Weatherbee J, Wlodawer A. Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure. 1995; 3: 591\u2013601.","DOI":"10.1016\/S0969-2126(01)00193-9"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Huang A, Cheng L, He M, Nie J, Wang J, Jiang K. Interleukin-35 on B cell and T cell induction and regulation. Journal of Inflammation. 2017; 14: 16.","DOI":"10.1186\/s12950-017-0164-5"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Daopin S, Piez KA, Ogawa Y, Davies DR. Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. Science. 1992; 257: 369\u2013373.","DOI":"10.1126\/science.1631557"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Gern BH, Adams KN, Plumlee CR, Stoltzfus CR, Shehata L, Moguche AO, et al. TGF\u03b2 restricts expansion, survival, and function of T cells within the tuberculous granuloma. Cell Host & Microbe. 2021; 29: 594\u2013606.e6.","DOI":"10.1016\/j.chom.2021.02.005"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Rosas-Taraco AG, Higgins DM, S\u00e1nchez-Campillo J, Lee EJ, Orme IM, Gonz\u00e1lez-Juarrero M. Local pulmonary immunotherapy with siRNA targeting TGF\u03b21 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. Tuberculosis. 2011; 91: 98\u2013106.","DOI":"10.1016\/j.tube.2010.11.004"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Almeida AS, Lago PM, Boechat N, Huard RC, Lazzarini LCO, Santos AR, et al. Tuberculosis is Associated with a down-Modulatory Lung Immune Response that Impairs Th1-Type Immunity. The Journal of Immunology. 2009; 183: 718\u2013731.","DOI":"10.4049\/jimmunol.0801212"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Bonecini-Almeida MG, Ho JL, Bo\u00e9chat N, Huard RC, Chitale S, Doo H, et al. Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors i and II in active tuberculosis. Infection and Immunity. 2004; 72: 2628\u20132634.","DOI":"10.1128\/IAI.72.5.2628-2634.2004"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Abdalla AE, Lambert N, Duan X, Xie J. Interleukin-10 Family and Tuberculosis: an Old Story Renewed. International Journal of Biological Sciences. 2016; 12: 710\u2013717.","DOI":"10.7150\/ijbs.13881"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Turner J, Gonzalez-Juarrero M, Ellis DL, Basaraba RJ, Kipnis A, Orme IM, et al. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL\/6 mice. Journal of Immunology. 2002; 169: 6343\u20136351.","DOI":"10.4049\/jimmunol.169.11.6343"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R, et al. Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA\/J mice. Journal of Immunology. 2008; 181: 5545\u20135550.","DOI":"10.4049\/jimmunol.181.8.5545"},{"key":"ref32","unstructured":"Ait-Khaled N, Enarson DA. Tuberculosis A Manual for medical students. 2003. Available at: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/68559\/WHO_CDS_TB_99.272.pdf (Accessed: 21 October 2021)."},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Visca D, Ong CWM, Tiberi S, Centis R, D\u2019Ambrosio L, Chen B, et al. Tuberculosis and COVID-19 interaction: a review of biological, clinical and public health effects. Pulmonology. 2021; 27: 151\u2013165.","DOI":"10.1016\/j.pulmoe.2020.12.012"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Jackson CB, Farzan M, Chen B, Choe H. Mechanisms of SARS-CoV-2 entry into cells. Nature Reviews Molecular Cell Biology. 2022; 23: 3\u201320.","DOI":"10.1038\/s41580-021-00418-x"},{"key":"ref35","unstructured":"U.S. National Library of Medicine. ACE2 angiotensin converting enzyme 2 [homo sapiens (human)]-gene-NCBI. National Center for Biotechnology Information. 2021. Available at: https:\/\/www.ncbi.nlm.nih.gov\/gene\/59272 (Accessed: 25 October 2021)."},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Ye R, Liu Z. ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway. Experimental and Molecular Pathology. 2020; 113: 104350.","DOI":"10.1016\/j.yexmp.2019.104350"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Wang H, Wang Z, Cao W, Wu Q, Yuan Y, Zhang X. Regulatory T cells in COVID-19. Aging and Disease. 2021; 12: 1545.","DOI":"10.14336\/AD.2021.0709"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, et al. Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19). Frontiers in Immunology. 