{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:45:32Z","timestamp":1791377132239,"version":"4.3.2"},"reference-count":63,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Peripheral vasoconstriction is a centrally mediated physiological effect known to play an important role in regulating body temperature by adjusting heat exchange with the external environment. However, peripheral vasoconstriction as a component of sympathetic activation also occurs following exposure to various salient stimuli and during motivated behavior at stable environmental temperatures. This review aims to consider available evidence suggesting a significant contribution of this peripheral effect to physiological increases in both brain temperature and entry of oxygen and glucose into the brain\u2019s extracellular space. While these effects are triggered by neuronal activation, constriction of blood vessels in the skin and most internal organs results in redistribution of blood from the peripheral to central domains, thus dilating cerebral vessels, increasing global cerebral blood flow, and enhancing the intra-brain entry of oxygen and glucose from arterial blood. This powerful influence appears to determine the long duration of physiological increases in both brain temperature and brain levels of glucose and oxygen and their basic similarity across different brain structures. This work underscores the tight interrelationship between the brain and periphery and a significant contribution of cardiovascular effects in providing the enhanced inflow of oxygen and glucose into brain tissue to prevent metabolic deficit during functional neural activation.<\/jats:p>","DOI":"10.31083\/j.jin2003080","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T08:02:03Z","timestamp":1632988923000},"source":"Crossref","is-referenced-by-count":20,"title":["Functional role of peripheral vasoconstriction: not only thermoregulation but much more"],"prefix":"10.31083","volume":"20","author":[{"given":"Eugene A.","family":"Kiyatkin","sequence":"first","affiliation":[{"name":"Behavioral Neuroscience Branch, National Institute on Drug Abuse\u2013Intramural Research Program, National Institutes of Health, DHHS, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Satinoff E. Neural organization and evolution of thermal regulation in mammals. Science. 1978; 201: 16\u201322.","DOI":"10.1126\/science.351802"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Blatteis CM. The onset of fever: new insights into its mechanism. Progress in Brain Research. 2007; 813: 3\u201314.","DOI":"10.1016\/S0079-6123(06)62001-3"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Morrison SF, Nakamura K. Central mechanisms of thermoregulation. Annual Review of Physiology. 2019; 81: 285\u2013308.","DOI":"10.1146\/annurev-physiol-020518-114546"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Romanovsky AA. Skin temperature and its role in thermoregulation. Acta Physiologica. 2014; 210: 498\u2013507.","DOI":"10.1111\/apha.12231"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Romanovsky AA. The thermoregulation system and how it works. Handbook of Clinical Neurology. 2018; 60: 3\u201343.","DOI":"10.1016\/B978-0-444-63912-7.00001-1"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA. Brain temperature: from physiology and pharmacology to neuropathology. Handbook of Clinical Neurology. 2018; 206: 483\u2013504.","DOI":"10.1016\/B978-0-444-64074-1.00030-6"},{"key":"ref7","unstructured":"Kiyatkin EA. The hidden side of drug action: brain temperature changes induced by neuroactive drugs. Psychopharmacology. 2007; 101: 3\u201317."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Delgado JM, Hanai T. Intracerebral temperatures in free-moving cats. American Journal of Physiology. 1967; 211: 755\u2013769.","DOI":"10.1152\/ajplegacy.1966.211.3.755"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Hayward JN, Baker MA. A comparative study of the role of the cerebral arterial blood in the regulation of brain temperature in five mammals. Brain Research. 1970; 16: 417\u2013440.","DOI":"10.1016\/0006-8993(69)90236-4"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Nybo L, Secher NH, Nielsen B. Inadequate heat release from the human brain during prolonged exercise with hyperthermia. Journal of Physiology. 