{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:59:12Z","timestamp":1787025552994,"version":"build-2736575974"},"reference-count":77,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Transcranial magnetic stimulation (TMS), a non-invasive brain stimulation method, is trying to emerge as a migraine management strategy for both attack treatment and prevention. This scoping review presents 16 among single-pulse (to manage episodic and chronic migraine) and repetitive TMS randomized clinical trials (to manage chronic migraine). The works we reviewed suggest that TMS may be adopted as add-on therapy in those patients who are refractory to pharmacological therapy only with special arrangements for individualized treatment strategies or research. There are still limited clinical research programs and metaanalysis to promote routinely TMS employment, as TMS has been shown either to have no significant effects for any outcome or to be effective for migraine. These diverging conclusions depend on several biasing factors, including the lack of reliable, large, sham-controlled clinical trials, the dyshomogeneity in study designs (including the area of stimulation, the frequency of stimulation, the number of pulses, pulse intensity, and the number of sessions), patient selection criteria (migraine w\/o aura, episodic and chronic migraine; TMS contraindication), and the lack of outcomes homogeneity and long-term real-world efficacy data. Therefore, in the future, it will be important to conduct larger randomized trials to confirm TMS usefulness in migraine management (acute attack and prophylactic treatment), identify those patients who may benefit from TMS, maybe independently of pharmacological treatments (i.e., using TMS as an alternative and not only as an add-on treatment). Otherwise, TMS will play a role in treating migraine only with special arrangements for individualized management strategies or research.<\/jats:p>","DOI":"10.31083\/j.jin2104110","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T22:46:43Z","timestamp":1654814803000},"source":"Crossref","is-referenced-by-count":6,"title":["Applications of transcranial magnetic stimulation in migraine: evidence from a scoping review"],"prefix":"10.31083","volume":"21","author":[{"given":"Rocco Salvatore","family":"Calabr\u00f2","sequence":"first","affiliation":[{"name":"IRCCS Centro Neurolesi Bonino Pulejo-Piemonte, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Billeri","sequence":"first","affiliation":[{"name":"Istituto Clinico Polispecialistico, C.O.T. Cure Ortopediche Traumatologiche s.p.a., 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Manuli","sequence":"first","affiliation":[{"name":"AOU Policlinico \u201cG. Martino\u201d, Rehabilitation Unit, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Iacono","sequence":"first","affiliation":[{"name":"Ospedali Riuniti Villa Sofia-Cervello, Neurology Unit, 90146 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Naro","sequence":"first","affiliation":[{"name":"AOU Policlinico \u201cG. Martino\u201d, Stroke Unit, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Straube A, Andreou A. Primary headaches during lifespan. Journal of Headache and Pain. 2019; 20: 35.","DOI":"10.1186\/s10194-019-0985-0"},{"key":"ref2","unstructured":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015; 386: 743\u2013800."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S. Pathophysiology of Migraine: a Disorder of Sensory Processing. Physiological Reviews. 2017; 97: 553\u2013622.","DOI":"10.1152\/physrev.00034.2015"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Clark O, Mahjoub A, Osman N, Surmava A, Jan S, Lagman-Bartolome AM. Non-invasive neuromodulation in the acute treatment of migraine: a systematic review and meta-analysis of randomized controlled trials. Neurological Sciences. 2022; 43: 153\u2013165.","DOI":"10.1007\/s10072-021-05664-7"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Evers S. Non-Invasive Neurostimulation Methods for Acute and Preventive Migraine Treatment-A Narrative Review. Journal of Clinical Medicine. 2021; 10: 3302.","DOI":"10.3390\/jcm10153302"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Burch R. Preventive Migraine Treatment. Continuum. 2021; 27: 613\u2013632.","DOI":"10.1212\/CON.0000000000000957"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Lambru G, Res JM, Biloshytska M, Andreou A. Noninvasive Neuromodulation in Headache: an Update. Neurology India. 2021; 69: S183\u2013S193.","DOI":"10.4103\/0028-3886.315998"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Blech B, Starling AJ. Noninvasive Neuromodulation in Migraine. Current Pain and Headache Reports. 