{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:40:10Z","timestamp":1783464010603,"version":"3.55.0"},"reference-count":41,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Foundation for the High-level Talents, Fujian University of Traditional Chinese Medicine","award":["X2019002-talents"],"award-info":[{"award-number":["X2019002-talents"]}]},{"name":"Science and technology platform construction project of Fujian science and Technology Department","award":["2018Y2002"],"award-info":[{"award-number":["2018Y2002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82004441"],"award-info":[{"award-number":["82004441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: This study aimed to investigate the effects of electroacupuncture (EA) treatment at Zusanli (ST36) and Quchi (LI11) on cortico-striatal network connectivity after ischemia stroke by resting-state functional magnetic resonance imaging (fMRI). Methods: A rat model of middle cerebral artery occlusion (MCAO) was established. Rats were randomly assigned into a sham-operated control group (SC group, n = 8), untreated MCAO model group (MCAO group, n = 8), and MCAO group receiving EA treatment at ST36 and LI11 (MCAO + EA group, n = 8). Rats in the SC and the MCAO groups received no treatment. The MCAO + EA group was treated with EA from the 1st day to the 7th day after surgery. The behavioral tests including Zea Longa test and modified neurologic severity score (mNSS) for all rats were performed before and after treatment for MCAO + EA group. fMRI scans were performed after behavioral tests on the 7th day after surgery. Results: The neurologic severity scores estimated by Zea Longa and mNSS were significantly improved in the rat ischemic stroke model of MCAO within 1 week after EA treatment at acupoints ST36 and LI11. Besides, voxel-wise analysis showed that EA could increase the functional connectivity of the left striatum with the bilateral sensory cortex, bilateral motor cortex, left retrosplenial cortex, right cerebellum, bilateral hippocampus, bilateral auditory cortex, bilateral visual cortex, left parietal cortex, left cingulate gyrus, and left superior colliculus. Further graph theory analysis showed that EA significantly decreased the characteristic path length and increased the global efficiency of the cortico-striatal network. Conclusions: EA at ST36 and LI11 could improve the cortico-striatal network to impact the brain\u2019s protective in MCAO, which is a potential treatment for ischemia stroke.<\/jats:p>","DOI":"10.31083\/j.jin2106162","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T01:40:05Z","timestamp":1664502005000},"source":"Crossref","is-referenced-by-count":13,"title":["Functional Connectivity of Ipsilateral Striatum in Rats with Ischemic Stroke Increased by Electroacupuncture"],"prefix":"10.31083","volume":"21","author":[{"given":"Lianhua","family":"Yin","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Tang","sequence":"first","affiliation":[{"name":"National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiao","family":"Lin","sequence":"first","affiliation":[{"name":"College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minguang","family":"Yang","sequence":"first","affiliation":[{"name":"National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Liu","sequence":"first","affiliation":[{"name":"National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiang","family":"Liang","sequence":"first","affiliation":[{"name":"National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"},{"name":"Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, 350122 Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Yang X, Chen YH, Xia F, Sawan M. Photoacoustic imaging for monitoring of stroke diseases: A review. Photoacoustics. 2021; 23: 100287.","DOI":"10.1016\/j.pacs.2021.100287"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Feigin VL, Norrving B, Mensah GA. Global Burden of Stroke. Circulation Research. 2017; 120: 439\u2013448.","DOI":"10.1161\/CIRCRESAHA.116.308413"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Gallego JA, Perich MG, Naufel SN, Ethier C, Solla SA, Miller LE. Cortical population activity within a preserved neural manifold underlies multiple motor behaviors. Nature Communications. 2018; 9: 4233.","DOI":"10.1038\/s41467-018-06560-z"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Russo AA, Bittner SR, Perkins SM, Seely JS, London BM, Lara AH, et al. Motor Cortex Embeds Muscle-like Commands in an Untangled Population Response. Neuron. 2018; 97: 953\u2013966.e8.","DOI":"10.1016\/j.neuron.2018.01.004"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Gray WA, Palmer JA, Wolf SL, Borich MR. Abnormal EEG Responses to TMS during the Cortical Silent Period are Associated with Hand Function in Chronic Stroke. Neurorehabilitation and Neural Repair. 