{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:46:55Z","timestamp":1787827615240,"version":"build-2784847793"},"reference-count":34,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>We evaluated the performance of arterial spin-labeled perfusion imaging and diffusion-weighted imaging in diagnosing full-term neonatal hypoxic-ischemic encephalopathy. Arterial spin-labeled, diffusion-weighted imaging and conventional magnetic resonance imaging (T1-weighted imaging, T2-weighted imaging and T2 fluid-attenuated inversion recovery) were performed in 23 full-term neonates with hypoxic-ischemic encephalopathy group 10 normal neonates (Control group). The cerebral blood flow and the apparent diffusion coefficient were measured in the bilateral basal ganglia, thalamus and frontal white matter. The effect of neonatal age on the CBF and apparent diffusion coefficient values were further investigated after dividing the 23 ischemic encephalopathy cases into three subgroups (1\u20133 days, 4\u20137 days, and 8\u201315 days). The cerebral blood flow values in the thalamus and lenticular nucleus were significantly higher. The apparent diffusion coefficient values in the thalamus, frontal white matter and lenticular nucleus head were significantly lower in the hypoxic-ischemic encephalopathy group than those in the Control group (p &lt; 0.05). There were no significant differences between the ischemic encephalopathy and Control groups in the cerebral blood flow values in the caudate nucleus head and frontal lobe white matter (p &gt; 0.05). The cerebral blood flow and apparent diffusion coefficient values in the thalamus and lenticular nucleus were negatively correlated. Comparison among different age subgroups of hypoxic-ischemic encephalopathyneonates showed that the cerebral blood flow value was higher. In comparison, the apparent diffusion coefficient value was lower in the 1\u20133 days old neonates than those in the older neonates (p &lt; 0.05). Arterial spin-labeled and diffusion-weighted imaging could reflect the ischemic encephalopathy pathological processes more comprehensively. The cerebral blood flow measurement and apparent diffusion coefficient values in the thalamus and the lenticular nucleus may represent a novel way to diagnose ischemic encephalopathy early.<\/jats:p>","DOI":"10.31083\/j.jin2004099","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T02:14:27Z","timestamp":1641262467000},"source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic performance of arterial spin-labeled perfusion imaging and diffusion-weighted imaging in full-term neonatal hypoxic-ischemic encephalopathy"],"prefix":"10.31083","volume":"20","author":[{"given":"Linlin","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Hospital of Shandong University, 250033 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Rizhao People\u2019s Hospital, 276800 Rizhao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Qilu Hospital of Shandong University, 250012 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Douglas-Escobar M, Weiss MD. Hypoxic-Ischemic Encephalopathy. JAMA Pediatrics. 2015; 169: 397.","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Massaro AN, Bouyssi-Kobar M, Chang T, Vezina LG, du Plessis AJ, Limperopoulos C. Brain perfusion in encephalopathic newborns after therapeutic hypothermia. American Journal of Neuroradiology. 2013; 34: 1649\u20131655.","DOI":"10.3174\/ajnr.A3422"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Wintermark P, Hansen A, Gregas MC, Soul J, Labrecque M, Robertson RL, et al. Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. American Journal of Neuroradiology. 2011; 32: 2023\u20132029.","DOI":"10.3174\/ajnr.A2708"},{"key":"ref4","unstructured":"Barkovich AJ, Westmark K, Partridge C, Sola A, Ferriero DM. Perinatal asphyxia: MR findings in the first 10 days. American Journal of Neuroradiology. 1995; 16: 427\u2013438."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Badve CA, Khanna PC, Ishak GE. Neonatal ischemic brain injury: what every radiologist needs to know. Pediatric Radiology. 2012; 42: 606\u2013619.","DOI":"10.1007\/s00247-011-2332-8"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Rutherford M, Ward P, Allsop J, Malamateniou C, Counsell S. Magnetic resonance imaging in neonatal encephalopathy. Early Human Development. 2005; 81: 13\u201325.","DOI":"10.1016\/j.earlhumdev.2004.10.011"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Tanner SF. Cerebral perfusion in infants and neonates: preliminary results obtained using dynamic susceptibility contrast enhanced magnetic resonance imaging. Archives of Disease in Childhood - Fetal and Neonatal Edition. 2003; 88: 525F\u20135530.","DOI":"10.1136\/fn.88.6.F525"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Tortora D, Mattei PA, Navarra R, Panara V, Salomone R, Rossi A, et al. Prematurity and brain perfusion: Arterial spin labeling MRI. NeuroImage Clinical. 2017; 15: 401\u2013407.","DOI":"10.1016\/j.nicl.2017.05.023"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"De Vis JB, Hendrikse J, Petersen ET, de Vries LS, van Bel F, Alderliesten T, et al. Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy. European Radiology. 2015; 25: 113\u2013121.","DOI":"10.1007\/s00330-014-3352-1"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Alderliesten T, de Vries LS, Benders MJ, Koopman C, Groenendaal F. MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and (1)H MR spectroscopy. Radiology. 2011; 261: 235\u2013242.","DOI":"10.1148\/radiol.11110213"},{"key":"ref11","unstructured":"Barkovich AJ, Miller SP, Bartha A, Newton N, Hamrick SEG, Mukherjee P, et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. American Journal of Neuroradiology. 2006; 27: 533\u2013547."