{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:34:58Z","timestamp":1788280498199,"version":"build-2803163510"},"reference-count":51,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: The differences in the resting state spectral power and functional connectivity of the default mode network between people with migraine without aura (MwoA) and its subgroups differentiated by frequency (episodic migraine (EM) and chronic migraine (CM)) and healthy controls (HC) were investigated using magnetoencephalography. Methods: In the resting state, the topological spatial structure of the brain in 33 MwoA patients and 22 HC was first studied using magnetoencephalography, followed by probing the neuroelectrical activity of 17 CM and 16 EM patients, to identify damage to their default mode network (DMN). The techniques used to investigate both spectral power and functional connectivity were minimum-paradigm estimation combined with Welch\u2019s technique and corrected amplitude envelope correlation. Results: The differences between MwoA and its subgroups (CM and EM) and HC based on spectral power were mainly in the delta, theta, and alpha bands, while the differences in functional connectivity were primarily in the delta, alpha, and beta bands. In the delta and theta bands, the spectral power of MwoA and its subgroups (CM and EM) was higher than in the HC group. The spectral power of MwoA and its subgroups (CM and EM) was lower in the alpha band. In terms of functional connectivity, the corrected amplitude envelope correlation of MwoA and its subgroups (CM and EM) was lower than the HC group in the bands with spectral differences. People with EM and CM differed in the spectral power in the left medial prefrontal cortex and the right lateral temporal cortex in the alpha band, where correlation analysis and logistic regression analysis showed that the intensity of the spectral power of the left medial prefrontal cortex was negatively correlated with headache frequency. Conclusions: The spectral power of the left medial prefrontal cortex in the alpha band may serve as a biomarker that is associated with the number of monthly headache attacks and may be a potential neuromodulatory target for controlling migraine chronicity.<\/jats:p>","DOI":"10.31083\/j.jin2301019","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T19:38:32Z","timestamp":1706038712000},"source":"Crossref","is-referenced-by-count":11,"title":["Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine)"],"prefix":"10.31083","volume":"23","author":[{"given":"Xiaofang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Chen","sequence":"first","affiliation":[{"name":"MEG Center, The Affiliated Brain Hospital of Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangling","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Torres-Ferr\u00fas M, Ursitti F, Alpuente A, Brunello F, Chiappino D, de Vries T, et al. From transformation to chronification of migraine: pathophysiological and clinical aspects. Journal of Headache and Pain. 2020; 21: 42.","DOI":"10.1186\/s10194-020-01111-8"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Pozo-Rosich P, Coppola G, Pascual J, Schwedt TJ. How does the brain change in chronic migraine? Developing disease biomarkers. Cephalalgia. 2021; 41: 613\u2013630.","DOI":"10.1177\/0333102420974359"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Silberstein SD, Lipton RB, Sliwinski M. Classification of daily and near-daily headaches: Field trial of revised IHS criteria. Neurology. 1996; 47: 871\u2013875.","DOI":"10.1212\/WNL.47.4.871"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003; 106: 81\u201389.","DOI":"10.1016\/S0304-3959(03)00293-8"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. Journal of Neurology, Neurosurgery and Psychiatry. 2010; 81: 428\u2013432.","DOI":"10.1136\/jnnp.2009.192492"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Munakata J, Hazard E, Serrano D, Klingman D, Rupnow MFT, Tierce J, et al. Economic Burden of Transformed Migraine: Results from the American Migraine Prevalence and Prevention (AMPP) Study. Headache: the Journal of Head and Face Pain. 2009; 49: 498\u2013508.","DOI":"10.1111\/j.1526-4610.2009.01369.x"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Hsiao FJ, Chen WT, Liu HY, Wang YF, Chen SP, Lai KL, et al. Migraine chronification is associated with beta-band connectivity within the pain-related cortical regions. Pain. 2021; 162: 2590\u20132598.","DOI":"10.1097\/j.pain.0000000000002255"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Wen JJ, Gao YY, Li MT, Hu S, Zhao MQ, Su C, et al. Regional abnormalities of spontaneous brain activity in migraine: A coordinate-based meta-analysis. Journal of Neuroscience Research. 2023; 101: 1205\u20131223.","DOI":"10.1002\/jnr.25191"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences. 2003; 100: 253\u2013258.","DOI":"10.1073\/pnas.0135058100"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Buckner RL, Andrews-Hanna JR, Schacter DL. The brain\u2019s default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences. 2008; 1124: 1\u201338.","DOI":"10.1196\/annals.1440.011"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Edes AE, Kozak LR, Magyar M, Zsombok T, Kokonyei G, Bagdy G, et al. Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report. BMC Research Notes. 2017; 10: 165.","DOI":"10.1186\/s13104-017-2484-1"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Tessitore A, Russo A, Giordano A, Conte F, Corbo D, De Stefano M, et al. Disrupted default mode network connectivity in migraine without aura. Journal of Headache and Pain. 2013; 14: 89.","DOI":"10.1186\/1129-2377-14-89"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Lee MJ, Park BY, Cho S, Kim ST, Park H, Chung CS. Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study. Journal of Headache and Pain. 2019; 20: 29.","DOI":"10.1186\/s10194-019-0986-z"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Androulakis XM, Krebs K, Peterlin BL, Zhang T, Maleki N, Sen S, et al. Modulation of intrinsic resting-state fMRI networks in women with chronic migraine. Neurology. 2017; 89: 163\u2013169.","DOI":"10.1212\/WNL.0000000000004089"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wu T, Fan J, Chen Y, Xiang J, Zhu D, Zhang J, et al. Interictal Abnormalities of Neuromagnetic Gamma Oscillations in Migraine Following Negative Emotional Stimulation. Frontiers in Behavioral Neuroscience. 2018; 12: 169.","DOI":"10.3389\/fnbeh.2018.00169"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38: 1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013; 33: 629\u2013808.","DOI":"10.1177\/0333102413485658"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Kanamori Y, Shigeto H, Hironaga N, Hagiwara K, Uehara T, Chatani H, et al. Minimum norm estimates in MEG can delineate the onset of interictal epileptic discharges: a comparison with ECoG findings. NeuroImage: Clinical. 2013; 2: 663\u2013669.","DOI":"10.1016\/j.nicl.2013.04.008"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Niso G, Tadel F, Bock E, Cousineau M, Santos A, Baillet S. Brainstorm Pipeline Analysis of Resting-State Data From the Open MEG Archive. Frontiers in Neuroscience. 2019; 13: 284.","DOI":"10.3389\/fnins.2019.00284"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Colclough GL, Woolrich MW, Tewarie PK, Brookes MJ, Quinn AJ, Smith SM. How reliable are MEG resting-state connectivity metrics? NeuroImage. 2016; 138: 284\u2013293.","DOI":"10.1016\/j.neuroimage.2016.05.070"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Brookes MJ, Hale JR, Zumer JM, Stevenson CM, Francis ST, Barnes GR, et al. Measuring functional connectivity using MEG: Methodology and comparison with fcMRI. NeuroImage. 2011; 56: 1082\u20131104.","DOI":"10.1016\/j.neuroimage.2011.02.054"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Colclough GL, Brookes MJ, Smith SM, Woolrich MW. A symmetric multivariate leakage correction for MEG connectomes. NeuroImage. 2015; 117: 439\u2013448.","DOI":"10.1016\/j.neuroimage.2015.03.071"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003; 126: 1079\u20131091.","DOI":"10.1093\/brain\/awg102"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Aderjan D, Stankewitz A, May A. Neuronal mechanisms during repetitive trigemino-nociceptive stimulation in migraine patients. Pain. 2010; 151: 97\u2013103.","DOI":"10.1016\/j.pain.2010.06.024"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, et al. Painful Heat Reveals Hyperexcitability of the Temporal Pole in Interictal and Ictal Migraine States. Cerebral Cortex. 2011; 21: 435\u2013448.","DOI":"10.1093\/cercor\/bhq109"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Afridi SK, Giffin NJ, Kaube H, Friston KJ, Ward NS, Frackowiak RS, et al. A Positron Emission Tomographic Study in Spontaneous Migraine. Archives of Neurology. 2005; 62: 1270\u20131275.","DOI":"10.1001\/archneur.62.8.1270"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98: 676\u2013682.","DOI":"10.1073\/pnas.98.2.676"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Zhang J, Su J, Wang M, Zhao Y, Yao Q, Zhang Q, et al. Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura. The Journal of Headache and Pain. 2016; 17: 98.","DOI":"10.1186\/s10194-016-0692-z"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Szabo E, Green S, Karunakaran KD, Sieberg CB, Elman I, Burstein R, et al. Migraine: interactions between brain\u2019s trait and state. CNS Spectrums. 2022; 27: 561\u2013569.","DOI":"10.1017\/S109285292100064X"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Le Pira F, Zappal\u00e0 G, Giuffrida S, Lo Bartolo M, Reggio E, Morana R, et al. Memory Disturbances in Migraine with and without Aura: a Strategy Problem? Cephalalgia. 2000; 20: 475\u2013478.","DOI":"10.1046\/j.1468-2982.2000.00074.x"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Camarda C, Monastero R, Pipia C, Recca D, Camarda R. Interictal Executive Dysfunction in Migraineurs without Aura: Relationship with Duration and Intensity of Attacks. Cephalalgia. 2007; 27: 1094\u20131100.","DOI":"10.1111\/j.1468-2982.2007.01394.x"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Pellegrino Baena C, Goulart AC, Santos IDS, Suemoto CK, Lotufo PA, Bensenor IJ. Migraine and cognitive function: Baseline findings from the Brazilian Longitudinal Study of Adult Health: ELSA-Brasil. Cephalalgia. 