2002; 545: 697\u2013704.","DOI":"10.1113\/jphysiol.2002.030023"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Kenefick RW, Cheuvront SN, Sawka MN. Thermoregulatory function during the marathon. Sports Medicine. 2007; 37: 312\u2013315.","DOI":"10.2165\/00007256-200737040-00010"},{"key":"ref12","unstructured":"Kalant H. The pharmacology and toxicology of \u201cecstasy\u201d (MDMA) and related drugs. Canadian Medical Association Journal. 2001; 165: 917\u2013928."},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Brown PL, Kiyatkin EA. Brain hyperthermia induced by MDMA (ecstasy): modulation by environmental conditions. European Journal of Neuroscience. 2004; 20: 51\u201358.","DOI":"10.1111\/j.0953-816X.2004.03453.x"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Moltz H. Fever: causes and consequences. Neuroscience & Biobehavioral Reviews. 1993; 17: 237\u2013269.","DOI":"10.1016\/S0149-7634(05)80009-0"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Andersen P, Moser EI. Brain temperature and hippocampal function. Hippocampus. 1995; 5: 491\u2013498.","DOI":"10.1002\/hipo.450050602"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Moser EI, Mathiesen LI. Relationship between neuronal activity and brain temperature in rats. Neuroreport. 1997; 7: 1876\u20131880.","DOI":"10.1097\/00001756-199607290-00038"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"McElligott JG, Melzack R. Localized thermal changes evoked in the brain by visual and auditory stimulation. Experimental Neurology. 1967; 17: 293\u2013312.","DOI":"10.1016\/0014-4886(67)90108-2"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Hayward J, Baker M. Role of cerebral arterial blood in the regulation of brain temperature in the monkey. American Journal of Physiology-Legacy Content. 1968; 215: 389\u2013403.","DOI":"10.1152\/ajplegacy.1968.215.2.389"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Maloney SK, Fuller A, Mitchell G, Mitchell D. Brain and arterial blood temperature of free-ranging oryx (Orix gazella). Pfl\u00fcgers Archiv. 2002; 443: 437\u2013445.","DOI":"10.1007\/s004240100704"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA, Brown PL, Wise RA. Brain temperature fluctuation: a reflection of functional neural activation. European Journal of Neuroscience. 2002; 16: 164\u2013168.","DOI":"10.1046\/j.1460-9568.2002.02066.x"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA. Brain temperature homeostasis: physiological fluctuations and pathological shifts. Frontiers in Bioscience. 2010; 15: 73\u201392.","DOI":"10.2741\/3608"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proceedings of the National Academy of Sciences of the United States of America. 1986; 83: 1140\u20131144.","DOI":"10.1073\/pnas.83.4.1140"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Fellows LK, Boutelle MG. Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat. Brain Research. 1993; 604: 225\u2013231.","DOI":"10.1016\/0006-8993(93)90373-U"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010; 468: 232\u2013243.","DOI":"10.1038\/nature09613"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Lecrux C, Hamel E. The neurovascular unit in brain function and disease. Acta Physiologica. 2011; 203: 47\u201359.","DOI":"10.1111\/j.1748-1716.2011.02256.x"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA. Physiological and drug-induced fluctuations in brain oxygen and glucose assessed by substrate-selective sensors coupled with high-speed amperiomentry. In Wilson GA, Michael AC (eds.) Compendium of in vivo monitoring in real time (pp. 219\u2013250). Singapore: World Scientific. 2019.","DOI":"10.1142\/9789811206238_0012"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Muoio V, Persson PB, Sendeski MM. The neurovascular unit\u2014concept review. Acta Physiologica. 2014; 210: 790\u2013798.","DOI":"10.1111\/apha.12250"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Thomas SA, Curay CM, Kiyatkin EA. Relationships between oxygen changes in the brain and periphery following physiological activation and the actions of heroin and cocaine. Scientific Reports. 