{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:59:42Z","timestamp":1787025582719,"version":"build-2736575974"},"reference-count":33,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: Camptocormia is one of the most common postural disorders of Parkinson\u2019s disease (PD) which has limited treatment options. In this review, we summarize the efficacy of deep brain stimulation (DBS) for camptocormia in PD. Methods: The PubMed (https:\/\/pubmed.ncbi.nlm.nih.gov\/) and EMBASE databases (https:\/\/www.embase.com\/) were searched for the terms \u201cParkinson Disease\u201d and \u201ccamptocormia\u201d in combination with \u201cdeep brain stimulation\u201d. We then explored the efficacy of DBS for camptocormia by statistical analysis of the bending angle, the Unified Parkinson\u2019s Disease Rating Scale III (UPDRS-III) and L-dopa equivalent daily dose (LEDD), and by evaluating the prognosis after DBS. Results: Twenty articles that reported results for 152 patients were included in this review. These comprised 136 patients from 16 studies who underwent subthalamic nucleus deep brain stimulation (STN-DBS), and 13 patients from 3 studies who underwent globus pallidus internus deep brain stimulation (GPi-DBS). One study used both STN-DBS (2 patients) and GPi-DBS (one patient). After 3\u201321 months of follow-up, the mean bending angle during the Off-period was significantly reduced compared to pre-DBS (31.5 \u00b1 21.4 vs. 53.6 \u00b1 22.7, respectively; p &lt; 0.0001). For the STN-DBS trials, the mean post-operative bending angles during both Off- and On-periods were significantly reduced compared to pre-operative (32.1 \u00b1 22.7 vs. 55.4 \u00b1 24.1, p = 0.0003; and 33.1 \u00b1 21.5 vs. 43.7 \u00b1 20.6, p = 0.0003, respectively). For GPi-DBS, the mean bending angle post-DBS during the Off-period was considerably lower than pre-DBS (28.5 \u00b1 10.7 vs. 42.9 \u00b1 9.9, p &lt; 0.001). The decrease in bending angle after DBS was negatively correlated with the duration of camptocormia (R = \u2013 0.433, p = 0.013), whereas positively associated with the pre-bending angle (R = 0.352, p = 0.03). Conclusions: DBS is an effective treatment for camptocormia in PD. Patients in the early stage of camptocormia with more significant bending angle may benefit more from DBS.<\/jats:p>","DOI":"10.31083\/j.jin2201011","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T03:29:04Z","timestamp":1673234944000},"source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Deep Brain Stimulation for Camptocormia in Parkinson's Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.31083","volume":"22","author":[{"given":"Fuli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hecong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref1","unstructured":"Srivanitchapoom P, Hallett M. Camptocormia in Parkinson\u2019s disease: definition, epidemiology, pathogenesis and treatment modalities. Journal of Neurology, Neurosurgery and Psychiatry. 2016; 87: 75\u201385."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Ali F, Matsumoto JY, Hassan A. Camptocormia: Etiology, diagnosis, and treatment response. Neurology Clinical Practice. 2018; 8: 240\u2013248.","DOI":"10.1212\/CPJ.0000000000000453"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Lai Y, Song Y, Huang P, Wang T, Wang L, Pan Y, et al. Subthalamic Stimulation for Camptocormia in Parkinson\u2019s Disease: Association of Volume of Tissue Activated and Structural Connectivity with Clinical Effectiveness. Journal of Parkinson\u2019s Disease. 2021; 11: 199\u2013210.","DOI":"10.3233\/JPD-202259"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Fasano A, Geroin C, Berardelli A, Bloem BR, Espay AJ, Hallett M, et al. Diagnostic criteria for camptocormia in Parkinson\u2019s disease: a consensus-based proposal. Parkinsonism and Related Disorders. 2018; 53: 53\u201357.","DOI":"10.1016\/j.parkreldis.2018.04.033"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Ruttiman R, Eltorai AEM, Daniels AH. Etiology and Management of Spinal Deformity in Patients With Parkinson\u2019s Disease. International Journal of Spine Surgery. 2018; 12: 15\u201321.","DOI":"10.14444\/5003"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Vorovenci RJ, Biundo R, Antonini A. Therapy-resistant symptoms in Parkinson\u2019s disease. Journal of Neural Transmission. 