{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:32:54Z","timestamp":1791973974472,"version":"4.4.0"},"reference-count":70,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31770381"],"award-info":[{"award-number":["31770381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific\u00a0Research\u00a0Fund\u00a0of\u00a0Wuhan\u00a0Municipal\u00a0Health\u00a0Commission","award":["WZ20D07"],"award-info":[{"award-number":["WZ20D07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Considerable evidence has shown that the breakdown of myelin has been linked to Alzheimer\u2019s disease (AD). Considering the vulnerability of oligodendrocytes to Alzheimer\u2019s disease, the myelin sheath breakdown and degeneration are easily induced, suggesting that dysfunction of the oligodendrocytes could be the first step in the progression at the early AD before the occurrence of amyloid and tau pathology. It is considered that amyloid \u03b2-peptide (A\u03b2)-mediated oligodendrocyte dysfunction and demyelination could be manifested through neuroinflammation, oxidative stress, and neuronal ferroptosis. With the development of single-cell sequencing technology, an oligodendrocyte state that increased in association with central nervous system brain pathology (designated as disease-associated oligodendrocytes) has been identified. In the current review, we examine the possible roles of oligodendrocytes in cognitive decline and their molecular characteristics in AD. Altogether, our findings elucidate that targeting oligodendrocytes may be a novel treatment or prevention option for AD.<\/jats:p>","DOI":"10.31083\/j.jin2204090","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T08:48:52Z","timestamp":1688719732000},"source":"Crossref","is-referenced-by-count":25,"title":["Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies"],"prefix":"10.31083","volume":"22","author":[{"given":"Peng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiLei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Wuhan Fourth Hospital, 430030 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mantzavinos V, Alexiou A. Biomarkers for Alzheimer\u2019s Disease Diagnosis. Current Alzheimer Research. 2017; 14: 1149\u20131154.","DOI":"10.2174\/1567205014666170203125942"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Tan C, Yu J, Tan L. Biomarkers for preclinical Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease. 2014; 42: 1051\u20131069.","DOI":"10.3233\/JAD-140843"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Golde TE. Disease-Modifying Therapies for Alzheimer\u2019s Disease: More Questions than Answers. Neurotherapeutics. 2022; 19: 209\u2013227.","DOI":"10.1007\/s13311-022-01201-2"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Cornell J, Salinas S, Huang H, Zhou M. Microglia regulation of synaptic plasticity and learning and memory. Neural Regeneration Research. 2022; 17: 705\u2013716.","DOI":"10.4103\/1673-5374.322423"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, et al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022; 185: 2213\u20132233.e25.","DOI":"10.1016\/j.cell.2022.05.017"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Sadick JS, O\u2019Dea MR, Hasel P, Dykstra T, Faustin A, Liddelow SA. Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer\u2019s disease. Neuron. 2022; 110: 1788\u20131805.e10.","DOI":"10.1016\/j.neuron.2022.03.008"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Allen NJ, Lyons DA. Glia as architects of central nervous system formation and function. Science. 2018; 362: 181\u2013185.","DOI":"10.1126\/science.aat0473"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Kang M, Yao Y. Laminin regulates oligodendrocyte development and myelination. Glia. 2022; 70: 414\u2013429.","DOI":"10.1002\/glia.24117"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Raffaele S, Boccazzi M, Fumagalli M. Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives. Cells. 2021; 10: 565.","DOI":"10.3390\/cells10030565"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Chen K, Wellman SM, Yaxiaer Y, Eles JR, Kozai TD. In vivo spatiotemporal patterns of oligodendrocyte and myelin damage at the neural electrode interface. Biomaterials. 2021; 268: 120526.","DOI":"10.1016\/j.biomaterials.2020.120526"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Neely SA, Williamson JM, Klingseisen A, Zoupi L, Early JJ, Williams A, et al. New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination. Nature Neuroscience. 2022; 25: 415\u2013420.","DOI":"10.1038\/s41593-021-01009-x"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Chen J, Wang F, Huang N, Xiao L, Mei F. Oligodendrocytes and myelin: Active players in neurodegenerative brains? Developmental Neurobiology. 2022; 82: 160\u2013174.","DOI":"10.1002\/dneu.22867"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Lee S, Rezzonico MG, Friedman BA, Huntley MH, Meilandt WJ, Pandey S, et al. TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease. Cell Reports. 