{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:43:47Z","timestamp":1776692627418,"version":"3.51.2"},"reference-count":42,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal axis and improve depression-like behavior caused by hypothalamus-pituitary-adrenal axis hyperactivity. The current study investigated the specific mechanism of action of this effect. A depression model was established by repeated injections of corticosterone to study the antidepressant-like effect of honokiol and its potential mechanism. Honokiol prevented the elevated activity of the hypothalamus-pituitary-adrenal axis and the depression-like behavior induced by corticosterone. Treatment with honokiol resulted in greater glucocorticoid receptor mRNA expression, greater glucocorticoid receptor-positive expression, and a greater ratio of glucocorticoid receptor to the mineralocorticoid receptor in the hippocampus. Moreover, honokiol treatment led to lower levels of interleukin-1\u03b2 in serum and the positive expression of the interleukin-1\u03b2 receptor in the hippocampus. These results demonstrate that the antidepressant-like mechanism of honokiol, which has effects on inflammatory factors, may act through restoring the typical activity of the hypothalamus-pituitary-adrenal axis by regulating the glucocorticoid receptor-mediated negative feedback mechanism and the balance between glucocorticoid and mineralocorticoid receptors.<\/jats:p>","DOI":"10.31083\/j.jin.2020.03.172","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T01:38:25Z","timestamp":1602639505000},"source":"Crossref","is-referenced-by-count":14,"title":["Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression"],"prefix":"10.31083","volume":"19","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hua","family":"Duan","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Li","family":"Hu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Na","family":"Li","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Yu","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Sheng","family":"Chang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Bellavance, M. and Rivest, S. 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