2021; 11: 6355.","DOI":"10.1038\/s41598-021-85798-y"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Carelli RM, West MO. Representation of the body by single neurons in the dorsolateral striatum of the awake, unrestrained rat. The Journal of Comparative Neurology. 1991; 309: 231\u2013249.","DOI":"10.1002\/cne.903090205"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA, Rebec GV. Dopaminrgic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats. Journal of Neurophysiology. 1996; 75: 142\u2013153.","DOI":"10.1152\/jn.1996.75.1.142"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA, Rebec GV. Modulation of striatal neuronal activity by glutamate and GABA: iontophoresis in awake, unrestrained rats. Brain Research. 1999; 822: 88\u2013106.","DOI":"10.1016\/S0006-8993(99)01093-8"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Rebec GV. Behavioral electrophysiology of psychostimulants. Neuropsychopharmacology. 2006; 31: 2341\u20132348.","DOI":"10.1038\/sj.npp.1301160"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Schultz W. Activity of pars retuculata neurons of monkey substantia nigra in relation to motor, sensory, and complex events. Journal of Neurophysiology. 1986; 55: 660\u2013677.","DOI":"10.1152\/jn.1986.55.4.660"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Schwarz M, Sontag KH, Wand P. Sensory-motor ptocessing in substantia nigra pars reticulata in conscious cats. Journal of Physiology. 1984; 347: 129\u2013147.","DOI":"10.1113\/jphysiol.1984.sp015057"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Nishino H, Ono T, Fukuda M, Sasaki K. Monkey substantia nigra (pars reticulata) neuron discharges during operant feeding. Brain Research. 1985; 334: 190\u2013193.","DOI":"10.1016\/0006-8993(85)90587-6"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Windels F, Kiyatkin EA. GABA, not glutamate, controls the activity of substantia nigra reticulate neurons in awake, unrestrained rats. Journal of Neuroscience. 2004; 24: 6751\u20136754.","DOI":"10.1523\/JNEUROSCI.1528-04.2004"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Solis E, Cameron-Burr KT, Kiyatkin EA. Rapid physiological fluctuations in nucleus accumbens oxygen levels induced by arousing stimuli: relationships with changes in brain glucose and metabolic neural activation. Frontiers in Integrative Neuroscience. 2019; 11: 9.","DOI":"10.3389\/fnint.2017.00009"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Foote SL, Bloom FE, Aston-Jones G. Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiological Reviews. 1983; 63: 844\u2013914.","DOI":"10.1152\/physrev.1983.63.3.844"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Moore RY, Bloom FE. Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Annual Review of Neuroscience. 1979; 2: 113\u2013168.","DOI":"10.1146\/annurev.ne.02.030179.000553"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Cannon WB. The wisdom of the body. New York: Norton. 1939.","DOI":"10.1097\/00000441-193907000-00031"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"McCorry LK. Physiology of the autonomic nervous system. American Journal of Pharmaceutical Education. 2007; 71: 78.","DOI":"10.5688\/aj710478"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Powley TL. Central control of autonomic functions. Fundamental Neuroscience. 2013; 262: 729\u2013747.","DOI":"10.1016\/B978-0-12-385870-2.00034-2"},{"key":"ref43","unstructured":"Edvinsson L. Vascular autonomic nerves and corresponding receptors in brain vessels. Pathologie Biologie. 1982; 30: 261\u2013268."},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. Journal of Applied Physiology. 2006; 100: 1059\u20131064.","DOI":"10.1152\/japplphysiol.00954.2005"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Lincoln J. Innervation of cerebral arteries by nerves containing 5-hydroxytryptamine and noradrenaline. Pharmacology & Therapeutics. 1996; 68: 473\u2013501.","DOI":"10.1016\/0163-7258(95)02017-9"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Purkayastha S, Raven PB. The functional role of the alpha-1 adrenergic receptors in cerebral blood regulation. Indian Journal of Pharmacology. 2011; 43: 502\u2013506.","DOI":"10.4103\/0253-7613.84950"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Yokoo H, Kobayashi H, Minami S, Shiraishi S, Yamamoto R, Yanagita T, et al. alpha(1)-Adrenergic receptor subtypes in rat cerebral microvessels. Brain Research. 