{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:32:41Z","timestamp":1769517161970,"version":"3.49.0"},"reference-count":49,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: The term Fetal Alcohol Spectrum Disorders (FASD) describes a range of neurodevelopmental conditions, the direct result of prenatal alcohol exposure. FASD encompasses a range of behavioural, cognitive and sleep patterns that are sometimes indiscernible from other neurodevelopmental conditions, one in particular being Autism Spectrum Disorders (ASD). This study aimed to provide a comparison of behavioural, cognitive, affect-related and sleep profiles in children aged between 6 and 15 years with diagnoses of FASD or ASD, in contrast to typically developing (TD) children. Methods: We compared 29 children with FASD, 21 children with ASD and 45 typically developing (TD) children on parental-reported questionnaires measuring behaviour and executive functioning: the Child Behaviour Checklist (CBCL), the Spence Children\u2019s Anxiety Scale (SCAS) and the Behaviour Rating Inventory for Executive Function (BRIEF). Additionally, parents completed the Children\u2019s Sleep Habits Questionnaire (CSHQ), and children wore actigraphy watches while sleeping to objectively capture their sleep habits. The three groups were compared using ANCOVA, controlling for age effects. Results: Children with FASD scored significantly higher than the other two groups on the CBCL subscales of attention problems, somatic complaints, social problems, delinquency, and aggressive behaviour, as well as the panic subscale of the SCAS. Children with FASD also scored higher on all measures of the BRIEF than the ASD and TD groups, indicating greater problems with working memory and more difficulty shifting between tasks, planning, organising, inhibiting their behaviour and exercising emotional control. Nocturnal sleep duration in children with FASD was reported as one hour less than TD children and 46 minutes less than children with ASD per night. Conclusions: The findings in this study highlight several syndrome specific features (shorter sleep duration, executive functioning difficulties, and higher levels of social and behavioural problems and panic) that potentially contribute to the unique phenotype of FASD. Whilst this research highlights the need for further work in this area, initial clinical screening for FASD should take such data on discernible characteristics, particularly the syndrome specificity of the BRIEF, into consideration.<\/jats:p>","DOI":"10.31083\/j.jin2203077","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:51:38Z","timestamp":1684716698000},"source":"Crossref","is-referenced-by-count":8,"title":["Towards a Distinct Sleep and Behavioural Profile of Fetal Alcohol Spectrum Disorder (FASD): A Comparison between FASD, Autism and Typically Developing Children"],"prefix":"10.31083","volume":"22","author":[{"given":"Amy A.","family":"Benson","sequence":"first","affiliation":[{"name":"Sleep Education and Research Laboratory (SERL), UCL Institute of Education, WC1H 0AL London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabya","family":"Mughal","sequence":"first","affiliation":[{"name":"Sleep Education and Research Laboratory (SERL), UCL Institute of Education, WC1H 0AL London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmara","family":"Dimitriou","sequence":"first","affiliation":[{"name":"Sleep Education and Research Laboratory (SERL), UCL Institute of Education, WC1H 0AL London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Halstead","sequence":"first","affiliation":[{"name":"Psychology and Human Development Department, IOE Faculty of Society and Education, University College London, WC1E 6BT London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"May PA, Baete A, Russo J, Elliott AJ, Blankenship J, Kalberg WO, et al. Prevalence and characteristics of fetal alcohol spectrum disorders. Pediatrics. 2014; 134: 855\u2013866.","DOI":"10.1542\/peds.2013-3319"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"May PA, Gossage JP, Kalberg WO, Robinson LK, Buckley D, Manning M, et al. Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Developmental Disabilities Research Reviews. 2009; 15: 176\u2013192.","DOI":"10.1002\/ddrr.68"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Popova S, Lange S, Probst C, Gmel G, Rehm J. Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. The Lancet. Global Health. 