2020; 11: 827.","DOI":"10.3389\/fimmu.2020.00827"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of Immune Response in Patients with Coronavirus 2019 (COVID-19) in Wuhan, China. Clinical Infectious Diseases. 2020; 71: 762\u2013768.","DOI":"10.1093\/cid\/ciaa248"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Tan M, Liu Y, Zhou R, Deng X, Li F, Liang K, et al. Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China. Immunology. 2020; 160: 261\u2013268.","DOI":"10.1111\/imm.13223"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerging Microbes & Infections. 2020; 9: 1123\u20131130.","DOI":"10.1080\/22221751.2020.1770129"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Gopalaswamy R, Subbian S. Corticosteroids for COVID-19 Therapy: Potential Implications on Tuberculosis. International Journal of Molecular Sciences. 2021; 22: 3773.","DOI":"10.3390\/ijms22073773"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Carlson FR, Bosukonda D, Keck PC, Carlson WD. Multiorgan Damage in Patients with COVID-19: Is the TGF-\u03b2\/BMP Pathway the Missing Link? JACC: Basic to Translational Science. 2020; 5: 1145\u20131148.","DOI":"10.1016\/j.jacbts.2020.09.003"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Chen W. A potential treatment of COVID-19 with TGF-\u03b2 blockade. International Journal of Biological Sciences. 2020; 16: 1954\u20131955.","DOI":"10.7150\/ijbs.46891"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Raniga K, Liang C. Interferons: Reprogramming the Metabolic Network against Viral Infection. Viruses. 2018; 10: 36.","DOI":"10.3390\/v10010036"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Schaller T, Hirschb\u00fchl K, Burkhardt K, Braun G, Trepel M, M\u00e4rkl B, et al. Postmortem Examination of Patients with COVID-19. The Journal of the American Medical Association. 2020; 323: 2518.","DOI":"10.1001\/jama.2020.8907"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Menter T, Haslbauer JD, Nienhold R, Savic S, Hopfer H, Deigendesch N, et al. Postmortem examination of COVID\u201019 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020; 77: 198\u2013209.","DOI":"10.1111\/his.14134"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Kant S, Tyagi R. The impact of COVID-19 on tuberculosis: challenges and opportunities. Therapeutic Advances in Infectious Disease. 2021; 8: 204993612110169.","DOI":"10.1177\/20499361211016973"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Chen Y, Wang Y, Fleming J, Yu Y, Gu Y, Liu C, et al. Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity. To be published in medRxiv. 2020. (Preprint)","DOI":"10.1101\/2020.03.10.20033795"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Petrone L, Petruccioli E, Vanini V, Cuzzi G, Gualano G, Vittozzi P, et al. Coinfection of tuberculosis and COVID-19 limits the ability to in vitro respond to SARS-CoV-2. International Journal of Infectious Diseases. 2021; 113: S82\u2013S87.","DOI":"10.1016\/j.ijid.2021.02.090"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Pathak L, Gayan S, Pal B, Talukdar J, Bhuyan S, Sandhya S, et al. Coronavirus Activates an Altruistic Stem Cell\u2013Mediated Defense Mechanism that Reactivates Dormant Tuberculosis: Implications in Coronavirus Disease 2019 Pandemic. The American Journal of Pathology. 2021; 191: 1255\u20131268.","DOI":"10.1016\/j.ajpath.2021.03.011"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Tadolini M, Codecasa LR, Garc\u00eda-Garc\u00eda J, Blanc F, Borisov S, Alffenaar J, et al. Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases. European Respiratory Journal. 2020; 56: 2001398.","DOI":"10.1183\/13993003.02328-2020"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Khayat M, Fan H, Vali Y. COVID-19 promoting the development of active tuberculosis in a patient with latent tuberculosis infection: a case report. Respiratory Medicine Case Reports. 2021; 32: 101344.","DOI":"10.1016\/j.rmcr.2021.101344"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Khan N, Vidyarthi A, Amir M, Mushtaq K, Agrewala JN. T-cell exhaustion in tuberculosis: pitfalls and prospects. Critical Reviews in Microbiology. 