{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:25:56Z","timestamp":1759991156721,"version":"3.41.2"},"reference-count":0,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Sudden cardiac death in athletes is rare and most oftenunexpectable. For a better understanding of cardiac remodeling,this study presents the effects of chronic vigorousexercise on cardiac structure and electrophysiologyin new rabbit and dog athlete\u2019s heart models. Rabbitsand dogs were randomized into sedentary (\u2018Sed\u2019), exercised(subjected to 16 weeks chronic treadmill exercise(\u2018Ex\u2019) groups, and a testosterone-treated (\u2018Dop\u2019) group indogs. Echocardiography and electrocardiogram wereperformed. Proarrhythmic sensitivity and autonomic responseswere tested in conscious dogs. \u2018Ex\u2019 animalsexhibited left ventricular enlargement with bradycardia(mean RR in \u2018Ex\u2019 vs. \u2018Sed\u2019 rabbits: 335\u00b1 15 vs. 288 \u00b119 ms, p \u2264 0.05, and in \u2018Dop\u2019 vs. \u2018Ex\u2019 vs. \u2018Sed\u2019 dogs:718\u00b1 6 vs. 638\u00b1 38 vs. 599\u00b1 49 ms) accompaniedby an increase of heart rate variability in both species(e.g. SD RR in \u2018Ex\u2019 vs. \u2018Sed\u2019 rabbits: 3.4\u00b1 0.9 vs. 1.4\u00b1 0.1 ms, p \u2264 0.05, and in \u2018Dop\u2019 vs. \u2018Ex\u2019 vs. \u2018Sed\u2019 dogs:156\u00b1 59 vs. 163\u00b1 44 vs. 111\u00b1 49 ms) indicatingan increased vagal tone. A lower response to parasympatholyticagent atropine and more pronounced QTc intervallengthening after dofetilide challenge were found in'Ex\u2019 and 'Dop\u2019 dogs compared to the \u2018Sed\u2019 group. Nomorphological and functional changes were found afterchronic steroid treatment in dogs. The structural-functionalfindings share more similarities with human athlete\u2019s heart.Slight repolarization sensitivity in the exercised dogs mayindicate an increased risk of arrhythmias in athletes underdifferent circumstances. These animal models might beuseful for the further investigations of the cardiovasculareffects of competitive training.<\/jats:p>","DOI":"10.31083\/j.rcm.2018.04.4161","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T03:13:40Z","timestamp":1557285220000},"source":"Crossref","is-referenced-by-count":9,"title":["Long-term endurance training-induced cardiac adaptation in new rabbit and dog animal models of the human athlete's heart"],"prefix":"10.31083","volume":"19","author":[{"given":"Alexandra","family":"Poly\u00e1k","sequence":"first","affiliation":[{"name":"Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged H-6725, Hungary"},{"name":"MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Kui","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolett","family":"Morvay","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Lepr\u00e1n","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"\u00c1goston","sequence":"first","affiliation":[{"name":"Institute and Outpatient Department of Family Medicine, University of Szeged, HungaryInstitute of Family Medicine, University of Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Varga","sequence":"first","affiliation":[{"name":"Institute and Outpatient Department of Family Medicine, University of Szeged, HungaryInstitute of Family Medicine, University of Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Nagy","sequence":"first","affiliation":[{"name":"MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged H-6720, Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Baczk\u00f3","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Farkas","sequence":"first","affiliation":[{"name":"Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged H-6725, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius Gy.","family":"Papp","sequence":"first","affiliation":[{"name":"MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged H-6720, Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Varr\u00f3","sequence":"first","affiliation":[{"name":"MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged H-6720, Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged H-6720, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila S.","family":"Farkas","sequence":"first","affiliation":[{"name":"Second Department of Medicine and Cardiology Centre, University of Szeged, Szeged H-6725, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2018,12,30]]},"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/19\/4\/10.31083\/j.rcm.2018.04.4161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:53:03Z","timestamp":1732726383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/19\/4\/10.31083\/j.rcm.2018.04.4161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,30]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"alternative-id":["1557131839196-2019654055"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm.2018.04.4161","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"type":"print","value":"1530-6550"},{"type":"electronic","value":"2153-8174"}],"subject":[],"published":{"date-parts":[[2018,12,30]]},"article-number":"135"}}