2016; 123: 19\u201330.","DOI":"10.1007\/s00702-015-1463-8"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Ameghino L, Bruno V, Merello M. Postural Disorders and Antiparkinsonian Treatments in Parkinson Disease: an Exploratory Case-Control Study. Clinical Neuropharmacology. 2018; 41: 123\u2013128.","DOI":"10.1097\/WNF.0000000000000285"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Lai Y, Song Y, Su D, Wang L, Zhang C, Sun B, et al. Pallidal stimulation as treatment for camptocormia in Parkinson\u2019s disease. NPJ Parkinson\u2019s Disease. 2021; 7: 8.","DOI":"10.1038\/s41531-020-00151-w"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Liang S, Yu Y, Li H, Wang Y, Cheng Y, Yang H. The Study of Subthalamic Deep Brain Stimulation for Parkinson Disease-Associated Camptocormia. Medical Science Monitor. 2020; 26: e919682.","DOI":"10.12659\/MSM.919682"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Sakai W, Nakane S, Urasaki E, Toyoda K, Sadakata E, Nagaishi A, et al. The Cross-Sectional Area of Paraspinal Muscles Predicts the Efficacy of Deep Drain Stimulation for Camptocormia. Journal of Parkinson\u2019s Disease. 2017; 7: 247\u2013253.","DOI":"10.3233\/JPD-160948"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Yamada K, Shinojima N, Hamasaki T, Kuratsu J. Subthalamic nucleus stimulation improves Parkinson\u2019s disease-associated camptocormia in parallel to its preoperative levodopa responsiveness. Journal of Neurology, Neurosurgery and Psychiatry. 2016; 87: 703\u2013709.","DOI":"10.1136\/jnnp-2015-310926"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Schulz\u2010Schaeffer WJ, Margraf NG, Munser S, Wrede A, Buhmann C, Deuschl G, et al. Effect of neurostimulation on camptocormia in Parkinson\u2019s disease depends on symptom duration. Movement Disorders. 2015; 30: 368\u2013372.","DOI":"10.1002\/mds.26081"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Umemura A, Oka Y, Ohkita K, Yamawaki T, Yamada K. Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease. Journal of Neurosurgery. 2010; 112: 1283\u20131288.","DOI":"10.3171\/2009.10.JNS09917"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Sako W, Nishio M, Maruo T, Shimazu H, Matsuzaki K, Tamura T, et al. Subthalamic nucleus deep brain stimulation for camptocormia associated with Parkinson\u2019s disease. Movement Disorders. 2009; 24: 1076\u20131079.","DOI":"10.1002\/mds.22529"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Soares C, Vilas-Boas MDC, Lopes EM, Choupina H, Soares-dos-Reis R, Fitas D, et al. Automated and objective measures of gait dynamics in camptocormia Parkinson\u2019s Disease subthalamic deep brain stimulation. Clinical Neurology and Neurosurgery. 2019; 186: 105537.","DOI":"10.1016\/j.clineuro.2019.105537"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Roediger J, Artusi CA, Romagnolo A, Boyne P, Zibetti M, Lopiano L, et al. Effect of subthalamic deep brain stimulation on posture in Parkinson\u2019s disease: a blind computerized analysis. Parkinsonism and Related Disorders. 2019; 62: 122\u2013127.","DOI":"10.1016\/j.parkreldis.2019.01.003"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Pandey S, Garg H. Postural & striatal deformities in Parkinson\u2018 s disease: Are these rare? Indian Journal of Medical Research. 2016; 143: 11\u201317.","DOI":"10.4103\/0971-5916.178577"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Kaptan H, Ekmekci H. Camptocormia and deep brain stimulation: the interesting overlapping etiologies and the therapeutic role of subthalamic nucleus-deep brain stimulation in Parkinson disease with camptocormia. Surgical Neurology International. 2016; 7: 103.","DOI":"10.4103\/2152-7806.176130"},{"key":"ref19","unstructured":"Lyons M, Boucher O, Patel N, Birch B, Evidente V. Long-term benefit of bilateral subthalamic deep brain stimulation on camptocormia in parkinson\u2019s disease. Turkish Neurosurgery. 2012; 22: 489\u201392."},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Asahi T, Taguchi Y, Hayashi N, Hamada H, Dougu N, Takashima S, et al. Bilateral Subthalamic Deep Brain Stimulation for Camptocormia Associated with Parkinson\u2019s Disease. Stereotactic and Functional Neurosurgery. 