{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:43:21Z","timestamp":1753890201566,"version":"3.41.2"},"reference-count":39,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the framework of state assignment","award":["121030100282-6"],"award-info":[{"award-number":["121030100282-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: Some individuals exhibit symptoms that resemble schizophrenia, but these manifestations are less in the degree to those seen in schizophrenia. Such a latent personality construct has been called schizotypy. It is known that schizotypal personality traits have an impact on cognitive control and semantic processing. The present study aimed to examine whether visual verbal information processing is modulated by enhancement of top-down processes applied to different words within one phrase in subjects with schizotypal personality traits. The tasks employed were based on differences in the involvement of cognitive control in visual verbal information processing and hypothesized that subjects with schizotypal traits would demonstrate failure in top-down modulation of word processing within a phrase. Methods: Forty-eight healthy undergraduate students were enrolled in the study. Participants were screened for schizotypy with the Schizotypal Personality Questionnaire. Word combinations consisting of an attribute and a noun were used as stimuli. Participants were asked to categorize one word in a phrase and to passively read the other word in the pair. To obtain neurophysiological data during task performance, the event-related brain potential N400 was measured. Results: In the low schizotypy scores group, an increased N400 amplitude was revealed for both attributes and nouns during passive reading compared to categorization. This effect was not observed in the high schizotypy scores group; therefore, word processing was modulated weakly by the experimental task in subjects with schizotypal personality traits. Conclusions: Changes observed in schizotypy can be regarded as a failure in top-down modulation of word processing within a phrase.<\/jats:p>","DOI":"10.31083\/j.jin2202035","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T07:33:00Z","timestamp":1676619180000},"source":"Crossref","is-referenced-by-count":0,"title":["Visual Verbal Information Processing under Conditions of Reading and Categorization in Schizotypy: An Event-Related Brain Potential Study"],"prefix":"10.31083","volume":"22","author":[{"given":"Natalia","family":"Nuzhina","sequence":"first","affiliation":[{"name":"Department of Normal Physiology named after N.Y. Belenkov, Privolzhsky Research Medical University, 603005 Nizhny Novgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Prodius","sequence":"first","affiliation":[{"name":"Department of Normal Physiology named after N.Y. Belenkov, Privolzhsky Research Medical University, 603005 Nizhny Novgorod, Russia"},{"name":"Department of Physiology and Anatomy, Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Mukhina","sequence":"first","affiliation":[{"name":"Department of Normal Physiology named after N.Y. Belenkov, Privolzhsky Research Medical University, 603005 Nizhny Novgorod, Russia"},{"name":"Department of Neurotechnologies, Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Lenzenweger MF. Schizotypy, schizotypic psychopathology and schizophrenia. World Psychiatry. 2018; 17: 25\u201326.","DOI":"10.1002\/wps.20479"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Lenzenweger MF. Schizotypy, Schizotypic Psychopathology, and Schizophrenia: Hearing Echoes, Leveraging Prior Advances, and Probing New Angles. Schizophrenia Bulletin. 2018; 44: S564\u2013S569.","DOI":"10.1093\/schbul\/sby083"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Kwapil TR, Barrantes-Vidal N. Schizotypy: looking back and moving forward. Schizophrenia Bulletin. 2015; 41: S366\u2013S373.","DOI":"10.1093\/schbul\/sbu186"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Kwapil TR, Gross GM, Silvia PJ, Barrantes-Vidal N. Prediction of psychopathology and functional impairment by positive and negative schizotypy in the Chapmans\u2019 ten-year longitudinal study. Journal of Abnormal Psychology. 2013; 122: 807\u2013815.","DOI":"10.1037\/a0033759"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Ettinger U, Mohr C, Gooding DC, Cohen AS, Rapp A, Haenschel C, et al. Cognition and brain function in schizotypy: a selective review. Schizophrenia Bulletin. 2015; 41: S417\u2013S426.","DOI":"10.1093\/schbul\/sbu190"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Radanovic M, Sousa RT, Valiengo L, Gattaz WF, Forlenza OV. Formal Thought Disorder and language impairment in schizophrenia. Arquivos De Neuro-psiquiatria. 