{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:38:51Z","timestamp":1782139131209,"version":"3.54.5"},"reference-count":55,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"crossref","award":["182300410389"],"award-info":[{"award-number":["182300410389"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Joint construction project of Henan Medical Science and technology research plan","award":["LHGJ20190437"],"award-info":[{"award-number":["LHGJ20190437"]}]},{"name":"Xinxiang Medical University Scientific Research Innovation Support Program Project","award":["YJSCX202185Y"],"award-info":[{"award-number":["YJSCX202185Y"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: Matrix metalloproteinase-9 (MMP-9) is a significant protease required for synaptic plasticity, learning, and memory. Yet, the role of MMP-9 in the occurrence and development of cognitive decline after ischemic stroke is not fully understood. In this study, we used clinical data experiments to further investigate whether MMP-9 and genetic polymorphism are associated with post-stroke cognitive impairment or dementia (PSCID). Materials and Methods: A total of 148 patients with PSCID confirmed by the Montreal Cognitive Assessment (MoCA) 3 months after onset (PSCID group) were included in the study. The MMP-9 rs3918242 polymorphisms were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism, and the serum level of MMP-9 was measured using enzyme-linked immunosorbent assay (ELISA). The same manipulations have been done on 169 ischemic stroke patients without cognitive impairment (NCI group) and 150 normal controls (NC group). Results: The expression level of serum MMP-9 in the PSCID group and NCI group was higher compared to the NC group, and the levels in the PSCID group were higher than that in the NCI group (all p &lt;math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"w1\" alttext=\" &lt; 0.05). Diabetes mellitus, hyperhomocysteinemia, and increased serum MMP-9 levels were the main risk factors of cognitive impairment after ischemic stroke. The serum level of MMP-9 was negatively correlated with the MoCA score, including visual-spatial executive, naming, attention, language, and delayed recall. Genetic polymorphism showed that TC genotype with MMP-9 rs3918242 and CC genotype were associated with a significantly increased risk of PSCID; moreover, the TC genotype significantly increased the risk of cognitive impairment. In the TCCC genotype of MMP-9 rs3918242, diabetes mellitus and hyperhomocysteinemia were associated with the increased risk of PSCID; also, hyperhomocysteinemia could increase the risk of cognitive impairment. Conclusions: MMP-9 level and MMP-9 rs3918242 polymorphism have an important role in the occurrence and development of post-stroke cognitive impairment or dementia (PSCID).<\/jats:p>","DOI":"10.31083\/j.jin2106160","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T01:40:05Z","timestamp":1664502005000},"source":"Crossref","is-referenced-by-count":7,"title":["Is Matrix Metalloproteinase-9 Associated with Post-Stroke Cognitive Impairment or Dementia?"],"prefix":"10.31083","volume":"21","author":[{"given":"Jianhua","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangli","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Neurology, the Sixth Hospital of Wuhan, Affiliated Hospital to Jianghan University, 430015 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxia","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Medical Record Management, First Affiliated Hospital of Xinxiang Medical University, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Imaging, First Affiliated Hospital of Xinxiang Medical University, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibei","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, 453100 Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomin","family":"Li","sequence":"first","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Harvard Medical 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