{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:20:44Z","timestamp":1777414844378,"version":"3.51.4"},"reference-count":35,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been considered as a treatment option for depression and anxiety. However, its role in epilepsy comorbid with depression and anxiety is unclear. Therefore, we evaluated whether low-frequency rTMS can alleviate depression- and anxiety-like behavior in epileptic rats. Forty-eight adult rats were allocated at random to four groups: Control, Pentylenetetrazol (PTZ), PTZ-rTMS and PTZ-Sham. The control group received intraperitoneal injections of normal saline, while the other groups received intraperitoneal injections of pentylenetetrazol (35 mg\/kg\/d) once a day for 15 days. Low-frequency rTMS or sham stimulation were administered to the PTZ-rTMS and PTZ-Sham group, respectively, over the two-week period. The open-field test (OFT), elevated plus-maze test (EPM) and forced swimming test (FST) were carried out before the experiment, on the 8th and 15th day to assess depression- and anxiety-like behavior in the rats. Two weeks of low-frequency rTMS treatment could not impair the increases of seizure severity in epileptic rats. However, relative to the PTZ and PTZ-Sham group, the two-week low-frequency rTMS treatment significantly reduced the immobility time in the forced swimming test and attenuated the progressive decrease in total distance traveled, frequency of rearing, velocity in the open-field test, number of entries in the open arms (%) and the time spent in the open arms (%) in the elevated plus-maze test of the PTZ-rTMS group. We proposed that low-frequency rTMS can benefit epileptic rats via amelioration of comorbid depression and anxiety, but it can not alleviate the seizure severity.<\/jats:p>","DOI":"10.31083\/j.jin.2019.03.1100","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T11:19:04Z","timestamp":1569842344000},"source":"Crossref","is-referenced-by-count":16,"title":["Effects of low-frequency repetitive transcranial magnetic stimulation on depression- and anxiety-like behaviors in epileptic rats"],"prefix":"10.31083","volume":"18","author":[{"given":"Shun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanping","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baozhen","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Anand, S. and Hotson, J. (2002) Transcranial magnetic stimulation: neurophysiological applications and safety. 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