{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:39Z","timestamp":1790009559619,"version":"4.0.1"},"reference-count":40,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>This research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were recruited, matched for weight, height, age, sex, and educational level. All participants underwent resting-state functional nuclear resonance imaging, and the characteristics of spontaneous brain activity were evaluated using the regional homogeneity technique. Each participant in the dysthyroid optic neuropathy group also completed the Hospital Anxiety and Depression scale. Receiver operating characteristic curves were used to compare brain activity between the two groups. Pearson correlation analysis evaluated the relationship between regional homogeneity and clinical manifestations in dysthyroid optic neuropathy patients. In addition, we analyzed the correlation between Hospital Anxiety and Depression scale and regional homogeneity. We found that the regional homogeneity values at the corpus callosum\/cingulate gyrus and parietal lobe\/middle frontal gyrus significantly decreased in dysthyroid optic neuropathy patients. Regional homogeneity values at the corpus callosum\/cingulate gyrus and parietal lobe\/middle frontal gyrus were negatively correlated with Hospital Anxiety and Depression scale and disease duration. It was found that the regional homogeneity signal values were significantly lower than in thyroid-associated ophthalmopathy without in dysthyroid optic neuropathy, which may indicate a risk of regional brain dysfunction in dysthyroid optic neuropathy. The results show that regional homogeneity has the potential for early diagnosis and prevent dysthyroid optic neuropathy. In addition, the findings suggest possible mechanisms of dysthyroid optic neuropathy optic nerve injury. They may provide a valuable basis for further research on the pathological mechanisms of dysthyroid optic neuropathy.<\/jats:p>","DOI":"10.31083\/j.jin2002037","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T05:04:01Z","timestamp":1625461441000},"source":"Crossref","is-referenced-by-count":23,"title":["Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study"],"prefix":"10.31083","volume":"20","author":[{"given":"Yi-Ping","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Chang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"},{"name":"Department of Anesthesiology, First College for Clinical Medicine, Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Zhongshan Hospital, Xiamen University, 361102 Xiamen, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Min","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Su","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"},{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ye","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cong","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Bin","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zhang Y, Li X, Guo C, Dong J, Liao L. Mechanisms of Spica Prunellae against thyroid-associated Ophthalmopathy based on network pharmacology and molecular docking. BMC Complementary Medicine and Therapies. 2020; 20: 229.","DOI":"10.1186\/s12906-020-03022-2"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Yu B. Predictive parameters on CT scan for dysthyroid optic neuropathy. International Journal of Ophthalmology. 2020; 13: 1266\u20131271.","DOI":"10.18240\/ijo.2020.08.13"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Bahn RS. Graves\u2019 ophthalmopathy. New England Journal of Medicine. 2010; 362: 726\u2013738.","DOI":"10.1056\/NEJMra0905750"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Joseph SS, Miller NR. Management of dysthyroid optic neuropathy. In Mukherjee B., Yuen H. (eds.) Emergencies of the Orbit and Adnexa (pp. 235\u2013257). New Delhi: Springer. 2017.","DOI":"10.1007\/978-81-322-1807-4_28"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Zah-Bi G, Abeillon-du Payrat J, Vie AL, Bournaud-Salinas C, Jouanneau E, Berhouma M. Minimal-access endoscopic endonasal management of dysthyroid optic neuropathy: the dysthone study. Neurosurgery. 2019; 85: E1059\u2013E1067.","DOI":"10.1093\/neuros\/nyz268"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves ACP, Silva LN, Gebrim EMMS, Matayoshi S, Monteiro MLR. Predicting dysthyroid optic neuropathy using computed tomography volumetric analyses of orbital structures. Clinics. 2012; 67: 891\u2013896.","DOI":"10.6061\/clinics\/2012(08)06"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves AC, Silva LN, Gebrim EM, Monteiro ML, Monteiro MLR. Quantification of orbital apex crowding for screening of dysthyroid optic neuropathy using multidetector CT. American Journal of Neuroradiology. 