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Occlusion of large arteries due to atherothrombosis, cerebral embolism (i.e., embolic infarction), no thrombotic occlusion in small, deep cerebral arteries (i.e., lacunar infarction), and stenosis of proximal arteries due to hypotension leading to decreased cerebral blood flow in arterial supply zones are the most common causes of ischemic stroke (i.e., hemodynamic stroke). It is now known that organelles play an important role in various signaling events and cellular functions. The molecular mechanisms of mitochondria are involved in cerebral ischemia by generating and scavenging reactive oxygen species, apoptosis, biogenesis, mitochondrial dynamics, and inflammation are all examples of electron transport chain dysfunction. More knowledge about the involvement of mitochondria in ischemia-induced neuronal death and neuronal protection will contribute to the development of better treatment programs for stroke syndromes such as ischemic stroke.<\/jats:p>","DOI":"10.31083\/j.jin2204088","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T08:48:52Z","timestamp":1688719732000},"source":"Crossref","is-referenced-by-count":19,"title":["The Role of Mitochondrial Biogenesis in Ischemic Stroke"],"prefix":"10.31083","volume":"22","author":[{"given":"Behrouz","family":"Shademan","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Ege University, 35040 Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigir Biray","family":"Avci","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Ege University, 35040 Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahidreza","family":"Karamad","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Ege University, 35040 Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza Jahangirzadeh","family":"Soureh","sequence":"first","affiliation":[{"name":"Department of Genetics, Tabriz Branch, Islamic Azad University, 43351-14543 Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalhe Bagheri Hamzyan","family":"Olia","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Khoy University of Medical Sciences, 58139-68197 Khoy, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Esmaily","sequence":"first","affiliation":[{"name":"Department of Biology, Sciences and Research Branch, Islamic Azad University, 43351-14543 Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Nourazarian","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Khoy University of Medical Sciences, 58139-68197 Khoy, Iran"},{"name":"Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, 91656-73117 Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Nikanfar","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, 91656-73117 Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Shademan B, Nourazarian A, Laghousi D, Karamad V, Nikanfar M. 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