{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:20:53Z","timestamp":1782231653956,"version":"3.54.5"},"reference-count":29,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>We investigated changes in the subcortical white matter in the unaffected hemisphere in patients with unilateral intracerebral hemorrhage (ICH) by applying tract-based spatial statistics (TBSS) analysis. Twenty-four patients with ICH and 17 healthy control subjects were recruited for this study. Diffusion tensor imaging (DTI) data were obtained at least four weeks after ICH onset. TBSS analysis was performed using fractional anisotropy (FA) DTI data. We calculated mean FA values across the tract skeleton and within 27 regions of interest (ROIs) based on the observed intersections between the FA skeleton and the probabilistic Johns Hopkins University white matter atlases. The FA values of 27 ROIs in the unaffected hemisphere in the patient group were significantly lower than those of the control group (p &lt; 0.05). In terms of a causal relationship between possible confounding factors (sex, age, lateralization [right], lesion volume), a negative correlation coefficient was observed in five ROIs (the tapetum, sagittal stratum, column and body of the fornix, posterior corona radiate, inferior cerebellar peduncle, superior cerebellar peduncle) in the regression analysis (p &lt; 0.05). In the patient group, moderate negative correlations were detected between ICH volume and the FA values of two ROIs: the sagittal stratum, r = \u20130.479, p &lt; 0.05; the tapetum, r = \u20130.414, p &lt; 0.05. We detected extensive neural injury of the subcortical white matter in the unaffected hemisphere in patients with unilateral ICH. In addition, injury severities of neural structures located around the mid-sagittal line or periventricular areas were correlated with ICH volume.<\/jats:p>","DOI":"10.31083\/j.jin2102063","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T07:59:22Z","timestamp":1648799962000},"source":"Crossref","is-referenced-by-count":5,"title":["Changes in subcortical white matter in the unaffected hemisphere following unilateral spontaneous intracerebral hemorrhage: a tract-based spatial statistics study"],"prefix":"10.31083","volume":"21","author":[{"given":"Young Hyeon","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 705-717 Namku, Taegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 705-717 Namku, Taegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Kase CS, Caplan LR. Intracerebral hemorrhage. Butterworth-Heinemann: Boston. 1994.","DOI":"10.1016\/B978-0-7506-9308-0.50012-9"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Fewel ME, Thompson BG, Hoff JT. Spontaneous intracerebral hemorrhage: a review. Neurosurgical Focus. 2003; 15: E1.","DOI":"10.3171\/foc.2003.15.4.0"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Brasil-Neto JP, de Lima AC. Sensory deficits in the unaffected hand of hemiparetic stroke patients. Cognitive and Behavioral Neurology. 2008; 21: 202\u2013205.","DOI":"10.1097\/WNN.0b013e3181864a24"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Noskin O, Krakauer JW, Lazar RM, Festa JR, Handy C, O\u2019Brien KA, et al. Ipsilateral motor dysfunction from unilateral stroke: implications for the functional neuroanatomy of hemiparesis. Journal of Neurology, Neurosurgery, and Psychiatry. 2008; 79: 401\u2013406.","DOI":"10.1136\/jnnp.2007.118463"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Bagnato S, Boccagni C, Boniforti F, Trinchera A, Guercio G, Letizia G, et al. Motor dysfunction of the \u201cnon-affected\u201d lower limb: a kinematic comparative study between hemiparetic stroke and total knee prosthesized patients. Neurological Sciences. 2009; 30: 107\u2013113.","DOI":"10.1007\/s10072-009-0031-0"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Tanaka A, Yoshinaga S, Nakayama Y, Kimura M, Tomonaga M. Cerebral blood flow and clinical outcome in patients with thalamic hemorrhages: a comparison with putaminal hemorrhages. Journal of the Neurological Sciences. 1996; 144: 191\u2013197.","DOI":"10.1016\/S0022-510X(96)00226-2"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. The Lancet Neurology. 2006; 5: 53\u201363.","DOI":"10.1016\/S1474-4422(05)70283-0"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Kalita J, Misra UK, Vajpeyee A, Phadke RV, Handique A, Salwani V. Brain herniations in patients with intracerebral hemorrhage. Acta Neurologica Scandinavica. 2009; 119: 254\u2013260.","DOI":"10.1111\/j.1600-0404.2008.01095.x"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Julkunen P, K\u00f6n\u00f6nen M, M\u00e4\u00e4tt\u00e4 S, Tarkka IM, Hiekkala SH, S\u00e4is\u00e4nen L, et al. Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke. Neuroscience Letters. 2016; 617: 88\u201393.","DOI":"10.1016\/j.neulet.2016.02.014"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Kim J, Kim Y, Kim S, Kim S, Park J, Kim T, et al. Contralateral Hemispheric brain atrophy after primary Intracerebral hemorrhage. World Neurosurgery. 