2012; 33: 1602\u20131607.","DOI":"10.3174\/ajnr.A3029"},{"key":"ref8","unstructured":"Gupta M, Bordoni B. Neuroanatomy, visual pathway. Treasure Island: StatPearls Publishing. 2021."},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Demeneix B. Evidence for prenatal exposure to thyroid disruptors and adverse effects on brain development. European Thyroid Journal. 2019; 8: 283\u2013292.","DOI":"10.1159\/000504668"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"\u00d6zkan B, Anik Y, Katre B, Altinta\u015f \u00d6, Gen\u00e7t\u00fcrk M, Y\u00fcksel N. Quantitative assessment of optic nerve with diffusion tensor imaging in patients with thyroid orbitopathy. Ophthalmic Plastic and Reconstructive Surgery. 2015; 31: 391\u2013395.","DOI":"10.1097\/IOP.0000000000000359"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Dai H, Morelli JN, Ai F, Yin D, Hu C, Xu D, et al. Resting-state functional MRI: functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients. Human Brain Mapping. 2013; 34: 2455\u20132463.","DOI":"10.1002\/hbm.22079"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Bhuva AN, Moralee R, Moon JC, Manisty CH. Making MRI available for patients with cardiac implantable electronic devices: growing need and barriers to change. European Radiology. 2020; 30: 1378\u20131384.","DOI":"10.1007\/s00330-019-06449-5"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Yurgelun-Todd DA, Renshaw PF, Goldsmith P, Uz T, Macek TA. A randomized, placebo-controlled, phase 1 study to evaluate the effects of TAK-063 on ketamine-induced changes in fMRI BOLD signal in healthy subjects. Psychopharmacology. 2020; 237: 317\u2013328.","DOI":"10.1007\/s00213-019-05366-1"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Xu M, Liu H, Tan G, Su T, Xiang C, Wu W, et al. Altered regional homogeneity in patients with corneal ulcer: a resting-state functional MRI study. Frontiers in Neuroscience. 2019; 13: 743.","DOI":"10.3389\/fnins.2019.00743"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Liao X, Yuan Q, Shi W, Li B, Su T, Lin Q, et al. Altered brain activity in patients with diabetic retinopathy using regional homogeneity: a resting-state fMRI study. Endocrine Practice. 2019; 25: 320\u2013327.","DOI":"10.4158\/EP-2018-0517"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Huang X, Ye C, Zhong Y, Ye L, Yang Q, Li H, et al. Altered regional homogeneity in patients with late monocular blindness: a resting-state functional MRI study. Neuroreport. 2017; 28: 1085\u20131091.","DOI":"10.1097\/WNR.0000000000000855"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Xiang C, Liu W, Xu Q, Su T, Yong-Qiang S, Min Y, et al. Altered spontaneous brain activity in patients with classical trigeminal neuralgia using regional homogeneity: a resting-state functional MRI study. Pain Practice. 2019; 19: 397\u2013406.","DOI":"10.1111\/papr.12753"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Tang L, Li H, Huang X, Bao J, Sethi Z, Ye L, et al. Assessment of synchronous neural activities revealed by regional homogeneity in individuals with acute eye pain: a resting-state functional magnetic resonance imaging study. Journal of Pain Research. 2018; 11: 843\u2013850.","DOI":"10.2147\/JPR.S156634"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Huang X, Li D, Li HJ, Zhong YL, Freeberg S, Bao J, et al. Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study. Neuropsychiatric Disease and Treatment. 2017; 13: 2849\u20132854.","DOI":"10.2147\/NDT.S147645"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Huang X, Li HJ, Ye L, Zhang Y, Wei R, Zhong YL, et al. Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study. Neuropsychiatric Disease and Treatment. 2016; 12: 1901\u20131906.","DOI":"10.2147\/NDT.S110541"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Zhang Y, Zhu F, Tang L, Li B, Zhu P, Shi W, et al. Altered regional homogeneity in patients with diabetic vitreous hemorrhage. World Journal of Diabetes. 2020; 11: 501\u2013513.","DOI":"10.4239\/wjd.v11.i11.501"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Shao Y, Cai F, Zhong Y, Huang X, Zhang Y, Hu P, et al. Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study. Neuropsychiatric Disease and Treatment. 2015; 11: 3065\u20133073.","DOI":"10.2147\/NDT.S92968"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Huang X, Li S, Zhou F, Zhang Y, Zhong Y, Cai F, et al. Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study. Neuropsychiatric Disease and Treatment. 2016; 12: 1303\u20131308.","DOI":"10.2147\/NDT.S105478"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Shao Y, Li Q, Li B, Lin Q, Su T, Shi W, et al. Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: a resting\u2011state functional magnetic resonance imaging study. Molecular Medicine Reports. 