{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:23:55Z","timestamp":1768314235151,"version":"3.49.0"},"reference-count":37,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: Sleep patterns often shift as people age, a phenomenon frequently associated with the onset of neurodegenerative conditions. Additionally, distinct alterations occur in brain structure as individuals grow older, particularly within the hippocampus, a region known for its role in cognition and sleep regulation. Yet, how exactly do changes in sleep relate to specific subfields within the hippocampus is still unclear. Methods: We conducted a study involving non-demented healthy adults from the Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) cohort. Participants underwent objective sleep measurements using wrist Actiwatch and WatchPAT devices. Further, all participants underwent the same Magnetic Resonance Imaging (MRI) protocol, including a 3D high resolution T1-weighted sequence, on the same 3.0 Tesla MRI scanner using an eight-channel head coil. The study aimed to examine the relationship between objectively measured sleep metrics and the morphology of twenty-two distinct hippocampal subregions. Results: In total, 75 non-demented participants with 63 mean years of age were included in the study. Results indicated that a higher frequency of awakenings during sleep was associated with increased volume in the right presubiculum body (beta = 0.630, p False Discovery Rate (FDR) &lt;0.036). Longer sleep duration showed a tendency to be associated with smaller volumes of the right presubiculum body, hinting at a possible negative impact of prolonged sleep on this brain region. Similar trends were observed regarding sleep apnea and the presubiculum body volume. Further analysis based on age stratification revealed that in younger participants, longer sleep duration was linked to decreased volume of the presubiculum body, while a greater number of awakenings was correlated with increased volume of the same region. Among older participants, higher frequencies of awakenings were associated with larger volumes in various hippocampal subfields. Conclusions: These findings shed light on the complex relationship between sleep characteristics and brain structure, highlighting potential age-related differences. The study provides valuable insights into how sleep disruptions may impact hippocampal morphology and cognitive function of cognitively healthy adults. Further research is warranted to elucidate the underlying mechanisms and implications for neurodegenerative diseases.<\/jats:p>","DOI":"10.31083\/j.jin2308159","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T10:04:28Z","timestamp":1724925868000},"source":"Crossref","is-referenced-by-count":3,"title":["Objective Sleep Function is Associated with Hippocampal Subfield Volumes in Community-Dwelling Adults"],"prefix":"10.31083","volume":"23","author":[{"given":"Niki","family":"Mourtzi","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki","family":"Tsapanou","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"},{"name":"Department of Neurology, Columbia University, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renia","family":"Morfakidou","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Angelopoulou","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Constantinides","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ntanasi","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Mamalaki","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Yannakoulia","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopeio University, 17676 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstratios","family":"Karavasilis","sequence":"first","affiliation":[{"name":"Research Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foteini","family":"Christidi","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Velonakis","sequence":"first","affiliation":[{"name":"Research Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Scarmeas","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"},{"name":"Department of Neurology, Columbia University, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"De Looze C, Feeney JC, Scarlett S, Hirst R, Knight SP, Carey D, et al. 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