2017; 102: 56\u201364.","DOI":"10.1016\/j.wneu.2017.02.105"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Kummer TT, Magnoni S, MacDonald CL, Dikranian K, Milner E, Sorrell J, et al. Experimental subarachnoid haemorrhage results in multifocal axonal injury. Brain. 2015; 138: 2608\u20132618.","DOI":"10.1093\/brain\/awv180"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Powers WJ. Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury. Stroke. 2010; 41: S107\u2013S110.","DOI":"10.1161\/STROKEAHA.110.595058"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Mori S, Crain BJ, Chacko VP, van Zijl PC. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Annals of Neurology. 1999; 45: 265\u2013269.","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Basser PJ, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. In vivo fiber tractography using DT-MRI data. Magnetic Resonance in Medicine. 2000; 44: 625\u2013632.","DOI":"10.1002\/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, et al. Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. NeuroImage. 2006; 31: 1487\u20131505.","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Anjari M, Srinivasan L, Allsop JM, Hajnal JV, Rutherford MA, Edwards AD, et al. Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants. NeuroImage. 2007; 35: 1021\u20131027.","DOI":"10.1016\/j.neuroimage.2007.01.035"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Koyama T, Uchiyama Y, Domen K. Comparison of fractional anisotropy from tract-based spatial statistics with and without lesion masking in patients with intracerebral hemorrhage: a technical note. Journal of Stroke and Cerebrovascular Diseases. 2019; 28: 104376.","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104376"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Koyama T, Uchiyama Y, Domen K. Associations of diffusion-tensor fractional anisotropy and FIM outcome assessments after intracerebral hemorrhage. Journal of Stroke and Cerebrovascular Diseases. 2018; 27: 2869\u20132876.","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.06.012"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M, et al. The ABCs of measuring intracerebral hemorrhage volumes. Stroke. 1996; 27: 1304\u20131305.","DOI":"10.1161\/01.STR.27.8.1304"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Miles J. Tolerance and variance inflation factor. Wiley StatsRef: Statistics Reference Online. 2014. Available at:  (Accessed: 18 March 2022).","DOI":"10.1002\/9781118445112.stat06593"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Cohen J. Statistical power analysis for the behavioral sciences. Psychological Bulletin. 1992; 112: 155\u2013159.","DOI":"10.1037\/\/0033-2909.112.1.155"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Zazulia AR, Diringer MN, Videen TO, Adams RE, Yundt K, Aiyagari V, et al. Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism. 2001; 21: 804\u2013810.","DOI":"10.1097\/00004647-200107000-00005"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Zazulia AR, Videen TO, Powers WJ. Transient Focal Increase in Perihematomal Glucose Metabolism after Acute Human Intracerebral Hemorrhage. Stroke. 2009; 40: 1638\u20131643.","DOI":"10.1161\/STROKEAHA.108.536037"},{"key":"ref24","unstructured":"Lim JS, Ryu YH, Kim BM, Lee JD. Crossed cerebellar diaschisis due to intracranial hematoma in basal ganglia or thalamus. Journal of Nuclear Medicine. 1998; 39: 2044\u20132047."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Fu J, Chen W, Wu G, Cheng J, Wang M, Zhuge Q, et al. Whole-brain 320-detector row dynamic volume CT perfusion detected crossed cerebellar diaschisis after spontaneous intracerebral hemorrhage. Neuroradiology. 2015; 57: 179\u2013187.","DOI":"10.1007\/s00234-014-1456-6"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Noguchi T, Nishihara M, Egashira Y, Azama S, Hirai T, Kitano I, et al. Arterial spin-labeling MR imaging of cerebral hemorrhages. Neuroradiology. 2015; 57: 1135\u20131144.","DOI":"10.1007\/s00234-015-1574-9"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Yin L, Cheng S, Xiao J, Zhu Y, Bu S, Zhang X, et al. 3D pseudocontinuous arterial spin-labeling perfusion imaging detected crossed cerebellar diaschisis in acute, subacute and chronic intracerebral hemorrhage. Clinical Imaging. 2018; 50: 37\u201342.","DOI":"10.1016\/j.clinimag.2017.12.007"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Sin DS, Kim MH, Park S, Joo MC, Kim MS. Crossed cerebellar diaschisis: risk factors and correlation to functional recovery in intracerebral hemorrhage. Annals of Rehabilitation Medicine. 2018; 42: 8\u201317.","DOI":"10.5535\/arm.2018.42.1.8"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Mac Donald CL, Johnson AM, Cooper D, Nelson EC, Werner NJ, Shimony JS, et al. Detection of blast-related traumatic brain injury in U.S. military personnel. 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