2017; 5: e290\u2013e299.","DOI":"10.1016\/S2214-109X(17)30021-9"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Chen ML, Olson HC, Picciano JF, Starr JR, Owens J. Sleep problems in children with fetal alcohol spectrum disorders. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine. 2012; 8: 421\u2013429.","DOI":"10.5664\/jcsm.2038"},{"key":"ref5","unstructured":"Coriale G, Fiorentino D, Di Lauro F, Marchitelli R, Scalese B, Fiore M, et al. Fetal Alcohol Spectrum Disorder (FASD): neurobehavioral profile, indications for diagnosis and treatment. Rivista Di Psichiatria. 2013; 48: 359\u2013369."},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Hayes N, Moritz KM, Reid N. Parent-reported sleep problems in school-aged children with fetal alcohol spectrum disorder: association with child behaviour, caregiver, and family functioning. Sleep Medicine. 2020; 74: 307\u2013314.","DOI":"10.1016\/j.sleep.2020.07.022"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Pesonen AK, R\u00e4ikk\u00f6nen K, Matthews K, Heinonen K, Paavonen JE, Lahti J, et al. Prenatal origins of poor sleep in children. Sleep. 2009; 32: 1086\u20131092.","DOI":"10.1093\/sleep\/32.8.1086"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Chen CP, Kuhn P, Advis JP, Sarkar DK. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Journal of Neurochemistry. 2006; 97: 1026\u20131033.","DOI":"10.1111\/j.1471-4159.2006.03839.x"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Donald KA, Eastman E, Howells FM, Adnams C, Riley EP, Woods RP, et al. Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review. Acta Neuropsychiatrica. 2015; 27: 251\u2013269.","DOI":"10.1017\/neu.2015.12"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Spadoni AD, McGee CL, Fryer SL, Riley EP. Neuroimaging and fetal alcohol spectrum disorders. Neuroscience and Biobehavioral Reviews. 2007; 31: 239\u2013245.","DOI":"10.1016\/j.neubiorev.2006.09.006"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Goril S, Zalai D, Scott L, Shapiro CM. Sleep and melatonin secretion abnormalities in children and adolescents with fetal alcohol spectrum disorders. Sleep Medicine. 2016; 23: 59\u201364.","DOI":"10.1016\/j.sleep.2016.06.002"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Dylag KA, Bando B, Baran Z, Dumnicka P, Kowalska K, Kulaga P, et al. Sleep problems among children with Fetal Alcohol Spectrum Disorders (FASD)- an explorative study. Italian Journal of Pediatrics. 2021; 47: 113.","DOI":"10.1186\/s13052-021-01056-x"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Green CR, Mihic AM, Nikkel SM, Stade BC, Rasmussen C, Munoz DP, et al. Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). Journal of Child Psychology and Psychiatry, and Allied Disciplines. 2009; 50: 688\u2013697.","DOI":"10.1111\/j.1469-7610.2008.01990.x"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Mazurek MO, Sohl K. Sleep and Behavioral Problems in Children with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. 2016; 46: 1906\u20131915.","DOI":"10.1007\/s10803-016-2723-7"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Mughal R, Hill CM, Joyce A, Dimitriou D. Sleep and Cognition in Children with Fetal Alcohol Spectrum Disorders (FASD) and Children with Autism Spectrum Disorders (ASD). Brain Sciences. 2020; 10: 863.","DOI":"10.3390\/brainsci10110863"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Fadini CC, Lam\u00f4nica DA, Fett-Conte AC, Os\u00f3rio E, Zuculo GM, Giacheti CM, et al. Influence of sleep disorders on the behavior of individuals with autism spectrum disorder. Frontiers in Human Neuroscience. 2015; 9: 347.","DOI":"10.3389\/fnhum.2015.00347"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Hirata I, Mohri I, Kato-Nishimura K, Tachibana M, Kuwada A, Kagitani-Shimono K, et al. Sleep problems are more frequent and associated with problematic behaviors in preschoolers with autism spectrum disorder. Research in Developmental Disabilities. 2016; 49-50: 86\u201399.","DOI":"10.1016\/j.ridd.2015.11.002"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Bishop S, Gahagan S, Lord C. Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 2007; 48: 1111\u20131121.","DOI":"10.1111\/j.1469-7610.2007.01782.x"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Kheirandish L, Gozal D. Neurocognitive dysfunction in children with sleep disorders. Developmental Science. 