2017; 31: 666\u2013676.","DOI":"10.1177\/1545968317712470"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Gardner RC, Peltz CB, Kenney K, Covinsky KE, Diaz-Arrastia R, Yaffe K. Remote Traumatic Brain Injury is Associated with Motor Dysfunction in Older Military Veterans. The Journals of Gerontology: Series A. 2017; 72: 1233\u20131238.","DOI":"10.1093\/gerona\/glw341"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Burgold J, Schulz-Trieglaff EK, Voelkl K, Guti\u00e9rrez-\u00c1ngel S, Bader JM, Hosp F, et al. Cortical circuit alterations precede motor impairments in Huntington\u2019s disease mice. Scientific Reports. 2019; 9: 6634.","DOI":"10.1038\/s41598-019-43024-w"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan C, Bertoux M, Hornberger M. Beyond and below the cortex: the contribution of striatal dysfunction to cognition and behaviour in neurodegeneration. Journal of Neurology, Neurosurgery & Psychiatry. 2014; 85: 371\u2013378.","DOI":"10.1136\/jnnp-2012-304558"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Liang S, Jiang X, Zhang Q, Duan S, Zhang T, Huang Q, et al. Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke. Neuroscience Bulletin. 2018; 34: 715\u2013724.","DOI":"10.1007\/s12264-018-0266-y"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Liu S, Wang Z, Su Y, Qi L, Yang W, Fu M, et al. A neuroanatomical basis for electroacupuncture to drive the vagal\u2013adrenal axis. Nature. 2021; 598: 641\u2013645.","DOI":"10.1038\/s41586-021-04001-4"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Cai Y, Zhang CS, Zhang AL, Da Costa C, Xue CC, Wen Z. Electroacupuncture for Poststroke Spasticity: Results of a Pilot Pragmatic Randomized Controlled Trial. Journal of Pain and Symptom Management. 2021; 61: 305\u2013314.","DOI":"10.1016\/j.jpainsymman.2020.07.034"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Ruan A, Wang Q, Ma Y, Zhang D, Yang L, Wang Z, et al. Efficacy and Mechanism of Electroacupuncture Treatment of Rabbits with Different Degrees of Knee Osteoarthritis: A Study Based on Synovial Innate Immune Response. Frontiers in Physiology. 2021; 12: 642178.","DOI":"10.3389\/fphys.2021.642178"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Chavez LM, Huang SS, MacDonald I, Lin JG, Lee YC, Chen YH. Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies. International Journal of Molecular Sciences. 2017; 18: 2270.","DOI":"10.3390\/ijms18112270"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Zhao P, Chen X, Han X, Wang Y, Shi Y, Ji J, et al. Involvement of microRNA-155 in the mechanism of electroacupuncture treatment effects on experimental autoimmune encephalomyelitis. International Immunopharmacology. 2021; 97: 107811.","DOI":"10.1016\/j.intimp.2021.107811"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wang W, Xie C, Lu L, Zheng G. A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke. Scientific Reports. 2014; 4: 3981.","DOI":"10.1038\/srep03981"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Xing Y, Wang M, Feng Y, Dong F, Zhang F. Possible Involvement of PTEN Signaling Pathway in the Anti-apoptotic Effect of Electroacupuncture Following Ischemic Stroke in Rats. Cellular and Molecular Neurobiology. 2018; 38: 1453\u20131463.","DOI":"10.1007\/s10571-018-0615-4"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989; 20: 84\u201391.","DOI":"10.1161\/01.STR.20.1.84"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, et al. Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits after Stroke in Rats. Stroke. 2001; 32: 2682\u20132688.","DOI":"10.1161\/hs1101.098367"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Liu X, Wang B, Si S, Wang J, Zhao H. Brain networks modeling for studying the mechanism underlying the development of Alzheimer\u2019s disease. Neural Regeneration Research. 2019; 14: 1805.","DOI":"10.4103\/1673-5374.257538"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in brain network efficiency and working memory performance in aging. PLoS ONE. 2015; 10: e123950.","DOI":"10.1371\/journal.pone.0123950"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Vados L, Ferreira A, Zhao S, Vercelino R, Wang S. Effectiveness of Acupuncture Combined with Rehabilitation for Treatment of Acute or Subacute Stroke: a Systematic Review. Acupuncture in Medicine. 2015; 33: 180\u2013187.","DOI":"10.1136\/acupmed-2014-010705"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Xu J, Pei J, Fu Q, Wang L, Zhan Y, Tao L. Earlier Acupuncture Enhancing Long-Term Effects on Motor Dysfunction in Acute Ischemic Stroke: Retrospective Cohort Study. The American Journal of Chinese Medicine. 2020; 48: 1787\u20131802.","DOI":"10.1142\/S0192415X20500895"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"de Pablo Y, Nilsson M, Pekna M, Pekny M. Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen\u2013glucose deprivation and reperfusion. Histochemistry and Cell Biology. 2013; 140: 81\u201391.","DOI":"10.1007\/s00418-013-1110-0"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Liu Z, Li Y, Cui Y, Roberts C, Lu M, Wilhelmsson U, et al. Beneficial effects of gfap\/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after stroke. Glia. 2014; 62: 2022\u20132033.","DOI":"10.1002\/glia.22723"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Li Z, Yang M, Lin Y, Liang S, Liu W, Chen B, et al. Electroacupuncture promotes motor function and functional connectivity in rats with ischemic stroke: an animal resting-state functional magnetic resonance imaging study. Acupuncture in Medicine. 