{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:16:47Z","timestamp":1770229007474,"version":"3.49.0"},"reference-count":38,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Committee of the University of Thessaly","award":["5287"],"award-info":[{"award-number":["5287"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: Microglial activation is considered to assume a role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). To date, the relationship between ALS and the rs3865444 polymorphism of the cluster of differentiation 33 (CD33) has not been explored. The current report aimed to investigate the potential connection between CD33 rs3865444 and ALS. Methods: Patients diagnosed with sporadic ALS according to the revised El Escorial criteria, as well as age and sex matched community controls, were enrolled. Two evenly numbered, age and sex matched groups of 155 participants each were genotyped. Results: No association was found between rs3865444 and ALS [log-additive odds ratio (OR) = 0.83 (0.57, 1.22), over-dominant OR = 0.86 (0.55, 1.36), recessive OR = 0.73 (0.25, 2.17), dominant OR = 0.82 (0.52, 1.29), co-dominant OR1 = 0.68 (0.23, 2.05) and co-dominant OR2 = 0.84 (0.53, 1.33)]. Moreover, no relationship was established between rs3865444 and the age of ALS onset based on both unadjusted and sex adjusted Cox-proportional hazards models. Finally, no association between rs3865444 and ALS was found in subgroup analyses based on the site of ALS onset (bulbar or spinal) and sex. Conclusions: The current analysis is the first to report that rs3865444 is not linked to ALS. Larger multi-racial studies are required to confirm these findings.<\/jats:p>","DOI":"10.31083\/j.jin2204106","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T05:42:19Z","timestamp":1690436539000},"source":"Crossref","is-referenced-by-count":2,"title":["Lack of Association between CD33 rs3865444 and Amyotrophic Lateral Sclerosis: A Case-Control Study"],"prefix":"10.31083","volume":"22","author":[{"given":"Vasileios","family":"Siokas","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Liampas","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina-Maria","family":"Aloizou","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Bakirtzis","sequence":"first","affiliation":[{"name":"B\u2019 Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zisis","family":"Tsouris","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Nousia","sequence":"first","affiliation":[{"name":"Department of Speech and Language Therapy, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigorios","family":"Nasios","sequence":"first","affiliation":[{"name":"Department of Speech and Language Therapy, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Papadimitriou","sequence":"first","affiliation":[{"name":"Neurological Department, Henry Dunant Hospital Center, 11526 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Lavdas","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of West Attica, 12243 Athens, Greece"},{"name":"Department of Medical Imaging, Animus Kyanoys Larisas Hospital, 41222 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Liakos","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios P.","family":"Bogdanos","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios M.","family":"Hadjigeorgiou","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"},{"name":"Department of Neurology, Medical School, University of Cyprus, 1678 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthimios","family":"Dardiotis","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41100 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Brooks BR. 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