{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:36Z","timestamp":1753890036790,"version":"3.41.2"},"reference-count":41,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>This preliminary research determines whether a combination of reverse end-to-side neurorrhaphy and rapamycin treatment achieves a better functional outcome than a single application after prolonged peripheral nerve injury. We found that the tibial nerve function of the reverse end-to-side + rapamycin group recovered better, with a higher tibial function index value, higher amplitude recovery rate, and shorter latency delay rate (P &lt; 0.05). The reverse end-to-side + rapamycin group better protected the gastrocnemius muscle with more forceful contractility, tetanic tension, and a higher myofibril cross-sectional area (P &lt; 0.05). Combining reverse end-to-side neurorrhaphy with rapamycin treatment is a practical approach to promoting the recovery of chronically denervated muscle atrophy after peripheral nerve injury.<\/jats:p>","DOI":"10.31083\/j.jin2002035","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T05:04:01Z","timestamp":1625461441000},"source":"Crossref","is-referenced-by-count":2,"title":["Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats"],"prefix":"10.31083","volume":"20","author":[{"given":"Yijian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqiong","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing Key Laboratory of Spinal Disease, 100044 Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanchen","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiujian","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bofu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingtian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Midha R. 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