2006; 9: 388\u2013399.","DOI":"10.1111\/j.1467-7687.2006.00504.x"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Maski KP, Kothare SV. Sleep deprivation and neurobehavioral functioning in children. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology. 2013; 89: 259\u2013264.","DOI":"10.1016\/j.ijpsycho.2013.06.019"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Mazzone L, Postorino V, Siracusano M, Riccioni A, Curatolo P. The Relationship between Sleep Problems, Neurobiological Alterations, Core Symptoms of Autism Spectrum Disorder, and Psychiatric Comorbidities. Journal of Clinical Medicine. 2018; 7: 102.","DOI":"10.3390\/jcm7050102"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Pagan C, Goubran-Botros H, Delorme R, Benabou M, Lemi\u00e8re N, Murray K, et al. Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders. Scientific Reports. 2017; 7: 2096.","DOI":"10.1038\/s41598-017-02152-x"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry. 2005; 57: 134\u2013138.","DOI":"10.1016\/j.biopsych.2004.11.003"},{"key":"ref24","unstructured":"Office for National Statistics. The National Statistics Socio-economic classification (NS-SEC). 2016. Available at: https:\/\/www.ons.gov.uk\/methodology\/classificationsandstandards\/otherclassifications\/thenationalstatisticssocioeconomicclassificationnssecrebasedonsoc2010 (Accessed: 1 March 2023)."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Schopler E, Reichler RJ, DeVellis RF, Daly K. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of Autism and Developmental Disorders. 1980; 10: 91\u2013103.","DOI":"10.1007\/BF02408436"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Garfin DG, McCallon D, Cox R. Validity and reliability of the Childhood Autism Rating Scale with autistic adolescents. Journal of Autism and Developmental Disorders. 1988; 18: 367\u2013378.","DOI":"10.1007\/BF02212193"},{"key":"ref27","unstructured":"Nash K, Koren G, Rovet J. A differential approach for examining the behavioural phenotype of fetal alcohol spectrum disorders. Journal of Population Therapeutics and Clinical Pharmacology = Journal De La Therapeutique Des Populations et De La Pharmacologie Clinique. 2011; 18: e440\u2013e453."},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Spence SH. A measure of anxiety symptoms among children. Behaviour Research and Therapy. 1998; 36: 545\u2013566.","DOI":"10.1016\/S0005-7967(98)00034-5"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Spence SH. Structure of anxiety symptoms among children: a confirmatory factor-analytic study. Journal of Abnormal Psychology. 1997; 106: 280\u2013297.","DOI":"10.1037\/\/0021-843X.106.2.280"},{"key":"ref30","unstructured":"Achenbach TM. Child Behavior Checklist. In Kreutzer JS, DeLuca J, Caplan B (eds.) Encyclopaedia of Clinical Neuropsychology. Springer: New York. 2011."},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Bean T, Mooijart A, Eurelings-Bontekoe E, Spinhoven P. Validation of the child behavior checklist for guardians of unaccompanied refugee minors. Children and Youth Services Review. 2006; 28: 867\u2013887.","DOI":"10.1016\/j.childyouth.2005.09.002"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Roth RM, Isquith PK, Gioia GA. Assessment of executive functioning using the behavior rating inventory of executive function (BRIEF). Handbook of Executive Functioning. Springer: Berlin. 2014.","DOI":"10.1007\/978-1-4614-8106-5_18"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Owens JA, Spirito A, McGuinn M. The Children\u2019s Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep. 2000; 23: 1043\u20131051.","DOI":"10.1093\/sleep\/23.8.1d"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Khoury JE, Jamieson B, Milligan K. Risk for Childhood Internalizing and Externalizing Behavior Problems in the Context of Prenatal Alcohol Exposure: A Meta-Analysis and Comprehensive Examination of Moderators. Alcoholism, Clinical and Experimental Research. 2018. (online ahead of print)","DOI":"10.1111\/acer.13805"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Ronen D, Senecky Y, Chodick G, Ganelin-Cohen E. The contribution of the Neurobehavioral Screening Tool to identifying fetal alcohol spectrum disorders in children at high risk of prenatal alcohol exposure and neurobehavioral deficits. Early Human Development. 