{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:14:02Z","timestamp":1793736842401,"version":"4.6.1"},"reference-count":149,"publisher":"IMR Press","issue":"12","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaanxi province key R & D plan-key industry innovation chain (group) project","award":["2024SF-ZDCYL-03-21"],"award-info":[{"award-number":["2024SF-ZDCYL-03-21"]}]},{"name":"The construction project of Shaanxi Provincial Academician Workstation-Wu Yiling Academician Workstation","award":["Shaanxi Group Tongzi [2019] No.49-30"],"award-info":[{"award-number":["Shaanxi Group Tongzi [2019] No.49-30"]}]},{"name":"Shaanxi Provincial Administration of Traditional Chinese Medicine Research Project of Traditional Chinese Medicine","award":["SZY-KJCYC-2023-009"],"award-info":[{"award-number":["SZY-KJCYC-2023-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>The coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be a promising focus in understanding and addressing the development of treatments for comorbid CHD and anxiety or depression. The HPA axis helps to regulate the levels of inflammatory factors, thereby reducing oxidative stress damage, promoting platelet activation, and stabilizing gut microbiota, which enhance the survival and regeneration of neurons, endothelial cells, and other cell types, leading to neuroprotective and cardioprotective benefits. This review addresses the relevance of the HPA axis to the cardiovascular and nervous systems, as well as the latest research advancements regarding its mechanisms of action. The discussion includes a detailed function of the HPA axis in regulating the processes mentioned. Above all, it summarizes the therapeutic potential of HPA axis function as a biomarker for coronary atherosclerotic heart disease combined with anxiety or depression.<\/jats:p>","DOI":"10.31083\/j.jin2312222","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T11:05:21Z","timestamp":1735556721000},"source":"Crossref","is-referenced-by-count":25,"title":["Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and\/or Depression in Coronary Artherosclerotic Heart Disease"],"prefix":"10.31083","volume":"23","author":[{"given":"Lan-Shuan","family":"Feng","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Wang","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"},{"name":"The Department of Traditional Chinese Medicine, the First Affiliated Hospital of the Air Force Military Medical University, 710038 Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ning","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-Bin","family":"Yu","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Lin","family":"Li","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Wang","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"},{"name":"Department of Cardiology, Affiliated Hospital of Shaanxi University of Chinese Medicine, 712000 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jun","family":"Zhao","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"},{"name":"Department of Cardiology, Affiliated Hospital of Shaanxi University of Chinese Medicine, 712000 Xianyang, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, China"},{"name":"The Department of Traditional Chinese Medicine, the First Affiliated Hospital of the Air Force Military Medical University, 710038 Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Opotowsky AR, Khairy P, Diller G, Kasparian NA, Brophy J, Jenkins K, et al. 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