2021; 37: 110158.","DOI":"10.1016\/j.celrep.2021.110158"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Xiao Y, Petrucco L, Hoodless LJ, Portugues R, Czopka T. Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Nature Neuroscience. 2022; 25: 280\u2013284.","DOI":"10.1038\/s41593-022-01023-7"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Clayton BLL, Tesar PJ. Oligodendrocyte progenitor cell fate and function in development and disease. Current Opinion in Cell Biology. 2021; 73: 35\u201340.","DOI":"10.1016\/j.ceb.2021.05.003"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Kim WS, Hsiao JT, Bhatia S, Glaros EN, Don AS, Tsuruoka S, et al. ABCA8 stimulates sphingomyelin production in oligodendrocytes. The Biochemical Journal. 2013; 452: 401\u2013410.","DOI":"10.1042\/BJ20121764"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Cohen CCH, Popovic MA, Klooster J, Weil M, M\u00f6bius W, Nave K, et al. Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. Cell. 2020; 180: 311\u2013322.e15.","DOI":"10.1016\/j.cell.2019.11.039"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Xu S, Lu J, Shao A, Zhang JH, Zhang J. Glial Cells: Role of the Immune Response in Ischemic Stroke. Frontiers in Immunology. 2020; 11: 294.","DOI":"10.3389\/fimmu.2020.00294"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Hase Y, Horsburgh K, Ihara M, Kalaria RN. White matter degeneration in vascular and other ageing-related dementias. Journal of Neurochemistry. 2018; 144: 617\u2013633.","DOI":"10.1111\/jnc.14271"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Zang C, Liu H, Ju C, Yuan F, Ning J, Shang M, et al. Gardenia jasminoides J. Ellis extract alleviated white matter damage through promoting the differentiation of oligodendrocyte precursor cells via suppressing neuroinflammation. Food & Function. 2022; 13: 2131\u20132141.","DOI":"10.1039\/D1FO02127C"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Nave KA, Werner HB. Myelination of the nervous system: mechanisms and functions. Annual Review of Cell and Developmental Biology. 2014; 30: 503\u2013533.","DOI":"10.1146\/annurev-cellbio-100913-013101"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Bonetto G, Belin D, K\u00e1rad\u00f3ttir RT. Myelin: A gatekeeper of activity-dependent circuit plasticity? Science. 2021; 374: eaba6905.","DOI":"10.1126\/science.aba6905"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Morelli AM, Chiantore M, Ravera S, Scholkmann F, Panfoli I. Myelin sheath and cyanobacterial thylakoids as concentric multilamellar structures with similar bioenergetic properties. Open Biology. 2021; 11: 210177.","DOI":"10.1098\/rsob.210177"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Gupta M, Weaver DF. Microsecond molecular dynamics studies of cholesterol-mediated myelin sheath degeneration in early Alzheimer\u2019s disease. Physical Chemistry Chemical Physics. 2021; 24: 222\u2013239.","DOI":"10.1039\/D1CP03844C"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Butt AM, Rivera AD, Fulton D, Azim K. Targeting the Subventricular Zone to Promote Myelin Repair in the Aging Brain. Cells. 2022; 11: 1809.","DOI":"10.3390\/cells11111809"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ. Triple-transgenic Alzheimer\u2019s disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia. 2009; 57: 54\u201365.","DOI":"10.1002\/glia.20734"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Pak K, Chan SL, Mattson MP. Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice. Neuromolecular Medicine. 2003; 3: 53\u201364.","DOI":"10.1385\/NMM:3:1:53"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Truong PH, Ciccotosto GD, Merson TD, Spoerri L, Chuei MJ, Ayers M, et al. Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons. Glia. 2019; 67: 525\u2013538.","DOI":"10.1002\/glia.23561"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Aires V, Ziegler-Waldkirch S, Friesen M, Reichardt W, Erny D, Loreth D, et al. Seed-induced A\u03b2 deposits in the corpus callosum disrupt white matter integrity in a mouse model of Alzheimer\u2019s disease. Frontiers in Cellular Neuroscience. 2022; 16: 862918.","DOI":"10.3389\/fncel.2022.862918"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Agosta F, Dalla Libera D, Spinelli EG, Finardi A, Canu E, Bergami A, et al. Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. Annals of Neurology. 2014; 76: 813\u2013825.","DOI":"10.1002\/ana.24235"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Behrendt G, Baer K, Buffo A, Curtis MA, Faull RL, Rees MI, et al. Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men. Glia. 2013; 61: 273\u2013286.","DOI":"10.1002\/glia.22432"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ. Early oligodendrocyte\/myelin pathology in Alzheimer\u2019s disease mice constitutes a novel therapeutic target. The American Journal of Pathology. 2010; 177: 1422\u20131435.","DOI":"10.2353\/ajpath.2010.100087"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin L, Itoh T, et al. Amyloid \u03b21-42 oligomer inhibits myelin sheet formation in vitro. Neurobiology of Aging. 