2011; 89: 173\u2013177.","DOI":"10.1159\/000324907"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Capelle H, Schrader C, Blahak C, Fogel W, Kinfe TM, Baezner H, et al. Deep brain stimulation for camptocormia in dystonia and Parkinson\u2019s disease. Journal of Neurology. 2011; 258: 96\u2013103.","DOI":"10.1007\/s00415-010-5695-0"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Yamada K, Goto S, Matsuzaki K, Tamura T, Murase N, Shimazu H, et al. Alleviation of camptocormia by bilateral subthalamic nucleus stimulation in a patient with Parkinson\u2019s disease. Parkinsonism and Related Disorders. 2006; 12: 372\u2013375.","DOI":"10.1016\/j.parkreldis.2006.02.003"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Hellmann MA, Djaldetti R, Israel Z, Melamed E. Effect of deep brain subthalamic stimulation on camptocormia and postural abnormalities in idiopathic Parkinson\u2019s disease. Movement Disorders. 2006; 21: 2008\u20132010.","DOI":"10.1002\/mds.21090"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Thani NB, Bala A, Kimber TE, Lind CRP. High-Frequency Pallidal Stimulation for Camptocormia in Parkinson Disease: Case Report. Neurosurgery. 2011; 68: E1501\u2013E1505.","DOI":"10.1227\/NEU.0b013e318210c859"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Micheli F, Cers\u00f3simo MG, Piedimonte F. Camptocormia in a patient with Parkinson disease: beneficial effects of pallidal deep brain stimulation. Journal of Neurosurgery. 2005; 103: 1081\u20131083.","DOI":"10.3171\/jns.2005.103.6.1081"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Schlenstedt C, Gavriliuc O, Bo\u00dfe K, Wolke R, Granert O, Deuschl G, et al. The Effect of Medication and Deep Brain Stimulation on Posture in Parkinson\u2019s Disease. Frontiers in Neurology. 2019; 10: 1254.","DOI":"10.3389\/fneur.2019.01254"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Chan AK, Chan AY, Lau D, Durcanova B, Miller CA, Larson PS, et al. Surgical management of camptocormia in Parkinson\u2019s disease: systematic review and meta-analysis. Journal of Neurosurgery. 2019; 131: 368\u2013375.","DOI":"10.3171\/2018.4.JNS173032"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Magrinelli F, Geroin C, Squintani G, Gandolfi M, Rizzo G, Barillari M, et al. Upper camptocormia in Parkinson\u2019s disease: Neurophysiological and imaging findings of both central and peripheral pathophysiological mechanisms. Parkinsonism and Related Disorders. 2020; 71: 28\u201334.","DOI":"10.1016\/j.parkreldis.2020.01.004"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Lepoutre A, Devos D, Blanchard-Dauphin A, Pardessus V, Maurage C, Ferriby D, et al. A specific clinical pattern of camptocormia in Parkinson\u2019s disease. Journal of Neurology, Neurosurgery and Psychiatry. 2006; 77: 1229\u20131234.","DOI":"10.1136\/jnnp.2005.083998"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Tierney TS. Deep brain stimulation foundations and future trends. Frontiers in Bioscience. 2018; 23: 162\u2013182.","DOI":"10.2741\/4586"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Ramirez-Zamora A, Ostrem JL. Globus Pallidus Interna or Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease. JAMA Neurology. 2018; 75: 367.","DOI":"10.1001\/jamaneurol.2017.4321"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, et al. Pallidal versus Subthalamic Deep-Brain Stimulation for Parkinson\u2019s Disease. New England Journal of Medicine. 2010; 362: 2077\u20132091.","DOI":"10.1056\/NEJMoa0907083"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Tagliati M. Turning tables: should GPi become the preferred DBS target for Parkinson disease? Neurology. 2012; 79: 19\u201320.","DOI":"10.1212\/WNL.0b013e31825dce96"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/1\/10.31083\/j.jin2201011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T11:02:14Z","timestamp":1732705334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/1\/10.31083\/j.jin2201011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,5]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"alternative-id":["S0219-6352(22)00470-3"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2201011","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"value":"0219-6352","type":"print"},{"value":"1757-448X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,5]]},"article-number":"11"}}