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Rutherford M, Counsell S, Allsop J, Boardman J, Kapellou O, Larkman D, et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics. 2004; 114: 1004\u20131014.","DOI":"10.1542\/peds.2004-0222"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Twomey E, Twomey A, Ryan S, Murphy J, Donoghue VB. MR imaging of term infants with hypoxic-ischemic encephalopathy as a predictor of neurodevelopmental outcome and late MRI appearances. Pediatric Radiology. 2010; 40: 1526\u20131535.","DOI":"10.1007\/s00247-010-1692-9"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Executive summary: Neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists Task Force on Neonatal Encephalopathy. Obstetrics and Gynecology. 2014; 123: 896\u2013901.","DOI":"10.1097\/01.AOG.0000445580.65983.d2"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Detre JA, Leigh JS, Williams DS, Koretsky AP. Perfusion imaging. Magnetic Resonance in Medicine. 1992; 23: 37\u201345.","DOI":"10.1002\/mrm.1910230106"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Roberts DA, Detre JA, Bolinger L, Insko EK, Leigh JS. Quantitative magnetic resonance imaging of human brain perfusion at 1.5 T using steady-state inversion of arterial water. Proceedings of the National Academy of Sciences of the United States of America. 1994; 91: 33\u201337.","DOI":"10.1073\/pnas.91.1.33"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Liu TT, Brown GG. Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods. Journal of the International Neuropsychological Society. 2007; 13: 517\u2013525.","DOI":"10.1017\/S1355617707070646"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Miranda MJ, Olofsson K, Sidaros K. Noninvasive measurements of regional cerebral perfusion in preterm and term neonates by magnetic resonance arterial spin labeling. Pediatric Research. 2006; 60: 359\u2013363.","DOI":"10.1203\/01.pdr.0000232785.00965.b3"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Wang J, Licht DJ. Pediatric perfusion MR imaging using arterial spin labeling. Neuroimaging Clinics of North America. 2006; 16: 149\u201367, ix.","DOI":"10.1016\/j.nic.2005.10.002"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Wu W, Wong EC. Feasibility of velocity selective arterial spin labeling in functional MRI. Journal of Cerebral Blood Flow and Metabolism. 2007; 27: 831\u2013838.","DOI":"10.1038\/sj.jcbfm.9600386"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Wang Z, Wang J, Connick TJ, Wetmore GS, Detre JA. Continuous ASL (CASL) perfusion MRI with an array coil and parallel imaging at 3T. Magnetic Resonance in Medicine. 2005; 54: 732\u2013737.","DOI":"10.1002\/mrm.20574"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Dai W, Garcia D, de Bazelaire C, Alsop DC. Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magnetic Resonance in Medicine. 2008; 60: 1488\u20131497.","DOI":"10.1002\/mrm.21790"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"L\u2019Abee C, de Vries LS, van der Grond J, Groenendaal F. Early diffusion-weighted MRI and 1H-Magnetic Resonance Spectroscopy in asphyxiated full-term neonates. Biology of the Neonate. 2005; 88: 306\u2013312.","DOI":"10.1159\/000087628"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Perlman JM. Summary proceedings from the neurology group on hypoxic-ischemic encephalopathy. Pediatrics. 2006; 117: S28\u2013S33.","DOI":"10.1542\/peds.2005-0620E"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Chau V, Poskitt KJ, Miller SP. Advanced Neuroimaging Techniques for the Term Newborn with Encephalopathy. Pediatric Neurology. 2009; 40: 181\u2013188.","DOI":"10.1016\/j.pediatrneurol.2008.09.012"},{"key":"ref26","unstructured":"Robertson RL, Ben-Sira L, Barnes PD, Mulkern RV, Robson CD, Maier SE, et al. MR line-scan diffusion-weighted imaging of term neonates with perinatal brain ischemia. American Journal of Neuroradiology. 1999; 20: 1658\u20131670."},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Wintermark P, Moessinger AC, Gudinchet F, Meuli R. Temporal evolution of MR perfusion in neonatal hypoxic-ischemic encephalopathy. Journal of Magnetic Resonance Imaging. 2008; 27: 1229\u20131234.","DOI":"10.1002\/jmri.21379"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Thornton C, Rousset CI, Kichev A, Miyakuni Y, Vontell R, Baburamani AA, et al. Molecular mechanisms of neonatal brain injury. Neurology Research International. 2012; 2012: 506320.","DOI":"10.1155\/2012\/506320"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Winter JD, Lee DS, Hung RM, Levin SD, Rogers JM, Thompson RT, et al. Apparent diffusion coefficient pseudonormalization time in neonatal hypoxic-ischemic encephalopathy. Pediatric Neurology. 2007; 37: 255\u2013262.","DOI":"10.1016\/j.pediatrneurol.2007.06.005"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Marchal G, Young AR, Baron JC. Early postischemic hyperperfusion: pathophysiologic insights from positron emission tomography. Journal of Cerebral Blood Flow and Metabolism. 1999; 19: 467\u2013482.","DOI":"10.1097\/00004647-199905000-00001"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Pienaar R, Paldino MJ, Madan N, Krishnamoorthy KS, Alsop DC, Dehaes M, et al. A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. NeuroImage. 2012; 63: 1510\u20131518.","DOI":"10.1016\/j.neuroimage.2012.07.062"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Aslan S, Lu H. On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow. Magnetic Resonance Imaging. 2010; 28: 928\u2013935.","DOI":"10.1016\/j.mri.2010.03.037"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Liauw L, van Wezel-Meijler G, Veen S, van Buchem MA, van der Grond J. Do apparent diffusion coefficient measurements predict outcome in children with neonatal hypoxic-ischemic encephalopathy? American Journal of Neuroradiology. 2009; 30: 264\u2013270.","DOI":"10.3174\/ajnr.A1318"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Rutherford M, Malamateniou C, McGuinness A, Allsop J, Biarge MM, Counsell S. Magnetic resonance imaging in hypoxic-ischaemic encephalopathy. 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