2013; 71: 55\u201360.","DOI":"10.1590\/S0004-282X2012005000015"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Tonelli HA. How semantic deficits in schizotypy help understand language and thought disorders in schizophrenia: a systematic and integrative review. Trends in Psychiatry and Psychotherapy. 2014; 36: 75\u201388.","DOI":"10.1590\/2237-6089-2013-0053"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Katsuki F, Constantinidis C. Bottom-up and top-down attention: different processes and overlapping neural systems. The Neuroscientist. 2014; 20: 509\u2013521.","DOI":"10.1177\/1073858413514136"},{"key":"ref9","unstructured":"Treiman R. Linguistics and reading. 2017. Available at: https:\/\/www.researchgate.net\/publication\/318508341_Linguistics_and_reading (Accessed: 15 August 2022)."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Javitt DC. When doors of perception close: bottom-up models of disrupted cognition in schizophrenia. Annual Review of Clinical Psychology. 2009; 5: 249\u2013275.","DOI":"10.1146\/annurev.clinpsy.032408.153502"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Meyer L, Lakatos P, He Y. Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)? Frontiers in Neuroscience. 2021; 15: 640502.","DOI":"10.3389\/fnins.2021.640502"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Teufel C, Subramaniam N, Dobler V, Perez J, Finnemann J, Mehta PR, et al. Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112: 13401\u201313406.","DOI":"10.1073\/pnas.1503916112"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Koychev I, Deakin JFW, Haenschel C, El-Deredy W. Abnormal neural oscillations in schizotypy during a visual working memory task: support for a deficient top-down network? Neuropsychologia. 2011; 49: 2866\u20132873.","DOI":"10.1016\/j.neuropsychologia.2011.06.012"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Rominger C, Fink A, Weiss EM, Bosch J, Papousek I. Allusive thinking (remote associations) and auditory top-down inhibition skills differentially predict creativity and positive schizotypy. Cognitive Neuropsychiatry. 2017; 22: 108\u2013121.","DOI":"10.1080\/13546805.2016.1278361"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Kiefer M. Top-down modulation of unconscious \u2018automatic\u2019 processes: A gating framework. Advances in Cognitive Psychology. 2008; 3: 289\u2013306.","DOI":"10.2478\/v10053-008-0031-2"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Kutas M, Federmeier KD. Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Annual Review of Psychology. 2011; 62: 621\u2013647.","DOI":"10.1146\/annurev.psych.093008.131123"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kiang M, Kutas M. Association of schizotypy with semantic processing differences: an event-related brain potential study. Schizophrenia Research. 2005; 77: 329\u2013342.","DOI":"10.1016\/j.schres.2005.03.021"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Kiang M, Prugh J, Kutas M. An event-related brain potential study of schizotypal personality and associative semantic processing. International Journal of Psychophysiology. 2010; 75: 119\u2013126.","DOI":"10.1016\/j.ijpsycho.2009.10.005"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Pr\u00e9vost M, Rodier M, Renoult L, Kwann Y, Dionne-Dostie E, Chapleau I, et al. Schizotypal traits and N400 in healthy subjects. Psychophysiology. 2010; 47: 1047\u20131056.","DOI":"10.1111\/j.1469-8986.2010.01016.x"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Kostova M, Bohec AL, Blanchet A. Event-related brain potential study of expectancy and semantic matching in schizotypy. International Journal of Psychophysiology. 2014; 92: 67\u201373.","DOI":"10.1016\/j.ijpsycho.2014.02.006"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Del Goleto S, Kostova M, Blanchet A. Impaired context processing during irony comprehension in schizotypy: An ERPs study. International Journal of Psychophysiology. 2016; 105: 17\u201325.","DOI":"10.1016\/j.ijpsycho.2016.04.009"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Mohammad OM, DeLisi LE. N400 in schizophrenia patients. Current Opinion in Psychiatry. 2013; 26: 196\u2013207.","DOI":"10.1097\/YCO.0b013e32835d9e56"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Nour Eddine S, Brothers T, Kuperberg GR. The N400 in silico: A review of computational models. 2022. Available at: https:\/\/www.researchgate.net\/publication\/361032050_The_N400_in_silico_A_review_of_computational_models (Accessed: 5 December 2022).","DOI":"10.1016\/bs.plm.2022.03.005"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Noppeney U, Price CJ, Penny WD, Friston KJ. Two distinct neural mechanisms for category-selective responses. Cerebral Cortex. 