2000; 878: 183\u2013187.","DOI":"10.1016\/S0006-8993(00)02616-0"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Goldman H. Catecholamine-induced redistribution of blood flow in the unaneshetized rat. American Journal of Physiology. 1966; 210: 1419\u20131423.","DOI":"10.1152\/ajplegacy.1966.210.6.1419"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Loewy AD, Spyer KM. Central regulation of autonomic functions. New York: Oxford University Press. 1990.","DOI":"10.1093\/oso\/9780195051063.001.0001"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Bola RA, Kiyatkin EA. Inflow of oxygen and glucose in brain tissue induced by intravenous norepinephrine: relationships with central and peripheral vascular tone. Journal of Neurophysiology. 2018; 119: 499\u2013508.","DOI":"10.1152\/jn.00692.2017"},{"key":"ref51","unstructured":"Bertler A, Falck B, Owman C, Rosengreen E. The localization of monoaminergic bood-brain barrier mechanisms. Pharmacological Reviews. 1966; 18: 369\u2013385."},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Oldendorf WH. Brain uptake of radiolabeled aminoacids, amines, and hexoses after arterial injection. American Journal of Physiology. 1971; 221: 1629\u20131639.","DOI":"10.1152\/ajplegacy.1971.221.6.1629"},{"key":"ref53","unstructured":"Hodgkin AL. The conduction of the nervous impulse. Liverpool: Liverpool University Press. 1967."},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Ritchie JM. Energetic aspects of nerve conduction: the relationships between heat production, electrical activity and metabolism. Progress in Biophysics and Molecular Biology. 1973; 26: 147\u2013187.","DOI":"10.1016\/0079-6107(73)90019-9"},{"key":"ref55","unstructured":"Siesjo B. Brain Energy Metabolism. New York: Wiley. 1978."},{"key":"ref56","unstructured":"Lee Y, Lee CH, Oh U. Painful channels in the rat. Journal of Nuclear Medicine. 2005; 25: 72\u201376."},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Tracey D. Somatosensory system. Rat Nervous System. 2004; 181: 797\u2013815.","DOI":"10.1016\/B978-012547638-6\/50026-2"},{"key":"ref58","unstructured":"Eble JN, Gowdey CW, Rudzik AD, Vane JR. Study of the mechanisms of the modifying actions of hexamethonium on the cardiovascular response to norepinephrine. Journal of Pharmacology and Experimental Therapeutics. 1973; 184: 649\u2013655."},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Kuschinsky W. Coupling of function, metabolism, and blood flow in the brain. Neurosurgical Review. 1991; 14: 163\u2013168.","DOI":"10.1007\/BF00310651"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Rothballer, AB. Studies on the adrenaline-sensitive component of the reticular activating system. Electroencephalography and Clinical Neurophysiology. 2002; 8: 603\u2013621.","DOI":"10.1016\/0013-4694(56)90084-0"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Baust W, Niemczyk H. Further studies on the action of adrenergic drugs on cortical activity. Electroencephalography and Clinical Neurophysiology. 1996; 17: 261\u2013271.","DOI":"10.1016\/0013-4694(64)90127-0"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Baust W, Niemczyk H, Vieth J. The action of blood pressure on the ascending reticular activating system with special reference to adrenaline-induced EEG arousal. Electroencephalography and Clinical Neurophysiology. 1998; 15: 63\u201372.","DOI":"10.1016\/0013-4694(63)90039-7"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Kiyatkin EA, Stein EA. Behavior-associated changes in blood pressure during heroin self-administration. Pharmacology Biochemistry and Behavior. 1993; 46: 561\u2013567.","DOI":"10.1016\/0091-3057(93)90544-4"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/20\/3\/10.31083\/j.jin2003080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T15:33:36Z","timestamp":1732721616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/20\/3\/10.31083\/j.jin2003080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"alternative-id":["1632962206845-486777538"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2003080","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"value":"0219-6352","type":"print"},{"value":"1757-448X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]},"article-number":"755"}}