2021; 39: 146\u2013155.","DOI":"10.1177\/0964528420920297"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Liang S, Lin Y, Lin B, Li J, Liu W, Chen L, et al. Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture. Journal of Stroke and Cerebrovascular Diseases. 2017; 26: 1953\u20131959.","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.018"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Klaus A, Alves da Silva J, Costa RM. What, if, and when to Move: Basal Ganglia Circuits and Self-Paced Action Initiation. Annual Review of Neuroscience. 2019; 42: 459\u2013483.","DOI":"10.1146\/annurev-neuro-072116-031033"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Gerfen CR, Surmeier DJ. Modulation of Striatal Projection Systems by Dopamine. Annual Review of Neuroscience. 2011; 34: 441\u2013466.","DOI":"10.1146\/annurev-neuro-061010-113641"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ebbesen CL, Brecht M. Motor cortex \u2014 to act or not to act? Nature Reviews Neuroscience. 2017; 18: 694\u2013705.","DOI":"10.1038\/nrn.2017.119"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Schneider DM. Reflections of action in sensory cortex. Current Opinion in Neurobiology. 2020; 64: 53\u201359.","DOI":"10.1016\/j.conb.2020.02.004"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"De Zeeuw CI, Ten Brinke MM. Motor Learning and the Cerebellum. Cold Spring Harbor Perspectives in Biology. 2015; 7: a021683.","DOI":"10.1101\/cshperspect.a021683"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Vogel M. The Cerebellum. American Journal of Psychiatry. 2005; 162: 1253\u20131253.","DOI":"10.1176\/appi.ajp.162.7.1253"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Garc\u00eda S, Orlandi JG, Garc\u00eda-D\u00edaz Barriga GA, Rodr\u00edguez MJ, Masana M, Soriano J, et al. Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington\u2019s disease. BMC Biology. 2020; 18: 58.","DOI":"10.1186\/s12915-020-00794-4"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Helmich RC, Derikx LC, Bakker M, Scheeringa R, Bloem BR, Toni I. Spatial Remapping of Cortico-striatal Connectivity in Parkinson\u2019s Disease. Cerebral Cortex. 2010; 20: 1175\u20131186.","DOI":"10.1093\/cercor\/bhp178"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"K\u00f6hling R, Koch U, Hamann M, Richter A. Increased excitability in cortico-striatal synaptic pathway in a model of paroxysmal dystonia. Neurobiology of Disease. 2004; 16: 236\u2013245.","DOI":"10.1016\/j.nbd.2004.01.012"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Fling BW, Gera Dutta G, Horak FB. Functional connectivity underlying postural motor adaptation in people with multiple sclerosis. NeuroImage: Clinical. 2015; 8: 281\u2013289.","DOI":"10.1016\/j.nicl.2015.04.023"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Yamawaki N, Radulovic J, Shepherd GMG. A Corticocortical Circuit Directly Links Retrosplenial Cortex to M2 in the Mouse. The Journal of Neuroscience. 2016; 36: 9365\u20139374.","DOI":"10.1523\/JNEUROSCI.1099-16.2016"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Berlot R, Rothwell JC, Bhatia KP, Kojovi\u0107 M. Variability of Movement Disorders: the Influence of Sensation, Action, Cognition, and Emotions. Movement Disorders. 2021; 36: 581\u2013593.","DOI":"10.1002\/mds.28415"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Monaco S, Malfatti G, Culham JC, Cattaneo L, Turella L. Decoding motor imagery and action planning in the early visual cortex: Overlapping but distinct neural mechanisms. NeuroImage. 2020; 218: 116981.","DOI":"10.1016\/j.neuroimage.2020.116981"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Khalilian M, Kazemi K, Fouladivanda M, Makki M, Helfroush MS, Aarabi A. Effect of Multishell Diffusion MRI Acquisition Strategy and Parcellation Scale on Rich-Club Organization of Human Brain Structural Networks. Diagnostics (Basel). 2021; 11: 970.","DOI":"10.3390\/diagnostics11060970"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Zdanovskis N, Platk\u0101jis A, Kostiks A, Karelis G, Grigorjeva O. Brain Structural Connectivity Differences in Patients with Normal Cognition and Cognitive Impairment. Brain Sciences. 2021; 11: 943.","DOI":"10.3390\/brainsci11070943"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/21\/6\/10.31083\/j.jin2106162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T15:44:12Z","timestamp":1732722252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/21\/6\/10.31083\/j.jin2106162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"alternative-id":["S0219-6352(22)00373-4"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2106162","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"value":"0219-6352","type":"print"},{"value":"1757-448X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]},"article-number":"162"}}