{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:02:56Z","timestamp":1787745776923,"version":"build-2784847793"},"reference-count":102,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>The purpose of this commentary is to investigate the pathophysiological mechanisms underlying hypersexuality and its manifestation in neurological diseases through a meta-analysis. Studies were identified by searching on PubMed, Web of Science and Cochrane databases. All results of each database between 2014 and 2020 were evaluated for possible inclusion. After an accurate revision of complete manuscripts, forty articles satisfied the inclusion\/exclusion criteria. Data from our meta-analysis indicated hypersexuality to be a frequent sexual disorder in patients with neurological disorders, especially neurodegenerative ones. Hypersexuality could negatively affect a patient\u2019s management and outcomes. This commentary discusses studies that are often incomplete for evaluation measures or sample selection. In our opinion, it is necessary to consider hypersexuality with particular attention, so more extensive sample studies are needed to find the most appropriate treatment to improve the quality of life for both the patient and the caregiver.<\/jats:p>","DOI":"10.31083\/j.jin2002051","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T05:04:01Z","timestamp":1625461441000},"source":"Crossref","is-referenced-by-count":8,"title":["Hypersexuality in neurological diseases: do we see only the tip of the iceberg?"],"prefix":"10.31083","volume":"20","author":[{"given":"Desiree","family":"Latella","sequence":"first","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d S.S. 113, Contrada Casazza, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Maggio","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biotechnological Science, University of Catania, Via S. Sofia, 98, 95123 Catania CT., Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Andaloro","sequence":"first","affiliation":[{"name":"tudio di Riabilitazione Nutrizionale e Cognitiva, Via Sant\u2019Agostino, 14, 98121, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenicaroberta","family":"Marchese","sequence":"first","affiliation":[{"name":"tudio di Riabilitazione Nutrizionale e Cognitiva, Via Sant\u2019Agostino, 14, 98121, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Manuli","sequence":"first","affiliation":[{"name":"OU Policlinico G. Martino, Via Consolare Valeria, 1, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco Salvatore","family":"Calabr\u00f2","sequence":"first","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d S.S. 113, Contrada Casazza, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Reid RC, Carpenter BN, Hook JN, Garos S, Manning JC, Gilliland R, et al. Report of findings in a DSM\u20105 field trial for hypersexual disorder. Journal of Sexual Medicine. 2012; 9: 2868\u20132877.","DOI":"10.1111\/j.1743-6109.2012.02936.x"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Stein DJ. Classifying hypersexual disorders: compulsive, impulsive, and addictive models. 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