2020; 24: 78.","DOI":"10.1007\/s11916-020-00914-3"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Andreou AP, Holland PR, Akerman S, Summ O, Fredrick J, Goadsby PJ. Transcranial magnetic stimulation and potential cortical and trigeminothalamic mechanisms in migraine. Brain. 2016; 139: 2002\u20132014.","DOI":"10.1093\/brain\/aww118"},{"key":"ref10","unstructured":"Holland PR, Schembri C, Fredrick J, Goadsby PJ. Transcranial magnetic stimulation for the treatment of migraine aura? Cephalalgia. 2009; 29: 22."},{"key":"ref11","unstructured":"Popay J, Roberts H, Sowden A, Petticrew M, Arai L, Rodgers M, et al. Guidance on the Conduct of Narrative Synthesis in Systematic Reviews. In A. P. f. t. E.M. Programme (Ed.) Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). 2006."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of Internal Medicine. 2009; 151: 264\u2013269.","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Tong A, Flemming K, McInnes E, Oliver S, Craig J. Enhancing transparency in reporting the synthesis of qualitative research: ENTREQ. BMC Medical Research Methodology. 2012; 12: 181.","DOI":"10.1186\/1471-2288-12-181"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Clarke BM, Upton ARM, Kamath MV, Al-Harbi T, Castellanos CM. Transcranial magnetic stimulation for migraine: clinical effects. Journal of Headache and Pain. 2006; 7: 341\u2013346.","DOI":"10.1007\/s10194-006-0329-8"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK, Pearlman SH, et al. Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurology. 2010; 9: 373\u2013380.","DOI":"10.1016\/S1474-4422(10)70054-5"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"O\u2019Reardon JP, Fontecha JF, Cristancho MA, Newman S. Unexpected Reduction in Migraine and Psychogenic Headaches Following rTMS Treatment for Major Depression: a Report of Two Cases. CNS Spectrums. 2007; 12: 921\u2013925.","DOI":"10.1017\/S1092852900015716"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Teepker M, H\u00f6tzel J, Timmesfeld N, Reis J, Mylius V, Haag A, et al. Low-frequency rTMS of the vertex in the prophylactic treatment of migraine. Cephalalgia. 2009; 30: 137\u2013144.","DOI":"10.1111\/j.1468-2982.2009.01911.x"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Hammad AB, Elsharkawy RE, Abdel Azim GS. Repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine. Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2021; 57: 5.","DOI":"10.1186\/s41983-020-00254-4"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Amin R, Emara T, Ashour S, Hemeda M, Salah Eldin N, Hamed S, et al. The role of left prefrontal transcranial magnetic stimulation in episodic migraine prophylaxis. Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2020; 56: 19.","DOI":"10.1186\/s41983-019-0140-5"},{"key":"ref20","unstructured":"Sahu AK, Sinha VK, Goyal N. Effect of adjunctive intermittent theta-burst repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine patients: a double-blind sham-controlled study. Indian Journal of Psychiatry. 2019; 61: 139\u2013145."},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Misra UK, Kalita J, Bhoi SK. High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in migraine prophylaxis: an open labeled study. Neurological Research. 2012; 34: 547\u2013551.","DOI":"10.1179\/1743132812Y.0000000045"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Kalita J, Laskar S, Bhoi SK, Misra UK. Efficacy of single versus three sessions of high rate repetitive transcranial magnetic stimulation in chronic migraine and tension-type headache. Journal of Neurology. 2016; 263: 2238\u20132246.","DOI":"10.1007\/s00415-016-8257-2"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Conforto AB, Amaro E, Gon\u00e7alves AL, Mercante JP, Guendler VZ, Ferreira JR, et al. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine. Cephalalgia. 2014; 34: 464\u2013472.","DOI":"10.1177\/0333102413515340"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Kumar A, Mattoo B, Bhatia R, Kumaran S, Bhatia R. Neuronavigation based 10 sessions of repetitive transcranial magnetic stimulation therapy in chronic migraine: an exploratory study. Neurological Sciences. 2021; 42: 131\u2013139.","DOI":"10.1007\/s10072-020-04505-3"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Shehata HS, Esmail EH, Abdelalim A, El-Jaafary S, Elmazny A, Sabbah A, et al. Repetitive transcranial magnetic stimulation versus botulinum toxin injection in chronic migraine prophylaxis: a pilot randomized trial. Journal of Pain Research. 2016; 9: 771\u2013777.","DOI":"10.2147\/JPR.S116671"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Brighina F, Piazza A, Vitello G, Aloisio A, Palermo A, Daniele O, et al. RTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. Journal of the Neurological Sciences. 