2022; 170: 105608.","DOI":"10.1016\/j.earlhumdev.2022.105608"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Fast DK, Conry J. Fetal alcohol spectrum disorders and the criminal justice system. Developmental Disabilities Research Reviews. 2009; 15: 250\u2013257.","DOI":"10.1002\/ddrr.66"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Stevens SA, Nash K, Koren G, Rovet J. Autism characteristics in children with fetal alcohol spectrum disorders. Child Neuropsychology. 2013; 19: 579\u2013587.","DOI":"10.1080\/09297049.2012.727791"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Alberry BLJ, Castellani CA, Singh SM. Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder. Journal of Neurodevelopmental Disorders. 2020; 12: 15.","DOI":"10.1186\/s11689-020-09316-3"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Alberry B, Singh SM. Developmental and behavioral consequences of early life maternal separation stress in a mouse model of fetal alcohol spectrum disorder. Behavioural Brain Research. 2016; 308: 94\u2013103.","DOI":"10.1016\/j.bbr.2016.04.031"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Mohamed Z, Carlisle ACS, Livesey AC, Mukherjee RAS. Comparisons of the BRIEF parental report and neuropsychological clinical tests of executive function in Fetal Alcohol Spectrum Disorders: data from the UK national specialist clinic. Child Neuropsychology. 2019; 25: 648\u2013663.","DOI":"10.1080\/09297049.2018.1516202"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Rai JK, Abecassis M, Casey JE, Flaro L, Erdodi LA, Roth RM. Parent rating of executive function in fetal alcohol spectrum disorder: A review of the literature and new data on Aboriginal Canadian children. Child Neuropsychology. 2017; 23: 713\u2013732.","DOI":"10.1080\/09297049.2016.1191628"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Rasmussen C, Horne K, Witol A. Neurobehavioral functioning in children with fetal alcohol spectrum disorder. Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence. 2006; 12: 453\u2013468.","DOI":"10.1080\/09297040600646854"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Mughal R, Joyce A, Hill C, Dimitriou D. Sleep disturbance as a predictor of anxiety in children with Fetal Alcohol Spectrum Disorders and typically developing children. Research in Developmental Disabilities. 2020; 101: 103610.","DOI":"10.1016\/j.ridd.2020.103610"},{"key":"ref44","unstructured":"Davis T, White S, Ollendick T. Handbook of autism and anxiety. In Autism and child psychopathology series. Springer, Switzerland, 2014."},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Hanft A, Burnham M, Goodlin-Jones B, Anders TF. Sleep Architecture in Infants of Substance-Abusing Mothers. Infant Mental Health Journal. 2006; 27: 141\u2013151.","DOI":"10.1002\/imhj.20085"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"D\u00edaz-Rom\u00e1n A, Zhang J, Delorme R, Beggiato A, Cortese S. Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies. Evidence-based Mental Health. 2018; 21: 146\u2013154.","DOI":"10.1136\/ebmental-2018-300037"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Humphreys JS, Gringras P, Blair PS, Scott N, Henderson J, Fleming PJ, et al. Sleep patterns in children with autistic spectrum disorders: a prospective cohort study. Archives of Disease in Childhood. 2014; 99: 114\u2013118.","DOI":"10.1136\/archdischild-2013-304083"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Perp\u00e9tuo C, Fernandes M, Ver\u00edssimo M. Comparison Between Actigraphy Records and Parental Reports of Child\u2019s Sleep. Frontiers in Pediatrics. 2020; 8: 567390.","DOI":"10.3389\/fped.2020.567390"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Werner H, Molinari L, Guyer C, Jenni OG. Agreement rates between actigraphy, diary, and questionnaire for children\u2019s sleep patterns. Archives of Pediatrics & Adolescent Medicine. 2008; 162: 350\u2013358.","DOI":"10.1001\/archpedi.162.4.350"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/3\/10.31083\/j.jin2203077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:10:02Z","timestamp":1732723802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/3\/10.31083\/j.jin2203077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"alternative-id":["S0219-6352(23)00531-4"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2203077","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"value":"0219-6352","type":"print"},{"value":"1757-448X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"article-number":"77"}}