2012; 33: 499\u2013509.","DOI":"10.1016\/j.neurobiolaging.2010.05.007"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Nasrabady SE, Rizvi B, Goldman JE, Brickman AM. White matter changes in Alzheimer\u2019s disease: a focus on myelin and oligodendrocytes. Acta Neuropathologica Communications. 2018; 6: 22.","DOI":"10.1186\/s40478-018-0515-3"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Desai MK, Guercio BJ, Narrow WC, Bowers WJ. An Alzheimer\u2019s disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia. 2011; 59: 627\u2013640.","DOI":"10.1002\/glia.21131"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Mitew S, Kirkcaldie MTK, Halliday GM, Shepherd CE, Vickers JC, Dickson TC. Focal demyelination in Alzheimer\u2019s disease and transgenic mouse models. Acta Neuropathologica. 2010; 119: 567\u2013577.","DOI":"10.1007\/s00401-010-0657-2"},{"key":"ref37","unstructured":"Feng W, Zhang Y, Sun P, Xiao M. Acquired immunity and Alzheimer\u2019s disease. Journal of Biomedical Research. 2022. (online ahead of print)"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Singhrao SK, Neal JW, Piddlesden SJ, Newman GR. New immunocytochemical evidence for a neuronal\/oligodendroglial origin for corpora amylacea. Neuropathology and Applied Neurobiology. 1994; 20: 66\u201373.","DOI":"10.1111\/j.1365-2990.1994.tb00958.x"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Povala G, Bellaver B, De Bastiani MA, Brum WS, Ferreira PCL, Bieger A, et al. Soluble amyloid-beta isoforms predict downstream Alzheimer\u2019s disease pathology. Cell & Bioscience. 2021; 11: 204.","DOI":"10.1186\/s13578-021-00712-3"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Yang H, Jiang L, Zhang Y, Liang X, Tang J, He Q, et al. Anti-LINGO-1 antibody treatment alleviates cognitive deficits and promotes maturation of oligodendrocytes in the hippocampus of APP\/PS1 mice. The Journal of Comparative Neurology. 2022; 530: 1606\u20131621.","DOI":"10.1002\/cne.25299"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, et al. Adenomatous polyposis coli regulates oligodendroglial development. The Journal of Neuroscience. 2013; 33: 3113\u20133130.","DOI":"10.1523\/JNEUROSCI.3467-12.2013"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Sarkar S. Neurofibrillary tangles mediated human neuronal tauopathies: insights from fly models. Journal of Genetics. 2018; 97: 783\u2013793.","DOI":"10.1007\/s12041-018-0962-4"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Zhang M, Wang X, Jiang F, Wang W, Vincent I, Bu B. Mitotic epitopes are incorporated into age-dependent neurofibrillary tangles in Niemann-Pick disease type C. Brain Pathology. 2010; 20: 367\u2013377.","DOI":"10.1111\/j.1750-3639.2009.00286.x"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Ferrer I, Gomez-Isla T, Puig B, Freixes M, Rib\u00e9 E, Dalf\u00f3 E, et al. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer\u2019s disease and tauopathies. Current Alzheimer Research. 2005; 2: 3\u201318.","DOI":"10.2174\/1567205052772713"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"G\u00f6tz J, Tolnay M, Barmettler R, Chen F, Probst A, Nitsch RM. Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. The European Journal of Neuroscience. 2001; 13: 2131\u20132140.","DOI":"10.1046\/j.0953-816x.2001.01604.x"},{"key":"ref46","unstructured":"Nishimura M, Tomimoto H, Suenaga T, Namba Y, Ikeda K, Akiguchi I, et al. Immunocytochemical characterization of glial fibrillary tangles in Alzheimer\u2019s disease brain. The American Journal of Pathology. 1995; 146: 1052\u20131058."},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Papu\u0107 E, Rejdak K. The role of myelin damage in Alzheimer\u2019s disease pathology. Archives of Medical Science. 2018; 16: 345\u2013351.","DOI":"10.5114\/aoms.2018.76863"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Cai Z, Xiao M. Oligodendrocytes and Alzheimer\u2019s disease. The International Journal of Neuroscience. 2016; 126: 97\u2013104.","DOI":"10.3109\/00207454.2015.1025778"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Jhelum P, Santos-Nogueira E, Teo W, Haumont A, Leno\u00ebl I, Stys PK, et al. Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination. The Journal of Neuroscience. 2020; 40: 9327\u20139341.","DOI":"10.1523\/JNEUROSCI.1749-20.2020"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Friedrich I, Reimann K, Jankuhn S, Kirilina E, Stieler J, Sonntag M, et al. Cell specific quantitative iron mapping on brain slices by immuno-\u00b5PIXE in healthy elderly and Parkinson\u2019s disease. Acta Neuropathologica Communications. 2021; 9: 47.","DOI":"10.1186\/s40478-021-01145-2"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Wang Z, Yuan L, Li W, Li J. Ferroptosis in Parkinson\u2019s disease: glia-neuron crosstalk. Trends in Molecular Medicine. 2022; 28: 258\u2013269.","DOI":"10.1016\/j.molmed.2022.02.003"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Mukherjee C, Kling T, Russo B, Miebach K, Kess E, Schifferer M, et al. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metabolism. 