2017; 43: 133\u2013141.","DOI":"10.1080\/1040841X.2016.1185603"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Riou C, du Bruyn E, Stek C, Daroowala R, Goliath RT, Abrahams F, et al. Relationship of SARS-CoV-2\u2013specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection. Journal of Clinical Investigation. 2021; 131: e149125.","DOI":"10.1172\/JCI149125"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Singh A, Prasad R, Gupta A, Das K, Gupta N. Severe acute respiratory syndrome coronavirus-2 and pulmonary tuberculosis: convergence can be fatal. Monaldi Archives for Chest Disease. 2020; 90.","DOI":"10.4081\/monaldi.2020.1368"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Myall KJ, Mukherjee B, Castanheira AM, Lam JL, Benedetti G, Mak SM, et al. Persistent Post\u2013COVID-19 Interstitial Lung Disease. an Observational Study of Corticosteroid Treatment. Annals of the American Thoracic Society. 2021; 18: 799\u2013806.","DOI":"10.1513\/AnnalsATS.202008-1002OC"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Ortiz-Martinez Y, Mejia-Alzate C, Vega-Vera A, Fajardo-Rivero JE, Rodriguez-Morales AJ. Drug-resistant tuberculosis and COVID-19 co-infection: A systematic review of case reports. International Journal of Mycobacteriology. 2021; 10: 214\u2013215.","DOI":"10.4103\/ijmy.ijmy_56_21"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Shabrawishi M, AlQarni A, Ghazawi M, Melibari B, Baljoon T, Alwafi H, et al. New disease and old threats: a case series of COVID\u201019 and tuberculosis coinfection in Saudi Arabia. Clinical Case Reports. 2021; 9: e04233.","DOI":"10.1002\/ccr3.4233"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. European Respiratory Review. 2018; 27: 170077.","DOI":"10.1183\/16000617.0077-2017"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Tham SM, Lim WY, Lee CK, Loh J, Premkumar A, Yan B, et al. Four Patients with COVID-19 and Tuberculosis, Singapore, April-May 2020. Emerging Infectious Diseases. 2020; 26: 2764\u20132766.","DOI":"10.3201\/eid2611.202752"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Ata F, Yousaf Q, Veliyankodan Parambil J, Parengal J, Mohamedali MG, Yousaf Z. A 28-Year-Old Man from India with SARS-Cov-2 and Pulmonary Tuberculosis Co-Infection with Central Nervous System Involvement. The American Journal of Case Reports. 2020; 21: e926034.","DOI":"10.12659\/AJCR.926034"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Kumar DR, Bhattacharya DB, Meena DV, Soneja DM, Wig DN. COVID-19 and TB co-infection-\u2019Finishing touch\u201d in perfect recipe to \u2018severity\u2019 or \u2018death\u2019. Journal of Infection. 2020; 81: e39\u2013e40.","DOI":"10.1016\/j.jinf.2020.06.062"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Mulale UK, Kashamba T, Strysko J, Kyokunda LT. Fatal SARS-CoV-2 and Mycobacterium tuberculosis coinfection in an infant: insights from Botswana. BMJ Case Reports. 2021; 14: e239701.","DOI":"10.1136\/bcr-2020-239701"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Sy KTL, Haw NJL, Uy J. Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19. Infectious Diseases. 2020; 52: 902\u2013907.","DOI":"10.1080\/23744235.2020.1806353"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Davies MA. HIV and risk of COVID-19 death: a population cohort study from the Western Cape Province, South Africa. To be published in medRxiv. 2020. (Preprint)","DOI":"10.1101\/2020.07.02.20145185"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Louie JK, Agraz-Lara R, Romo L, Crespin F, Chen L, Graves S. Tuberculosis-Associated Hospitalizations and Deaths after COVID-19 Shelter-In-Place, San Francisco, California, USA. Emerging Infectious Diseases. 2021; 27: 2227\u20132229.","DOI":"10.3201\/eid2708.210670"}],"container-title":["Frontiers in Bioscience-Scholar"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBS\/14\/1\/10.31083\/j.fbs1401006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T14:55:49Z","timestamp":1732719349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBS\/14\/1\/10.31083\/j.fbs1401006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["S1945-0516(22)00051-X"],"URL":"https:\/\/doi.org\/10.31083\/j.fbs1401006","relation":{},"ISSN":["1945-0516","1945-0524"],"issn-type":[{"value":"1945-0516","type":"print"},{"value":"1945-0524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]},"article-number":"6"}}