2018; 38: 1525\u20131534.","DOI":"10.1177\/0333102417737784"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Yu D, Yuan K, Zhao L, Zhao L, Dong M, Liu P, et al. Regional homogeneity abnormalities in patients with interictal migraine without aura: a resting-state study. NMR in Biomedicine. 2012; 25: 806\u2013812.","DOI":"10.1002\/nbm.1796"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Farag\u00f3 P, Szab\u00f3 N, T\u00f3th E, Tuka B, Kir\u00e1ly A, Csete G, et al. Ipsilateral Alteration of Resting State Activity Suggests that Cortical Dysfunction Contributes to the Pathogenesis of Cluster Headache. Brain Topography. 2017; 30: 281\u2013289.","DOI":"10.1007\/s10548-016-0535-x"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Hu S, Hao Z, Li M, Zhao M, Wen J, Gao Y, et al. Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis. Frontiers in Neuroscience. 2023; 17: 1136790.","DOI":"10.3389\/fnins.2023.1136790"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Gomez-Pilar J, Garc\u00eda-Azor\u00edn D, Gomez-Lopez-de-San-Roman C, Guerrero \u00c1L, Hornero R. Exploring EEG Spectral Patterns in Episodic and Chronic Migraine during the Interictal State: Determining Frequencies of Interest in the Resting State. Pain Medicine. 2020; 21: 3530\u20133538.","DOI":"10.1093\/pm\/pnaa117"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Pan LH, Chen WT, Wang YF, Chen SP, Lai KL, Liu HY, et al. Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine. Pain. 2022; 163: 1324\u20131334.","DOI":"10.1097\/j.pain.0000000000002516"},{"key":"ref38","unstructured":"Kremenchugskaia MR, VIu O, Sokolov PL, Filatova EG. Bioelectrical activity of the brain in paroxysmal and chronic forms of primary headache. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2003; 103: 38\u201342. (In Russian)"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Cao Z, Lin CT, Chuang CH, Lai KL, Yang AC, Fuh JL, et al. Resting-state EEG power and coherence vary between migraine phases. Journal of Headache and Pain. 2016; 17: 102.","DOI":"10.1186\/s10194-016-0697-7"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Stern J, Jeanmonod D, Sarnthein J. Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients. NeuroImage. 2006; 31: 721\u2013731.","DOI":"10.1016\/j.neuroimage.2005.12.042"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Wu S, Ren X, Zhu C, Wang W, Zhang K, Li Z, et al. A c-Fos activation map in nitroglycerin\/levcromakalim-induced models of migraine. Journal of Headache and Pain. 2022; 23: 128.","DOI":"10.1186\/s10194-022-01496-8"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Chen XY, Chen ZY, Dong Z, Liu MQ, Yu SY. Regional volume changes of the brain in migraine chronification. Neural Regeneration Research. 2020; 15: 1701\u20131708.","DOI":"10.4103\/1673-5374.276360"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Ong WY, Stohler CS, Herr DR. Role of the Prefrontal Cortex in Pain Processing. Molecular Neurobiology. 2019; 56: 1137\u20131166.","DOI":"10.1007\/s12035-018-1130-9"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Misra G, Wang WE, Archer DB, Roy A, Coombes SA. Automated classification of pain perception using high-density electroencephalography data. Journal of Neurophysiology. 2017; 117: 786\u2013795.","DOI":"10.1152\/jn.00650.2016"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Seminowicz DA, Davis KD. Cortical responses to pain in healthy individuals depends on pain catastrophizing. Pain. 2006; 120: 297\u2013306.","DOI":"10.1016\/j.pain.2005.11.008"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Perlaki G, Orsi G, Schwarcz A, Bodi P, Plozer E, Biczo K, et al. Pain-related autonomic response is modulated by the medial prefrontal cortex: an ECG\u2013fMRI study in men. Journal of the Neurological Sciences. 2015; 349: 202\u2013208.","DOI":"10.1016\/j.jns.2015.01.019"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Chung G, Kim CY, Yun YC, Yoon SH, Kim MH, Kim YK, et al. Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats. Scientific Reports. 2017; 7: 9743.","DOI":"10.1038\/s41598-017-09991-8"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Vincent JL, Snyder AZ, Fox MD, Shannon BJ, Andrews JR, Raichle ME, et al. Coherent Spontaneous Activity Identifies a Hippocampal-Parietal Memory Network. Journal of Neurophysiology. 2006; 96: 3517\u20133531.","DOI":"10.1152\/jn.00048.2006"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Margulies DS, Vincent JL, Kelly C, Lohmann G, Uddin LQ, Biswal BB, et al. Precuneus shares intrinsic functional architecture in humans and monkeys. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106: 20069\u201320074.","DOI":"10.1073\/pnas.0905314106"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Leech R, Braga R, Sharp DJ. Echoes of the Brain within the Posterior Cingulate Cortex. Journal of Neuroscience. 2012; 32: 215\u2013222.","DOI":"10.1523\/JNEUROSCI.3689-11.2012"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Torres-Ferr\u00fas M, Quintana M, Fernandez-Morales J, Alvarez-Sabin J, Pozo-Rosich P. When does chronic migraine strike? A clinical comparison of migraine according to the headache days suffered per month. 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