2004; 227: 67\u201371.","DOI":"10.1016\/j.jns.2004.08.008"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Kalita J, Kumar S, Singh VK, Misra UK. A Randomized Controlled Trial of High Rate rTMS Versus rTMS and Amitriptyline in Chronic Migraine. Pain Physician. 2021; 24: E733\u2013E741.","DOI":"10.36076\/ppj.2021.24.E733"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Leahu P, Bange M, Ciolac D, Scheiter S, Matei A, Gonzalez-Escamilla G, et al. Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation. Brain Stimulation. 2021; 14: 1544\u20131552.","DOI":"10.1016\/j.brs.2021.10.383"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Starling AJ, Tepper SJ, Marmura MJ, Shamim EA, Robbins MS, Hindiyeh N, et al. A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study). Cephalalgia. 2018; 38: 1038\u20131048.","DOI":"10.1177\/0333102418762525"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Gr\u00fcnner O. Cerebral use of a pulsating magnetic field in neuropsychiatry patients with long-term headache. Klinische Neurophysiologie. 1985; 16: 227\u2013230. (In German)","DOI":"10.1055\/s-2008-1060988"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Pelka RB, Jaenicke C, Gruenwald J. Impulse magnetic-field therapy for migraine and other headaches: a double-blind, placebo-controlled study. Advances in Therapy. 2001; 18: 101\u2013109.","DOI":"10.1007\/BF02850298"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Bhola R, Kinsella E, Giffin N, Lipscombe S, Ahmed F, Weatherall M, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. Journal of Headache and Pain. 2015; 16: 535.","DOI":"10.1186\/s10194-015-0535-3"},{"key":"ref33","unstructured":"Conforto A, Gon\u00e7alves AL, Mercante J, Guendler V, Amaro Jr E, Moraes M, et al. Effects of repetitive transcranial magnetic stimulation in chronic migraine: A pilot study. Cephalalgia. 2011; 31: 94."},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Rapinesi C, Del Casale A, Scatena P, Kotzalidis GD, Di Pietro S, Ferri VR, et al. Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treatment of chronic migraine: a preliminary study. Neuroscience Letters. 2016; 623: 7\u201312.","DOI":"10.1016\/j.neulet.2016.04.058"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Irwin SL, Qubty W, Allen IE, Patniyot I, Goadsby PJ, Gelfand AA. Transcranial Magnetic Stimulation for Migraine Prevention in Adolescents: a Pilot Open-Label Study. Headache. 2018; 58: 724\u2013731.","DOI":"10.1111\/head.13284"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Shirahige L, Melo L, Nogueira F, Rocha S, Monte-Silva K. Efficacy of Noninvasive Brain Stimulation on Pain Control in Migraine Patients: a Systematic Review and Meta-Analysis. Headache. 2016; 56: 1565\u20131596.","DOI":"10.1111\/head.12981"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Zhu S, Marmura MJ. Non-Invasive Neuromodulation for Headache Disorders. Current Neurology and Neuroscience Reports. 2016; 16: 2\u201311.","DOI":"10.1007\/s11910-015-0620-7"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Dodick DW, Schembri CT, Helmuth M, Aurora SK. Transcranial magnetic stimulation for migraine: a safety review. Headache. 2010; 50: 1153\u20131163.","DOI":"10.1111\/j.1526-4610.2010.01697.x"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Almaraz AC, Dilli E, Dodick DW. The Effect of Prophylactic Medications on TMS for Migraine Aura. Headache. 2010; 50: 1630\u20131633.","DOI":"10.1111\/j.1526-4610.2010.01787.x"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Br\u00fcggenj\u00fcrgen B, Baker T, Bhogal R, Ahmed F. Cost impact of a non-invasive, portable device for patient self-administration of chronic migraine in a UK National Health Service setting. SpringerPlus. 2016; 5: 1249.","DOI":"10.1186\/s40064-016-2924-8"},{"key":"ref41","unstructured":"Mwamburi M, Liebler EJ, Tenaglia AT. Cost-effectiveness of gammaCore (non-invasive vagus nerve stimulation) for acute treatment of episodic cluster headache. American Journal of Managed Care. 2017; 23: S300\u2013S306."},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Wong HT, Ahmed F. Clinical and Cost Effectiveness of Neuromodulation Devices in the Treatment of Headaches: Focus on Non-invasive Therapies. In Lambru G, Lanteri-Minet M (eds.) Neuromodulation in headache and facial pain management: Principles, rationale and clinical data (pp. 241\u2013257). Springer: Berlin. 2020.","DOI":"10.1007\/978-3-030-14121-9_18"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Andreou AP, Trimboli M, Al-Kaisy A, Murphy M, Palmisani S, Fenech C, et al. Prospective real-world analysis of OnabotulinumtoxinA in chronic migraine post-National Institute for Health and Care Excellence UK technology appraisal. European Journal of Neurology. 