{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:55Z","timestamp":1753889995879,"version":"3.41.2"},"reference-count":32,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Schol Ed)"],"abstract":"<jats:p>Background: Significant hemodynamic, hormonal, and metabolic impairment of a brain-dead organ donor is often associated with the deterioration of graft viability. This study aimed to compare the effect of heparin therapy as a therapeutic dose after brain death confirmation on early graft survival in kidney and liver recipients. Method and Materials: The deceased donors were sorted into two groups based on their D-dimer level. After confirming brain death, one group was given a heparin injection (case group), while the other group did not receive any heparin (control group). A total of 71 brain death donors and matched kidney and liver transplants were included in the case group. A total of 43 brain death donors and matched kidney and liver transplants were included in the control group. A total of 5000 units of heparin were administered every 6 hours to the deceased donor case group. Results: The mean age of the case and control groups were 36.27 \u00b1 16.13 and 36.15 \u00b1 18.45, respectively. An independent t test showed that there were no differences between the number of procured organs in both groups (p = 0.29). There was no significant difference between the graft survival rate and the doses of heparin injection to the liver recipients (p = 0.06). However, a significant difference was revealed between the graft survival rate and the dose of heparin injection (p = 0.004) in kidney recipients. Conclusions: The data suggest that administering low therapeutic doses of heparin to donors before organ donation may potentially prevent thrombosis and provide a protective benefit. We showed that heparin therapy had no significant effect on the number of donated organs and graft survival.<\/jats:p>","DOI":"10.31083\/j.fbs1502007","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T01:41:58Z","timestamp":1687916518000},"source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Heparin Therapy in Deceased Donors on Early Graft Survival for Kidney and Liver Recipients: A Clinical Trial Study"],"prefix":"10.31083","volume":"15","author":[{"given":"Marzieh","family":"Latifi","sequence":"first","affiliation":[{"name":"Medical Ethics and Law Research Center, Shaheed Beheshti University of Medical Sciences, 1985717443 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elahe","family":"Pourhosein","sequence":"first","affiliation":[{"name":"Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences, 46911 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Rahban","sequence":"first","affiliation":[{"name":"Cardiovascular Research Foundation of Southern California, Beverly Hills, CA 90210, USA"},{"name":"Southern California Medical Education Consortium, Temecula Valley Hospital, Universal Health System, Temecula, CA 92592, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Khajavi","sequence":"first","affiliation":[{"name":"Anesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, 1136746911 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaz","family":"Dehghani","sequence":"first","affiliation":[{"name":"Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences, 46911 Tehran, Iran"},{"name":"Iranian Tissue Bank & Research Center, Tehran University of Medical Sciences, 1419733141 Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Gastala J, Fattal D, Kirby PA, Capizzano AA, Sato Y, Moritani T. 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Transplantation Proceedings. 2013; 45: 222\u2013224.","DOI":"10.1016\/j.transproceed.2012.02.043"}],"container-title":["Frontiers in Bioscience-Scholar"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBS\/15\/2\/10.31083\/j.fbs1502007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T15:05:08Z","timestamp":1732719908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBS\/15\/2\/10.31083\/j.fbs1502007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,25]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"alternative-id":["S1945-0516(23)00085-0"],"URL":"https:\/\/doi.org\/10.31083\/j.fbs1502007","relation":{},"ISSN":["1945-0516","1945-0524"],"issn-type":[{"type":"print","value":"1945-0516"},{"type":"electronic","value":"1945-0524"}],"subject":[],"published":{"date-parts":[[2023,6,25]]},"article-number":"7"}}