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Neurosci."],"abstract":"<jats:p>In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To complete this review, comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, and PsycINFO databases for English scientific peer-reviewed articles through December 2022. This short review addressed the different sources of oxidative stress and its effects on blood-brain barrier (BBB) dysfunction, mitochondrial damage, and changes in a variety of inflammatory molecules associated with central nervous system (CNS) injury. At last, we explained the potential efficacy of the Nrf2 transcription factor in reducing oxidative stress-mediated secondary damages after a CNS injury. The role of CPUY192018, an inhibitor of Nrf2-Keap1 protein-protein interaction in protecting the injured brain cells is given as evidence of Nrf2\u2019s role in activating antioxidant genes. Overall, the scope of Nrf2 in developing therapeutic interventions for a variety of pathophysiological conditions associated with CNS injury-induced free radical\/inflammatory signaling is acknowledged. Nrf2 has a widespread application in basic and clinical neuroscience for understanding and treating free radical\/inflammatory signaling disorders, including neurological diseases. The development of innovative therapeutic strategies using Nrf2-inducing agents can be applied to reduce the complications of TBI before advancing it to posttraumatic stress disorder (PTSD).<\/jats:p>","DOI":"10.31083\/j.jin2204081","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T21:01:59Z","timestamp":1687899719000},"source":"Crossref","is-referenced-by-count":38,"title":["Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury"],"prefix":"10.31083","volume":"22","author":[{"given":"P. M.","family":"Abdul-Muneer","sequence":"first","affiliation":[{"name":"Laboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian JFK University Medical Center, Edison, NJ 08820, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Abdul-Muneer PM, Schuetz H, Wang F, Skotak M, Jones J, Gorantla S, et al. Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast. Free Radical Biology & Medicine. 2013; 60: 282\u2013291.","DOI":"10.1016\/j.freeradbiomed.2013.02.029"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Bhowmick S, D\u2019Mello V, Ponery N, Abdul-Muneer PM. Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury. 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