{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:41:54Z","timestamp":1789962114236,"version":"4.0.1"},"reference-count":38,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Purpose: To investigate the relationship of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) parameters with dysfunction in acute focal cerebral ischemia (ACI) rabbits. Methods: The model of ACI in the middle cerebral artery was made using 30 adult male New Zealand rabbits. The dysfunction severities of the ACI rabbits were assessed using Purdy\u2019s score. A paired-sample rank sum test was adopted to compare the abnormal signal zone (ASZ) volumes from T2 weighted imaging (T2WI), dynamic susceptibility contrast-enhanced (DSC) imaging, and DWI with a relative cerebral blood flow (rCBF) map; correlations were analyzed between the volume of each ASZ and Purdy\u2019s score by Spearman\u2019s rank correlation coefficient. The degree of necrotic and apoptotic cells was evaluated in the ASZ from DWI and DSC PWI-DWI mismatch (PDM) zone. Correlations were analyzed between the index of cellular damage and Purdy\u2019s score, the volume of ASZs by Spearman\u2019s rank correlation coefficient. Results: The ASZ volumes from DSC-PWI and the rCBF maps were larger than those from DWI (p &lt; 0.001 and p &lt; 0.001, respectively); those from the rCBF map (Z = 0.959, p &lt; 0.001) and DSC-PWI (Z = 0.970, p &lt; 0.001) were positively correlated with DWI; a positive correlation was found between Purdy\u2019s score and the ASZ volumes from DSC-PWI (Z = 0.889, p &lt; 0.001), DWI (Z = 0.921, p &lt; 0.001), and rCBF (Z = 0.891, p &lt; 0.001). A significant difference was observed between the ASZ from DWI and the PDM zone in terms of the degree of necrotic (p &lt; 0.001) and apoptotic cells (p &lt; 0.001). The degree of cellular damage in the ASZ of DWI and PDM zone had no relationship with Purdy\u2019s score and the volumes of ASZs. Conclusion: The ASZ volumes from DSC-PWI, rCBF, and particularly DWI reflected the level of dysfunction in rabbits with ACI.<\/jats:p>","DOI":"10.31083\/j.jin2308156","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T10:04:28Z","timestamp":1724925868000},"source":"Crossref","is-referenced-by-count":3,"title":["Diffusion- and Perfusion-Weighted Imaging to Detect Neurological Deficits in Acute Focal Cerebral Ischemia in Rabbits"],"prefix":"10.31083","volume":"23","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, The 901st Hospital of the Joint Logistics Support Force of PLA, 230031 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Deng","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Anhui Medical University, 230032 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangdong","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Radiology, The 901st Hospital of the Joint Logistics Support Force of PLA, 230031 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, The 901st Hospital of the Joint Logistics Support Force of PLA, 230031 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Radiology, The 901st Hospital of the Joint Logistics Support Force of PLA, 230031 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, The 901st Hospital of the Joint Logistics Support Force of PLA, 230031 Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Kim BJ, Kang HG, Kim HJ, Ahn SH, Kim NY, Warach S, et al. 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