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Integr. Neurosci."],"abstract":"<jats:p>Background: Physical exercise has been shown to be beneficial for individuals with Alzheimer\u2019s disease (AD), although the underlying mechanisms are not fully understood. Methods: Six-month-old Amyloid precursor protein\/Presenilin 1 (APP\/PS1) transgenic (Tg) mice and wild-type (Wt) mice were randomly assigned to either a sedentary group (Tg-Sed, Wt-Sed) or an exercise group (Tg-Ex, Wt-Ex) undertaking a 12-week, moderate-intensity treadmill running program. Consequently, all mice were tested for memory function and amyloid \u03b2 (A\u03b2) levels and phosphorylation of tau and protein kinase B (Akt)\/glycogen synthase kinase-3 (GSK3) were examined in tissues of both the cortex and hippocampus. Results: Tg-Sed mice had severely impaired memory, higher levels of A\u03b2, and increased phosphorylation of tau, GSK3\u03b1 tyrosine279, and GSK3\u03b2 tyrosine216, but less phosphorylation of GSK3\u03b1 serine21, GSK3\u03b2 serine9, and Akt serine473 in both tissues than Wt-Sed mice in respective tissues. Tg-Ex mice showed significant improvement in memory function along with lower levels of A\u03b2 and less phosphorylation of tau (both tissues), GSK3\u03b1 tyrosine279 (both tissues), and GSK3\u03b2 tyrosine216 (hippocampus only), but increased phosphorylation of GSK3\u03b1 serine21 (both tissues), GSK3\u03b2 serine9 (hippocampus only), and Akt serine473 (both tissues) compared with Tg-Sed mice in respective tissues. Conclusions: Moderate-intensity aerobic exercise is highly effective in improving memory function in 9-month-old APP\/PS1 mice, most likely through differential modulation of GSK3\u03b1\/\u03b2 phosphorylation in the cortex and hippocampus.<\/jats:p>","DOI":"10.31083\/j.jin2307136","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T09:33:16Z","timestamp":1721986396000},"source":"Crossref","is-referenced-by-count":5,"title":["Moderate-Intensity Treadmill Exercise Regulates GSK3\u03b1\/\u03b2 Activity in the Cortex and Hippocampus of APP\/PS1 Transgenic Mice"],"prefix":"10.31083","volume":"23","author":[{"given":"Peng","family":"Han","sequence":"first","affiliation":[{"name":"College of Sports and Human Sciences, Harbin Sport University, 150008 Harbin, Heilongjiang, China"},{"name":"Department of Exercise Physiology, Beijing Sport University, 100084 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Gu","sequence":"first","affiliation":[{"name":"China Institute of Sport and Health Science, Beijing Sport University, 100084 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianwei","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, Beijing Sport University, 100084 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Guo","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Community Medicine and Rehabilitation, Sports Medicine Unit, Ume\u00e5 University, 90187 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, Beijing Sport University, 100084 Beijing, China"},{"name":"China Institute of Sport and Health Science, Beijing Sport University, 100084 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"De Strooper B, Karran E. 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