2018; 25: 1069\u2013e83.","DOI":"10.1111\/ene.13657"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Andreou AP, Fuccaro M, Lambru G. The role of erenumab in the treatment of migraine. Therapeutic Advances in Neurological Disorders. 2020; 13: 1756286420927119.","DOI":"10.1177\/1756286420927119"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Lambru G, Hill B, Murphy M, Tylova I, Andreou AP. A prospective real-world analysis of erenumab in refractory chronic migraine. Journal of Headache and Pain. 2020; 21: 61.","DOI":"10.1186\/s10194-020-01127-0"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Lambru G, Andreou AP, Guglielmetti M, Martelletti P. Emerging drugs for migraine treatment: an update. Expert Opinion on Emerging Drugs. 2018; 23: 301\u2013318.","DOI":"10.1080\/14728214.2018.1552939"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Barker AT, Shields K. Transcranial Magnetic Stimulation: Basic Principles and Clinical Applications in Migraine. Headache. 2017; 57: 517\u2013524.","DOI":"10.1111\/head.13002"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Hulla R, Liegey-Dougall A. A systematic review of high-frequency transcranial magnetic stimulation on motor cortex areas as a migraine preventive treatment. Cephalalgia Reports. 2019; 2: 2515816319889971.","DOI":"10.1177\/2515816319889971"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Mohamad Safiai NI, Amir NA, Basri H, Inche Mat LN, Hoo FK, Yusof Khan AHK, et al. Effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine: a single-centre, randomised, double-blind, sham-controlled phase 2 trial (Magnet-EM). Trials. 2020; 21: 923.","DOI":"10.1186\/s13063-020-04832-y"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Garcia JO, Grossman ED, Srinivasan R. Evoked potentials in large-scale cortical networks elicited by TMS of the visual cortex. Journal of Neurophysiology. 2011; 106: 1734\u20131746.","DOI":"10.1152\/jn.00739.2010"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Lambru G, Lanteri-Minet M. Neuromodulation in Headache and Facial Pain Management: Principles, Rationale and Clinical Data. Springer Nature: Berlin. 2019.","DOI":"10.1007\/978-3-030-14121-9"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Burke MJ, Joutsa J, Cohen AL, Soussand L, Cooke D, Burstein R, et al. Mapping migraine to a common brain network. Brain. 2020; 43: 541\u2013553.","DOI":"10.1093\/brain\/awz405"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Cosentino G, Fierro B, Vigneri S, Talamanca S, Palermo A, Puma A, et al. Impaired glutamatergic neurotransmission in migraine with aura? Evidence by an input-output curves transcranial magnetic stimulation study. Headache. 2011; 51: 726\u2013733.","DOI":"10.1111\/j.1526-4610.2011.01893.x"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Naeije G, Fogang Y, Ligot N, Mavroudakis N. Occipital transcranial magnetic stimulation discriminates transient neurological symptoms of vascular origin from migraine aura without headache. Neurophysiologie Clinique. 2017; 47: 269\u2013274.","DOI":"10.1016\/j.neucli.2017.05.093"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Brighina F, Piazza A, Daniele O, Fierro B. Modulation of visual cortical excitability in migraine with aura: effects of 1 Hz repetitive transcranial magnetic stimulation. Experimental Brain Research. 2002; 145: 177\u2013181.","DOI":"10.1007\/s00221-002-1096-7"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Palermo A, Fierro B, Giglia G, Cosentino G, Puma AR, Brighina F. Modulation of visual cortex excitability in migraine with aura: Effects of valproate therapy. Neuroscience Letters. 2009; 467: 26\u201329.","DOI":"10.1016\/j.neulet.2009.09.054"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Aurora SK, Ahmad BK, Welch KM, Bhardhwaj P, Ramadan NM. Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology. 1998; 50: 1111\u20131114.","DOI":"10.1212\/WNL.50.4.1111"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Aurora SK, Cao Y, Bowyer SM, Welch KM. The occipital cortex is hyperexcitable in migraine: experimental evidence. Headache. 1999; 39: 469\u2013476.","DOI":"10.1046\/j.1526-4610.1999.3907469.x"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Dasilva AF, Mendonca ME, Zaghi S, Lopes M, Dossantos MF, Spierings EL, et al. TDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache. 2012; 52: 1283\u20131295.","DOI":"10.1111\/j.1526-4610.2012.02141.x"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Mhalla A, de Andrade DC, Baudic S, Perrot S, Bouhassira D. Alteration of cortical excitability in patients with fibromyalgia. Pain. 2010; 149: 495\u2013500.","DOI":"10.1016\/j.pain.2010.03.009"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Castillo Saavedra L, Mendonca M, Fregni F. Role of the primary motor cortex in the maintenance and treatment of pain in fibromyalgia. Medical Hypotheses. 