2006; 16: 437\u2013445.","DOI":"10.1093\/cercor\/bhi123"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Kreher DA, Goff D, Kuperberg GR. Why all the confusion? Experimental task explains discrepant semantic priming effects in schizophrenia under \u201cautomatic\u201d conditions: evidence from Event-Related Potentials. Schizophrenia Research. 2009; 111: 174\u2013181.","DOI":"10.1016\/j.schres.2009.03.013"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Shang M, Debruille JB. N400 processes inhibit inappropriately activated representations: adding a piece of evidence from a high-repetition design. Neuropsychologia. 2013; 51: 1989\u20131997.","DOI":"10.1016\/j.neuropsychologia.2013.06.006"},{"key":"ref27","unstructured":"Mar\u2019ina IV, Strelets VB. Verbal stimuli semantics and relevance of ERPs. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova. 2010; 60: 22\u201331. (In Russian)"},{"key":"ref28","unstructured":"Mar\u2019ina IV, Strelets VB, Garakh ZhV, Novototski\u012d-Vlasov VIu, Za\u012dtseva IuS. Analysis of event-related potentials to verbal stimuli in healthy subjects and schizophrenia patients. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova. 2012; 62: 157\u2013164. (In Russian)"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Noesselt T, Shah NJ, J\u00e4ncke L. Top-down and bottom-up modulation of language related areas\u2013an fMRI study. BMC Neuroscience. 2003; 4: 13.","DOI":"10.1186\/1471-2202-4-13"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin. 1991; 17: 555\u2013564.","DOI":"10.1093\/schbul\/17.4.555"},{"key":"ref31","unstructured":"Lyashevskaya ON, Sharov SA. Frequency dictionary of the modern Russian language. Azbykovnic: Moscow. 2009. (In Russian)"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Ilankovic LM, Allen PP, Engel R, Kambeitz J, Riedel M, M\u00fcller N, et al. Attentional modulation of external speech attribution in patients with hallucinations and delusions. Neuropsychologia. 2011; 49: 805\u2013812.","DOI":"10.1016\/j.neuropsychologia.2011.01.016"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Aleman A, B\u00f6cker KBE, Hijman R, de Haan EHF, Kahn RS. Cognitive basis of hallucinations in schizophrenia: role of top-down information processing. Schizophrenia Research. 2003; 64: 175\u2013185.","DOI":"10.1016\/S0920-9964(03)00060-4"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Vercammen A, de Haan EHF, Aleman A. Hearing a voice in the noise: auditory hallucinations and speech perception. Psychological Medicine. 2008; 38: 1177\u20131184.","DOI":"10.1017\/S0033291707002437"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Strijkers K, Costa A, Thierry G. Tracking lexical access in speech production: electrophysiological correlates of word frequency and cognate effects. Cerebral Cortex. 2010; 20: 912\u2013928.","DOI":"10.1093\/cercor\/bhp153"},{"key":"ref36","unstructured":"National Corpus of the Russian Language. 2022. Available at: https:\/\/ruscorpora.ru\/new\/corpora-stat.html (Accessed: 15 August 2022)."},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Bemis DK, Pylkk\u00e4nen L. Simple composition: a magnetoencephalography investigation into the comprehension of minimal linguistic phrases. The Journal of Neuroscience. 2011; 31: 2801\u20132814.","DOI":"10.1523\/JNEUROSCI.5003-10.2011"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Halgren E, Dhond RP, Christensen N, Van Petten C, Marinkovic K, Lewine JD, et al. N400-like magnetoencephalography responses modulated by semantic context, word frequency, and lexical class in sentences. NeuroImage. 2002; 17: 1101\u20131116.","DOI":"10.1006\/nimg.2002.1268"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Payne BR, Lee CL, Federmeier KD. Revisiting the incremental effects of context on word processing: Evidence from single-word event-related brain potentials. Psychophysiology. 2015; 52: 1456\u20131469.","DOI":"10.1111\/psyp.12515"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/2\/10.31083\/j.jin2202035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:08:11Z","timestamp":1732723691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/2\/10.31083\/j.jin2202035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"alternative-id":["S0219-6352(23)00509-0"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2202035","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"type":"print","value":"0219-6352"},{"type":"electronic","value":"1757-448X"}],"subject":[],"published":{"date-parts":[[2023,2,16]]},"article-number":"35"}}