2019; 19: 4832\u20134840.","DOI":"10.3892\/mmr.2019.10147"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Bartley GB, Gorman CA. Diagnostic criteria for Graves\u2019 ophthalmopathy. American Journal of Ophthalmology. 1995; 119: 792\u2013795.","DOI":"10.1016\/S0002-9394(14)72787-4"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Satterthwaite TD, Elliott MA, Gerraty RT, Ruparel K, Loughead J, Calkins ME, et al. An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. NeuroImage. 2013; 64: 240\u2013256.","DOI":"10.1016\/j.neuroimage.2012.08.052"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Chaudhari D, Renjen PN, Arora AS. Acute corpus callosum infarct. Neurology India. 2019; 67: 930\u2013931.","DOI":"10.4103\/0028-3886.263234"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Rolls ET. Limbic systems for emotion and for memory, but no single limbic system. Cortex. 2015; 62: 119\u2013157.","DOI":"10.1016\/j.cortex.2013.12.005"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Rolls ET. The cingulate cortex and limbic systems for action, emotion, and memory. Cingulate Cortex. 2019; 166: 23\u201337.","DOI":"10.1016\/B978-0-444-64196-0.00002-9"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Yu YJ, Liang RB, Yang QC, Ge QM, Li QY, Li B, et al. Altered spontaneous brain activity patterns in patients after Lasik surgery using amplitude of low-frequency fluctuation: a resting-state functional MRI study. Neuropsychiatric Disease and Treatment. 2020; 16: 1907\u20131917.","DOI":"10.2147\/NDT.S252850"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Kolling N, Behrens T, Wittmann MK, Rushworth M. Multiple signals in anterior cingulate cortex. Current Opinion in Neurobiology. 2016; 37: 36\u201343.","DOI":"10.1016\/j.conb.2015.12.007"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Vogt BA. Cingulate cortex in Parkinson\u2019s disease. Cingulate Cortex. 2019; 60: 253\u2013266.","DOI":"10.1016\/B978-0-444-64196-0.00013-3"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Bian X, Qin C, Cai C, Zhou Y, Tao Y, Lin Y, et al. Anterior cingulate cortex to ventral hippocampus circuit mediates contextual fear generalization. Journal of Neuroscience. 2019; 39: 5728\u20135739.","DOI":"10.1523\/JNEUROSCI.2739-18.2019"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Chen HJ, Zhang L, Ke J, Qi R, Xu Q, Zhong Y, et al. Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder. Australian & New Zealand Journal of Psychiatry. 2019; 53: 68\u201379.","DOI":"10.1177\/0004867418812674"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Coslett HB, Schwartz MF. The parietal lobe and language. Handbook of Clinical Neurology. 2018; 151: 365\u2013375.","DOI":"10.1016\/B978-0-444-63622-5.00018-8"},{"key":"ref36","unstructured":"Kobayashi Y. Neuroanatomy of the parietal association areas. Brain and Nerve. 2016; 68: 1301\u20131312."},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Caspers S, Zilles K. Microarchitecture and connectivity of the parietal lobe. Handbook of Clinical Neurology. 2018; 151: 53\u201372.","DOI":"10.1016\/B978-0-444-63622-5.00003-6"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Wu Y, Wang J, Zhang Y, Zheng D, Zhang J, Rong M, et al. The neuroanatomical basis for posterior superior parietal lobule control lateralization of visuospatial attention. Frontiers in Neuroanatomy. 2016; 10: 32.","DOI":"10.3389\/fnana.2016.00032"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Song P, Lin H, Liu C, Jiang Y, Lin Y, Xue Q, et al. Transcranial magnetic stimulation to the middle frontal gyrus during attention modes induced dynamic module reconfiguration in brain networks. Frontiers in Neuroinformatics. 2019; 13: 22.","DOI":"10.3389\/fninf.2019.00022"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Wu YY, Yuan Q, Li B, Lin Q, Zhu PW, Min YL, et al. Altered spontaneous brain activity patterns in patients with retinal vein occlusion indicated by the amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study. Experimental and Therapeutic Medicine. 2019; 18: 2063\u20132071.","DOI":"10.3892\/etm.2019.7770"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/20\/2\/10.31083\/j.jin2002037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T15:23:23Z","timestamp":1732721003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/20\/2\/10.31083\/j.jin2002037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"alternative-id":["1625014733739-1652602723"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2002037","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"value":"0219-6352","type":"print"},{"value":"1757-448X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"article-number":"375"}}