2014; 83: 332\u2013336.","DOI":"10.1016\/j.mehy.2014.06.007"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Uglem M, Omland PM, Engstr\u00f8m M, Gravdahl GB, Linde M, Hagen K, et al. Non-invasive cortical modulation of experimental pain in migraine. Clinical Neurophysiology. 2016; 127: 2362\u20132369.","DOI":"10.1016\/j.clinph.2016.03.016"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Fregni F, Freedman S, Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurology. 2007; 6: 188\u2013191.","DOI":"10.1016\/S1474-4422(07)70032-7"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Naro A, Milardi D, Russo M, Terranova C, Rizzo V, Cacciola A, et al. Non-invasive Brain Stimulation, a Tool to Revert Maladaptive Plasticity in Neuropathic Pain. Frontiers in Human Neuroscience. 2016; 10: 376.","DOI":"10.3389\/fnhum.2016.00376"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Conforto AB, Moraes MS, Amaro E, Young WB, Lois LA, Gon\u00e7alves AL, et al. Increased variability of motor cortical excitability to transcranial magnetic stimulation in migraine: a new clue to an old enigma. Journal of Headache and Pain. 2012; 13: 29\u201337.","DOI":"10.1007\/s10194-011-0379-4"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Brighina F, Giglia G, Scalia S, Francolini M, Palermo A, Fierro B. Facilitatory effects of 1 Hz rTMS in motor cortex of patients affected by migraine with aura. Experimental Brain Research. 2005; 161: 34\u201338.","DOI":"10.1007\/s00221-004-2042-7"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Cosentino G, Di Marco S, Ferlisi S, Valentino F, Capitano WM, Fierro B, et al. Intracortical facilitation within the migraine motor cortex depends on the stimulation intensity. a paired-pulse TMS study. Journal of Headache and Pain. 2018; 19: 65.","DOI":"10.1186\/s10194-018-0897-4"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Brighina F, Cosentino G, Vigneri S, Talamanca S, Palermo A, Giglia G, et al. Abnormal facilitatory mechanisms in motor cortex of migraine with aura. European Journal of Pain. 2011; 15: 928\u2013935.","DOI":"10.1016\/j.ejpain.2011.03.012"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Conte A, Barbanti P, Frasca V, Iacovelli E, Gabriele M, Giacomelli E, et al. Differences in short-term primary motor cortex synaptic potentiation as assessed by repetitive transcranial magnetic stimulation in migraine patients with and without aura. Pain. 2010; 148: 43\u201348.","DOI":"10.1016\/j.pain.2009.09.031"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Granato A, Fantini J, Monti F, Furlanis G, Musho Ilbeh S, Semenic M, et al. Dramatic placebo effect of high frequency repetitive TMS in treatment of chronic migraine and medication overuse headache. Journal of Clinical Neuroscience. 2019; 60: 96\u2013100.","DOI":"10.1016\/j.jocn.2018.09.021"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Zardouz S, Shi L, Leung A. A feasible repetitive transcranial magnetic stimulation clinical protocol in migraine prevention. SAGE Open Medical Case Reports. 2016; 4: 2050313X16675257.","DOI":"10.1177\/2050313X16675257"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Hansen JM, Baca SM, Vanvalkenburgh P, Charles A. Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording. Brain. 2013; 136: 3589\u20133595.","DOI":"10.1093\/brain\/awt309"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Martelletti P, Jensen RH, Antal A, Arcioni R, Brighina F, de Tommaso M, et al. Neuromodulation of chronic headaches: position statement from the European Headache Federation. Journal of Headache and Pain. 2013; 14: 86.","DOI":"10.1186\/1129-2377-14-86"},{"key":"ref74","unstructured":"U.S. Food and Drug Administration De Novo Summary (K130556). 2013. Available at: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/reviews\/k130556.pdf (Accessed: 5 March 2013)."},{"key":"ref75","unstructured":"National Institute for Health and Care Excellence (NICE) Transcranial magnetic stimulation for treating and preventing migraine. Interventional procedures guidance. 2014. Available at: https:\/\/www.nice.org.uk\/guidance\/ipg477\/resources\/transcranial-magnetic-stimulation-for-treating-and-preventing-migraine-pdf-1899869936447941 (Accessed: 23 January 2014)."},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Magis D, Schoenen J. Advances and challenges in neurostimulation for headaches. Lancet Neurology. 2012; 11: 708\u2013719.","DOI":"10.1016\/S1474-4422(12)70139-4"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Tepe N, Filiz A, Dilekoz E, Akcali D, Sara Y, Charles A, et al. The thalamic reticular nucleus is activated by cortical spreading depression in freely moving rats: prevention by acute valproate administration. 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