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Neurosci."],"abstract":"<jats:p>Purpose: To determine whether individuals with subjective cognitive decline (SCD) have changes in whole-brain network characteristics and intracerebral node characteristics in the structural network, and whether there is a difference between SCD with and without Apolipoprotein E4 (APOE\u03b54). Methods: This cross-sectional study included 36 individuals without SCD without APOE\u03b54 (healthy control, HC group), 21 individuals with SCD with APOE\u03b54 (APOE\u03b54+ group), and 33 individuals with SCD without APOE\u03b54 (APOE\u03b54- group). The white matter structural network was constructed using the fractional anisotropy (FA) based deterministic fiber tracking method. Graph theory was used to analyze the whole-brain network characteristics and intracerebral node characteristics of the three groups. Results: Regarding the whole-brain network characteristics, all three groups exhibited small-worldness in their structural networks. The clustering coefficient (Cp) and local efficiency (Eloc) in the APOE\u03b54+ and APOE\u03b54- groups were significantly lower than in the HC group (p &lt; 0.05), but no significant difference in Cp or Eloc was observed between the APOE\u03b54+ and APOE\u03b54- groups. Regarding intracerebral node characteristics, there were significant differences in some brain regions, mainly the default mode network (DMN), the occipital lobe, the temporal lobe, and subcortical regions. The change in intracerebral node characteristics was different between the APOE\u03b54+ group and the APOE\u03b54- group. Conclusions: Individuals with SCD demonstrate changes in whole-brain network characteristics and intracerebral node characteristics in the structural network. Moreover, differences exist between APOE\u03b54+ and APOE\u03b54- individuals.<\/jats:p>","DOI":"10.31083\/j.jin2306117","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T09:26:52Z","timestamp":1718357212000},"source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of the White Matter Structural Network in Individuals with Subjective Cognitive Decline with and without APOE\u03b54 Based on Graph Theory Study"],"prefix":"10.31083","volume":"23","author":[{"given":"Simin","family":"Deng","sequence":"first","affiliation":[{"name":"School of Public Health, Sun Yat-sen University, 510080 Guangzhou, Guangdong, China"},{"name":"Department of Rehabilitation Medicine, Dongguan Eighth People\u2019s Hospital, 523000 Dongguan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Chen","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, 523000 Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suibin","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Dongguan Eighth People\u2019s Hospital, 523000 Dongguan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huote","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Dongguan Eighth People\u2019s Hospital, 523000 Dongguan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Radiology, Dongguan Eighth People\u2019s Hospital, 523000 Dongguan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Rabin LA, Smart CM, Amariglio RE. 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