2020; 32: 259\u2013272.e10.","DOI":"10.1016\/j.cmet.2020.05.019"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Baldacchino K, Peveler WJ, Lemgruber L, Smith RS, Scharler C, Hayden L, et al. Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system. Experimental Neurology. 2022; 354: 114113.","DOI":"10.1016\/j.expneurol.2022.114113"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Wyss-Coray T, Rogers J. Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harbor Perspectives in Medicine. 2012; 2: a006346.","DOI":"10.1101\/cshperspect.a006346"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Kenigsbuch M, Bost P, Halevi S, Chang Y, Chen S, Ma Q, et al. A shared disease-associated oligodendrocyte signature among multiple CNS pathologies. Nature Neuroscience. 2022; 25: 876\u2013886.","DOI":"10.1038\/s41593-022-01104-7"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation. The Journal of Neuroscience. 2006; 26: 10129\u201310140.","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, et al. A Unique Microglia Type Associated with Restricting Development of Alzheimer\u2019s Disease. Cell. 2017; 169: 1276\u20131290.e17.","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Habib N, McCabe C, Medina S, Varshavsky M, Kitsberg D, Dvir-Szternfeld R, et al. Disease-associated astrocytes in Alzheimer\u2019s disease and aging. Nature Neuroscience. 2020; 23: 701\u2013706.","DOI":"10.1038\/s41593-020-0624-8"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Venegas C, Heneka MT. Danger-associated molecular patterns in Alzheimer\u2019s disease. Journal of Leukocyte Biology. 2017; 101: 87\u201398.","DOI":"10.1189\/jlb.3MR0416-204R"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Chen W, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, et al. Spatial Transcriptomics and in Situ Sequencing to Study Alzheimer\u2019s Disease. Cell. 2020; 182: 976\u2013991.e19.","DOI":"10.1016\/j.cell.2020.06.038"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Lee S, Meilandt WJ, Xie L, Gandham VD, Ngu H, Barck KH, et al. Trem2 restrains the enhancement of tau accumulation and neurodegeneration by \u03b2-amyloid pathology. Neuron. 2021; 109: 1283\u20131301.e6.","DOI":"10.1016\/j.neuron.2021.02.010"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, et al. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nature Communications. 2017; 8: 717.","DOI":"10.1038\/s41467-017-00769-0"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Ji J, Qian L, Zhu Y, Wu Y, Guo J, Ma G, et al. Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway. Cellular Signalling. 2020; 75: 109745.","DOI":"10.1016\/j.cellsig.2020.109745"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Haile Y, Carmine-Simmen K, Olechowski C, Kerr B, Bleackley RC, Giuliani F. Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo. Journal of Neuroinflammation. 2015; 12: 157.","DOI":"10.1186\/s12974-015-0376-7"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, et al. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer\u2019s disease [published correction appears in Nature Medicine. 2020; 26: 981]. Nature Medicine. 2020; 26: 131\u2013142.","DOI":"10.1038\/s41591-020-0922-4"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Falc\u00e3o AM, van Bruggen D, Marques S, Meijer M, J\u00e4kel S, Agirre E, et al. Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis. Nature Medicine. 2018; 24: 1837\u20131844.","DOI":"10.1038\/s41591-018-0236-y"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, et al. Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model. Nature Neuroscience. 2019; 22: 719\u2013728.","DOI":"10.1038\/s41593-019-0372-9"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Masters CL, Bateman R, Blennow K, Rowe CC, Sperling RA, Cummings JL. Alzheimer\u2019s disease. Nature Reviews Disease Primers. 2015; 1: 15056.","DOI":"10.1038\/nrdp.2015.56"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Hashimoto R, Hori K, Owa T, Miyashita S, Dewa K, Masuyama N, et al. Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mechanisms of Development. 2016; 140: 25\u201340.","DOI":"10.1016\/j.mod.2016.02.004"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Pandey S, Shen K, Lee S, Shen YA, Wang Y, Otero-Garc\u00eda M, et al. Disease-associated oligodendrocyte responses across neurodegenerative diseases. Cell Reports. 2022; 40: 111189.","DOI":"10.1016\/j.celrep.2022.111189"}],"container-title":["Journal of Integrative Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/4\/10.31083\/j.jin2204090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T15:57:39Z","timestamp":1732723059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/JIN\/22\/4\/10.31083\/j.jin2204090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,7]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"alternative-id":["S0219-6352(22)00498-3"],"URL":"https:\/\/doi.org\/10.31083\/j.jin2204090","relation":{},"ISSN":["0219-6352","1757-448X"],"issn-type":[{"value":"0219-6352","type":"print"},{"value":"1757-448X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,7]]},"article-number":"90"}}